K Uchida

Summary

Affiliation: Teikyo University
Country: Japan

Publications

  1. ncbi request reprint In vitro antifungal activity of luliconazole against clinical isolates from patients with dermatomycoses
    Hiroyasu Koga
    Research Center, Nihon Nohyaku Co, Ltd, 345 Oyamada cho, Kawachi Nagano, Osaka, 586 0094, Japan
    J Infect Chemother 12:163-5. 2006
  2. ncbi request reprint In vitro antifungal activity of posaconazole against various pathogenic fungi
    K Uchida
    Institute of Medical Mycology, Teikyo University, 359 Otsuka, Hachioji, 192 0395 Tokyo, Japan
    Int J Antimicrob Agents 18:167-72. 2001
  3. ncbi request reprint In vitro activity of novel imidazole antifungal agent NND-502 against Malassezia species
    Katsuhisa Uchida
    Institute of Medical Mycology, Teikyo University, 359 Otsuka, Hachioji, Tokyo 192 0395, Japan
    Int J Antimicrob Agents 21:234-8. 2003
  4. ncbi request reprint Achievement of complete mycological cure by topical antifungal agent NND-502 in guinea pig model of tinea pedis
    Katsuhisa Uchida
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo 192 0395, Japan
    Microbiol Immunol 47:143-6. 2003
  5. ncbi request reprint The postantifungal effect (PAFE) of itraconazole, in comparison with those of miconazole and fluconazole, on Candida Species
    Katsuhisa Uchida
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    Microbiol Immunol 50:679-85. 2006
  6. ncbi request reprint In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent
    Katsuhisa Uchida
    Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192 0395, Japan
    J Infect Chemother 10:216-9. 2004
  7. pmc Phylogenetic classification and species identification of dermatophyte strains based on DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions
    K Makimura
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    J Clin Microbiol 37:920-4. 1999
  8. ncbi request reprint Role of bacterial capsule in local and systemic inflammatory responses of mice during pulmonary infection with Klebsiella pneumoniae
    K Yoshida
    Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    J Med Microbiol 49:1003-10. 2000
  9. pmc Phylogenetic classification of Trichophyton mentagrophytes complex strains based on DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions
    K Makimura
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    J Clin Microbiol 36:2629-33. 1998
  10. ncbi request reprint Induction of interleukin-10 and down-regulation of cytokine production by Klebsiella pneumoniae capsule in mice with pulmonary infection
    K Yoshida
    Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    J Med Microbiol 50:456-61. 2001

Collaborators

Detail Information

Publications95

  1. ncbi request reprint In vitro antifungal activity of luliconazole against clinical isolates from patients with dermatomycoses
    Hiroyasu Koga
    Research Center, Nihon Nohyaku Co, Ltd, 345 Oyamada cho, Kawachi Nagano, Osaka, 586 0094, Japan
    J Infect Chemother 12:163-5. 2006
    ..These results showed that luliconazole was very potent in vitro against pathogenic fungi isolated from patients with dermatomycoses, and these findings emphasized the utility of luliconazole for the topical management of this condition...
  2. ncbi request reprint In vitro antifungal activity of posaconazole against various pathogenic fungi
    K Uchida
    Institute of Medical Mycology, Teikyo University, 359 Otsuka, Hachioji, 192 0395 Tokyo, Japan
    Int J Antimicrob Agents 18:167-72. 2001
    ..The activities of posaconazole for all the fungal species far surpassed those of fluconazole and were even superior to those of itraconazole for Aspergillus spp. as well as for many other fungal species...
  3. ncbi request reprint In vitro activity of novel imidazole antifungal agent NND-502 against Malassezia species
    Katsuhisa Uchida
    Institute of Medical Mycology, Teikyo University, 359 Otsuka, Hachioji, Tokyo 192 0395, Japan
    Int J Antimicrob Agents 21:234-8. 2003
    ..The results suggest that NND-502 might be beneficial in the treatment of Malassezia-associated skin diseases...
  4. ncbi request reprint Achievement of complete mycological cure by topical antifungal agent NND-502 in guinea pig model of tinea pedis
    Katsuhisa Uchida
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo 192 0395, Japan
    Microbiol Immunol 47:143-6. 2003
    ..The topical treatment with NND-502 achieved a mycological cure. Thus NND-502 can be considered a promising candidate as a new anti-dermatophytic agent for topical use...
  5. ncbi request reprint The postantifungal effect (PAFE) of itraconazole, in comparison with those of miconazole and fluconazole, on Candida Species
    Katsuhisa Uchida
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    Microbiol Immunol 50:679-85. 2006
    ..In general, ITCZ, as well as MCZ, produced greater extents of PAFE than those for FLCZ against C. albicans and several non-albicans Candida species...
