Hisashi Hisatomi

Summary

Affiliation: SRL Inc
Country: Japan

Publications

  1. ncbi request reprint Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival
    Masayoshi Shichiri
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Res 62:13-7. 2002
  2. doi request reprint Alternative RNA splicing in expression of the glutathione synthetase gene in human cells
    Marie Uchida
    Laboratory of Cellular and Molecular Biochemistry, Department of Materials and Life Science, Seikei University, 3 3 1 Kichijoji Kita machi, Musashino shi, Tokyo, 180 8633, Japan
    Mol Biol Rep 37:2105-9. 2010
  3. pmc Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL Inc, 5 6 50 Shin machi Hino, Tokyo, Japan
    Neoplasia 5:193-7. 2003
  4. ncbi request reprint Differential alternative splicing expressions of thymidylate synthase isoforms
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL, Inc, 5 6 50 Shin machi Hino, Tokyo 191 0002, Japan
    Cancer Lett 193:127-31. 2003
  5. ncbi request reprint Novel alternatively spliced variant with a deletion of 52 BP in exon 6 of the progesterone receptor gene is observed frequently in breast cancer tissues
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL Inc, Tokyo, Japan
    Int J Cancer 105:182-5. 2003
  6. ncbi request reprint Detection of circulating prostate tumor cells: alternative spliced variant of PSM induced false-positive result
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL, Inc, Hino, Tokyo, Japan
    Int J Mol Med 10:619-22. 2002
  7. ncbi request reprint Expression of a novel splicing variant deleting exons 4 and 6 of the progesterone receptor gene is a rare event in breast cancer
    Kumi Nagao
    Center for Molecular Biology and Cytogenetics, SRL, Inc, Tokyo 191 0002, Japan
    Oncol Rep 10:305-8. 2003
  8. ncbi request reprint Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction
    Hiroyuki Hirata
    Center for Molecular Biology and Cytogenetics, SRL, Inc, 5 6 50 Shin machi Hino, Tokyo 191 0002, Japan
    Oncol Rep 10:963-6. 2003
  9. ncbi request reprint Differential alternative splicing expressions of telomerase reverse transcriptase in gastrointestinal cell lines
    Kumi Nagao
    Center for Molecular Biology and Cytogenetics, SRL Inc, Tokyo 191 0002, Japan
    Oncol Rep 11:127-31. 2004
  10. ncbi request reprint Expression of hTERT mRNA in a mortal liver cell line during S phase without detectable telomerase activity
    Kumi Nagao
    Center for Molecular Biology and Cytogenetics, SRL, Inc, Hachioiji, Tokyo 192 0031, Japan
    Int J Mol Med 15:683-8. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival
    Masayoshi Shichiri
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Res 62:13-7. 2002
    ..005) and shorter relapse-free survival after surgery (P = 0.006). Thus, hBUB1 and hBUBR1 may contribute to a specific driving force in tumor metastasis and progression as a result of nonmutational, as well as mutational, inactivation...
  2. doi request reprint Alternative RNA splicing in expression of the glutathione synthetase gene in human cells
    Marie Uchida
    Laboratory of Cellular and Molecular Biochemistry, Department of Materials and Life Science, Seikei University, 3 3 1 Kichijoji Kita machi, Musashino shi, Tokyo, 180 8633, Japan
    Mol Biol Rep 37:2105-9. 2010
    ..Understanding the regulation of GSS expression is very important for the development of new strategies for controlling the development of GSH-based redox homeostasis...
  3. pmc Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL Inc, 5 6 50 Shin machi Hino, Tokyo, Japan
    Neoplasia 5:193-7. 2003
    ..Both gamma- and alpha-deletion variants were occasionally detected, but the beta-deletion variant was frequently observed. Our results may provide important information for more detailed studies on the regulation of telomerase activity...
  4. ncbi request reprint Differential alternative splicing expressions of thymidylate synthase isoforms
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL, Inc, 5 6 50 Shin machi Hino, Tokyo 191 0002, Japan
    Cancer Lett 193:127-31. 2003
    ..However, another isoform was found in only seven of 39 cancerous tissues. Our results provide important information to assist more detailed studies on the regulation of thymidylate synthase activity...
  5. ncbi request reprint Novel alternatively spliced variant with a deletion of 52 BP in exon 6 of the progesterone receptor gene is observed frequently in breast cancer tissues
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL Inc, Tokyo, Japan
    Int J Cancer 105:182-5. 2003
    ..0001), which suggests a possible relationship between the expression of PR delta6/2 and breast cancer. Our observations may provide a novel strategy for the genetic diagnosis of breast cancer...
  6. ncbi request reprint Detection of circulating prostate tumor cells: alternative spliced variant of PSM induced false-positive result
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL, Inc, Hino, Tokyo, Japan
    Int J Mol Med 10:619-22. 2002
    ..The advances in the uniquely designed primer sets may allow researchers to detect a real PSM mRNA without PSM' mRNA...
  7. ncbi request reprint Expression of a novel splicing variant deleting exons 4 and 6 of the progesterone receptor gene is a rare event in breast cancer
    Kumi Nagao
    Center for Molecular Biology and Cytogenetics, SRL, Inc, Tokyo 191 0002, Japan
    Oncol Rep 10:305-8. 2003
