Gang Hong Lee

Summary

Affiliation: Toranomon Hospital
Country: Japan

Publications

  1. ncbi request reprint Fine chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas
    G H Lee
    Department of Pathology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo 105 8470, Japan
    Oncogene 20:3979-85. 2001
  2. ncbi request reprint Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2
    Gang Hong Lee
    Department of Pathology, Toramomon Hospital and Okinaka Memorial Institute for Medical Research 2 2 2 Toranomon, Minatoku, Tokyo 105 8470, Japan
    Oncogene 22:2374-82. 2003
  3. ncbi request reprint Hyaline globule-like structures in undifferentiated sarcoma cells of malignant müllerian mixed tumor of the fallopian tube
    Naoto Kuroda
    Department of Pathology, Kochi Red Cross Hospital, Kochi 780 8562, Japan
    Med Mol Morphol 40:46-9. 2007
  4. doi request reprint The Kras2 oncogene and mouse lung carcinogenesis
    Gang Hong Lee
    Department of Pathology, Kochi University School of Medicine, Kohasu, Oko cho, Nankoku, Kochi, 783 8505, Japan
    Med Mol Morphol 41:199-203. 2008
  5. doi request reprint The retinoic acid-metabolizing enzyme CYP26A1 upregulates fascin and promotes the malignant behavior of breast carcinoma cells
    Makoto Osanai
    Department of Pathology, Kochi University School of Medicine, Nankoku, Kochi 783 8505, Japan
    Oncol Rep 34:850-8. 2015
  6. pmc NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells
    Yoshihiro Hayashi
    Department of Pathology, Kochi University School of Medicine, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    Oncol Rep 34:1650-8. 2015
  7. pmc Increased expression of the retinoic acid-metabolizing enzyme CYP26A1 during the progression of cervical squamous neoplasia and head and neck cancer
    Makoto Osanai
    Department of Pathology, Kochi University School of Medicine, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    BMC Res Notes 7:697. 2014
  8. doi request reprint Insulin-independent promotion of chemically induced hepatocellular tumor development in genetically diabetic mice
    Kohtaro Yamasaki
    Department of Pathology, Kochi University School of Medicine, Nankoku, Kochi, Japan
    Cancer Sci 101:65-72. 2010
  9. ncbi request reprint Prostatic acid phosphatase is a possible tumor marker for intravascular large B-cell lymphoma
    Kunihiko Seki
    Department of Pathology, University of Tokyo, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
    Am J Surg Pathol 28:1384-8. 2004
  10. doi request reprint Nicotine-mediated suppression of the retinoic acid metabolizing enzyme CYP26A1 limits the oncogenic potential of breast cancer
    Makoto Osanai
    Department of Pathology, Kochi University School of Medicine, Kohasu, Kochi, Japan
    Cancer Sci 102:1158-63. 2011

