A Masamune

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi Differential roles of the SPINK1 gene mutations in alcoholic and nonalcoholic chronic pancreatitis
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Gastroenterol 42:135-40. 2007
  2. ncbi Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines
    A Masamune
    Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Gastroenterology 116:1330-41. 1999
  3. ncbi Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells
    Atsushi Masamune
    Department of Gastroenterology, Division of Internal Medicine, Tohoku University School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Pancreas 24:130-8. 2002
  4. doi Signal transduction in pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Graduate School of Medicine, Tohoku University, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Gastroenterol 44:249-60. 2009
  5. ncbi Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    J Pharmacol Exp Ther 302:36-42. 2002
  6. doi Effects of ethanol and its metabolites on human pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Dig Dis Sci 55:204-11. 2010
  7. doi Fibrinogen induces cytokine and collagen production in pancreatic stellate cells
    A Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574 Japan
    Gut 58:550-9. 2009
  8. doi Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer
    Atsushi Masamune
    Div of Gastroenterology, Tohoku Univ Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Am J Physiol Gastrointest Liver Physiol 295:G709-17. 2008
  9. ncbi Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Pharmacol Exp Ther 304:8-14. 2003
  10. ncbi A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574 Japan
    J Pharmacol Exp Ther 310:520-7. 2004

Collaborators

Detail Information

Publications74

  1. ncbi Differential roles of the SPINK1 gene mutations in alcoholic and nonalcoholic chronic pancreatitis
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Gastroenterol 42:135-40. 2007
    ..We here examined the prevalence of the serine protease inhibitor Kazal type 1 (SPINK1) gene mutations in Japanese patients with CP, and whether the disease course was different between mutation-positive and -negative patients...
  2. ncbi Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines
    A Masamune
    Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Gastroenterology 116:1330-41. 1999
    ....
  3. ncbi Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells
    Atsushi Masamune
    Department of Gastroenterology, Division of Internal Medicine, Tohoku University School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Pancreas 24:130-8. 2002
    ..Roles of PPAR-gamma activation in pancreatic acinar cells are poorly characterized...
  4. doi Signal transduction in pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Graduate School of Medicine, Tohoku University, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Gastroenterol 44:249-60. 2009
    ....
  5. ncbi Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    J Pharmacol Exp Ther 302:36-42. 2002
    ..Specific activation of these signal transduction pathways may play a role in the pathogenesis of alcohol-induced pancreatic injury...
  6. doi Effects of ethanol and its metabolites on human pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Dig Dis Sci 55:204-11. 2010
    ..Specific activation of signal transduction pathways and cell functions by ethanol and its metabolites may play a role in alcohol-induced pancreatic injury...
  7. doi Fibrinogen induces cytokine and collagen production in pancreatic stellate cells
    A Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574 Japan
    Gut 58:550-9. 2009
    ..The effects of fibrinogen on cell functions in PSCs were examined here...
  8. doi Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer
    Atsushi Masamune
    Div of Gastroenterology, Tohoku Univ Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Am J Physiol Gastrointest Liver Physiol 295:G709-17. 2008
    ..In addition to their established profibrogenic roles, PSCs might play proangiogenic roles during the development of pancreatic fibrosis, where they are subjected to hypoxia...
  9. ncbi Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Pharmacol Exp Ther 304:8-14. 2003
    ..Thus, inhibition of p38 MAP kinase modulated profibrogenic and proinflammatory actions in PSCs, implying a potential application of p38 MAP kinase inhibitors for the treatment of pancreatic fibrosis and inflammation...
  10. ncbi A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574 Japan
    J Pharmacol Exp Ther 310:520-7. 2004
    ..Collectively, our results suggest a role of JNK in the activation of PSCs, and a potential application of JNK inhibitors for the treatment of pancreatic fibrosis and inflammation...
  11. pmc Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo cyo, Aoba ku, Sendai 980 8574, Japan
    World J Gastroenterol 11:3368-74. 2005
    ..To clarify the effects of epigallocatechin-3-gallate (EGCG) on the platelet-derived growth factor (PDGF)-BB-induced proliferation and migration of pancreatic stellate cells (PSCs)...
