T Fukai

Summary

Affiliation: Toho University
Country: Japan

Publications

  1. ncbi request reprint Accurate mass measurement of low molecular weight compounds by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    T Fukai
    Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan
    J Am Soc Mass Spectrom 11:458-63. 2000
  2. ncbi request reprint Antinephritis and radical scavenging activity of prenylflavonoids
    Toshio Fukai
    School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Fitoterapia 74:720-4. 2003
  3. ncbi request reprint Antimicrobial activities of hydrophobic 2-arylbenzofurans and an isoflavone against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus
    Toshio Fukai
    Department of Biophysical Chemistry, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funaba shi, Chiba 274 8510, Japan
    Planta Med 70:685-7. 2004
  4. ncbi request reprint Antimicrobial activity of isoprenoid-substituted xanthones from Cudrania cochinchinensis against vancomycin-resistant enterococci
    T Fukai
    Department of Biophysical Chemistry, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Phytomedicine 12:510-3. 2005
  5. ncbi request reprint Antimicrobial activity of 2-arylbenzofurans from Morus species against methicillin-resistant Staphylococcus aureus
    Toshio Fukai
    School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Fitoterapia 76:708-11. 2005
  6. ncbi request reprint Antimicrobial activity of hydrophobic xanthones from Cudrania cochinchinensis against Bacillus subtilis and methicillin-resistant Staphylococcus aureus
    Toshio Fukai
    Department of Biophysical Chemistry, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Chem Biodivers 1:1385-90. 2004
  7. ncbi request reprint Anti-Helicobacter pylori flavonoids from licorice extract
    Toshio Fukai
    Department of Physico chemical Analysis, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Life Sci 71:1449-63. 2002
  8. ncbi request reprint Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines
    T Fukai
    Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan
    Anticancer Res 20:2525-36. 2000
  9. ncbi request reprint Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra
    Toshio Fukai
    Department of Physico chemical Analysis, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Fitoterapia 74:624-9. 2003
  10. ncbi request reprint Cytotoxic and DNA damage-inducing activities of low molecular weight phenols from rhubarb
    Y Q Shi
    School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    Anticancer Res 21:2847-53. 2001

