A Sugawara

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes
    A Sugawara
    Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 24:229-33. 2001
  2. ncbi Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cells
    A Sugawara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Endocrinology 142:3125-34. 2001
  3. ncbi Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells
    Akira Sugawara
    Division of Nephrology, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    J Biol Chem 277:9676-83. 2002
  4. ncbi A case of aldosterone-producing adrenocortical adenoma associated with a probable post-operative adrenal crisis: histopathological analyses of the adrenal gland
    Akira Sugawara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 26:663-8. 2003
  5. ncbi Characterization of mouse retinoid X receptor (RXR)-beta gene promoter: negative regulation by tumor necrosis factor (TNF)-alpha
    A Sugawara
    The 2nd Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Endocrinology 139:3030-3. 1998
  6. ncbi Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2
    Y Ikeda
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Biol Chem 275:33142-50. 2000
  7. ncbi Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer Res Treat 65:31-40. 2001
  8. ncbi Renal tubule-specific transcription and chromosomal localization of rat thiazide-sensitive Na-Cl cotransporter gene
    Y Taniyama
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Biol Chem 276:26260-8. 2001
  9. ncbi Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr Relat Cancer 13:233-50. 2006
  10. ncbi Novel effects of beraprost sodium on vasculatures
    A Sugawara
    Department of Advanced Biological Sciences for Regeneration, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int Angiol 29:28-32. 2010