  12. ncbi Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells
    Atsushi Masamune
    Pancreas Research Group, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Tohoku J Exp Med 199:69-84. 2003
    ..In conclusion, our results suggest that ERK pathway regulates proliferation and migration in response to PDGF-BB, whereas PI 3-kinase mediates cellular migration, but not proliferation of PSCs...
  13. ncbi Protease-activated receptor-2-mediated proliferation and collagen production of rat pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Pharmacol Exp Ther 312:651-8. 2005
    ..Taken together, our results suggest a role of PAR-2 in the sustenance of pancreatic fibrosis through the increased proliferation and collagen production in PSCs...
  14. ncbi NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells
    Atsushi Masamune
    Div of Gastroenterology, Tohoku Univ Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574 Japan
    Am J Physiol Gastrointest Liver Physiol 294:G99-G108. 2008
    ..In conclusion, PSCs express NADPH oxidase to generate ROS, which mediates key cell functions and activation of PSCs. NADPH oxidase might be a potential target for the treatment of pancreatic fibrosis...
  15. ncbi Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Biol Chem 277:141-7. 2002
    ..In conclusion, activation of PPAR-gamma inhibited profibrogenic and proinflammatory actions in activated PSCs, suggesting a potential application of PPAR-gamma ligands in the treatment of pancreatic fibrosis and inflammation...
  16. ncbi Galectin-1 induces chemokine production and proliferation in pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Am J Physiol Gastrointest Liver Physiol 290:G729-36. 2006
    ..In conclusion, our results suggest a role of galectin-1 in chemokine production and proliferation through its beta-galactoside binding activity in activated PSCs...
  17. ncbi Nitric oxide decreases endothelial activation by rat experimental severe pancreatitis-associated ascitic fluids
    A Masamune
    Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Pancreas 20:297-304. 2000
    ..The ability of NO to limit endothelial activation and inhibit leukocyte adhesion might contribute to its antiinflammatory properties in AP...
  18. ncbi Curcumin blocks activation of pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Cell Biochem 97:1080-93. 2006
    ..In addition, curcumin inhibited transformation of freshly isolated cells to myofibroblast-like phenotype. In conclusion, curcumin inhibited key cell functions and activation of PSCs...
  19. ncbi Lysophosphatidylcholine induces apoptosis in AR42J cells
    A Masamune
    Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Pancreas 22:75-83. 2001
    ..Apoptosis induction by lyso-PC (at 25 microM) was not inhibited by a specific antagonist of platelet-activating factor (PAF) receptor, suggesting that the action was independent of th..
  20. ncbi Establishment and characterization of a rat pancreatic stellate cell line by spontaneous immortalization
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    World J Gastroenterol 9:2751-8. 2003
    ..A continuous cell line may therefore be valuable in studying molecular mechanisms of these pancreatic disorders. The aim of this study was to establish a cell line of rat PSCs by spontaneous immortalization...
  21. pmc Endothelin-1 stimulates contraction and migration of rat pancreatic stellate cells
    Atsushi Masamune
    Division of Gastro enterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    World J Gastroenterol 11:6144-51. 2005
    ..Endothelin-1 (ET-1), which acts through G-protein coupled ET(A) and ET(B) receptors, has several biological activities. We here examined the ability of ET-1 to affect the cell functions of PSCs and the underlying molecular mechanisms...
  22. ncbi Rebamipide inhibits ceramide-induced interleukin-8 production in Kato III human gastric cancer cells
    A Masamune
    Department of Gastroenterology, Division of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Pharmacol Exp Ther 298:485-92. 2001
    ..pylori-dependent increase in the intracellular ceramide level. These results suggest a novel mechanism by which rebamipide may protect against the mucosal inflammation associated with H. pylori infection...