  6. ncbi request reprint In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent
    Katsuhisa Uchida
    Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192 0395, Japan
    J Infect Chemother 10:216-9. 2004
    ..Again the anti-yeastlike fungi activity of luliconazole was at the same level as LCZ and was greater than that of BFZ and TBF. In contrast to BFZ and TBF, however, luliconazole and LCZ were virtually inactive against zygomycetes...
  7. pmc Phylogenetic classification and species identification of dermatophyte strains based on DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions
    K Makimura
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    J Clin Microbiol 37:920-4. 1999
    ..The ITS1 sequences of 11 clinical isolates were also determined to identify the species, and all strains were successfully identified by comparison of their base sequences with those in the ITS1 DNA sequence database...
  8. ncbi request reprint Role of bacterial capsule in local and systemic inflammatory responses of mice during pulmonary infection with Klebsiella pneumoniae
    K Yoshida
    Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    J Med Microbiol 49:1003-10. 2000
    ..These results suggest that K. pneumoniae capsule may suppress the host immunological responses,thus allowing the bacteria to grow, causing pneumonia, septicaemia and death...
  9. pmc Phylogenetic classification of Trichophyton mentagrophytes complex strains based on DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions
    K Makimura
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    J Clin Microbiol 36:2629-33. 1998
    ..This system was applicable to the phylogenetic analysis of closely related strains. Using this technique, human and animal isolates of T. mentagrophytes were also clearly distinguishable from each other...
  10. ncbi request reprint Induction of interleukin-10 and down-regulation of cytokine production by Klebsiella pneumoniae capsule in mice with pulmonary infection
    K Yoshida
    Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    J Med Microbiol 50:456-61. 2001
    ..The results suggest that the capsule of K. pneumoniae may induce IL-10 production at the site of infection and, thereafter, these high IL-10 levels may serve to down-regulate the expression of pro-inflammatory cytokines...
  11. ncbi request reprint Experimental disseminated trichosporonosis in mice: tissue distribution and therapy with antifungal agents
    K Yamamoto
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    J Med Vet Mycol 35:411-8. 1997
    ..The serum level of (1-->3)-beta-D-glucan was reduced by antifungal therapy and correlated well with the CFU/organ in kidney, but not CFU/ml in blood...
  12. ncbi request reprint Species identification and strain typing of Malassezia species stock strains and clinical isolates based on the DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions
    K Makimura
    Teikyo University, Institute of Medical Mycology, Hachioji, Tokyo, Japan
    J Med Microbiol 49:29-35. 2000
    ..sympodialis (22 strains: 7 from pityriasis versicolor, 3 from seborrhoeic dermatitis, 1 from atopic dermatitis and 11 from healthy controls) and M. slooffiae (five strains: three from chronic otitis media and two from healthy controls)...
  13. ncbi request reprint Soluble osteopontin and vascular calcification in hemodialysis patients
    K Nitta
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Nephron 89:455-8. 2001
    ..As osteopontin (OPN) is not only involved in the physiological but also the pathological calcification of tissues, OPN may be associated with the pathogenesis of aortic calcification in hemodialysis (HD) patients...
  14. ncbi request reprint Cluster analysis of human and animal pathogenic Microsporum species and their teleomorphic states, Arthroderma species, based on the DNA sequences of nuclear ribosomal internal transcribed spacer 1
    K Makimura
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo, Japan
    Microbiol Immunol 45:209-16. 2001
    ....
  15. ncbi request reprint In-vitro and in-vivo anti-Trichophyton activity of essential oils by vapour contact
    S Inouye
    Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192-03, Japan
    Mycoses 44:99-107. 2001
    ..mentagrophytes. These results indicated potent anti-Trichophyton action of essential oils by vapour contact...
  16. ncbi request reprint Effect of sealing and Tween 80 on the antifungal susceptibility testing of essential oils
    S Inouye
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo, Japan
    Microbiol Immunol 45:201-8. 2001
    ..Addition of Tween 80 caused a rise of the MICs against A. fumigatus by two to four-fold in broth dilution assay, but little affected the MICs in agar dilution assay...
  17. doi request reprint 6-Mercaptopurine (6-MP) induces cell cycle arrest and apoptosis of neural progenitor cells in the developing fetal rat brain
    H Kanemitsu
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Neurotoxicol Teratol 31:104-9. 2009
    ..These results suggest that 6-MP induced G2/M arrest, delayed S-phase progression, and finally induced apoptosis of neural progenitor cells mediated by p53 in the fetal rat telencephalon...
  18. ncbi request reprint Serum levels of macrophage colony-stimulating factor and aortic calcification in hemodialysis patients
    K Nitta
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Am J Nephrol 21:465-70. 2001
    ..A positive correlation was observed between serum M-CSF levels and ACI in HD patients (r = 0.596, p < 0.01). These results suggest that M-CSF may be involved in the process of aortosclerosis in HD patients...
  19. ncbi request reprint Synergy of lysozyme and lanoconazole on the morphology of Candida albicans
    Y Nishiyama
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo, Japan
    J Electron Microsc (Tokyo) 50:41-9. 2001
    ....
