K Ito

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint ["tRNA mimicry" in translation termination revisited]
    Koichi Ito
    Tanpakushitsu Kakusan Koso 48:329-37. 2003
  2. ncbi request reprint Ribosomal protein L11 mutations in two functional domains equally affect release factors 1 and 2 activity
    Hanae Sato
    Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Microbiol 60:108-20. 2006
  3. pmc Two components of exocytosis and endocytosis in phaeochromocytoma cells studied using caged Ca2+ compounds
    H Kasai
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    J Physiol 494:53-65. 1996
  4. ncbi request reprint Analysis of visitation frequency through particle tracking method based on LES and model experiment
    S Kato
    Institute of Industrial Science, University of Tokyo, Japan
    Indoor Air 13:182-93. 2003
  5. ncbi request reprint Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related secondary acute myeloid leukaemia
    J Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Br J Haematol 114:834-6. 2001
  6. ncbi request reprint Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
  7. ncbi request reprint Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, School of Medicine, Tokyo University, Bunkyo ku, Tokyo 113, Japan
    Am J Physiol Lung Cell Mol Physiol 278:L906-13. 2000
  8. ncbi request reprint Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells
    M Desaki
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 267:124-8. 2000
  9. ncbi request reprint Dynamin and rab5 regulate GRK2-dependent internalization of dopamine D2 receptors
    K Iwata
    Department of Neurochemistry, Faculty of Medicine, University of Tokyo, Japan
    Eur J Biochem 263:596-602. 1999
  10. ncbi request reprint How protein reads the stop codon and terminates translation
    Y Nakamura
    Department of Tumor Biology, The Institute of Medical Science, The University of Tokyo, Japan
    Genes Cells 3:265-78. 1998

Collaborators

  • M Tanaka
  • Yoshikazu Nakamura
  • S Murakami
  • S Kato
  • S Omura
  • T Suzuki
  • A Yoshida
  • K Yamamoto
  • T Shimizu
  • Mitsuru Koizumi
  • David Barford
  • Kenji Ikehara
  • Lev Kisselev
  • Stephanie Kervestin
  • Norbert Polacek
  • Tohru Yamami
  • H Takizawa
  • Toshinobu Fujiwara
  • Andrey L Karamyshev
  • Zemfira N Karamysheva
  • Masayoshi Kuwahara
  • Oanh Thi Phuong Kim
  • Xia Li
  • Reiko Motohashi
  • Hiroyuki Kodama
  • Hanae Sato
  • T Ohtoshi
  • Chunguang Kong
  • Maiko Oshikawa
  • Emi Ito-Kato
  • B Kelly Blake
  • Makiko Uno
  • J Ooi
  • K Takami
  • F Yamasawa
  • M Satoh
  • Y Okada
  • A Umeda
  • M Desaki
  • Hirokazu Tsubone
  • Tomohiro Kawaguchi
  • Aki Sakurai
  • K Iwata
  • Terue Harumoto
  • Kazuki Saito
  • Hiroji Aiba
  • Masakazu Satou
  • Noriko Nagata
  • Masatomo Kobayashi
  • Kazuo Shinozaki
  • Kan Tanaka
  • Shigeo Yoshida
  • Fumiyoshi Myouga
  • Takuya Ito
  • Akitomo Nagashima
  • Takanori Yamazaki
  • Seiji Takahashi
  • Teruaki Yokota
  • Masao Maeno
  • Tsuyoshi Takada
  • Kyoko Ikeda
  • Tadahiro Takayama
  • Miki Wada
  • Martin A Walsh
  • Natsuko Tanabe
  • Naoto Suzuki
  • Naoyuki Sugano
  • Sundramurthy Kumar
  • Kichibee Otsuka
  • Ryosuke Koshi
  • Haiwei Song
  • Z I Honda
  • Yuying Liu
  • Takashi Yokogawa
  • Kazuya Nishikawa
  • Senya Matsufuji
  • H Kasai
  • Steven L Alam
  • A Tojo
  • K Tani
  • K Nakahara
  • S Asano
  • H Nagayama
  • T Iseki
  • N Shirafuji
  • A Tomonari
  • T Kasama
  • T Sunazuka
  • K Kobayashi
  • T Haga