  23. ncbi Ellagic acid blocks activation of pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Biochem Pharmacol 70:869-78. 2005
    ..In addition, ellagic acid inhibited transformation of freshly isolated cells to an activated, myofibroblast-like phenotype. In conclusion, ellagic acid inhibited key cell functions and activation of PSCs...
  24. pmc Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo cyo, Aoba ku, Sendai 980 8574, Japan
    World J Gastroenterol 11:3385-91. 2005
    ..To clarify the role of Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway in platelet-derived growth factor (PDGF) induced proliferation in activated pancreatic stellate cells (PSCs)...
  25. ncbi N34S mutation in the SPINK1 gene is not associated with alternative splicing
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Pancreas 34:423-8. 2007
    ..The aberrant splicing caused by the cosegregating intronic mutations might play a role, but this hypothesis has not been tested. We here examined the messenger RNA sequences of the SPINK1 gene in patients carrying the mutations...
  26. pmc Rho kinase inhibitors block activation of pancreatic stellate cells
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Br J Pharmacol 140:1292-302. 2003
    ....
  27. doi A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders
    K Kume
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574 Japan
    Gut 58:820-4. 2009
    ..571G>A (p.G191R), in the anionic trypsinogen (PRSS2) gene protects against chronic pancreatitis in European populations. Here we examined the association of the p.G191R variant with pancreatic disorders in Japan...
  28. ncbi Tumor necrosis factor-related apoptosis-inducing ligand and its receptor expression and the pathway of apoptosis in human pancreatic cancer
    K Satoh
    Department of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Pancreas 23:251-8. 2001
    ....
  29. ncbi Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors
    K Satoh
    Department of Gastroenterology, Division of Internal Medicine, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Cancer 92:271-8. 2001
    ..To our knowledge, the relation between survivin expression and apoptosis or tumorigenesis has not yet been studied in pancreatic neoplasms...
  30. ncbi Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats
    A Satoh
    Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Gastroenterology 119:829-36. 2000
    ..However, the role of adenosine in the pathogenesis of acute pancreatitis has not been described. We examined the effect of adenosine-receptor stimulation or inhibition on the pathologic changes of the pancreas...
  31. ncbi LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells
    Jun Unno
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai City, Miyagi, Japan
    Int J Oncol 35:813-21. 2009
    ..These findings indicate that LIV-1 may be involved in acquisition of the aggressive phenotype of human pancreatic carcinoma cells through the induction of epithelial to mesenchymal transition...
  32. ncbi Ascites of rat experimental model of severe acute pancreatitis induces lung injury
    M Fujita
    Department of Gastroenterology, Tohoku University School of Medicine, Sendai, Japan
    Pancreas 22:409-18. 2001
    ..Inhibition of NF-kappaB ameliorated the histologic findings and improved the survival rates. Our results suggest that PAAF play a role in the pathogenesis of lung injury in severe AP, at least in part through the activation of NF-kappaB...
  33. ncbi Bone morphogenetic protein 4 induces epithelial-mesenchymal transition through MSX2 induction on pancreatic cancer cell line
    Shin Hamada
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Cell Physiol 213:768-74. 2007
    ..These findings indicate that BMP4 may be involved in pancreatic carcinoma development through the promotion of EMT and that MSX2 is indispensable to this process...
  34. ncbi Lysophosphatidylcholine activates transcription factor NF-kappaB and AP-1 in AR42J cells
    A Masamune
    Department of Gastroenterology, Tohoku University School of Medicine, Sendai, Japan
    Dig Dis Sci 46:1871-81. 2001
    ..These molecular events may suggest a novel role of lyso-PC for the modulation of acinar cell function...
  35. ncbi Establishment and characterization of a simian virus 40-immortalized rat pancreatic stellate cell line
    Masahiro Satoh
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Tohoku J Exp Med 198:55-69. 2002
    ..Thus, SAM-K would be useful for in vitro studies of cell biology and signal transduction of PSCs...
  36. ncbi Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis
    Kiyoshi Kume
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreatology 5:354-60. 2005
    ..We here examined the prevalence of SPINK1 mutations in Japanese patients with pancreatitis...