  20. ncbi request reprint Development of reference procedures for broth microdilution antifungal susceptibility testing of yeasts with standardized endpoint determination
    K Makimura
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo, Japan
    Microbiol Immunol 42:55-9. 1998
    ..The endpoint was 80% inhibition for azoles and 100% inhibition for other drugs. The method provided good reproducibility, and a wide range of MIC distribution was observed in all antifungal agents except amphotericin B...
  21. doi request reprint Pathologic Features of Colorectal Inflammatory Polyps in Miniature Dachshunds
    E Uchida
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    Vet Pathol 53:833-9. 2016
    ....
  22. doi request reprint Safety of a novel galacto-oligosaccharide: Genotoxicity and repeated oral dose studies
    T Kobayashi
    Yakult Central Institute for Microbiological Research, Safety Research Center, Kunitachi shi, Tokyo, Japan
    Hum Exp Toxicol 28:619-30. 2009
    ..The no observed adverse effect level (NOAEL) of GOS was at least 2000 mg/kg/day in both males and females...
  23. ncbi request reprint Differentiation and angiogenesis of central nervous system stem cells implanted with mesenchyme into ischemic rat brain
    A Fukunaga
    Department of Neurosurgery, Keio University School of Medicine, Tokyo, Japan
    Cell Transplant 8:435-41. 1999
    ....
  24. ncbi request reprint Deposition, Clearance, and Reinduction of Amyloid A Amyloid in Interleukin 1 Receptor Antagonist Knockout Mice
    K Watanabe
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    Vet Pathol . 2016
    ..Therefore, increased SAA and/or its dimer in serum during the recovery process may markedly exacerbate the development of AA amyloidosis...
  25. doi request reprint Decreased immunoglobulin A concentrations in feces, duodenum, and peripheral blood mononuclear cells of dogs with inflammatory bowel disease
    S Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Intern Med 27:47-55. 2013
    ..Although immunoglobulin A (IgA) plays a key role in regulating gut homeostasis, its role in canine inflammatory bowel disease (IBD) is unknown...
  26. ncbi request reprint Fungal flora on board the Mir-Space Station, identification by morphological features and ribosomal DNA sequences
    K Makimura
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo, Japan
    Microbiol Immunol 45:357-63. 2001
    ..Therefore, to prevent infection or other health disorders caused by these fungi, easy and reliable methods should be established to survey the fungal flora in a space station...
  27. doi request reprint Risk factors for deterioration of renal function after donor nephrectomy
    T Nozaki
    Department of Urology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Transplant Proc 42:1476-8. 2010
    ..The aim of this study was to identify factors that protect renal function among actual live kidney donors...
  28. doi request reprint Expression of Autophagy-Related Proteins in the Spinal Cord of Pembroke Welsh Corgi Dogs With Canine Degenerative Myelopathy
    M Ogawa
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Vet Pathol 52:1099-107. 2015
    ..These findings suggest that altered autophagosome degradation may result in LC3 and p62 accumulation in the DM spinal cord, whereas the early stage of membrane formation is likely to be downregulated...
  29. doi request reprint Changes in Foxp3-Positive Regulatory T Cell Number in the Intestine of Dogs With Idiopathic Inflammatory Bowel Disease and Intestinal Lymphoma
    S Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    Vet Pathol 53:102-12. 2016
    ..These results suggest that a change in the number of Foxp3-positive Tregs contributes to the pathogenesis of canine IBD and intestinal lymphoma by disrupting mucosal tolerance and suppressing antitumor immunity, respectively. ..
  30. doi request reprint Clinical and Pathologic Study of Feline Merkel Cell Carcinoma With Immunohistochemical Characterization of Normal and Neoplastic Merkel Cells
    A Dohata
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Vet Pathol 52:1012-8. 2015
    ..Tumor cells were commonly immunopositive for CK20, CK18, p63, neuron-specific enolase, and synaptophysin, representing the characteristics of normal Merkel cells. ..
  31. doi request reprint The origin and role of autophagy in the formation of cytoplasmic granules in canine lingual granular cell tumors
    S Suzuki
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Vet Pathol 52:456-64. 2015
    ..In conclusion, canine lingual GCTs originate from the neural crest and develop cytoplasmic granules via autophagy. In addition, the microenvironment of GCT cells affects their morphology...
  32. doi request reprint Pancreatic carcinosarcoma in a cat
    R Yamamoto
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Comp Pathol 147:223-6. 2012
    ..The pancreatic lesion is proposed to be a primary carcinosarcoma with metastasis of only the mesenchymal component to distant sites. This the first report of pancreatic carcinosarcoma in a cat...
  33. ncbi request reprint [Specific and rapid identification of Malassezia species based on the DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions]
    A Murakami
    Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo, 192-0395 Japan
    Nippon Ishinkin Gakkai Zasshi 42:211-3. 2001
    ..A specific and rapid identification system based on sequences of internal transcribed spacer 1 of ribosomal DNA has therefore been developed. Using this system, we could identify two or more species mixed in the clinical samples...
