Yoshio Tanaka

Summary

Affiliation: Toho University
Country: Japan

Publications

  1. ncbi request reprint [Molecular mechanisms for cAMP-independent activation of MaxiK channel: G protein direct channel regulation and contribution to the tuning of vascular smooth muscle tone]
    Fumiko Yamaki
    Departments of Chemical Pharmacology and Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    Nihon Yakurigaku Zasshi 122:37P-39P. 2003
  2. ncbi request reprint Beta1-subunit of MaxiK channel in smooth muscle: a key molecule which tunes muscle mechanical activity
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    J Pharmacol Sci 94:339-47. 2004
  3. ncbi request reprint cAMP-independent mechanism is significantly involved in beta2-adrenoceptor-mediated tracheal relaxation
    Katsuo Koike
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    Eur J Pharmacol 492:65-70. 2004
  4. ncbi request reprint Changes in cytosolic Ca2+ measured by use of fura-2 and contraction produced by quick stretch and various stimulants in canine cerebral artery
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    Res Commun Mol Pathol Pharmacol 102:79-92. 1998
  5. ncbi request reprint New insights into beta-adrenoceptors in smooth muscle: distribution of receptor subtypes and molecular mechanisms triggering muscle relaxation
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    Clin Exp Pharmacol Physiol 32:503-14. 2005
  6. ncbi request reprint Pharmacological evidence that tetraethylammonium-sensitive, iberiotoxin-insensitive K+ channels function as a negative feedback element for sympathetic neurotransmission by suppressing omega-conotoxin-GVIA-insensitive Ca2+ channels in the relaxation of ra
    Yoshio Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    Naunyn Schmiedebergs Arch Pharmacol 367:35-42. 2003
  7. ncbi request reprint Bk(Ca) channel activity enhances with muscle stretch in guinea-pig urinary bladder smooth muscle
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    Res Commun Mol Pathol Pharmacol 113:247-52. 2003
  8. ncbi request reprint Adrenaline produces the relaxation of guinea-pig airway smooth muscle primarily through the mediation of beta(2)-adrenoceptors
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Science, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    J Smooth Muscle Res 41:153-61. 2005
  9. ncbi request reprint Phospholipase C inhibitors suppress spontaneous mechanical activity of guinea pig urinary bladder smooth muscle
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    Biol Pharm Bull 26:1192-4. 2003
  10. ncbi request reprint MaxiK channel roles in blood vessel relaxations induced by endothelium-derived relaxing factors and their molecular mechanisms
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City Chiba 274 8510, Japan
    J Smooth Muscle Res 40:125-53. 2004

Collaborators

Detail Information

Publications66

  1. ncbi request reprint [Molecular mechanisms for cAMP-independent activation of MaxiK channel: G protein direct channel regulation and contribution to the tuning of vascular smooth muscle tone]
    Fumiko Yamaki
    Departments of Chemical Pharmacology and Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    Nihon Yakurigaku Zasshi 122:37P-39P. 2003
    ..Direct regulation by Gs seems to partly account for MaxiK channel-mediated, cAMP-independent mechanism...
  2. ncbi request reprint Beta1-subunit of MaxiK channel in smooth muscle: a key molecule which tunes muscle mechanical activity
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    J Pharmacol Sci 94:339-47. 2004
    ..In this review, we discuss MaxiK channel roles as a tuner of smooth muscle contractility, especially focusing attention on the modulatory beta1-subunit...
  3. ncbi request reprint cAMP-independent mechanism is significantly involved in beta2-adrenoceptor-mediated tracheal relaxation
    Katsuo Koike
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    Eur J Pharmacol 492:65-70. 2004
    ..These results provide evidence for the first time that a cAMP-independent mechanism(s) is involved in beta2-adrenoceptor-mediated tracheal smooth muscle relaxation in the guinea pig...
