Jun Udagawa

Summary

Affiliation: Shimane University
Country: Japan

Publications

  1. ncbi request reprint Roles of leptin in prenatal and perinatal brain development
    Jun Udagawa
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 47:77-83. 2007
  2. ncbi request reprint Leptin deficiency causes pycnotic change in fetal cingulate cortical cells
    Jun Udagawa
    Research Project Promotion Institute, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 46:16-20. 2006
  3. doi request reprint Analysis of the harmonized growth pattern of fetal organs by multidimensional scaling and hierarchical clustering
    Jun Udagawa
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 50:175-85. 2010
  4. ncbi request reprint The role of leptin in the development of the cortical neuron in mouse embryos
    Jun Udagawa
    Research Project Promotion Institute, Shimane University, Izumo 693 8501, Japan
    Brain Res 1120:74-82. 2006
  5. ncbi request reprint Leptin affects oligodendroglial development in the mouse embryonic cerebral cortex
    Jun Udagawa
    Research Project Promotion Institute, Shimane University, Izumo, Japan
    Neuro Endocrinol Lett 27:177-82. 2006
  6. doi request reprint Leptin and its intracellular signaling pathway maintains the neurosphere
    Jun Udagawa
    Department of Developmental Biology, Shimane University, Izumo, Japan
    Neuroreport 21:1140-5. 2010
  7. ncbi request reprint The role of leptin in the development of the cerebral cortex in mouse embryos
    Jun Udagawa
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Endocrinology 147:647-58. 2006
  8. doi request reprint Effect of leptin administration on myelination in ob/ob mouse cerebrum after birth
    Ryuju Hashimoto
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Neuroreport 24:22-9. 2013
  9. doi request reprint Ror2 is required for midgut elongation during mouse development
    Makiko Yamada
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Dev Dyn 239:941-53. 2010
  10. doi request reprint Mathematical analysis of mandibular morphogenesis by micro-CT-based mouse and alizarin red S-stained-based human studies during development
    Ashiq Mahmood Rafiq
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
    Anat Rec (Hoboken) 295:313-27. 2012