  34. ncbi request reprint Protection of C3H/HE J mice from development of Candida albicans infection by oral administration of Juzen-taiho-to and its component, Ginseng radix: possible roles of macrophages in the host defense mechanisms
    G Akagawa
    Department of Microbiology and Immunology, Teikyo University School of Medicine, Tokyo, Japan
    Immunopharmacol Immunotoxicol 18:73-89. 1996
    ..On the base of these findings, the mechanisms underlying the protective action of TJ-48 against systemic Candida infection was discussed in relation with its possible activity to activate the macrophage function...
  35. doi request reprint Involvement of Rho kinase in the pathogenesis of acute pulmonary embolism-induced polystyrene microspheres in rats
    M Toba
    Department of Respiratory Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 298:L297-303. 2010
    ..0, 89.1 +/- 8.5 Torr, PE, PE+HA1077, PE+Y27632) in the PE rats. These results suggest that pulmonary endothelial dysfunction and activation of Rho kinase may contribute to the potentiation of vasoconstriction and hypoxemia in the PE rats...
  36. doi request reprint GM2 gangliosidosis variant 0 (Sandhoff-like disease) in a family of toy poodles
    S Tamura
    Tamura Animal Clinic, Hiroshima, Japan Laboratory of Veterinary Pathology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo, Japan
    J Vet Intern Med 24:1013-9. 2010
    ....
  37. ncbi request reprint Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients
    K Maebashi
    Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192 0395, Japan
    J Antimicrob Chemother 47:527-36. 2001
    ....
  38. ncbi request reprint Identification of T helper cell subsets in continuous ambulatory peritoneal dialysis patients
    T Yokoyama
    Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan
    Nephron 89:215-8. 2001
    ..7 +/- 0.4%. CONCLUSION: These data demonstrate that Th cells from CAPD patients manifest a dysregulated differentiation profile characterized by a major increase in the percentage of Th2 cells and by a normal percentage of Th1 cells...
  39. doi request reprint Changes in the Small Intestine of a Cat Associated with Barium Sulphate Following Contrast Radiography
    H Igarashi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Comp Pathol 154:235-8. 2016
    ..This is the first report in animals of the rare complication of barium sulphate incorporation into the gastrointestinal mucosa after contrast radiography. ..
  40. doi request reprint Lachrymal Gland Basal Cell Adenocarcinoma in a Ferret (Mustela putorius furo)
    J K Chambers
    Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo, Japan
    J Comp Pathol 155:259-62. 2016
    ..In addition to the tumour, the retina of the left eye was detached and folded at the centre of the globe. This is the first report of a non-human case of basal cell adenocarcinoma of the lachrymal gland. ..
  41. doi request reprint Thymic Carcinoma with Cartilage Formation in a Dog
    J K Chambers
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo, Japan
    J Comp Pathol 154:38-41. 2016
    ..This case represents a novel variant of canine thymic epithelial tumour that exhibits cartilage differentiation. ..
  42. doi request reprint Histopathological Studies on the Neuropathogenicity of the Iriki and OBE-1 Strains of Akabane Virus in BALB/cAJcl Mice
    Y Murata
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Science, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo, Japan
    J Comp Pathol 153:140-9. 2015
    ..Furthermore, Akabane virus infects neuronal cells in the brainstem and spreads to the spinal cord via an unidentified transneuronal pathway. ..
  43. ncbi request reprint Analysis of cytotoxicity induced by proinflammatory cytokines in the human alveolar epithelial cell line A549
    Mitsuaki Muroya
    Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Biosci Trends 6:70-80. 2012
    ....
  44. ncbi request reprint Standardization of perioperative management on hepato-biliary-pancreatic surgery
    J J Gao
    Department of Surgery, The University of Tokyo, Tokyo, Japan
    Drug Discov Ther 6:108-11. 2012
    ....
  45. ncbi request reprint Protection against pulmonary infection with Klebsiella pneumoniae in mice by interferon-gamma through activation of phagocytic cells and stimulation of production of other cytokines
    K Yoshida
    Department of Internal Medicine II, Toho University School of Medicine, Tokyo, Japan
    J Med Microbiol 50:959-64. 2001
    ....
  46. doi request reprint Independent histological risk factors for lymph node metastasis of superficial esophageal squamous cell carcinoma; implication of claudin-5 immunohistochemistry for expanding the indications of endoscopic resection
    T Chiba
    Department of Human Pathology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Dis Esophagus 23:398-407. 2010
    ....
  47. ncbi request reprint Fractal analysis of senile plaque observed in various animal species
    H Nakayama
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, 113 8657, Tokyo, Japan
    Neurosci Lett 297:195-8. 2001
    ..In addition, specific shapes and different FD values of the diffuse plaque among animals suggested that the original conditions for plaque formation would be different...
