Takahisa Furuta

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Association of mast cell-derived VEGF and proteases in Dengue shock syndrome
    Takahisa Furuta
    Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS Negl Trop Dis 6:e1505. 2012
  2. pmc Elevated levels of vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor (VEGFR)-2 in human malaria
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Am J Trop Med Hyg 82:136-9. 2010
  3. doi Mast cell-mediated immune responses through IgE antibody and Toll-like receptor 4 by malarial peroxiredoxin
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Eur J Immunol 38:1341-50. 2008
  4. ncbi Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 18:1655-62. 2006
  5. ncbi Protective roles of mast cells and mast cell-derived TNF in murine malaria
    Takahisa Furuta
    Department of Microbiology and Immunology, Division of Infectious Genetics, University of Tokyo, Japan
    J Immunol 177:3294-302. 2006
  6. ncbi Agonistic antibody to TLR4/MD-2 protects mice from acute lethal hepatitis induced by TNF-alpha
    Sachiko Akashi-Takamura
    Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 176:4244-51. 2006
  7. ncbi Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
    Shinobu Saijo
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Immunol 8:39-46. 2007
  8. ncbi Kinetics of the nucleoside triphosphate hydrolase of Toxoplasma gondii in mice with acute and chronic toxoplasmosis
    T Kikuchi
    Department of Parasitology, The Institute of Medical Science, The University of Tokyo, Japan
    Ann Trop Med Parasitol 96:35-41. 2002
  9. pmc Therapeutic effects of water-soluble echinocandin compounds on Pneumocystis pneumonia in mice
    T Furuta
    Department of Parasitology, The Institute of Medical Science, The University of Tokyo, Japan
    Antimicrob Agents Chemother 42:37-9. 1998
  10. ncbi Membrane localization and demonstration of isoforms of nucleoside triphosphate hydrolase from Toxoplasma gondii
    T Kikuchi
    Department of Parasitology, Institute of Medical Science, The University of Tokyo, Japan
    Parasitology 122:15-23. 2001

