Iku Utsunomiya

Summary

Affiliation: Showa Pharmaceutical University
Country: Japan

Publications

  1. ncbi request reprint Expression and localization of Kv1 potassium channels in rat dorsal and ventral spinal roots
    Iku Utsunomiya
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Exp Neurol 210:51-8. 2008
  2. doi request reprint Identification of amino acids in the pore region of Kv1.2 potassium channel that regulate its glycosylation and cell surface expression
    Iku Utsunomiya
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Tokyo, Japan
    J Neurochem 112:913-23. 2010
  3. doi request reprint IgM anti-GQ1b monoclonal antibody inhibits voltage-dependent calcium current in cerebellar granule cells
    Yoshihiko Nakatani
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo 195 8543, Japan
    Exp Neurol 219:74-80. 2009
  4. doi request reprint Effect of beta-phenylethylamine on extracellular concentrations of dopamine in the nucleus accumbens and prefrontal cortex
    Mikio Murata
    Department of Medicinal Pharmacology, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 0042, Japan
    Brain Res 1269:40-6. 2009
  5. ncbi request reprint Neurophysiological and immunohistochemical studies on Guillain-Barre syndrome with IgG anti-GalNAc-GD1a antibodies-effects on neuromuscular transmission
    Kyoji Taguchi
    Department of Neuroscience, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    J Neurol Sci 225:91-8. 2004
  6. doi request reprint Cav2.1 voltage-dependent Ca2+ channel current is inhibited by serum from select patients with Guillain-Barré syndrome
    Yoshihiko Nakatani
    Departments of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194 8543, Japan
    Neurochem Res 34:149-57. 2009
  7. doi request reprint Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion
    Tomomi Hara
    Department of Medicinal Pharmacology, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Pain 154:882-9. 2013
  8. doi request reprint IgG anti-Galnac-GD1a antibodies bind to neuromuscular junctions of rat hemidiaphragm
    Takumi Nagaoka
    Department of Medicinal Pharmacology, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    Muscle Nerve 46:705-10. 2012
  9. ncbi request reprint Beta-phenylethylamine stimulates striatal acetylcholine release through activation of the AMPA glutamatergic pathway
    Kota Ishida
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Tokyo, Japan
    Biol Pharm Bull 28:1626-9. 2005
  10. ncbi request reprint IgG anti-GalNAc-GD1a antibody inhibits the voltage-dependent calcium channel currents in PC12 pheochromocytoma cells
    Yoshihiko Nakatani
    Department of Pharmacotherapics, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    Exp Neurol 204:380-6. 2007