  37. ncbi Hydrogen peroxide activates activator protein-1 and mitogen-activated protein kinases in pancreatic stellate cells
    Kazuhiro Kikuta
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Cell Biochem 291:11-20. 2006
    ..Specific activation of these signal transduction pathways and collagen gene expression by H(2)O(2) may play a role in the pathogenesis of pancreatic fibrosis...
  38. ncbi A case of hemosuccus pancreaticus associated with hereditary pancreatitis
    H Mizutamari
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 195:191-5. 2001
    ..Mutational screening is useful for the diagnosis of hereditary pancreatitis, especially in patients whose diagnosis is inconclusive based on the traditional clinical criteria...
  39. doi Pancreatic stellate cells express Toll-like receptors
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Gastroenterol 43:352-62. 2008
    ..This study aimed to clarify whether pancreatic stellate cells (PSCs), a major profibrogenic cell type in the pancreas, expressed TLRs and responded to PAMPs...
  40. ncbi Fas ligand is frequently expressed in human pancreatic duct cell carcinoma
    K Satoh
    Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Pancreas 19:339-45. 1999
    ..The frequent expression of Fas-L in PDCs may partly explain the notorious biologic behavior of PDCs...
  41. ncbi 4-hydroxy-2, 3-nonenal activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells
    Kazuhiro Kikuta
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    World J Gastroenterol 10:2344-51. 2004
    ..The aim of this study was to clarify the effects of HNE on the activation of signal transduction pathways and cellular functions in PSCs...
  42. ncbi MSX2 overexpression inhibits gemcitabine-induced caspase-3 activity in pancreatic cancer cells
    Shin Hamada
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1, Seiryo machi, Aobaku, Sendai City, Miyagi 980 8574, Japan
    World J Gastroenterol 11:6867-70. 2005
    ..To evaluate the effect of MSX2 on gemcitabine-induced caspase-3 activation in pancreatic cancer cell line Panc-1...
  43. ncbi Microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene is associated with susceptibility to acute pancreatitis in Japan
    Yasuhiko Takagi
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hum Immunol 70:200-4. 2009
    ..No Asp299Gly and Thr399Ile polymorphisms were detected. In conclusion, microsatellite polymorphism in intron 2 of the TLR2 gene was associated with susceptibility to AP and its severity in Japan...
  44. doi Bone marrow contributes to the population of pancreatic stellate cells in mice
    Takashi Watanabe
    Tohoku Univ Graduate School of Medicine, Sendai, Japan
    Am J Physiol Gastrointest Liver Physiol 297:G1138-46. 2009
    ..The contribution of BM-derived cells to pancreatic ductal cells (positive for cytokeratin-19) was rare and less than 1%. In conclusion, our results suggested that BM-derived cells contributed to the population of PSCs in mice...
  45. doi Ellagic acid inhibits pancreatic fibrosis in male Wistar Bonn/Kobori rats
    Noriaki Suzuki
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    Dig Dis Sci 54:802-10. 2009
    ..Our results suggest that ellagic acid might be a candidate for treatment of chronic pancreatitis...
  46. doi Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells
    Atsushi Kanno
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai City, Miyagi, Japan
    Int J Cancer 122:2707-18. 2008
    ..On the other hand, high concentration of recombinant periostin (1 microg/ml) promoted cell migration with AKT activation. The findings suggest that periostin has biphasic effect on the development of pancreatic cancer...
  47. ncbi Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury
    Tetsuya Yamagiwa
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Gastroenterol 39:41-9. 2004
    ..The aim of this study was to examine the effects of inosine on the course of acute pancreatitis...
  48. ncbi Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice
    Kenji Kimura
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai City, Miyagi, 980 8574, Japan
    Cancer Sci 98:155-62. 2007
    ..Therefore, Notch signaling is required to form the tubular complexes and its continuous activation might lead to the transition from tubular complexes to premalignant or malignant lesions and carcinoma cell development in the pancreas...