  4. ncbi request reprint Changes in cytosolic Ca2+ measured by use of fura-2 and contraction produced by quick stretch and various stimulants in canine cerebral artery
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    Res Commun Mol Pathol Pharmacol 102:79-92. 1998
    ..The apparent low Ca2+ sensitivity of stretch-induced contraction in dog cerebral artery might be related to the low efficiency of cytosolic Ca2+ elevated by the Ca2+ release from intracellular storage sites upon stretch...
  5. ncbi request reprint New insights into beta-adrenoceptors in smooth muscle: distribution of receptor subtypes and molecular mechanisms triggering muscle relaxation
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    Clin Exp Pharmacol Physiol 32:503-14. 2005
    ....
  6. ncbi request reprint Pharmacological evidence that tetraethylammonium-sensitive, iberiotoxin-insensitive K+ channels function as a negative feedback element for sympathetic neurotransmission by suppressing omega-conotoxin-GVIA-insensitive Ca2+ channels in the relaxation of ra
    Yoshio Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    Naunyn Schmiedebergs Arch Pharmacol 367:35-42. 2003
    ....
  7. ncbi request reprint Bk(Ca) channel activity enhances with muscle stretch in guinea-pig urinary bladder smooth muscle
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    Res Commun Mol Pathol Pharmacol 113:247-52. 2003
    ..BK(Ca) channels seem activated more strongly to counteract enhanced spontaneous mechanical activity with UBSM stretch...
  8. ncbi request reprint Adrenaline produces the relaxation of guinea-pig airway smooth muscle primarily through the mediation of beta(2)-adrenoceptors
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Science, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    J Smooth Muscle Res 41:153-61. 2005
    ..The present findings provide evidence that the relaxant response of the smooth muscle of the guinea-pig trachea to the adrenal medulla hormone, adrenaline, is mainly mediated through beta(2)-adrenoceptors...
  9. ncbi request reprint Phospholipase C inhibitors suppress spontaneous mechanical activity of guinea pig urinary bladder smooth muscle
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    Biol Pharm Bull 26:1192-4. 2003
    ..The present results support the idea that the action potential is not the sole pacemaker mechanism by which spontaneous contraction is induced in UBSM...
  10. ncbi request reprint MaxiK channel roles in blood vessel relaxations induced by endothelium-derived relaxing factors and their molecular mechanisms
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City Chiba 274 8510, Japan
    J Smooth Muscle Res 40:125-53. 2004
    ....
  11. ncbi request reprint Evidence for a significant role of a Gs-triggered mechanism unrelated to the activation of adenylyl cyclase in the cyclic AMP-independent relaxant response of guinea-pig tracheal smooth muscle
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Chiba 274 8510, Funabashi City, Japan
    Naunyn Schmiedebergs Arch Pharmacol 368:437-41. 2003
    ..This mechanism may account in part for the cyclic AMP-independent relaxant response of tracheal smooth muscle...
  12. ncbi request reprint New insights into the intracellular mechanisms by which PGI2 analogues elicit vascular relaxation: cyclic AMP-independent, Gs-protein mediated-activation of MaxiK channel
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    Curr Med Chem Cardiovasc Hematol Agents 2:257-65. 2004
    ..Our recent work demonstrates a functional tight coupling between IPR and MaxiK channel through a cAMP-independent, G(s)-protein mediated mechanism(s) in vascular smooth muscle...
  13. ncbi request reprint Beta1-adrenoceptor-mediated relaxation with isoprenaline and the role of MaxiK channels in guinea-pig esophageal smooth muscle
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    J Smooth Muscle Res 40:43-52. 2004
    ....
  14. ncbi request reprint MaxiK channel mediates beta2-adrenoceptor-activated relaxation to isoprenaline through cAMP-dependent and -independent mechanisms in guinea-pig tracheal smooth muscle
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    J Smooth Muscle Res 39:205-19. 2003
    ....
  15. ncbi request reprint Pharmacological characterization of the beta-adrenoceptor that mediates the relaxant response to noradrenaline in guinea-pig tracheal smooth muscle
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba, 274 8510, Japan
    Naunyn Schmiedebergs Arch Pharmacol 375:51-64. 2007
    ..Under physiological conditions, beta1(Low) rather than beta1(High) seems to play a more significant role in noradrenaline-regulated airway smooth muscle tone...