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Accurate mass measurement of low molecular weight compounds by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    T Fukai
    Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan
    J Am Soc Mass Spectrom 11:458-63. 2000
    ....
  2. ncbi request reprint Antinephritis and radical scavenging activity of prenylflavonoids
    Toshio Fukai
    School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Fitoterapia 74:720-4. 2003
    ..Morusin, licoricidin (3), licochalcone A and licorisoflavan A showed weak scavenging activity against superoxide anion radical...
  3. ncbi request reprint Antimicrobial activities of hydrophobic 2-arylbenzofurans and an isoflavone against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus
    Toshio Fukai
    Department of Biophysical Chemistry, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funaba shi, Chiba 274 8510, Japan
    Planta Med 70:685-7. 2004
    ..13-6.25 microg/mL). Five compounds also showed antibacterial activity against ten MRSA strains (MIC80 = 3.13 microg/mL)...
  4. ncbi request reprint Antimicrobial activity of isoprenoid-substituted xanthones from Cudrania cochinchinensis against vancomycin-resistant enterococci
    T Fukai
    Department of Biophysical Chemistry, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Phytomedicine 12:510-3. 2005
    ..56 microg/ml). Four xanthones, 1,3,7-trihydroxy-2-prenylxanthone, gerontoxanthone I, alvaxanthone and isoalvaxanthone, showed weaker antibacterial activity against these VREs (MICs = 3.13-6.25 microg/ml). ...
  5. ncbi request reprint Antimicrobial activity of 2-arylbenzofurans from Morus species against methicillin-resistant Staphylococcus aureus
    Toshio Fukai
    School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Fitoterapia 76:708-11. 2005
    ..Among these compounds, chalcomoracin (a leaf phytoalexine of mulberry tree) exhibited considerable antibacterial activity against MRSAs (MICs 0.78 mug/ml)...
  6. ncbi request reprint Antimicrobial activity of hydrophobic xanthones from Cudrania cochinchinensis against Bacillus subtilis and methicillin-resistant Staphylococcus aureus
    Toshio Fukai
    Department of Biophysical Chemistry, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Chem Biodivers 1:1385-90. 2004
    ..13-6.25 microg/ml). These compounds also exhibited similar MIC values against methicillin-sensitive S. aureus, MRSAs, and Micrococcus luteus...
  7. ncbi request reprint Anti-Helicobacter pylori flavonoids from licorice extract
    Toshio Fukai
    Department of Physico chemical Analysis, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Life Sci 71:1449-63. 2002
    ..pylori activity. These compounds may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals...
  8. ncbi request reprint Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines
    T Fukai
    Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan
    Anticancer Res 20:2525-36. 2000
    ..Most of the polyphenols failed to reduce the cytophathic effect of HIV infection in MT-4 cells...
  9. ncbi request reprint Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra
    Toshio Fukai
    Department of Physico chemical Analysis, School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Fitoterapia 74:624-9. 2003
    ..ESR spectroscopy demonstrated that glabridin neither produced radical, nor affected the radical intensity of sodium ascorbate, suggesting the lack of correlation between the antinephritis activity and radical scavenging activity...
  10. ncbi request reprint Cytotoxic and DNA damage-inducing activities of low molecular weight phenols from rhubarb
    Y Q Shi
    School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    Anticancer Res 21:2847-53. 2001
    ..Spore rec-assay with a recombination deficient mutant of Bacillus subtilis M45 demonstrated the DNA damage-inducing activity of emodin and aloe-emodin 15-O-beta-D-glucopyranoside among, rhubarb phenols...
  11. ncbi request reprint Cytotoxic flavonoids with isoprenoid groups from Morus mongolica
    Y Q Shi
    Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
    J Nat Prod 64:181-8. 2001
    ..On the other hand, seven 2-arylbenzofurans exhibited lower cytotoxicity and tumor specificity as compared with flavanones...
  12. ncbi request reprint Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis
    A Hou
    Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
    J Nat Prod 64:65-70. 2001
    ..The presence of two sets of hydrophobic and hydrophilic groups in separate domains in each molecule might play a role in the mediation of tumor-specific action...
  13. ncbi request reprint Collision-induced dissociation of ring-opened cyclic depsipeptides with a guanidino group by electrospray ionization/ion trap mass spectrometry
    J Kuroda
    Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
    J Mass Spectrom 36:30-7. 2001
    ..The measurements with electrospray ionization (ESI)/ion trap MS of depsipeptides with a side chain containing polar groups may provide useful information for structural determination...
  14. ncbi request reprint Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats
    Abdel Nasser B Singab
    Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt
    J Ethnopharmacol 100:333-8. 2005
    ..However, this is the first biological screening of the Egyptian Morus alba root bark; further future merit studies including clinical study will be necessary in order to confirm the results obtained from this study...
  15. ncbi request reprint Isoflavonoids from roots of Erythrina zeyheri
    Hitoshi Tanaka
    Faculty of Pharmacy, Meijo University, Yagoto, Tempaku ku, Nagoya 468 8503, Japan
    Phytochemistry 64:753-8. 2003
    ..Their structures were established on the basis of spectroscopic evidence, and their antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) were estimated by determining minimum inhibitory concentrations...
  16. ncbi request reprint Antimicrobial activity of licorice flavonoids against methicillin-resistant Staphylococcus aureus
    Toshio Fukai
    School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Fitoterapia 73:536-9. 2002
    ..aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa...
  17. ncbi request reprint A new 2-arylbenzofuran from the root bark of Chinese Morus cathayana
    Ya Qin Shi
    Department of Physico chemical Analysis, Faculty of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Fitoterapia 78:617-8. 2007
    ..A new 2-arylbenzofuran, sanggenofuran B (3',5'-dihydroxy-6-methoxy-4'-prenyl-2-arylbenzofuran), from the root bark of Chinese Morus cathayana is reported...
  18. ncbi request reprint An arylbenzofuran and four isoflavonoids from the roots of Erythrina poeppigiana
    Hitoshi Tanaka
    Faculty of Pharmacy, Meijo University, Yagoto, Tempaku ku, Nagoya 468 8503, Japan
    Phytochemistry 63:597-602. 2003
    ..Erypoegin F is a rare 2-arylbenzofuran possessing a formyl group from a natural source, and erypoegin I is the first naturally occurring isoflavonoid with a 2-oxo-3-methylbutyl group...
  19. ncbi request reprint Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species
    Toshio Fukai
    School of Pharmaceutical Sciences, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    J Nat Prod 66:1118-20. 2003
    ..nidulans (MICs = 2-8 microg/mL). Compounds 1 and 3 also showed antifungal activity against Candida glabrata (MICs = 4-8 microg/mL)...
  20. ncbi request reprint Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. II. Structure elucidation
    Yasutaka Hoshino
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Chiba 260 8673, Japan
    J Antibiot (Tokyo) 57:803-7. 2004
    ..Transvalencin A is comprised of o-substituted p-chlorophenol, tetrasubstituted oxazoline, disubstituted thiazolyl-N-methylthiazolidine and monosubstituted N-methylthiazolidine...
  21. ncbi request reprint Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. I. Taxonomy, fermentation, isolation and biological activities
    Yasutaka Hoshino
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba, Chiba 260 8673, Japan
    J Antibiot (Tokyo) 57:797-802. 2004
    ..The antibiotic is also active against Gram-positive bacteria such as Micrococcus luteus. We observed higher activity for fungi in an acidic medium than in a neutral medium...
  22. ncbi request reprint Two diphenylpropan-1,2-diol syringates from the roots of Erythrina variegata
    Hitoshi Tanaka
    Faculty of Pharmacy, Meijo University, Yagoto, Tempaku ku, Nagoya 468 8503, Japan
    J Nat Prod 65:1933-5. 2002
    ..Both these compounds are unusual diphenylpropan-1,2-diols with a syringyl group...
  23. ncbi request reprint Transvalencin Z, a new antimicrobial compound with salicylic acid residue from Nocardia transvalensis IFM 10065
    Akira Mukai
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan
    J Antibiot (Tokyo) 59:366-9. 2006
    ..Transvalencin Z shows a strong antimicrobial activity against Gram-positive bacteria, but shows no activity against Gram-negative bacteria, fungi and tumor cells...
  24. ncbi request reprint Six new constituents from the roots of Erythrina variegata
    Hitoshi Tanaka
    Faculty of Pharmacy, Meijo University, Yagoto, Tempaku ku, Nagoya 468 8503, Japan
    Chem Biodivers 1:1101-8. 2004
    ..Eryvarin R (6) is an unusual 3-aryl-2,3-dihydrobenzofuran derivative with a formyl (CHO) group. Eryvarin Q (5) showed potent antibacterial activity against methicillin-resistant Staphylococcus aureus...
  25. ncbi request reprint Eryvarins F and G, two 3-phenoxychromones from the roots of Erythrina variegata
    Hitoshi Tanaka
    Faculty of Pharmacy, Meijo University, Yagoto, Tempaku ku, Nagoya 468 8503, Japan
    Phytochemistry 62:1243-6. 2003
    ..Eryvarins F and G are unusual 3-phenoxychromone derivatives with two isoprenoid groups...