  48. ncbi request reprint Colocalization of Bcl-2 and 4-hydroxynonenal modified proteins in microglial cells and neurons of rat brain following transient focal ischemia
    T Urabe
    Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan
    Neurosci Lett 247:159-62. 1998
    ..Bcl-2 may play an important role in the antioxidant system promoting survival of the neurons and activated microglia following reperfusion injury...
  49. ncbi request reprint Physical activity level in healthy free-living Japanese estimated by doubly labelled water method and International Physical Activity Questionnaire
    K Ishikawa-Takata
    Health Promotion and Exercise Program, National Institute of Health and Nutrition, Tokyo, Japan
    Eur J Clin Nutr 62:885-91. 2008
    ....
  50. ncbi request reprint Successful therapeutic use of a single-dose of rituximab on relapse in adults with minimal change nephrotic syndrome
    Y Sawara
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Clin Nephrol 72:69-72. 2009
    ..Complete remission occurred 10 days later, when no CD19/20-positive B cells were detected in the blood. This the first report of efficacy of single-dose rituximab therapy to treat multi-relapsing MCNS in an adult patient...
  51. ncbi request reprint Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel member of the G protein family
    M Watanabe
    Department of Virology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Gene 256:51-8. 2000
    ..In situ hybridization analysis revealed that Gtpbp2 was predominantly expressed in spermatocytes and round-spermatids in the testis. These novel genes were localized to human chromosome 6p21.1-2 and mouse chromosome 17qC-D...
  52. doi request reprint Establishment of a rat model for canine necrotizing meningoencephalitis (NME)
    E S Park
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Vet Pathol 51:1151-64. 2014
    ..All the present findings indicate that autoantibodies together with microglia and T cells may play a major role in the pathogenesis of idiopathic canine meningoencephalomyelitis. ..
  53. doi request reprint Experimental transmission of AA amyloidosis by injecting the AA amyloid protein into interleukin-1 receptor antagonist knockout (IL-1raKO) mice
    K Watanabe
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Vet Pathol 52:505-12. 2015
    ..These results indicated that IL-1raKO mice are a useful animal model for investigating AA amyloidogenesis...
  54. doi request reprint The effects of tumor location on diagnostic criteria for canine malignant peripheral nerve sheath tumors (MPNSTs) and the markers for distinction between canine MPNSTs and canine perivascular wall tumors
    S Suzuki
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Vet Pathol 51:722-36. 2014
    ..In particular, NGFR and Olig2 were almost negative in the rest of PWT cases. These findings suggest that NGFR and Olig2 are useful to distinguish these 2 tumors. ..
  55. doi request reprint 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain
    H Kanemitsu
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Neurotoxicol Teratol 31:198-202. 2009
    ..These results may suggest that the p53-mediated intrinsic pathway is essential for 6-MP-induced apoptosis of neural progenitor cells in the developing telencephalon of rats and mice...
  56. doi request reprint Galectin-1 suppresses alpha2(I) collagen through Smad3 in renal epithelial cells
    K Okano
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, 162 8666, Japan
    Cell Mol Life Sci 65:3304-11. 2008
    ..Taken together, the results suggest that galectin-1 decreases Smad3-complex from binding to the SBE, down-regulating transcription of COL1A2 in TGF-beta1-stimulated renal epithelial cells...
  57. doi request reprint Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis
    K Uchida
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Kidney Int 73:926-32. 2008
    ..Our study suggests that tyrosine phosphorylation of nephrin by regulating F-actin formation may be important for the maintenance of normal podocyte morphology and function...
  58. ncbi request reprint Transformation of bile acids and sterols by clostridia (fusiform bacteria) in Wistar rats
    K Uchida
    Strategic Information Unit, Shionogi and Co, Ltd, Shibuya, Tokyo, Japan
    Lipids 34:269-73. 1999
    ..Escherichia coli transformed neither bile acids nor sterols. These data suggest that clostridia play an important role in the formation of secondary bile acids and coprostanol in rats...
  59. ncbi request reprint Successful treatment of 115 pediatric renal transplant recipients with tacrolimus-based immunosuppressive therapy: a 7-year multicenter study in Japan
    A Hasegawa
    Department of Nephrology, Toho University School of Medicine, Omori Nishi, Tokyo, Japan
    Transplant Proc 37:1769-70. 2005
    ..6%), and impaired glucose tolerance (20.9%). The incidences of these adverse events were significantly decreased among patients who had undergone transplantation after March 2000 (n = 43), namely, 30.2%, 18.6%, and 11.6%, respectively...
  60. ncbi request reprint Effects of long-term treatment with mizoribine in patients with proliferative lupus nephritis
    W Yumura
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Clin Nephrol 64:28-34. 2005
    ..We studied whether maintenance therapy with MZR and prednisolone (PSL) in severe proliferative lupus nephritis patients could improve immunity, reduce proteinuria, prevent renal relapse, and reduce steroid dose...