  16. ncbi request reprint Comparison of the Ca2+ entry channels responsible for mechanical responses of guinea-pig aorta to noradrenaline and thapsigargin using SK&F 96365 and LOE 908
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi shi, Chiba, Japan
    Naunyn Schmiedebergs Arch Pharmacol 362:160-8. 2000
    ....
  17. ncbi request reprint Role of MaxiK channels in vasoactive intestinal peptide-induced relaxation of rat mesenteric artery
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi, Japan
    Eur J Pharmacol 383:291-6. 1999
    ..These results suggest that activation of MaxiK channels significantly contributes to the relaxant response of rat mesenteric artery to VIP, possibly via cAMP-mediated pathways...
  18. ncbi request reprint Effects of endothelin-1 on the myogenic contraction of canine cerebral artery in response to quick stretch
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    Res Commun Mol Pathol Pharmacol 109:95-101. 2001
    ..These findings suggest that lower concentrations (pM range) of ET- 1 potentiates myogenic tension development of cerebral artery in response to mechanical stretch possibly via an increased Ca2+ influx through voltage-gated Ca2+ channel...
  19. ncbi request reprint A review of HNS-32: a novel azulene-1-carboxamidine derivative with multiple cardiovascular protective actions
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    Cardiovasc Drug Rev 19:297-312. 2001
    ..These multiple ion channel blocking effects are largely responsible for the antiarrhythmic and vasorelaxant actions of HNS-32. This drug may represent a novel approach to the treatment of arrhythmias...
  20. ncbi request reprint Evidence for the possible involvement of Ca2+ entry blockade in the relaxation by class I antiarrhythmic drugs in the isolated pig coronary smooth muscle
    Yoshio Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    Naunyn Schmiedebergs Arch Pharmacol 365:56-66. 2002
    ..Blockade of Na+ channel and/or opening of K+ channels does not seem to play the principal role in the mechanism by which these antiarrhythmic drugs relax coronary artery...
  21. ncbi request reprint Pharmacologic characteristics of non-prostanoid, non-nitric oxide mediated and endothelium-dependent relaxation of guinea-pig aorta in response to substance P
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    Res Commun Mol Pathol Pharmacol 103:65-81. 1999
    ....
  22. ncbi request reprint HNS-32, a novel azulene-1-carboxamidine derivative, inhibits nifedipine-sensitive and -insensitive contraction of the isolated rabbit aorta
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    Naunyn Schmiedebergs Arch Pharmacol 363:344-52. 2001
    ..On the other hand, HNS-32 seems to inhibit Ca2+ channel-independent contraction via mechanism(s) other than elevation of cyclic nucleotides (cAMP and cGMP) and opening of K+ channels...
  23. ncbi request reprint NO-mediated MaxiK(Ca) channel activation produces relaxation of guinea pig aorta independently of voltage-dependent L-type Ca(2+) channels
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Chiba 274 8510, Funabashi, Japan
    Gen Pharmacol 34:159-65. 2000
    ..These findings suggest that blockade of L-type Ca(2+) channels is not a major mechanism responsible for the vascular relaxation due to NO-mediated MaxiK(Ca) channel activation in guinea pig aorta...
  24. ncbi request reprint Endothelium is involved in the vasorelaxation by an ATP-sensitive K+ channel opener, NIP-121
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    Eur J Pharmacol 366:R9-10. 1999
    ..These findings suggest that the presence of endothelium plays a role in the vasorelaxation in response to K(ATP) channel openers...
  25. ncbi request reprint Glycyrrhetinic acid-sensitive mechanism does not make a major contribution to non-prostanoid, non-nitric oxide mediated endothelium-dependent relaxation of rat mesenteric artery in response to acetylcholine
    Y Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    Res Commun Mol Pathol Pharmacol 103:227-39. 1999
    ....