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Roles of leptin in prenatal and perinatal brain development
    Jun Udagawa
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 47:77-83. 2007
    ....
  2. ncbi request reprint Leptin deficiency causes pycnotic change in fetal cingulate cortical cells
    Jun Udagawa
    Research Project Promotion Institute, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 46:16-20. 2006
    ..Leptin deficiency may also alter the gross morphology of the brain in development, but not the formation of the corpus callosum...
  3. doi request reprint Analysis of the harmonized growth pattern of fetal organs by multidimensional scaling and hierarchical clustering
    Jun Udagawa
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 50:175-85. 2010
    ..These relationships include the existence of common factors in organ development, such as cross-talk mediated by humoral factors, and the presence of an anatomical and functional relationship in the fetal circulatory system...
  4. ncbi request reprint The role of leptin in the development of the cortical neuron in mouse embryos
    Jun Udagawa
    Research Project Promotion Institute, Shimane University, Izumo 693 8501, Japan
    Brain Res 1120:74-82. 2006
    ..These results suggest that leptin promotes the migration of neuronal lineage cells to CP and that the leptin-NPY axis in neurons works in the cerebral cortex on E16...
  5. ncbi request reprint Leptin affects oligodendroglial development in the mouse embryonic cerebral cortex
    Jun Udagawa
    Research Project Promotion Institute, Shimane University, Izumo, Japan
    Neuro Endocrinol Lett 27:177-82. 2006
    ..These findings suggest that leptin affects the development of glial cells. In this study, therefore, we investigated oligodendrocyte development in the cerebral cortex of ob/ob and wild-type mouse embryos by histochemistry...
  6. doi request reprint Leptin and its intracellular signaling pathway maintains the neurosphere
    Jun Udagawa
    Department of Developmental Biology, Shimane University, Izumo, Japan
    Neuroreport 21:1140-5. 2010
    ..These results suggest that leptin maintains the self-renewal ability and EGF reactivity of immature neural lineage cells and the signal is mediated, at least in part, by the PI3 K pathway...
  7. ncbi request reprint The role of leptin in the development of the cerebral cortex in mouse embryos
    Jun Udagawa
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Endocrinology 147:647-58. 2006
    ..The neuropeptide Y mRNA level in the cortical plate was lower in ob/ob than the wild type at E16 and E18. These results suggest that leptin maintains neural progenitors and is related to glial and neuronal development in embryos...
  8. doi request reprint Effect of leptin administration on myelination in ob/ob mouse cerebrum after birth
    Ryuju Hashimoto
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Neuroreport 24:22-9. 2013
    ..Our results suggested that leptin regulates the myelination of oligodendrocytes and that the replenishment of leptin in OB recovered myelination but did not affect the differentiation of OPCs from P7 to P28...
  9. doi request reprint Ror2 is required for midgut elongation during mouse development
    Makiko Yamada
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Dev Dyn 239:941-53. 2010
    ..These findings suggest that Ror2 plays important roles in midgut elongation by means of an epithelial convergent extension mechanism...
  10. doi request reprint Mathematical analysis of mandibular morphogenesis by micro-CT-based mouse and alizarin red S-stained-based human studies during development
    Ashiq Mahmood Rafiq
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
    Anat Rec (Hoboken) 295:313-27. 2012
    ..These results suggest that TPS and Procrustes analyses are useful for assessing the morphogenesis and deformity of the mandible...
  11. doi request reprint Individual variation in organ histogenesis as a causative factor in the developmental origins of health and disease: unnoticed congenital anomalies?
    Hiroki Otani
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
    Congenit Anom (Kyoto) 50:205-11. 2010
    ....
  12. ncbi request reprint Expression of regenerating gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival
    Dipok Kumar Dhar
    Second Department of Surgery, Shimane Medical University, Izumo, Japan
    Cancer 100:1130-6. 2004
    ..REG expression was observed in various tumors including gastric carcinoma, but to the authors' knowledge, the correlation between REG expression and clinicopathologic characteristics and patient prognosis have not been evaluated...
  13. doi request reprint Adrenocorticotropic tumor cells transplanted into mouse embryos affect pancreatic histogenesis
    Mai Kawamoto
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 51:62-9. 2011
    ..These results suggest that the high level of ACTH and/or glucocorticoid affects histogenesis of the pancreas...
  14. doi request reprint Interkinetic nuclear migration during early development of midgut and ureteric epithelia
    Makiko Yamada
    Department of Developmental Biology, Shimane University, Enya cho, Izumo, Shimane, Japan
    Anat Sci Int 88:31-7. 2013
    ..Our findings reveal INM in gut and ureteric progenitors that is similar to that in ventricular neurogenesis, and suggest that INM is a general strategy for the expansion of epithelial progenitors...
  15. ncbi request reprint Quantitative analyses of leukemia inhibitory factor in the cerebrospinal fluid in mouse embryos
    Toshihisa Hatta
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
    Neuroreport 17:1863-6. 2006
    ..These findings correspond to the timing of cortical neuron production in mouse cerebrum...
  16. doi request reprint Direct and indirect effects of neuropeptide Y and neurotrophin 3 on myelination in the neonatal brains
    Ryuju Hashimoto
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Brain Res 1373:55-66. 2011
    ..These results suggest that NPY, partially via Y1R, induces NT3 which, via Trk C phosphorylation, accelerates myelination by oligodendrocytes in the mouse brain during the neonatal period...
  17. ncbi request reprint Maternal environment affects endogenous virus induction in the offspring of type 1 diabetes model non-obese diabetic mice
    Yukiko Kagohashi
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
    Congenit Anom (Kyoto) 45:80-4. 2005
    ..These findings suggest that the observed virus is endogenous and that maternal environmental factors, including hormone levels, affect the induction of endogenous viruses and cause the earlier onset of insulitis...
  18. doi request reprint Fetal jaw movement affects Ihh signaling in mandibular condylar cartilage development: the possible role of Ihh as mechanotransduction mediator
    Esrat Jahan
    Department of Developmental Biology, Faculty of Medicine, Shimane University, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan Electronic address
    Arch Oral Biol 59:1108-18. 2014
    ..We hypothesized that this treatment affects the expression of mechanosensitive molecules, namely Indian hedgehog (Ihh) and Parathyroid hormone related protein (PTHrP) in the condyle...
  19. ncbi request reprint Development of the pons in human fetuses
    Toshihisa Hatta
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
    Congenit Anom (Kyoto) 47:63-7. 2007