Detail Information

Publications22

  1. ncbi request reprint Fine chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas
    G H Lee
    Department of Pathology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo 105 8470, Japan
    Oncogene 20:3979-85. 2001
    ..The map information obtained in this study should enable subsequent positional cloning of the Par2 gene...
  2. ncbi request reprint Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2
    Gang Hong Lee
    Department of Pathology, Toramomon Hospital and Okinaka Memorial Institute for Medical Research 2 2 2 Toranomon, Minatoku, Tokyo 105 8470, Japan
    Oncogene 22:2374-82. 2003
    ..Consequently, the Poli is an intriguing Par2 candidate clearly deserving further evaluation...
  3. ncbi request reprint Hyaline globule-like structures in undifferentiated sarcoma cells of malignant müllerian mixed tumor of the fallopian tube
    Naoto Kuroda
    Department of Pathology, Kochi Red Cross Hospital, Kochi 780 8562, Japan
    Med Mol Morphol 40:46-9. 2007
    ..Finally, pathologists should keep in mind that undifferentiated sarcoma cells in MMMT of the fallopian tube may contain hyaline globule-like structures in the cytoplasm...
  4. doi request reprint The Kras2 oncogene and mouse lung carcinogenesis
    Gang Hong Lee
    Department of Pathology, Kochi University School of Medicine, Kohasu, Oko cho, Nankoku, Kochi, 783 8505, Japan
    Med Mol Morphol 41:199-203. 2008
    ..Because mouse and human lung tumors share considerable similarities, the experimental information should provide clues to personalized medicine in the human setting...
  5. doi request reprint The retinoic acid-metabolizing enzyme CYP26A1 upregulates fascin and promotes the malignant behavior of breast carcinoma cells
    Makoto Osanai
    Department of Pathology, Kochi University School of Medicine, Nankoku, Kochi 783 8505, Japan
    Oncol Rep 34:850-8. 2015
    ..CYP26A1 exerts oncogenic functions during breast carcinogenesis. Therefore, CYP26A1-mediated oncogenic characteristics may be partially responsible for the elevated expression of fascin. ..
  6. pmc NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells
    Yoshihiro Hayashi
    Department of Pathology, Kochi University School of Medicine, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    Oncol Rep 34:1650-8. 2015
    ..These findings suggested that the NOTCH2 signaling may confer aggressive behavior and immature morphology in human HCC cells...
  7. pmc Increased expression of the retinoic acid-metabolizing enzyme CYP26A1 during the progression of cervical squamous neoplasia and head and neck cancer
    Makoto Osanai
    Department of Pathology, Kochi University School of Medicine, Kohasu, Oko cho, Nankoku, Kochi 783 8505, Japan
    BMC Res Notes 7:697. 2014
    ..However, the relevance of elevated CYP26A1 expression in human cancers remains to be clarified...
  8. doi request reprint Insulin-independent promotion of chemically induced hepatocellular tumor development in genetically diabetic mice
    Kohtaro Yamasaki
    Department of Pathology, Kochi University School of Medicine, Nankoku, Kochi, Japan
    Cancer Sci 101:65-72. 2010
    ..In conclusion, our results indicate that insulin-independent liver tumor promotion occurred in diabetic mice. Clearly, insulin-independent mechanisms for the human case also deserve consideration...
  9. ncbi request reprint Prostatic acid phosphatase is a possible tumor marker for intravascular large B-cell lymphoma
    Kunihiko Seki
    Department of Pathology, University of Tokyo, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
    Am J Surg Pathol 28:1384-8. 2004
    ..We conclude that serum PAP is a useful tumor marker for intravascular LBCL and that it deserves further investigation in this context...
  10. doi request reprint Nicotine-mediated suppression of the retinoic acid metabolizing enzyme CYP26A1 limits the oncogenic potential of breast cancer
    Makoto Osanai
    Department of Pathology, Kochi University School of Medicine, Kohasu, Kochi, Japan
    Cancer Sci 102:1158-63. 2011
    ..These data show that nicotine can limit CYP26A1-mediated oncogenic characteristics, and suggest mechanisms by which nicotine might inhibit breast cancer development...
  11. doi request reprint Fascin-1 expression correlates with repression of E-cadherin expression in hepatocellular carcinoma cells and augments their invasiveness in combination with matrix metalloproteinases
    Yoshihiro Hayashi
    Department of Pathology, Kochi University School of Medicine, Kohasu, Oko cho, Nankoku, Japan
    Cancer Sci 102:1228-35. 2011