  26. ncbi request reprint Nitric oxide (NO) primarily accounts for endothelium-dependent component of beta-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline
    Yurie Akimoto
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    J Smooth Muscle Res 38:87-99. 2002
    ..Activation of propranolol (3 x 10(-6) M)-inhibitable beta-adrenoceptors seems to be primarily responsible for the NO-mediated endothelium-dependent pathway in isoprenaline-elicited relaxant response of mouse aorta...
  27. ncbi request reprint Kv channels contribute to nitric oxide- and atrial natriuretic peptide-induced relaxation of a rat conduit artery
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    J Pharmacol Exp Ther 317:341-54. 2006
    ..1 subunit, as downstream effectors of NO/ANP-signaling cascade regulating aortic vasorelaxation and further demonstrate vessel-specific K(+) channel involvement in NO/ANP-induced relaxation...
  28. ncbi request reprint Evidence for the primary role for 4-aminopyridine-sensitive K(v) channels in beta(3)-adrenoceptor-mediated, cyclic AMP-independent relaxations of guinea-pig gastrointestinal smooth muscles
    Takahiro Horinouchi
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, 274 8510, Funabashi, Chiba, Japan
    Naunyn Schmiedebergs Arch Pharmacol 367:193-203. 2003
    ..In these smooth muscles, BK(Ca) channels seem to apparently contribute insignificantly to cyclic AMP-independent relaxations following stimulation of beta(3)-type of adrenoceptors...
  29. ncbi request reprint The beta3-adrenoceptor-mediated relaxation induced by dopamine in guinea pig taenia caecum
    Yurie Akimoto
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1, Miyama, Funabashi, Chiba 274 8510, Japan
    J Smooth Muscle Res 39:39-45. 2003
    ..55 and the slope of the regression line was 1.13. These results suggest that the relaxant response to dopamine in the guinea pig taenia caecum is mainly mediated by the beta3-adrenoceptors...
  30. ncbi request reprint Endocardial endothelium-dependent positive inotropy by Ca2+ pump inhibitors: possible involvement of store-operated Ca2+ entry
    Kazuhide Nishimaru
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Funabashi, Chiba, Japan
    Pharmacology 80:200-6. 2007
    ....
  31. doi request reprint Enhanced vascular contractility in alpha1-adrenergic receptor-deficient mice
    Atsushi Sanbe
    Department of Pharmacology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    Life Sci 84:713-8. 2009
    ....
  32. ncbi request reprint The beta2- and beta3-adrenoceptor-mediated relaxation induced by fenoterol in guinea pig taenia caecum
    Yurie Akimoto
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1, Miyama, Funabashi, Chiba 274 8510, Japan
    J Smooth Muscle Res 38:145-51. 2002
    ..80. These results suggest that the relaxant response to fenoterol in the guinea pig taenia caecum is mediated by both the beta2- and the beta3-adrenoceptors...
  33. ncbi request reprint Functional contribution of voltage-dependent and Ca2+ activated K+ (BK(Ca)) channels to the relaxation of guinea-pig aorta in response to natriuretic peptides
    Kazuoki Otsuka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    J Smooth Muscle Res 38:117-29. 2002
    ....
  34. ncbi request reprint [BK channels play an important role as a negative feedback mechanism in the regulation of spontaneous rhythmic contraction of urinary bladder smooth muscles]
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    Nihon Yakurigaku Zasshi 120:106P-108P. 2002
    ..BK channel openers including beta-subunit activators may be a potentially useful therapeutic remedy for the treatment of urinary bladder dysfunctions such as frequent urination...
  35. ncbi request reprint Studies on the mechanisms underlying beta-adrenoceptor-mediated relaxation of rat abdominal aorta
    Mayumi Matsushita
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    J Smooth Muscle Res 42:217-25. 2006
    ....
  36. ncbi request reprint 2-Aminoethoxydiphenyl borate causes dissociation between membrane electrical and mechanical activity in guinea-pig urinary bladder smooth muscle
    Toshiyasu Imai
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    Naunyn Schmiedebergs Arch Pharmacol 366:282-5. 2002
    ..The alteration of membrane electrical activity might not be the exclusive trigger mechanism responsible for the generation of spontaneous rhythmic contraction of this smooth muscle...