    ..According to Weigert stained preparations, the first myelinated fibers in each motor root of the trigeminal, abducent, and facial nerves were recognized at 130-140 mm in CRL and the medial lemniscus at 230-235 mm...
  20. doi request reprint Development of olfactory epithelium in the human fetus: scanning electron microscopic observations
    Mitsuhiro Kimura
    Department of Otorhinolaryngology, Faculty of Medicine, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 49:102-7. 2009
    ..Human olfactory epithelium becomes functional at birth, but prenatal development remains unclear. In the present study, we aimed to clarify the development of human olfactory epithelium using scanning electron microscopy (SEM)...
  21. doi request reprint In vivo analysis of Arg-Gly-Asp sequence/integrin α5β1-mediated signal involvement in embryonic enchondral ossification by exo utero development system
    Takayuki Inoue
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Shimane, Japan
    J Bone Miner Res 29:1554-63. 2014
    ....
  22. ncbi request reprint Spatial and temporal patterns of expression of melanocortin type 2 and 5 receptors in the fetal mouse tissues and organs
    Masayuki Nimura
    Department of Developmental Biology, Faculty of Medicine, Shimane University, 693 8501 Izumo, Japan
    Anat Embryol (Berl) 211:109-17. 2006
    ..These findings show the spatio-temporal specific expression patterns of MC2R and MC5R in the mouse embryo and suggest that ACTH may be related to histogenesis and/or prenatal function of various tissues and organs via MC2R and/or MC5R...
  23. doi request reprint Morphometric study on the characteristic external features of normal and abnormal human embryos
    Hiroki Otani
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 48:18-28. 2008
    ....
  24. doi request reprint Effects of restriction of fetal jaw movement on prenatal development of the temporalis muscle
    Esrat Jahan
    Department of Developmental Biology, Shimane University, Enya cho, Izumoshi, Japan
    Arch Oral Biol 55:919-27. 2010
    ..The present study revealed that the prenatal jaw movement influences the development of the temporalis muscle...
  25. doi request reprint Interkinetic nuclear migration in the mouse embryonic ureteric epithelium: Possible implication for congenital anomalies of the kidney and urinary tract
    Tomoyuki Motoya
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
    Congenit Anom (Kyoto) 56:127-34. 2016
    ..The present study showed that INM exists in the ureteric epithelium and suggests that INM may be related with the CAKUT etiology via primary ciliary protein function. ..
  26. ncbi request reprint Maternal factors in a model of type 1 diabetes differentially affect the development of insulitis and overt diabetes in offspring
    Yukiko Kagohashi
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane, 693 8501, Japan
    Diabetes 54:2026-31. 2005
    ..The present study indicates that altered maternal factors modify the immune response to islets, which in turn might affect the pathogenic course from insulitis to overt diabetes...
  27. ncbi request reprint Expression of cytoplasmic TFF2 is a marker of tumor metastasis and negative prognostic factor in gastric cancer
    Dipok Kumar Dhar
    Department of Digestive and General Surgery, Shimane Medical University, Izumo, Japan
    Lab Invest 83:1343-52. 2003
    ..Taken together, our results suggest that TFF2 expression may play a role in gastric cancer invasion and as such could be a useful target for therapeutic intervention...
  28. doi request reprint Adrenocorticotropic hormone affects nonapoptotic cell death of undifferentiated germ cells in the fetal mouse testis: in vivo study by exo utero transplantation of corticotropic tumor cells into embryos
    Masayuki Nimura
    Research Project Promoting Institute, Shimane University, Izumo, Shimane, Japan
    Congenit Anom (Kyoto) 48:81-6. 2008
    ..These results suggest that ACTH, via MC2R and/or MC5R, may be involved in the nonapoptotic cell death of fetal mouse spermatogonia that is observed during the normal perinatal period...
  29. doi request reprint Morphological and morphometric study on sphenoid and basioccipital ossification in normal human fetuses
    Qinghua Zhang
    Department of Developmental Biology, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 51:138-48. 2011
    ..The results contribute to the quantitative and qualitative information about the growth patterns and variations during human fetal cranial base development...
  30. ncbi request reprint Strategic compartmentalization of Toll-like receptor 4 in the mouse gut
    Cesar F Ortega-Cava
    Department of Internal Medicine II, Shimane Medical University, Izumo, Japan
    J Immunol 170:3977-85. 2003
    ..Our findings demonstrate that TLR4, CD14, and TLR2 are expressed in a compartmentalized manner in the mouse gut and provide novel information about the in vivo localization of PRRs...
  31. pmc Statistical analyses in trials for the comprehensive understanding of organogenesis and histogenesis in humans and mice
    Hiroki Otani
    Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane 693 8501, Japan Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane 693 8501, Japan
    J Biochem 159:553-61. 2016
    ....
  32. ncbi request reprint Statistical analysis with dilatation for development process of human fetuses
    Kanta Naito
    Department of Mathematics, Shimane University, Japan
    Stat Methods Med Res . 2014
    ..The asymptotics for dilatation have been developed using certain efficient models of quasiconformal mapping. The proposed method of dilatation is effectively applied to the human fetus data...
  33. doi request reprint The LMSR method for providing a multidimensional understanding of growth standard in human fetuses
    Kanta Naito
    1 Division of Mathematical Science, Shimane University, Matsue, Japan
    Stat Methods Med Res . 2017
    ..It will be shown that the LMSR method and some associated tools are clearly efficient in analyzing development process of human fetuses...
  34. ncbi request reprint Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer
    Kohkichi Hata
    Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan
    Oncology 62:340-8. 2002
    ..Ang1 and Ang2 bind with similar affinity to the endothelial cell tyrosine kinase receptor Tie2. Our purpose was to assess the potential role of the Ang/Tie2 system in physiological and pathological angiogenesis in the ovary...
  35. doi request reprint Role of interleukin-15 in the development of mouse olfactory nerve
    Tsuyoshi Umehara
    Department of Otorhinolaryngology, Faculty of Medicine, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 49:253-7. 2009
    ..Adult IL-15R alpha knockout mice had fewer mature olfactory neurons and proliferating cells than wild-type. Our results suggest that IL-15 plays an important role in regulating cell proliferation in olfactory neurogenesis...
  36. ncbi request reprint Gi2 signaling enhances proliferation of neural progenitor cells in the developing brain
    Haruo Shinohara
    Department of Anatomy, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    J Biol Chem 279:41141-8. 2004
    ..These findings indicate that Gi2 mediates signaling from receptors such as the endothelin-B receptor to maintain mitogenic activity in the neural progenitor cells of developing brain...
  37. pmc Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization
    Hajime Kanda
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 115:291-301. 2005
    ....