Collaborators

Detail Information

Publications19

  1. pmc Association of mast cell-derived VEGF and proteases in Dengue shock syndrome
    Takahisa Furuta
    Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS Negl Trop Dis 6:e1505. 2012
    ....
  2. pmc Elevated levels of vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor (VEGFR)-2 in human malaria
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Am J Trop Med Hyg 82:136-9. 2010
    ..This is the first report to suggest that the interaction of VEGF and sVEGFR-2 is involved in the host immune response to malarial infection and that malarial parasites induce VEGF secretion from human mast cells...
  3. doi Mast cell-mediated immune responses through IgE antibody and Toll-like receptor 4 by malarial peroxiredoxin
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Eur J Immunol 38:1341-50. 2008
    ....
  4. ncbi Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 18:1655-62. 2006
    ..gondii ME49. These results suggest that the small intestine plays an important role in the induction of innate immunity in naturally acquired toxoplasmosis...
  5. ncbi Protective roles of mast cells and mast cell-derived TNF in murine malaria
    Takahisa Furuta
    Department of Microbiology and Immunology, Division of Infectious Genetics, University of Tokyo, Japan
    J Immunol 177:3294-302. 2006
    ..These findings propose a novel mechanism that mast cells and mast cell-derived TNF play protective roles in malaria...
  6. ncbi Agonistic antibody to TLR4/MD-2 protects mice from acute lethal hepatitis induced by TNF-alpha
    Sachiko Akashi-Takamura
    Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 176:4244-51. 2006
    ..These results demonstrated that an agonistic mAb to TLR4/MD-2 protected mice from LPS/d-galactosamine-induced acute lethal hepatitis by delivering a protective signal activating NF-kappaB through TLR4/MD-2...
  7. ncbi Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
    Shinobu Saijo
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Immunol 8:39-46. 2007
    ..Thus, dectin-1 is required for immune responses to some fungal infections, as protective immunity to pneumocystis, but not to candida, required dectin-1 for the production of antifungal reactive oxygen species...
  8. ncbi Kinetics of the nucleoside triphosphate hydrolase of Toxoplasma gondii in mice with acute and chronic toxoplasmosis
    T Kikuchi
    Department of Parasitology, The Institute of Medical Science, The University of Tokyo, Japan
    Ann Trop Med Parasitol 96:35-41. 2002
    ..Since detectable serum concentrations of NTPase appear to be associated with parasitaemia in both acute and chronic toxoplasmosis, the ABS-ELISA of the enzyme may make a useful diagnostic tool...
  9. pmc Therapeutic effects of water-soluble echinocandin compounds on Pneumocystis pneumonia in mice
    T Furuta
    Department of Parasitology, The Institute of Medical Science, The University of Tokyo, Japan
    Antimicrob Agents Chemother 42:37-9. 1998
    ..The studies demonstrated the potential usefulness of the compounds...
  10. ncbi Membrane localization and demonstration of isoforms of nucleoside triphosphate hydrolase from Toxoplasma gondii
    T Kikuchi
    Department of Parasitology, Institute of Medical Science, The University of Tokyo, Japan
    Parasitology 122:15-23. 2001
    ..These data suggest that the molecule recognized by 6C6 might be considered a potential candidate antigen for vaccines against T. gondii tachyzoites...
  11. ncbi Direct experimental occlusion of the distal middle cerebral artery induces high reproducibility of brain ischemia in mice
    Mutsuki Kuraoka
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan
    Exp Anim 58:19-29. 2009
    ..0 +/- 20.8 and 33.2 +/- 24.2%, respectively. In conclusion, distal MCAO produces high reproducibility of ischemic insults and survivability compared to unilateral CCAO. Thus, distal MCAO is a useful method for the focal ischemic model...
  12. ncbi An alternate pathway for type 1 T cell differentiation
    C Feng
    Department of Microbiology and Immunology, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    Int Immunol 11:1185-94. 1999
    ..This leads to the hypothesis that the IL-12-independent novel pathway for inducing IFN-gamma-producing T cells is distinct from the classical type 1/type 2 T cell subset differentiation pathway...
  13. ncbi Detection of circulating antigens of Pneumocystis carinii in human sera by a sandwich enzyme-immunoassay
    K Tanabe
    Department of Infectious Diseases, University of Tokyo, Japan
    Zentralbl Bakteriol Mikrobiol Hyg A 264:373-8. 1987
    ..Since the sandwich enzyme-immunoassay has an ability of comparing serially monitored levels of the antigen in a quantitative value, the method is to be widely used as a clinical laboratory examination...
  14. ncbi Horizontal transmission of Toxoplasma gondii in squirrel monkeys (Saimiri sciureus)
    T Furuta
    Devision of Infections Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    Exp Anim 50:299-306. 2001
    ..gondii tachyzoites were recovered from the bronchoalveolar lavages of the three T. gondii-inoculated monkeys, we suggest that aerosol infection plays an important role for the enzootic toxoplasmosis in colonies of squirrel monkeys...
  15. ncbi Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Gastroenterol Hepatol 22:1443-9. 2007
    ..The aim of the present study was to clarify the association between the IL-10 polymorphism, one of the representative anti-inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan...
  16. ncbi Treatment strategy to eradicate Helicobacter pylori infection: impact of pharmacogenomics-based acid inhibition regimen and alternative antibiotics
    Mitsushige Sugimoto
    Hamamatsu University School of Medicine, First Department of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, 431 3192, Japan
    Expert Opin Pharmacother 8:2701-17. 2007
    ..For attaining higher eradication rates, the tailored regimen based on the relevant pharmacogenomics is preferable...
  17. ncbi Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy
    Mitsushige Sugimoto
    First Department of Medicine, Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Pharmacol Ther 80:41-50. 2006
    ..We investigated whether inflammation-related cytokine polymorphisms would influence the eradication rates of H pylori by a triple-therapy regimen...
  18. ncbi Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes
    Takahisa Furuta
    Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Biol Chem 278:20303-12. 2003
    ..These results demonstrate a conserved gammaH2AX response for double-strand breaks induced by replication fork collision. gammaH2AX foci are required for recruiting repair and checkpoint protein complexes to the replication break sites...
  19. ncbi Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Gastroenterol Hepatol 22:51-9. 2007
    ..The aim of this study was to clarify the association of polymorphisms of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha with susceptibility to peptic ulcer diseases and gastric cancer in Japan...