  37. ncbi request reprint Effects of aging on alpha1-adrenoceptor mechanisms in the isolated mouse aortic preparation
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi, Chiba, Japan
    J Smooth Muscle Res 42:131-8. 2006
    ....
  38. ncbi request reprint H₂receptor-mediated positive inotropic effect of histamine in neonatal guinea-pig left atria
    Naoki Agata
    Department of Pharmacology, Toho University, Chiba, Japan
    Biol Pharm Bull 33:2033-5. 2010
    ..Receptor binding studies revealed the presence of both H₁ and H₂ receptor types. These results suggest that the positive inotropic effect of histamine in the neonatal guinea-pig atrium is mediated by H₂ receptors...
  39. ncbi request reprint Possible involvement of prostaglandins F(2alpha) and D(2) in acetylcholine-induced positive inotropy in isolated mouse left atria
    Hikaru Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    Pharmacology 67:157-62. 2003
    ..These findings suggest that prostaglandins induce positive inotropic response in mouse atria through FP and EP receptor stimulation and that the former mechanism mediates in part the positive inotropic response to acetylcholine...
  40. ncbi request reprint Function of beta1-adrenoceptors and mRNA expression of beta1- and beta2-adrenoceptors in guinea-pig esophagus
    Takahiro Horinouchi
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Eur J Pharmacol 473:79-82. 2003
    ..These results clearly suggest that not all beta-adrenoceptor mRNA expressed strictly reflect functional receptors in guinea-pig esophageal muscularis mucosae...
  41. ncbi request reprint Inhibition of agonist-induced positive inotropy by a selective Rho-associated kinase inhibitor, Y-27632
    Kazuhide Nishimaru
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    J Pharmacol Sci 92:424-7. 2003
    ..These results provide the first evidence that the Rho/ROCK pathway is involved in endothelin-1-, angiotensin-II-, and PGF(2)(alpha)-induced positive inotropy, but not in beta-adrenoceptor-mediated positive inotropy...
  42. ncbi request reprint Characterization of beta 3-adrenoceptor-mediated relaxation in rat abdominal aorta smooth muscle
    Mayumi Matsushita
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Eur J Pharmacol 482:235-44. 2003
    ..These results clearly suggest that beta(3)-adrenoceptors are involved in beta-adrenoceptor-mediated relaxation of rat abdominal aorta smooth muscle...
  43. pmc Correlation between vasoconstrictor roles and mRNA expression of alpha1-adrenoceptor subtypes in blood vessels of genetically engineered mice
    Chihiro Hosoda
    Department of Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan
    Br J Pharmacol 146:456-66. 2005
    ..No dramatic compensatory change of alpha(1)-AR subtype in mutant mice was observed in pharmacological or quantitative mRNA expression analysis...
  44. ncbi request reprint Comparison of the inhibitory effects of docosahexaenoic acid (DHA) on U46619- and phenylephrine-induced contractions in guinea-pig aorta
    Kazuoki Otsuka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    Biol Pharm Bull 28:1298-300. 2005
    ..Selective inhibition by DHA of TP receptor-mediated contraction of blood vessels seems underlie in part the mechanisms by which this polyunsaturated fatty acid exerts its circulatory-protective effects...
  45. ncbi request reprint Pharmacological characterization of alpha1-adrenoceptor in mouse iliac artery
    Mari Shibano
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1, Miyama, Funabashi, Chiba, Japan
    Eur J Pharmacol 456:77-9. 2002
    ..62. These results indicate that the contractile response to noradrenaline in the mouse iliac artery is predominantly mediated by the alpha(1A) -adrenoceptor subtype...
  46. ncbi request reprint Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells
    Iyuki Namekata
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274 8510, Japan
    Biol Pharm Bull 34:153-5. 2011
    ..2 µM and 4.9 µM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current...
  47. ncbi request reprint Pharmacological evidence for involvement of phospholipase D, protein kinase C, and sodium-calcium exchanger in alpha-adrenoceptor-mediated negative inotropy in adult mouse ventricle
    Kazuhide Nishimaru
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    J Pharmacol Sci 92:196-202. 2003
    ..These findings suggest that alpha-adrenoceptor-mediated negative inotropy in adult mouse ventricle is mediated by activation of tyrosine kinase, the phospholipase D-phosphatidate phosphohydrolase pathway, and protein kinase C...
