Keiichi Hatakeyama

Summary

Affiliation: Shizuoka Cancer Center
Country: Japan

Publications

  1. pmc Placenta-specific novel splice variants of Rho GDP dissociation inhibitor β are highly expressed in cancerous cells
    Keiichi Hatakeyama
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi cho, Sunto gun, Shizuoka, Japan
    BMC Res Notes 5:666. 2012
  2. pmc Novel protein extraction approach using micro-sized chamber for evaluation of proteins eluted from formalin-fixed paraffin-embedded tissue sections
    Keiichi Hatakeyama
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi cho, Sunto gun, Shizuoka 411 8777, Japan
    Proteome Sci 10:19. 2012
  3. doi request reprint Identification of a novel protein isoform derived from cancer-related splicing variants using combined analysis of transcriptome and proteome
    Keiichi Hatakeyama
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Sunto gun, Shizuoka, Japan
    Proteomics 11:2275-82. 2011
  4. doi request reprint Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells
    Keiichi Ohshima
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan
    Proteomics 14:2297-306. 2014
  5. doi request reprint Investigation of proNT/NMN secretion from small cell lung carcinoma cells using a mouse xenograft model
    Kanako Wakabayashi-Nakao
    Medical Genetics Division, Experimental Animal Facility, Shizuoka Cancer Center Research Institute, Shizuoka, Japan
    Oncol Rep 28:1181-6. 2012
  6. doi request reprint A novel splice variant of XIAP-associated factor 1 (XAF1) is expressed in peripheral blood containing gastric cancer-derived circulating tumor cells
    Keiichi Hatakeyama
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan
    Gastric Cancer 18:751-61. 2015
  7. pmc Novel protein isoforms of carcinoembryonic antigen are secreted from pancreatic, gastric and colorectal cancer cells
    Keiichi Hatakeyama
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi cho, Sunto gun, Shizuoka 411 8777, Japan
    BMC Res Notes 6:381. 2013
  8. ncbi request reprint Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells
    Kanako Wakabayashi-Nakao
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan
    Biomed Res 35:237-42. 2014
  9. pmc Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
    Keiichi Ohshima
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan
    PLoS ONE 5:e13247. 2010

Collaborators

Detail Information

Publications9

  1. pmc Placenta-specific novel splice variants of Rho GDP dissociation inhibitor β are highly expressed in cancerous cells
    Keiichi Hatakeyama
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi cho, Sunto gun, Shizuoka, Japan
    BMC Res Notes 5:666. 2012
    ..Although the Rho GDP dissociation inhibitor β (ARHGDIB) gene has been found to be ubiquitously expressed in normal tissues and involved in cancer development, the presence of splice variants of ARHGDIB has not yet been investigated...
  2. pmc Novel protein extraction approach using micro-sized chamber for evaluation of proteins eluted from formalin-fixed paraffin-embedded tissue sections
    Keiichi Hatakeyama
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi cho, Sunto gun, Shizuoka 411 8777, Japan
    Proteome Sci 10:19. 2012
    ..Our approach may contribute to an understanding of the mechanism of HIAR...
  3. doi request reprint Identification of a novel protein isoform derived from cancer-related splicing variants using combined analysis of transcriptome and proteome
    Keiichi Hatakeyama
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Sunto gun, Shizuoka, Japan
    Proteomics 11:2275-82. 2011
    ..Our combined analysis will be a promising technique for screening of cancer-related splicing variants and their protein isoforms...
  4. doi request reprint Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells
    Keiichi Ohshima
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan
    Proteomics 14:2297-306. 2014
    ..In addition, PABP1 has a potential use as a biomarker for metastatic duodenal cancer. ..
  5. doi request reprint Investigation of proNT/NMN secretion from small cell lung carcinoma cells using a mouse xenograft model
    Kanako Wakabayashi-Nakao
    Medical Genetics Division, Experimental Animal Facility, Shizuoka Cancer Center Research Institute, Shizuoka, Japan
    Oncol Rep 28:1181-6. 2012
    ..Moreover, proNT/NMN was expressed in SBC3 tumors, suggesting that proNT/NMN was secreted into blood from the tumor, and this secretion may be specific to SCLC...
  6. doi request reprint A novel splice variant of XIAP-associated factor 1 (XAF1) is expressed in peripheral blood containing gastric cancer-derived circulating tumor cells
    Keiichi Hatakeyama
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan
    Gastric Cancer 18:751-61. 2015
    ..Here, we identified a novel XAF1 splice variant in cancer cells and then investigated the expression level of this variant in peripheral blood containing gastric cancer-derived circulating tumor cells (CTCs)...
  7. pmc Novel protein isoforms of carcinoembryonic antigen are secreted from pancreatic, gastric and colorectal cancer cells
    Keiichi Hatakeyama
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi cho, Sunto gun, Shizuoka 411 8777, Japan
    BMC Res Notes 6:381. 2013
    ..In this study, we demonstrated the existence of novel CEACAM5 splice variants and splice variant-derived protein isoforms in gastrointestinal cancer cell lines...
  8. ncbi request reprint Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells
    Kanako Wakabayashi-Nakao
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan
    Biomed Res 35:237-42. 2014
    ....
  9. pmc Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line
    Keiichi Ohshima
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan
    PLoS ONE 5:e13247. 2010
    ..Thus, profiling exosomal miRNAs are in need to clarify intercellular signaling and discover a novel disease marker as well...