  61. ncbi request reprint Basilar artery occlusion due to mucormycotic emboli, preceded by acute hydrocephalus
    J Inamasu
    Department of Neurosurgery, Keio University School of Medicine, Shinanomachi 35, Shinjuku ku, Tokyo, Japan
    Clin Neurol Neurosurg 102:18-22. 2000
    ....
  62. ncbi request reprint Phylogenic analysis of echovirus type 30 isolated from a large epidemic of aseptic meningitis in Japan during 1997-1998
    H Yoshida
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Jpn J Infect Dis 52:160-3. 1999
    ..All isolates identified during 1997-1998 belonged to only two genomic groups; these two groups are thought to be the causative viral agents involved in the recent epidemic...
  63. ncbi request reprint Antitumor effects of the intravesical instillation of heat killed cells of the Lactobacillus casei strain Shirota on the murine orthotopic bladder tumor MBT-2
    T Takahashi
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    J Urol 166:2506-11. 2001
    ..Furthermore, the antitumor effect of LC9018 is exerted via the augmentation of local cell mediated antitumor immunity...
  64. ncbi request reprint Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase
    K Uchida
    Virology Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 148:617-22. 1987
    ..Within the 3' untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer...
  65. pmc In vitro and in vivo activities of CS-758 (R-120758), a new triazole antifungal agent
    Yasuki Kamai
    Biological Research Laboratories, Sankyo Co, Ltd, Shinagawa ku, Tokyo 140 8710, Japan
    Antimicrob Agents Chemother 46:367-70. 2002
    ..The 50% effective doses against these infections were 0.41 to 5.0 mg/kg of body weight. These results suggest that CS-758 may be useful in the treatment of candidiasis, cryptococcosis, and aspergillosis...
  66. ncbi request reprint Comparative evaluation of standard dilution method and commercial kit for frozen plate antifungal susceptibility testing of yeasts using 200 clinical isolates
    Koichi Makimura
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo, Japan
    Microbiol Immunol 48:747-53. 2004
    ..0%, 97.5%, 97.0%, and 97.0%, respectively. Overall, the frozen plate antifungal susceptibility testing kit provided convenient and reproducible results comparable to those obtained with the JSMM standard method...
  67. ncbi request reprint A novel murine model of oral candidiasis with local symptoms characteristic of oral thrush
    Natsuko Takakura
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa 228 8583, Japan
    Microbiol Immunol 47:321-6. 2003
    ..This model would be a useful experimental oral candidiasis for investigating the pathogenesis of C. albicans oral infection and the efficacy of various antifungal agents microbiologically and symptomatically...
  68. ncbi request reprint Proliferation of intracellular structure corresponding to reduced affinity of fluconazole for cytochrome P-450 in two low-susceptibility strains of Candida albicans isolated from a Japanese AIDS patient
    Kazunori Maebashi
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo 192 0395, Japan
    Microbiol Immunol 47:117-24. 2003
    ..In addition to the reduced intracellular accumulation, the decreased affinity of fluconazole for CYP in TIMM 3164 and 3165 is assumed to be associated with the fluconazole-resistance phenotype...
  69. pmc Efficacy of CS-758, a novel triazole, against experimental fluconazole-resistant oropharyngeal candidiasis in mice
    Yasuki Kamai
    Biological Research Laboratories, Laboratory Animal Science and Toxicology Research Laboratories, Sankyo Co, Ltd, Shinagawa ku, Tokyo 140 8710, Japan
    Antimicrob Agents Chemother 47:601-6. 2003
    ..These results suggest that CS-758 is a promising compound for the treatment of oropharyngeal candidiasis including fluconazole-refractory infections...
  70. ncbi request reprint Morphological changes of Candida albicans induced by micafungin (FK463), a water-soluble echinocandin-like lipopeptide
    Yayoi Nishiyama
    J Electron Microsc (Tokyo) 51:247-55. 2002
    ..In addition, the structure of cell membranes as well as of membranous cytoplasmic organelles was slightly impaired. These data suggest that micafungin principally affects the normal formation of the cell wall in growing Candida cells...
  71. ncbi request reprint A novel mechanism of fluconazole resistance associated with fluconazole sequestration in Candida albicans isolates from a myelofibrosis patient
    Kazunori Maebashi
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo, Japan
    Microbiol Immunol 46:317-26. 2002
    ..These results suggest that fluconazole sequestration caused by vesicular vacuoles of the resistant isolate might act as a novel mechanism of fluconazole resistance besides the decreased affinity of cytochrome P-450...
  72. ncbi request reprint A Queensland koala kept in a Japanese zoological park was carrier of an imported fungal pathogen, Filobasidiella neoformans var. bacillispora (Cryptococcus neoformans var. gattii)
    Koichi Makimura
    Teikyo University Institute of Medical Mycology, Tokyo 192 0395, Japan
    Jpn J Infect Dis 55:31-2. 2002
  73. ncbi request reprint [Issues in the development of drugs for treating deep-seated mycosis]
    Katsuhisa Uchida
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    Nihon Ishinkin Gakkai Zasshi 43:239-47. 2002
    ....