Detail Information

Publications32

  1. ncbi request reprint ["tRNA mimicry" in translation termination revisited]
    Koichi Ito
    Tanpakushitsu Kakusan Koso 48:329-37. 2003
  2. ncbi request reprint Ribosomal protein L11 mutations in two functional domains equally affect release factors 1 and 2 activity
    Hanae Sato
    Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Microbiol 60:108-20. 2006
    ..These L11 mutations were located on the surface of two domains of L11, and interpreted to affect the interaction between L11 and rRNA or the RFs thereby leading to the altered translation termination...
  3. pmc Two components of exocytosis and endocytosis in phaeochromocytoma cells studied using caged Ca2+ compounds
    H Kasai
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    J Physiol 494:53-65. 1996
    ..They seem to couple selectively with specific endocytotic mechanisms. Our data suggest that the two vesicles belong to two distinct secretory pathways...
  4. ncbi request reprint Analysis of visitation frequency through particle tracking method based on LES and model experiment
    S Kato
    Institute of Industrial Science, University of Tokyo, Japan
    Indoor Air 13:182-93. 2003
    ..In the room model, VF shows a value of 5.70 when the local domain occupies half of the room. It becomes smaller when the size of the local domain is reduced...
  5. ncbi request reprint Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related secondary acute myeloid leukaemia
    J Ooi
    Department of Haematology and Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Br J Haematol 114:834-6. 2001
    ..These preliminary results suggest that adult MDS-related secondary AML patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT...
  6. ncbi request reprint Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
    ..Our study showed a close link between smoking and expression of TGF-beta1 in small airways. Our results also suggested that small airway epithelial cells might be involved in obstructive changes found in smokers and patients with COPD...
  7. ncbi request reprint Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, School of Medicine, Tokyo University, Bunkyo ku, Tokyo 113, Japan
    Am J Physiol Lung Cell Mol Physiol 278:L906-13. 2000
    ..Our results also suggested that this new ultrathin bronchofiberscope promised a good approach for the evaluation of cellular changes in the small airways...
  8. ncbi request reprint Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells
    M Desaki
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 267:124-8. 2000
    ..Our findings support the concept that the recruitment of neutrophils in airway diseases may be regulated by NF-kappaB and AP-1...
  9. ncbi request reprint Dynamin and rab5 regulate GRK2-dependent internalization of dopamine D2 receptors
    K Iwata
    Department of Neurochemistry, Faculty of Medicine, University of Tokyo, Japan
    Eur J Biochem 263:596-602. 1999
    ..These results indicate that the internalization of D2Rs is dependent on the action of dynamin as well as GRK2, and is regulated by the action of rab5A...
  10. ncbi request reprint How protein reads the stop codon and terminates translation
    Y Nakamura
    Department of Tumor Biology, The Institute of Medical Science, The University of Tokyo, Japan
    Genes Cells 3:265-78. 1998
    ....
  11. ncbi request reprint Roles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signaling
    Z I Honda
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 272:25753-60. 1997
    ....
  12. ncbi request reprint Bilateral pseudo-internuclear ophthalmoplegia in myasthenia gravis
    K Ito
    Department of Otolaryngology, University of Tokyo, Bunkyo ku, Japan
    ORL J Otorhinolaryngol Relat Spec 59:122-6. 1997
    ..Dissociated nystagmus and monocular overshoot might be the results of central compensation...
  13. ncbi request reprint Making sense of mimic in translation termination
    Yoshikazu Nakamura
    Department of Basic Medical Sciences, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Trends Biochem Sci 28:99-105. 2003
    ..All of this evidence seriously questions the simple concept of structural mimicry between proteins and RNA and, thus, leaves only functional mimicry of protein factors of translation to be investigated...
  14. doi request reprint Effects of taurine on cardiovascular and autonomic nervous functions in cold exposed rats
    Masayoshi Kuwahara
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Adv Exp Med Biol 643:533-40. 2009
    ..These results suggested that taurine might provide some reservoir for cardiovascular and autonomic nervous function to cold stress in rats...
  15. ncbi request reprint A tripeptide discriminator for stop codon recognition
    Yoshikazu Nakamura
    Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, 108 8630, Tokyo, Japan
    FEBS Lett 514:30-3. 2002
    ..Here we review the experimental background and process leading to this discovery, and strengthen functional evidence for the tripeptide determinant for deciphering stop codons in mRNAs in prokaryotes...
  16. ncbi request reprint Reduced action of polypeptide release factors induces mRNA cleavage and tmRNA tagging at stop codons in Escherichia coli
    Xia Li
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464 8602, Japan
    Mol Microbiol 63:116-26. 2007
    ....
  17. ncbi request reprint Transient idling of posttermination ribosomes ready to reinitiate protein synthesis
    Andrey L Karamyshev
    Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochimie 86:933-8. 2004
    ....
  18. ncbi request reprint Ribosome recycling factor disassembles the post-termination ribosomal complex independent of the ribosomal translocase activity of elongation factor G
    Toshinobu Fujiwara
    Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Microbiol 53:517-28. 2004
    ..These findings suggest that RRF is not a functional mimic of tRNA and disassembles the post-termination ribosomal complex independently of the translocation activity of EF-G...
  19. ncbi request reprint Elongation factor G participates in ribosome disassembly by interacting with ribosome recycling factor at their tRNA-mimicry domains
    Koichi Ito
    Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cell 9:1263-72. 2002
    ..These mutational studies suggest that EF-G motor action is transmitted to RRF by specific surface contacts between the domains that mimic the anticodon arm...
  20. pmc Antizyme frameshifting as a functional probe of eukaryotic translational termination
    Zemfira N Karamysheva
    Department of Biochemistry II, The Jikei University, School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Nucleic Acids Res 31:5949-56. 2003
    ..The system affords a convenient assay for release factor activity and has provided some novel views of the mechanism of antizyme frameshifting...
  21. pmc Polypeptide release at sense and noncognate stop codons by localized charge-exchange alterations in translational release factors
    Makiko Uno
    Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 99:1819-24. 2002
    ..Our results also establish that the charge flipping creates a phenotype/translation termination by "codon bypassing" via relaxed positioning of the RF tripeptide-anticodon in the decoding pocket of the ribosome...
  22. ncbi request reprint The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination
    Norbert Polacek
    Center for Pharmaceutical Biotechnology m c 870, University of Illinois, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Mol Cell 11:103-12. 2003
    ..This indicates that the mechanism of peptide release is distinct from that of peptide bond formation, with A2602 playing a critical role in peptide release during translation termination...
  23. ncbi request reprint Isolation and expression of two genes encoding eukaryotic release factor 1 from Paramecium tetraurelia
    Stephanie Kervestin
    Unite de Biochimie Cellulaire, CNRS UMR 7098, Universite Pierre et Marie Curie, Paris, France
    J Eukaryot Microbiol 49:374-82. 2002
    ..Besides, analysis of the expression of the two genes by Northern blotting and primer extension reveals that these genes exhibit a differential expression during vegetative growth and autogamy...
  24. ncbi request reprint Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe
    Chunguang Kong
    Laboratory of Macromolecular Structure, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Japan
    Mol Cell 14:233-45. 2004
    ..The N-terminal extension, rich in acidic amino acids, blocks the proposed eRF1 binding site, potentially regulating eRF1 binding to eRF3 in a competitive manner...
  25. doi request reprint Ciliates use both variant and universal genetic codes: evidence of omnipotent eRF1s in the class Litostomatea
    Oanh Thi Phuong Kim
    Department of Chemistry, Faculty of Science, Nara Women s University, Kitauoyanishi machi, Nara 630 8506, Japan
    Gene 417:51-8. 2008
    ..The results clearly showed that Didinium and Dileptus eRF1s efficiently recognize all three stop codons. This is the first experimental evidence that strongly supports the hypothesis that litostome ciliates use universal genetic code...
  26. ncbi request reprint The role of N-terminal domain of translational release factor eRF3 for the control of functionality and stability in S. cerevisiae
    Hiroyuki Kodama
    Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Genes Cells 12:639-50. 2007
    ..These findings suggest that NED functions to switch the functional mode of eRF3 depending on the nature of binding factors...
  27. ncbi request reprint Chloroplast ribosome release factor 1 (AtcpRF1) is essential for chloroplast development
    Reiko Motohashi
    Faculty of Agriculture, University of Shizuoka, 836 Ohya, Suruga ku, Shizuoka, 422 8529, Japan
    Plant Mol Biol 64:481-97. 2007
    ....
  28. ncbi request reprint Backbone 1H, 13C, and 15N assignments of the ribosome recycling factor from Thermus thermophillus
    B Kelly Blake
    J Biomol NMR 24:81-2. 2002
  29. ncbi request reprint Heterologous expression of Aquifex aeolicus ribosome recycling factor in Escherichia coli is dominant lethal by forming a complex that lacks functional co-ordination for ribosome disassembly
    Tohru Yamami
    Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Microbiol 55:150-61. 2005
    ..coli. These aaRRF mutations are spatially distinct from mutations previously described and suggest a novel active centre for coupling EF-G's G domain motor action to ribosome disassembly...
  30. pmc Omnipotent decoding potential resides in eukaryotic translation termination factor eRF1 of variant-code organisms and is modulated by the interactions of amino acid sequences within domain 1
    Koichi Ito
    Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 99:8494-9. 2002
    ....
  31. ncbi request reprint Effect of carnosine on runt-related transcription factor-2/core binding factor alpha-1 and Sox9 expressions of human periodontal ligament cells
    Emi Ito-Kato
    Department of Biochemistry, Nihon University School of Dentistry, Tokyo, Japan
    J Periodontal Res 39:199-204. 2004
    ....
  32. ncbi request reprint Differential gene induction in macrophage-like human cells by two types of Porphyromonas gingivalis: a microarray study
    Maiko Oshikawa
    Nihon University Graduate School of Dentistry, Tokyo, Japan
    J Oral Sci 46:9-14. 2004
    ..Our results indicate that compared with Pg-I, Pg-II induces a low host response as measured by its weak induction of gene expression...