  49. ncbi [Anti-cytokine therapy for severe acute pancreatitis]
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine
    Nihon Rinsho 62:2116-21. 2004
    ..include the suitability of AP to cytokine antagonism in clinical settings, the possibility that such a therapy may lead to the development of immunosuppression and consequent infection, and whether a therapeutic window for such antagonism..
  50. ncbi Human leukocyte antigen-DR expression on peripheral monocytes as a predictive marker of sepsis during acute pancreatitis
    Akihiko Satoh
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Pancreas 25:245-50. 2002
    ..However, objective parameters for the risk of sepsis in acute pancreatitis have not been established...
  51. doi Expression of the calcium-binding protein S100P is regulated by bone morphogenetic protein in pancreatic duct epithelial cell lines
    Shin Hamada
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8574, Japan
    Cancer Sci 100:103-10. 2009
    ..These findings are the first of their kind, and this Smad4-dependent regulation of S100P by BMP signaling might explain the migratory mechanism of cancer cells, which is still unknown...
  52. ncbi Activated rat pancreatic stellate cells express intercellular adhesion molecule-1 (ICAM-1) in vitro
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 25:78-85. 2002
    ..Activated pancreatic stellate cells (PSCs) have recently been implicated in the pathogenesis of pancreatic fibrosis...
  53. doi SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan
    Tooru Shimosegawa
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Gastroenterol Hepatol 23:S82-6. 2008
    ..Furthermore, we revealed the amount of wild-type PSTI was decreased in patients with IVS3 + 2T > C mutation. Variants of alcohol-metabolizing enzymes appeared in the relation to alcoholic CP...
  54. ncbi Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro
    Kenzo Kaneko
    Department of Gastroenterology, Division of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Pancreas 24:251-7. 2002
    ..Results of previous studies showed that the elevated activity of ROCK-1, one of the isomers of ROCK kinases, led to an increase in the activity of invasion and metastasis of cancer cell lines...
  55. ncbi Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis
    Akihiko Satoh
    Department of Gastroenterology, Division of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Pancreas 24:75-82. 2002
    ..Recent studies have shown that adenosine exerts potent anti-inflammatory properties that are chiefly brought about through the occupancy of the A2a receptor...
  56. ncbi Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines
    Kenzo Kaneko
    Department of Gastroenterology, Division of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyaga, Japan
    Pancreas 24:34-41. 2002
    ..A cytoskeletal component indispensable for these processes is myosin II, the cytoplasmic analogue of smooth and skeletal muscle myosin...
  57. doi Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Clin Gastroenterol Hepatol 7:S48-54. 2009
    ..Further elucidation of the roles of PSCs in pancreatic fibrosis should promote development of rational approaches for the treatment of chronic pancreatitis and pancreatic cancer...
  58. doi -651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Gastroenterol 45:225-33. 2010
    ..This study aimed to clarify the association of the promoter variants in the CD14 gene with pancreatic diseases in Japan...
  59. doi Expression of MSX2 predicts malignancy of branch duct intraductal papillary mucinous neoplasm of the pancreas
    Kennichi Satoh
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aobaku, Sendai, Miyagi, 980 8574, Japan
    J Gastroenterol 45:763-70. 2010
    ..The aim of this study was to assess the involvement of MSX2 in IPMN development and whether its expression would differentiate malignant from benign IPMN...
  60. ncbi Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis
    Yoshitaka Sakai
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Gastroenterology 124:725-36. 2003
    ..The aim of this study was to clarify the role of MIF in acute pancreatitis (AP)...
  61. doi Nuclear expression of interleukin-33 in pancreatic stellate cells
    Atsushi Masamune
    Tohoku Univ Graduate School of Medicine, Sendai, Japan
    Am J Physiol Gastrointest Liver Physiol 299:G821-32. 2010
    ..Decreased IL-33 expression by small interfering RNA resulted in decreased proliferation in response to PDGF-BB. In conclusion, activated PSCs expressed IL-33 in the nucleus. IL-33 might regulate the PDGF-induced proliferation in PSCs...