    ..The expressions of ASVs that induced the mimic PR transcripts need to be considered when designing strategies for regulation analysis of the PR gene...
  8. ncbi request reprint Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction
    Hiroyuki Hirata
    Center for Molecular Biology and Cytogenetics, SRL, Inc, 5 6 50 Shin machi Hino, Tokyo 191 0002, Japan
    Oncol Rep 10:963-6. 2003
    ..The data are particularly important in that the molecular detection of micrometastasis in the blood by means of UP II mRNA identification is feasible for UP II-positive neoplasms, including lung and pancreatic cancers...
  9. ncbi request reprint Differential alternative splicing expressions of telomerase reverse transcriptase in gastrointestinal cell lines
    Kumi Nagao
    Center for Molecular Biology and Cytogenetics, SRL Inc, Tokyo 191 0002, Japan
    Oncol Rep 11:127-31. 2004
    ..Our results provide important information of use for more detailed studies on the regulation of telomerase activity...
  10. ncbi request reprint Expression of hTERT mRNA in a mortal liver cell line during S phase without detectable telomerase activity
    Kumi Nagao
    Center for Molecular Biology and Cytogenetics, SRL, Inc, Hachioiji, Tokyo 192 0031, Japan
    Int J Mol Med 15:683-8. 2005
    ..hTERT was always expressed in the HLE and Huh-7 hepatocellular carcinoma cell lines, regardless of the cell cycle. Our results suggest the possibility that telomerase is regulated in a cell cycle-dependent manner in normal liver cells...
  11. ncbi request reprint Expression of molecular marker genes in various types of normal tissue: implication for detection of micrometastases
    Kumi Nagao
    Center for Molecular Biology and Cytogenetics, SRL, Inc, Shin machi Hino, Tokyo 191 0002, Japan
    Int J Mol Med 10:307-10. 2002
    ..Conversely, these biomarkers can be utilized for attempts to define micrometastases in various types of tumors whose cells express these tissue-specific genes...
  12. pmc Improved method of plasma 8-Isoprostane measurement and association analyses with habitual drinking and smoking
    Soichi Kitano
    Development Planning Section, Technology Development Department, SRL Inc, 5 6 50 Shinmachi, Hino shi, Tokyo, 191 0002, Japan
    World J Gastroenterol 12:5846-52. 2006
    ....
  13. ncbi request reprint ARHI/NOEY2 inactivation may be important in breast tumor pathogenesis
    Hisashi Hisatomi
    Center for Molecular Biology and Cytogenetics, SRL, Inc, Tokyo, Japan
    Oncology 62:136-40. 2002
    ..ARHI/NOEY2 expression was lost or markedly reduced in 12 of 26 (46.15%) breast cancer tissue samples. In summary, we conclude that decreased ARHI/NOEY2 mRNA expression may play an important role in the pathogenesis of breast cancer...
  14. ncbi request reprint [An association between plasma levels of 8-isoprostane and alcohol drinking habits in Japanese volunteers]
    Soichi Kitano
    Research Testing Group Analysis Center for Medical Science First Laboratories, Department of Technology Development and Assessment, IVD, SRL, Inc, 153 Komiya, Hachioji, Tokyo 192 0031, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 39:105-17. 2004
    ..8 +/- 7.4 pg/ml, p>0.05). We suppose that plasma 8-isoprostane may increase in the habitual drinkers due to the oxidization stress induced by alcohol intake, and it may become a useful marker to estimate drinking habit..
  15. pmc The C allele of JAK2 rs4495487 is an additional candidate locus that contributes to myeloproliferative neoplasm predisposition in the Japanese population
    Junko H Ohyashiki
    Department of Molecular Oncology, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan
    BMC Med Genet 13:6. 2012
    ..This study examined the impact of single nucleotide polymorphisms (SNPs) of the JAK2 locus on MPNs in a Japanese population...
  16. doi request reprint Poloxamer 188 enhances apoptosis in a human leukemia cell line
    Nobuo Aoki
    Department of Materials and Life Science, Seikei University, Tokyo, Japan
    Mol Med Report 3:669-72. 2010
    ..Although the mechanisms behind the function of pluronic F68 are not fully understood, the results suggests that pluronic F68 may act as a useful carrier in DDS for the purpose of leukemia therapy...
  17. ncbi request reprint Second case of CML with aberrant BCR-ABL fusion transcript (e8/a2) with insertion of an inverted ABL intron 1b sequence
    Takeshi Sugimoto
    Clinical Research Division, Hyogo Medical Center for Adults, Akashi, Japan
    Am J Hematol 77:164-6. 2004
    ..The nucleotide sequences of the aberrant transcript were identical to those of a previously reported CML patient. These are the only two CML cases in the literature with identical aberrant BCR-ABL transcripts...
  18. ncbi request reprint Identification of an alternative splicing transcript for the resistin gene and distribution of its mRNA in human tissue
    Tomoyoshi Nohira
    Department of Obstetrics and Gynecology, Hachioji Medical Center of Tokyo Medical University, Tokyo 193 0998, Japan
    Eur J Endocrinol 151:151-4. 2004
    ..In the present study, we investigated the occurrence of a novel ASV of the resistin gene in human normal tissues...
  19. ncbi request reprint Telomerase activity and hTERT mRNA in development and progression of adenoma to colorectal cancer
    Taichi Kanamaru
    Division of Surgery, Kobe Rosai Hospital, 4 1 23 Kagoikedori, Chuo Ku, Kobe 651 0053, Japan
    Int J Mol Med 10:205-10. 2002
    ....