    ..In conclusion, we propose that fascin-1 primarily acts as a migration factor associated with EMT in HCC cells and facilitates their invasiveness in combination with MMPs...
  12. doi request reprint CYP24A1-induced vitamin D insufficiency promotes breast cancer growth
    Makoto Osanai
    Department of Pathology, Kochi University School of Medicine, Nankoku, Kochi 783 8505, Japan
    Oncol Rep 36:2755-2762. 2016
    ..These data provide substantial evidence for a pro-survival and stimulatory oncogenic effect of CYP24A1 in breast carcinoma cells...
  13. doi request reprint Elevated expression of the retinoic acid-metabolizing enzyme CYP26C1 in primary breast carcinomas
    Makoto Osanai
    Department of Pathology, Kochi University School of Medicine, Kohasu, Oko cho, Nankoku, Kochi, 783 8505, Japan
    Med Mol Morphol 49:22-7. 2016
    ..This report is the first to demonstrate elevated expression of CYP26C1 in primary breast carcinomas. Based on the RA-catabolizing activity of CYP26C1, our data suggest that CYP26C1 expression may contribute to neoplasia in the breast. ..
  14. doi request reprint Dedifferentiated liposarcoma with rhabdomyoblastic differentiation in an 8-year-old girl
    Sumika Okamoto
    Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Pathol Res Pract 206:191-6. 2010
    ..The identical cells were co-mingling with the well-differentiated liposarcoma component. This is the first description of such a case of liposarcoma occurring in a child...
  15. ncbi request reprint Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures
    Naoto Kuroda
    Department of Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi City, Kochi 780 8562, Japan
    Med Mol Morphol 40:168-71. 2007
    ..Ultrastructurally, hyaline globule-like structures corresponded to lysosomes. Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures...
  16. doi request reprint Enhanced expression of retinoic acid-metabolizing enzyme CYP26A1 in sunlight-damaged human skin
    Makoto Osanai
    Department of Pathology, Kochi University School of Medicine, Kohasu, Oko cho, Nankoku, Kochi, Japan
    Med Mol Morphol 44:200-6. 2011
    ..Our observation suggests an involvement of enhanced CYP26A1 expression causing a functional VAD state in skin that can potentially lead to neoplastic transformation of keratinocytes in an early phase during skin carcinogenesis...
  17. ncbi request reprint Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice
    Gang Hong Lee
    Department of Biomolecular Science, Faculty of Science, Toho University, 2 2 1 Miyama, Funabashi shi, Chiba 274 8510, Japan
    Cancer Sci 96:256-9. 2005
    ..The result indicates a possibility that the Pol iota gene may participate in error-free repair of damaged DNA and prevention of lung tumor development...
  18. ncbi request reprint Large cell neuroendocrine carcinoma of the lung with calcification and expression of osteopontin
    Naoto Kuroda
    Departments of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi City, Kochi, Japan
    Med Mol Morphol 40:218-20. 2007
    ..Immunohistochemically, parts of neoplastic cells of LCNEC and calcified foci were positive for osteopontin. Finally, we suggest that osteopontin as well as dystrophy within the tumor may be involved in the stromal calcification of LCNEC...
  19. doi request reprint Significance of D2-40 expression in the diagnosis of gastrointestinal stromal tumor
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, Japan
    Med Mol Morphol 41:109-12. 2008
    ..In conclusion, we suggest that D2-40 may be an available marker of GISTs, but the expression of D2-40 seems to be not associated with the degree of risk of aggressive behavior...
  20. doi request reprint Basal-like carcinoma of the breast: further evidence of the possibility that most metaplastic carcinomas may be actually basal-like carcinomas
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi, Japan
    Med Mol Morphol 41:117-20. 2008
    ..Our results supply further evidence that most metaplastic carcinomas may be actually be basallike carcinomas...
  21. ncbi request reprint Pulmonary squamous cell carcinoma with foci of adenocarcinoma containing micropapillary carcinoma in the metastatic lesion of regional lymph nodes
    Naoto Kuroda
    Pathol Int 57:299-301. 2007
  22. ncbi request reprint Askin tumor with metastasis to the scalp: a histochemical, immunohistochemical and ultrastructural study
    Naoto Kuroda
    Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi City, Kochi, 780 8562, Japan
    Med Mol Morphol 39:221-5. 2006
    ..Even if results are immunohistochemically negative for neuroendocrine markers, the combination of immunohistochemistry of CD99 (MIC2) and Fil-1 may be useful in diagnosing Askin tumor or its metastatic lesion...