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Expression and localization of Kv1 potassium channels in rat dorsal and ventral spinal roots
    Iku Utsunomiya
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Exp Neurol 210:51-8. 2008
    ..1 and Kv1.2 were coassembled. These findings indicate that Kv1 subtypes in DRs and VRs are somewhat different from those in spinal cord, and that the numbers of Kv1.1 and Kv1.2 channels are higher in DRs than VRs...
  2. doi request reprint Identification of amino acids in the pore region of Kv1.2 potassium channel that regulate its glycosylation and cell surface expression
    Iku Utsunomiya
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Tokyo, Japan
    J Neurochem 112:913-23. 2010
    ..2 is regulated by specific amino acids in the pore region in a similar manner to Kv1.1 and Kv1.4, and that the cell surface expression of Kv1.2, a channel intermediate between Kv1.1 and Kv1.4, can be attributed to these specific residues...
  3. doi request reprint IgM anti-GQ1b monoclonal antibody inhibits voltage-dependent calcium current in cerebellar granule cells
    Yoshihiko Nakatani
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo 195 8543, Japan
    Exp Neurol 219:74-80. 2009
    ..Therefore, the clinical symptoms of Miller-Fisher syndrome, such as cerebellar-like ataxia, may be explained by the inhibitory effects of anti-GQ1b antibodies on VDCC current in cerebellar granule cells...
  4. doi request reprint Effect of beta-phenylethylamine on extracellular concentrations of dopamine in the nucleus accumbens and prefrontal cortex
    Mikio Murata
    Department of Medicinal Pharmacology, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 0042, Japan
    Brain Res 1269:40-6. 2009
    ..Similarly, beta-PEA increased extracellular dopamine levels in the prefrontal cortex. Thus, beta-PEA may increase extracellular dopamine concentrations in the mesocorticolimbic pathway...
  5. ncbi request reprint Neurophysiological and immunohistochemical studies on Guillain-Barre syndrome with IgG anti-GalNAc-GD1a antibodies-effects on neuromuscular transmission
    Kyoji Taguchi
    Department of Neuroscience, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    J Neurol Sci 225:91-8. 2004
    ..The anti-GalNAc-GD1a antibodies may block neuromuscular transmission by attacking on presynaptic motor axon, probably affecting the ion channels in the presynaptic motor axon...
  6. doi request reprint Cav2.1 voltage-dependent Ca2+ channel current is inhibited by serum from select patients with Guillain-Barré syndrome
    Yoshihiko Nakatani
    Departments of Pharmacotherapeutics, Showa Pharmaceutical University, Machida, Tokyo, 194 8543, Japan
    Neurochem Res 34:149-57. 2009
    ..1 VDCC current. These results suggest that in some case of GBS, particularly of AMAN patients with IgG anti-GM1 mAb, muscle weakness may be induced by dysfunction of Cav2.1 VDCC functioning at the motor nerve terminals...
  7. doi request reprint Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion
    Tomomi Hara
    Department of Medicinal Pharmacology, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Pain 154:882-9. 2013
    ..These results suggest that paclitaxel treatment increases TRPV1 expression in DRG neurons and may contribute to functional peripheral neuropathic pain...
  8. doi request reprint IgG anti-Galnac-GD1a antibodies bind to neuromuscular junctions of rat hemidiaphragm
    Takumi Nagaoka
    Department of Medicinal Pharmacology, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    Muscle Nerve 46:705-10. 2012
    ..We investigated the localization of a ganglioside, N-acetylgalactosaminyl GD1a (GalNAc-GD1a), in peripheral nerves with an IgG anti-GalNAc-GD1a antibody, which was produced in rabbits immunized with GalNAc-GD1a...
  9. ncbi request reprint Beta-phenylethylamine stimulates striatal acetylcholine release through activation of the AMPA glutamatergic pathway
    Kota Ishida
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Tokyo, Japan
    Biol Pharm Bull 28:1626-9. 2005
    ..These results suggest a regulatory function of beta-PEA, mediated by AMPA-type glutamatergic receptors, on the release of acetylcholine in the rat striatum...
  10. ncbi request reprint IgG anti-GalNAc-GD1a antibody inhibits the voltage-dependent calcium channel currents in PC12 pheochromocytoma cells
    Yoshihiko Nakatani
    Department of Pharmacotherapics, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    Exp Neurol 204:380-6. 2007
    ..These results indicate that anti-GalNAc-GD1a antibodies inhibit the VDCCs currents in NGF-differentiated PC12 cells...
  11. ncbi request reprint Paclitaxel increases high voltage-dependent calcium channel current in dorsal root ganglion neurons of the rat
    Kazuyoshi Kawakami
    Department of Medicinal Pharmacology, Showa Pharmaceutical University, Machida, Tokyo, Japan
    J Pharmacol Sci 120:187-95. 2012
    ..The antihyperalgesic action of gabapentin may be due to inhibition of paclitaxel-induced increases in the VDCC current in DRG neurons...
  12. ncbi request reprint Spontaneous muscle action potentials are blocked by N-type and P/Q-calcium channels blockers in the rat spinal cord-muscle co-culture system
    Kyoji Taguchi
    Department of Neuroscience, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    Brain Res 1034:62-70. 2005
    ..These results indicate that blockers of N- and P/Q-type voltage-dependent calcium channels inhibit transmitter release at neuromuscular junctions in the rat spinal cord-muscle co-culture system...
  13. ncbi request reprint Glycosylation and cell surface expression of Kv1.2 potassium channel are regulated by determinants in the pore region
    Tetsuhiro Fujita
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Tokyo, Machida, Japan
    Neurochem Res 31:589-96. 2006
    ..2 and cells coexpressing beta2and S360A. These results suggest that amino acids in the pore region help regulate ion permeability or cellular trafficking by affecting glycosylation of Kv1.2...