  62. ncbi Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas
    Kennichi Satoh
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi 980 8574, Japan
    Oncol Rep 19:1185-90. 2008
    ..These findings suggested that HH signaling was activated in IPMNs and contributed to tumorigenesis in these types of neoplasms...
  63. pmc Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cells
    Kennichi Satoh
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Siryo machi, Aobaku, Sendai City, Miyagi, Japan
    Am J Pathol 172:926-39. 2008
    ..These data indicate that MSX2 plays a crucial role in pancreatic cancer development by inducing changes consistent with epithelial to mesenchymal transition through enhanced expression of Twist 1...
  64. ncbi SPINK1 gene mutations and pancreatitis in Japan
    Tooru Shimosegawa
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Gastroenterol Hepatol 21:S47-51. 2006
    ..In conclusion, in Japan the [-215G > A; IVS3 + 2T > C] mutation in the SPINK1 gene may form a unique genetic background for pancreatitis...
  65. ncbi Pancreatic ischemia associated with vasospasm in the early phase of human acute necrotizing pancreatitis
    Kazunori Takeda
    Division of Gastroenterological Surgery, Tohoku University, Graduate School of Medicine, Sendai, Japan
    Pancreas 30:40-9. 2005
    ..We investigated the role of vasospasm in pancreatic ischemia and necrosis in the early phase of human ANP...
  66. ncbi The expression of MUC4 and MUC5AC is related to the biologic malignancy of intraductal papillary mucinous neoplasms of the pancreas
    Atsushi Kanno
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 33:391-6. 2006
    ..Recently, MUC4 and MUC5AC expressions have been demonstrated to correlate with the unfavorable and the favorable prognosis of pancreatic duct cell carcinoma, respectively. However, little is known about these mucin expressions in IPMNs...
  67. ncbi Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis
    K Kaneko
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Hum Genet 46:293-7. 2001
    ..Our results suggested that the -215G>A alteration, as well as the N34S alteration, is a predisposing factor for CP...
  68. ncbi Acute pancreatitis due to pancreatic arteriovenous malformation: 2 case reports and review of the literature
    Atsushi Kanno
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 32:422-5. 2006
    ..The respective pancreatic AVM lesions of patients were resected to prevent the recurrence of pancreatitis. They are asymptomatic after the surgery. Pancreatic AVM is thought to be the one of the reasons for acute pancreatitis...
  69. ncbi [Prospective review of treatment for chronic pancreatitis: genetic background and control of pancreatic fibrosis]
    Tooru Shimosegawa
    Division of Gastroenterology, Tohoku University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 102:1-9. 2005
  70. ncbi Hereditary pancreatitis as the premalignant disease: a Japanese case of pancreatic cancer involving the SPINK1 gene mutation N34S
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 28:305-10. 2004
    ..Further prospective, multicenter trials investigating secondary screening for pancreatic cancer in hereditary pancreatitis are necessary to clarify the role of SPINK1 mutations in the development of pancreatic cancer...
  71. ncbi Nuclear factor kappa B expression in peripheral blood mononuclear cells of patients with acute pancreatitis
    Akihiko Satoh
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi, Japan
    Pancreas 26:350-6. 2003
    ..AIMTo investigate the expression of NF-kappaB and its characteristics in peripheral blood mononuclear cells (PBMCs) of patient with acute pancreatitis...
  72. ncbi [Evidence-based clinical guidelines for acute pancreatitis--diagnosis of the severity]
    Toru Shimosegawa
    Nihon Naika Gakkai Zasshi 93:10-5. 2004
  73. ncbi [Recent findings on chronic pancreatitis]
    Tooru Shimosegawa
    Nihon Naika Gakkai Zasshi 95:2105-11. 2006
  74. ncbi A patient with multiple endocrine neoplasia type 1 with a novel MEN1 gene mutation (237delC)
    Yoshitaka Sakai
    J Gastroenterol 37:485-7. 2002