  74. ncbi request reprint Characterization of mechanisms of fluconazole resistance in a Candida albicans isolate from a Japanese patient with chronic mucocutaneous candidiasis
    Yasuki Kamai
    Teikyo University Institute of Medical Mycology, Hachioji, 192 0395, Japan
    Microbiol Immunol 48:937-43. 2004
    ..These mutations are thought to confer the above-mentioned characteristics to Erg11p...
  75. ncbi request reprint Effects of micafungin on the morphology of Aspergillus fumigatus
    Yayoi Nishiyama
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo 192 0395, Japan
    J Electron Microsc (Tokyo) 54:67-77. 2005
    ..This cytological effect of micafungin on the hyphal growth of A. fumigatus can explain its potent anti-Aspergillus activity...
  76. ncbi request reprint A novel method to estimate the contribution of the vapor activity of essential oils in agar diffusion assay
    Shigeharu Inouye
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    Nihon Ishinkin Gakkai Zasshi 47:91-8. 2006
    ....
  77. ncbi request reprint [Studies on the correlation of the method currently used by the Japanese Society for Medical Mycology and its modified method with the NCCLS M27-A2 microdilution method for azole susceptibility testing of Candida species]
    Katsuhisa Uchida
    Teikyo University Research Institute of Medical Mycology, Tokyo, Japan
    Nihon Ishinkin Gakkai Zasshi 47:209-17. 2006
    ..These results suggest that there is an urgent need to revise the current JSMM method...
  78. ncbi request reprint Oral administration of itraconazole solution has superior efficacy in experimental oral and oesophageal candidiasis in mice than its intragastric administration
    Hiroko Ishibashi
    Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192 0395, Japan
    J Antimicrob Chemother 59:317-20. 2007
    ..The therapeutic activities of cyclodextrin-associated itraconazole oral solution (itraconazole OS) by two administration routes in experimental oral and oesophageal candidiasis in mice were examined and compared...
  79. ncbi request reprint Evaluation of the effect of terpenoid quinones on Trichophyton mentagrophytes by solution and vapor contact
    Shigeharu Inouye
    Teikyo University Institute of Medical Mycology, 256 Otsuka, Hachioji, Tokyo 192 0395, Japan
    J Infect Chemother 12:100-4. 2006
    ..The antibacterial activity was related to the orthoquinone structure (1,2-chloranil and 1,2-naphthoquinone) and the antifungal activity was related to the paraquinone structure (chloranil, ubiquinone 0, thymoquinone, and menadione)...
  80. ncbi request reprint [Pharmacological, pharmacokinetic, and clinical profile of itraconazole oral solution (ITRIZOLE Oral Solution 1%)]
    Hisaya Otani
    Nihon Yakurigaku Zasshi 130:69-76. 2007
  81. ncbi request reprint In vitro and in vivo antifungal activities of FX0685, a novel triazole antifungal agent with potent activity against fluconazole-resistant Candida albicans
    Sho Takahata
    Pharmaceutical Research Department, Meiji Seika Kaisha Ltd, Kohoku Ku, Yokohama, Japan
    Med Mycol 43:227-33. 2005
    ..albicans, as well as for the treatment of pulmonary aspergillosis...
  82. ncbi request reprint A novel mycological analysis valuable for evaluating therapeutic efficacy of antimycotics against experimental dermatophytosis in guinea pigs
    Toshiro Majima
    Pharmaceutical R and D Laboratories, POLA Chemical Industries, Inc, Yokohama, Kanagawa, Japan
    Mycoses 48:108-13. 2005
    ..This new analytical method may also be applicable to the in vivo assessment of the therapeutic effect against dermatophytosis experimentally produced in guinea pigs...
  83. ncbi request reprint DNA base alignment and taxonomic study of genus Malassezia based upon partial sequences of mitochondrial large subunit ribosomal RNA gene
    Yohko Yamada
    Department of Chemical and Biological Sciences, Faculty of Science, Japan Women s University, Bunkyo ku, Tokyo 112 8681, Japan
    Microbiol Immunol 47:475-8. 2003
    ..The dendrogram obtained from this gene supports the previous study of Malassezia species based upon the chromosomal genes. This is the first report of taxonomic analysis of Malassezia species based upon the mitochondrial gene...
  84. ncbi request reprint PCR identification system for the genus Aspergillus and three major pathogenic species: Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger
    Chise Sugita
    First Department of Internal Medicine, Tokyo Woman s Medical University Shinjuku, Tokyo, Japan
    Med Mycol 42:433-7. 2004
    ..The PCR based identification system reported here will be a powerful tool to control difficult pulmonary fungal infections and to speed the application of effective treatment...