  14. doi request reprint Transient Receptor Potential Ankyrin 1 that is Induced in Dorsal Root Ganglion Neurons Contributes to Acute Cold Hypersensitivity after Oxaliplatin Administration
    Ken Yamamoto
    Department of Medicinal Pharmacology, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    Mol Pain 11:. 2015
    ..However, the mechanism of oxaliplatin-induced cold hyperalgesia is unknown. In the present study, we investigated the effects of oxaliplatin on transient receptor potential ankyrin 1 (TRPA1) in dorsal root ganglion (DRG) neurons of rats...
  15. doi request reprint Oxaliplatin administration increases expression of the voltage-dependent calcium channel α2δ-1 subunit in the rat spinal cord
    Ken Yamamoto
    Department of Education and Research Center for Clinical Pharmacy, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    J Pharmacol Sci 130:117-22. 2016
    ..These results suggest that oxaliplatin treatment increases Cavα2δ-1 subunit expression in the superficial layers of the spinal cord and may contribute to functional peripheral acute cold hypersensitivity. ..
  16. ncbi request reprint Characterization of muscarinic receptor subtypes in the rostral ventrolateral medulla and effects on morphine-induced antinociception in rats
    Kenji Abe
    Department of Neuroscience, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, 194 8543, Tokyo, Japan
    Eur J Pharmacol 465:237-49. 2003
    ..These results suggest that the antinociceptive effects induced by morphine in part involve the muscarinic M(1) and M(3) receptors of the rat nucleus reticularis gigantocellularis/nucleus reticularis gigantocellularis alpha...
  17. doi request reprint Paclitaxel-induced peripheral neuropathy increases substance P release in rat spinal cord
    Terumasa Chiba
    Departments of Medicinal Pharmacology, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    Eur J Pharmacol 770:46-51. 2016
    ..These results suggest that paclitaxel treatment increases release of substance P, but not CGRP in the superficial layers of the spinal dorsal horn and may contribute to paclitaxel-induced painful peripheral neuropathy. ..
  18. ncbi request reprint Effect of rabbit anti-asialo-GM1 (GA1) polyclonal antibodies on neuromuscular transmission and acetylcholine-induced action potentials: neurophysiological and immunohistochemical studies
    Kyoji Taguchi
    Department of Neuroscience, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    Neurochem Res 29:953-60. 2004
    ..The ACh-induced potential was not reduced by the addition of sera, suggesting the blockade is presynaptic. Thus, anti-GA1 antibodies may block neuromuscular transmission by suppressing VGCC on axonal terminals of motor nerves...
  19. ncbi request reprint Effects of beta-phenylethylamine on dopaminergic neurons of the ventral tegmental area in the rat: a combined electrophysiological and microdialysis study
    Kota Ishida
    Department of Neuroscience, Showa Pharmaceutical University, 3 3165, Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    J Pharmacol Exp Ther 314:916-22. 2005
    ..These findings indicate that beta-phenylethylamine inhibits DA neuron activity via DA D(2) autoreceptors in the rat VTA and that this inhibitory effect is mediated by the somatodendritic DA release...
  20. pmc Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration
    Ken Yamamoto
    Department of Medicinal Pharmacology, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo, 194 8543, Japan
    Mol Pain 11:69. 2015
    ..However, the mechanism of oxaliplatin-induced cold hyperalgesia is unknown. In the present study, we investigated the effects of oxaliplatin on transient receptor potential ankyrin 1 (TRPA1) in dorsal root ganglion (DRG) neurons of rats...
  21. ncbi request reprint Synthesis and neurotoxicity of tetrahydroisoquinoline derivatives for studying Parkinson's disease
    Kenji Abe
    Department of Neuroscience, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 0042, Japan
    Biol Pharm Bull 28:1355-62. 2005
    ..In this article, we focus on the synthesis and pharmacological aspects of 1,2,3,4-tetrahydroisoquinoline derivatives in Parkinson's disease...
  22. ncbi request reprint Modulation of noradrenergic and serotonergic transmission by noxious stimuli and intrathecal morphine differs in the dorsal raphe nucleus of anesthetized rat: in vivo voltammetric studies
    Toichiro Chuma
    Department of Neuroscience, Showa Pharmaceutical University, 3 3165, Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
    Neurosci Res 44:37-44. 2002
    ..The intrathecal administration of morphine affects the noxious stimulation-induced activity of noradrenergic and serotonergic neurotransmission in the DRN...
  23. ncbi request reprint Chronic administration of cardanol (ginkgol) extracted from ginkgo biloba leaves and cashew nutshell liquid improves working memory-related learning in rats
    Seisho Tobinaga
    Showa Pharmaceutical University, Higashi tamagawagakuen, Machida, Tokyo 194 8543, Japan
    Biol Pharm Bull 35:127-9. 2012
    ..These findings suggest that cardanol is one of the components in Ginkgo biloba leaves that improves cognitive learning ability...
  24. ncbi request reprint AIDP and CIDP having specific antibodies to the carbohydrate epitope (-NeuAcalpha2-8NeuAcalpha2-3Galbeta1-4Glc-) of gangliosides
    Seigo Usuki
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912 2697, USA
    J Neurol Sci 232:37-44. 2005
    ..High titers of anti-GD3 antibody and the distortion of antibody recognition found in CIDP seem to have no immediate effect on electrophysiologic function in the PNS...
  25. ncbi request reprint GalNAc-GD1a is localized specifically in ventral spinal roots, but not in dorsal spinal roots
    Hiide Yoshino
    Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry, 1 7 1 Kohnodai, Ichikawa, Chiba 2720 8516, Japan
    Brain Res 1057:177-80. 2005
    ..71 +/- 0.49 microg/g wet tissue, respectively. These results suggest that IgG anti-GalNAc-GD1a antibody may be involved in disturbance of peripheral motor nerves and in the pathogenesis of pure motor neuropathy...