  48. ncbi request reprint Effects of HNS-32, a novel antiarrhythmic agent, on guinea-pig myocardium
    Kazuo Noguchi
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi, Chiba, Japan
    Pharmacology 64:36-42. 2002
    ..These results suggest that NHS-32 has V(max) reducing activity on myocardial tissue, which may be responsible for antiarrhythmic effect. The drug may also have additional effect on the Ca(2+) channel at higher concentrations...
  49. ncbi request reprint [Beta 3-adrenoceptor-mediated relaxation of guinea-pig gastric funds smooth muscle: cAMP-independent characteristics and a primary role of 4-aminopyridine-sensitive voltage-dependent K+ (Kv) channels]
    Takahiro Horinouchi
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi City, Chiba 274 8510, Japan
    Nihon Yakurigaku Zasshi 120:109P-111P. 2002
    ..The present results indicate that 4-aminopyridine-sensitive Kv channels play a primary role in cAMP-independent relaxation of guinea-pig gastric fundus smooth muscle in response to the stimulations of beta 3-adrenoceptors...
  50. pmc Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta
    Kyosuke Sato
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
    J Smooth Muscle Res 49:63-77. 2013
    ..Selective inhibition by either DHA or EPA of prostanoid receptor-mediated blood vessel contractions may partly underlie the mechanisms by which these ω-3 polyunsaturated fatty acids exert their circulatory-protective effects...
  51. ncbi request reprint Effect of NIP-142 on potassium channel alpha-subunits Kv1.5, Kv4.2 and Kv4.3, and mouse atrial repolarization
    Hikaru Tanaka
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Funabashi, Chiba 274 8510, Japan
    Biol Pharm Bull 33:138-41. 2010
    ..These results suggest that NIP-142 blocks the potassium channels underlying the transient and sustained outward currents, which may contribute to its antiarrhythmic activity...
  52. doi request reprint Pharmacological characteristics of the inhibitory effects of docosahexaenoic acid on vascular contractions studied in rat mesenteric artery
    Kyosuke Sato
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi, Japan
    Pharmacology 93:229-43. 2014
    ..Effects of docosahexaenoic acid (DHA) on blood vessel contractions to various constrictors were investigated in rat mesenteric artery and compared with those of eicosapentaenoic acid (EPA) and linoleic acid (LA)...
  53. ncbi request reprint [beta-adrenoceptor subtypes involved in relaxations of guinea-pig gastrointestinal smooth muscles: distribution and signaling pathway of beta 3-adrenoceptors]
    Takahiro Horinouchi
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Nihon Yakurigaku Zasshi 122:54P-56P. 2003
    ....
  54. ncbi request reprint Pharmacological evidence showing significant roles for potassium channels and CYP epoxygenase metabolites in the relaxant effects of docosahexaenoic acid on the rat aorta contracted with U46619
    Kyosuke Sato
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences
    Biol Pharm Bull 37:394-403. 2014
    ..The relaxant effect of DHA metabolites seems to be partly triggered by the activation of K(+) channels though the role for BK channel is insignificant. ..
  55. doi request reprint Functional analysis of guinea pig β1-adrenoceptor
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi City, Chiba, Japan
    J Recept Signal Transduct Res 31:395-401. 2011
    ..These results suggest that the G(i)-coupling efficacy of guinea pig and human ADRB1s may be higher than that of rat ADRB1...
  56. pmc Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents
    Hikaru Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi, Chiba 274 8510, Japan
    Br J Pharmacol 135:1096-100. 2002
    ..These results indicate that SEA0400 is a potent and highly selective inhibitor of NCX, and would be a powerful tool for further studies on the role of NCX in the heart and the therapeutic potential of its inhibition...