Collaborators

Detail Information

Publications26

  1. ncbi Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes
    A Sugawara
    Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 24:229-33. 2001
    ..We therefore speculate that the strong transcriptional suppression of the TXR and AT1R genes by troglitazone may be mediated in part by its antioxidant effect...
  2. ncbi Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cells
    A Sugawara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Endocrinology 142:3125-34. 2001
    ..PPAR-gamma ligands, thus, may inhibit AII-induced cell growth and hypertrophy in VSMCs by AT1R expression suppression and possibly be beneficial for treatment of diabetic patients with hypertension and atherosclerosis...
  3. ncbi Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells
    Akira Sugawara
    Division of Nephrology, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    J Biol Chem 277:9676-83. 2002
    ..In conclusion, PPAR-gamma suppresses TXR gene transcription via an interaction with Sp1. PPAR-gamma may possibly have an antiatherosclerotic action by inhibiting TXR gene expression in VSMCs...
  4. ncbi A case of aldosterone-producing adrenocortical adenoma associated with a probable post-operative adrenal crisis: histopathological analyses of the adrenal gland
    Akira Sugawara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 26:663-8. 2003
    ..Post-operative adrenocortical insufficiency should be considered in clinical management of patients with relatively large APA, even when physical signs of autonomous cortisol overproduction are not apparent...
  5. ncbi Characterization of mouse retinoid X receptor (RXR)-beta gene promoter: negative regulation by tumor necrosis factor (TNF)-alpha
    A Sugawara
    The 2nd Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Endocrinology 139:3030-3. 1998
    ..We thus have first shown a relation between the retinoic acid receptor and a cytokine TNF-alpha...
  6. ncbi Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2
    Y Ikeda
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Biol Chem 275:33142-50. 2000
    ..In conclusion, the NRF2-binding site (-98/-88) is the major promoter of 5'FL-TXS which can be suppressed by activated PPARgamma via a protein-protein interaction with NRF2 in macrophages...
  7. ncbi Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer Res Treat 65:31-40. 2001
    ..76-fold (p < 0.001), five days following treatment with 10 nM retinoic acid. These data suggest that retinoid receptors modulate various effects of retinoids, including estrogen metabolism in human breast carcinomas...
  8. ncbi Renal tubule-specific transcription and chromosomal localization of rat thiazide-sensitive Na-Cl cotransporter gene
    Y Taniyama
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Biol Chem 276:26260-8. 2001
    ..The transcription regulatory region of the TSC gene confers DCT-specific gene expression. DCT-specific transcription factor HFH-3 may be involved in the renal tubule-specific transcription of TSC gene...
  9. ncbi Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic actions
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr Relat Cancer 13:233-50. 2006
    ..These results suggest that PPARgamma is mainly expressed in well-differentiated and ER-positive breast carcinomas, and modulates estrogenic actions...
  10. ncbi Novel effects of beraprost sodium on vasculatures
    A Sugawara
    Department of Advanced Biological Sciences for Regeneration, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int Angiol 29:28-32. 2010
    ..Further studies are needed to clarify molecular mechanisms of these BPS effects including the involvement of peroxisome proliferator-activated receptor-delta...
  11. ncbi Primary care in the treatment of functional gastrointestinal symptoms in Japan: prescription preferences and impression of results
    M Hongo
    Department of Comprehensive Medicine, Tohoku Univeristy Hospital, Aoba, Sendai, Japan
    Aliment Pharmacol Ther 21:47-54. 2005
    ..Meta-analysis of pharmacological approaches to functional GI disorders failed to identify the solid cluster of patients' symptoms...
  12. ncbi Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase
    K Ito
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai 980 8557, Japan
    J Clin Endocrinol Metab 86:2721-7. 2001
    ..These results all suggest that retinoic acids may be involved in modulation of in situ estrogen metabolism in both normal and neoplastic human endometrium possibly through RXR gamma by stimulating the expression of 17 beta-HSD type 2...
  13. pmc The expression and function of histamine H₃ receptors in pancreatic beta cells
    T Nakamura
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Br J Pharmacol 171:171-85. 2014
    ..Histamine and its receptors in the CNS play important roles in energy homeostasis. Here, we have investigated the expression and role of histamine receptors in pancreatic beta cells, which secrete insulin...
  14. doi Interspecies somatic cell nucleus transfer with porcine oocytes as recipients: A novel bioassay system for assessing the competence of canine somatic cells to develop into embryos
    S Sugimura
    Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Theriogenology 72:549-59. 2009
    ..We inferred that iSCNT performed using porcine oocytes as recipients could represent a novel bioassay system for evaluating the developmental competence of canine somatic cells...
  15. ncbi Mutations in the E-domain of RAR portion of the PML/RAR chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia
    M Imaizumi
    Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan
    Blood 92:374-82. 1998
    ..These findings suggest that mutations in the RARalpha /E-domain of the PML/RARalpha chimeric gene may confer clinical resistance to ATRA therapy in patients with APL...
  16. ncbi Plasma GH responses to human GHRH-antagonist in normal subjects
    K Hanew
    Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Eur J Endocrinol 134:67-72. 1996
    ..05). Other anterior pituitary hormones remained unaffected by GHRH-antagonist. In conclusion, our data suggest that evening basal GH secretion, but not morning GH secretion, is maintained by endogenous GHRH...
  17. ncbi Development of rat tetraploid and chimeric embryos aggregated with diploid cells
    T Shinozawa
    Tohoku University, Sendai, Japan
    Zygote 14:287-97. 2006
    ..Our results suggest that rat tetraploid embryos are able to prolong the development of diploid blastomeres that cannot develop independently, although postimplantation development was incomplete...
  18. ncbi Molecular cloning and expression of a novel klotho-related protein
    K Yahata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    J Mol Med (Berl) 78:389-94. 2000
    ..In conclusion, we describe the primary structure and gene expression of a novel protein related to klotho protein...
  19. ncbi Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis
    H Yokoi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Kidney Dis 38:S134-8. 2001
    ..These results indicate that CTGF has a crucial role in the profibrotic action of TGF-beta in renal fibroblasts, providing a potential therapeutic target against tubulointerstitial fibrosis...
  20. ncbi Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas
    N Sanno
    Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan
    Neuroendocrinology 65:299-306. 1997
    ....
  21. doi Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis
    T Nagae
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Kidney Int 74:70-80. 2008
    ....
  22. ncbi Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice
    H Yokoi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Kidney Int 73:446-55. 2008
    ..Our findings suggest that overexpression of CTGF in podocytes is sufficient to exacerbate proteinuria and mesangial expansion through a functional impairment and loss of podocytes...
  23. ncbi Kidney-specific expression of a novel mouse organic cation transporter-like protein
    K Mori
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    FEBS Lett 417:371-4. 1997
    ....
  24. ncbi Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney
    K Mori
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 274:15701-5. 1999
    ..In conclusion, we have cloned a functional cDNA encoding a novel membrane-bound CA. This study will bring new insights into our understanding of carbon dioxide metabolism and acid-base balance...
  25. ncbi Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy
    T Nagae
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Biochem Biophys Res Commun 270:89-93. 2000
    ..Thus, RAMPs are regulated differently in obstructive nephropathy, suggesting their distinct roles in renal pathophysiology...
  26. ncbi Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats
    T Suganami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    J Hypertens 19:1095-103. 2001
    ..The altered EP4 signaling may play a critical role in the exaggerated mesangial growth in SHRSPs...