  85. ncbi request reprint [Status and issues of preclinical evaluation of the therapeutic effects of newly developed antifungal agents]
    Katsuhisa Uchida
    Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192 0395, Japan
    Nihon Ishinkin Gakkai Zasshi 45:83-91. 2004
    ..This review presents the present status of preclinical evaluation test methods and discusses the issues...
  86. ncbi request reprint Vapor activity of 72 essential oils against a Trichophyton mentagrophytes
    Shigeharu Inouye
    Teikyo University Institute of Medical Mycology, 256 Otsuka, Hachioji, Tokyo 192 0395, Japan
    J Infect Chemother 12:210-6. 2006
    ..But oils containing sesquiterpenes showed weaker vapor activity than that expected from the contact activity. Based on the activity-chemical structure relationship, the 72 oils were classified into seven functional groups...
  87. ncbi request reprint Rapid identification of Trichophyton tonsurans by specific PCR based on DNA sequences of nuclear ribosomal internal transcribed spacer (ITS) 1 region
    Eri Yoshida
    Department of Dermatology, Tokyo Medical University, Nishishinjuku, 6 1 1 Shinjuku ku, and Department of Dermatology, Fraternity Memorial Hospital, Tokyo 160 0023, Japan
    J Dermatol Sci 42:225-30. 2006
    ..Trichophyton tonsurans, a dermatophyte implicated in an international epidemic of tinea capitis, was also found to be responsible for infecting wrestling and Judo athletes nationwide in Japan since 2001...
  88. ncbi request reprint Isolation of a promoter region of a secreted metalloprotease gene from Microsporum canis
    Tsuyoshi Yamada
    Teikyo University Institute of Medical Mycology, Tokyo 192 0395, Japan
    Jpn J Infect Dis 57:25-8. 2004
    ..Further analyses of the regulatory sequence may be useful for understanding the molecular basis of the coordinated expression of the various genes involved in dermatophytosis...
  89. ncbi request reprint The vapor activity of oregano, perilla, tea tree, lavender, clove, and geranium oils against a Trichophyton mentagrophytes in a closed box
    Shigeharu Inouye
    Teikyo University Institute of Medical Mycology, 256 Otsuka, Hachioji, Hachioji, Tokyo 192 0395, Japan
    J Infect Chemother 12:349-54. 2006
    ..This suggested that the active constituent accumulated on the fungal cells around 15 h caused irreversible damage, which eventually led to cellular death...
  90. ncbi request reprint Combined effect of heat, essential oils and salt on fungicidal activity against Trichophyton mentagrophytes in a foot bath
    Shigeharu Inouye
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    Nihon Ishinkin Gakkai Zasshi 48:27-36. 2007
    ..The inhibitory effect of heat and oils was also observed against mycelia of T. rubrum and conidia of T. mentagrophytes. Thermotherapy combined with essential oils and salt would be promising to treat tinea pedis in a foot bath...
  91. ncbi request reprint Effect of lactoferrin feeding on the host antifungal response in guinea-pigs infected or immunised with Trichophyton mentagrophytes
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan
    J Med Microbiol 51:844-50. 2002
    ..In conclusion, LF feeding may potentiate the host antifungal defence systems by modulating MNC function rather than plasma antifungal activity or peripheral blood neutrophil PMNL activity...
  92. ncbi request reprint Development of the adenohypophysis in the lamprey: evolution of epigenetic patterning programs in organogenesis
    Katsuhisa Uchida
    Laboratory for Evolutionary Morphology, Center for Developmental Biology, RIKEN, Kobe, Hyogo 650 0047, Japan
    J Exp Zool B Mol Dev Evol 300:32-47. 2003
    ....
  93. ncbi request reprint Histopathological study on experimental endophthalmitis induced by bloodstream infection with Candida albicans
    Junko Omuta
    First Department of Ophthalmology, Toho University School of Medicine, Tokyo 143 8541, Japan
    Jpn J Infect Dis 60:33-9. 2007
    ..Our results indicate that ophthalmic examination is useful to monitor the development and systemic involvement of endophthalmitis in patients with candidemia...
  94. ncbi request reprint Reproducible genetic transformation system for two dermatophytes, Microsporum canis and Trichophyton mentagrophytes
    Tsuyoshi Yamada
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo, Japan
    Med Mycol 43:533-44. 2005
    ..This reproducible transformation system provides a method for the genetic manipulation of these pathogens, which will facilitate detailed molecular analysis of dermatophytosis...
  95. ncbi request reprint Usefulness of a colorimetric method for testing antifungal drug susceptibilities of Aspergillus species to voriconazole
    Hideyo Yamaguchi
    Research Institute of Medical Mycology, Teikyo University, Tokyo, Japan
    J Infect Chemother 8:374-7. 2002
    ..Our study suggests the potential value of the Alamar Blue method as a convenient alternative to the NCCLS M38-P method for routine testing of Aspergillus species susceptibility to at least voriconazole and ITCZ...