  57. ncbi request reprint Inhibitory Effects of Antidepressants on Acetylcholine-Induced Contractions in Isolated Guinea Pig Urinary Bladder Smooth Muscle
    Junji Uno
    Department of Chemical Pharmacology, Toho University, Funabashi, Japan
    Pharmacology 99:89-98. 2016
    ....
  58. ncbi request reprint Effects of Distigmine on Electrical Field Stimulation-Induced Contraction of Mouse Urinary Bladder Smooth Muscles
    Keisuke Obara
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University Miyama, Funabashi, Japan
    Pharmacology 99:106-113. 2016
    ....
  59. doi request reprint Electrophysiological characterization of human Na⁺/taurocholate cotransporting polypeptide (hNTCP) heterologously expressed in Xenopus laevis oocytes
    Masayuki Masuda
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274 8510, Japan
    Arch Biochem Biophys 562:115-21. 2014
    ..These results in the hNTCP heterologously expressed in Xenopus oocytes directly demonstrated that hNTCP is an electrogenic Na(+)-dependent transporter...
  60. ncbi request reprint Role of BK channels in testosterone-induced relaxation of the aorta in spontaneously hypertensive rats
    Tamao Unemoto
    Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Biol Pharm Bull 30:1477-80. 2007
    ..This attenuation in SHR was not observed after endothelium removal. The above results suggest that the relaxation induced by Tes following NA-induced vasoconstriction in SHR results from hyperpolarization due to BK channel opening...
  61. ncbi request reprint Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol
    Takahiro Horinouchi
    Division of Pharmacology, Department of Biochemistry and Bioinformative Sciences, School of Medicine, University of Fukui, Fukui 910 1193, Japan
    Life Sci 81:399-404. 2007
    ....
  62. ncbi request reprint Pharmacological evaluation of plasma membrane beta-adrenoceptors in rat hearts using the tissue segment binding method
    Takahiro Horinouchi
    Division of Pharmacology, Department of Biochemistry and Bioinformative Sciences, School of Medicine, University of Fukui, Matsuoka, Fukui 910 1193, Japan
    Life Sci 79:941-8. 2006
    ..In summary, the tissue segment binding method with [(3)H]-CGP12177 enables a more precise quantitation of plasma membrane beta(1)- and beta(2)-adrenoceptors in rat hearts and is suitable for studying their regulation...
  63. ncbi request reprint MaxiK channel-triggered negative feedback system is preserved in the urinary bladder smooth muscle from streptozotocin-induced diabetic rats
    Tsutomu Nakahara
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Smooth Muscle Res 40:97-109. 2004
    ..However, in diabetic UBSM, the main negative-feedback system triggered by MaxiK channel is still preserved enough to counteract the possible enhancement of this smooth muscle mechanical activity...
  64. ncbi request reprint Prefabricated engineered skin flap using an arteriovenous vascular bundle as a vascular carrier in rabbits
    Yoshio Tanaka
    Division of Plastic and Reconstructive Surgery, Shinko Hospital, Kobe, Japan
    Plast Reconstr Surg 117:1860-75. 2006
    ..They hypothesized that increased tissue volume could be obtained by the application of basic fibroblast growth factor (bFGF) and/or by increasing the chamber size and porosity...
  65. ncbi request reprint Purification and characterization of a novel fungal alpha-glucosidase from Mortierella alliacea with high starch-hydrolytic activity
    Yoshio Tanaka
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, 1 3 1 Kagamiyama, Higashi Hiroshima 739 8530, Japan
    Biosci Biotechnol Biochem 66:2415-23. 2002
    ..0-6.0, and in the presence of ethanol, the transglucosylation reaction to form ethyl-alpha-D-glucoside was optimal at pH 5.0 and a temperature range of 45-50 degrees C...
  66. ncbi request reprint Aging, ion channel expression, and vascular function
    Ligia Toro
    Department of Anesthesiology, Department of Molecular and Medical Pharmacology, Brain Research Institute, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1778, USA
    Vascul Pharmacol 38:73-80. 2002
    ..Altogether, these changes increase the risk of coronary artery vasospasm, myocardial ischemia, and infarct in the elderly...