K Yamanouchi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
    Yoshinori Tanaka
    Acta Neuropathol Commun 2:78. 2014
  2. pmc Age-related resistance of skeletal muscle-derived progenitor cells to SPARC may explain a shift from myogenesis to adipogenesis
    Katsuyuki Nakamura
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Aging (Albany NY) 4:40-8. 2012
  3. pmc Expression of aldo-keto reductase family 1 member C1 (AKR1C1) gene in porcine ovary and uterine endometrium during the estrous cycle and pregnancy
    Kyeong Seok Seo
    Animal Biotechnology, Graduate School of Bio and Information Technology, Institute of Genetic Engineering, Hankyong National University, Ansung 456 749, Korea
    Reprod Biol Endocrinol 9:139. 2011
  4. ncbi request reprint Satellite cell differentiation in goat skeletal muscle single fiber culture
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
    J Reprod Dev 55:252-5. 2009
  5. ncbi request reprint 18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Tokyo, Japan
    Cell Physiol Biochem 20:781-90. 2007
  6. ncbi request reprint Both PPARgamma and C/EBPalpha are sufficient to induce transdifferentiation of goat fetal myoblasts into adipocytes
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Reprod Dev 53:563-72. 2007
  7. ncbi request reprint Myogenic and adipogenic properties of goat skeletal muscle stem cells
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Reprod Dev 53:51-8. 2007
  8. ncbi request reprint Analyses of hind leg skeletons in human growth hormone transgenic rats
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Gerontol 39:1179-88. 2004
  9. ncbi request reprint Increased adipogenicity of cells from regenerating skeletal muscle
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Cell Res 312:2701-11. 2006
  10. ncbi request reprint Expression of myostatin gene in regenerating skeletal muscle of the rat and its localization
    K Yamanouchi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Biochem Biophys Res Commun 270:510-6. 2000

Collaborators

  • Masugi Nishihara
  • Y Tanaka
  • K Sugiura
  • S Goto
  • S Ohashi
  • Hideaki Tojo
  • M Takahashi
  • Y Kanai
  • H Sato
  • K Kitamura
  • S Tanaka
  • S Matsuyama
  • Y Morikawa
  • T Sawasaki
  • M Matsumoto
  • M Aoki
  • M Suzuki
  • H Nagashima
  • Masakatsu Kato
  • Takashi Matsuwaki
  • Tomohiro Yonezawa
  • Tohru Hosoyama
  • Maho Ishida
  • Kazutaka Mogi
  • Hitomi Fujioka
  • Walimuni Samantha Nilanthi Jayasekara
  • Jae hyek Choi
  • C Tachi
  • Jun You Li
  • Keiji Hirabayashi
  • Katsuyuki Nakamura
  • T Nedachi
  • Kyeong Seok Seo
  • Shingo Shibata
  • Ayako Ban
  • Ryuji Sako
  • Shuichi Chiba
  • Hyun Kim
  • Yoshitake Cho
  • Hiroyuki Hozumi
  • Erica Yada
  • Ryota Ikemura
  • T Uekita
  • Keisuke Yonehara
  • Jun Kubo
  • Kunihiko Naito
  • Shunichi Suzuki
  • K Nishino
  • H Inuzuka
  • Shin Ichi Nakano
  • Takahiro Miyoshi
  • Hakhyun Ka
  • Sang Hwan Kim
  • T Matsuwaki
  • Seong Jo Yun
  • Tseeleema Nanjidsuren
  • Myung Hwa Kang
  • Jong Ju Park
  • Jong Taek Yoon
  • Purevjargal Naidansuren
  • Sue Yun Hwang
  • Bo Woong Sim
  • Cha Won Park
  • Kwan Sik Min
  • Nam Hyung Kim
  • T Kawai
  • Heewon Seo
  • Chiori Ueno
  • Noboru Manabe
  • Tsuyoshi Ito
  • K Naito
  • H Murasawa
  • Naomi Ishiguro
  • Y Sugawara
  • Tatsuo Akema
  • Yoichiro Iwakura
  • Katsuko Sudo
  • Reiko Horai
  • Y Yoshikawa
  • Kumi Kimura
  • Shin Ichiro Takahashi
  • Jeung Yon Rho
  • Fumihiko Hakuno
  • Y Toyooka
  • Miyako Ariga
  • Yasufumi Furuhata
  • Yasunobu Uchijima
  • Yuko Kayasuga
  • Chikashi Tachi
  • Ding Sheng Chen

Detail Information

Publications64

  1. pmc Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
    Yoshinori Tanaka
    Acta Neuropathol Commun 2:78. 2014
    ..The present results also suggest that these pathological changes in the VPM/VPL are likely a result of lysosomal dysfunction. How PGRN prevents lysosomal dysfunction with aging remains to be elucidated...
  2. pmc Age-related resistance of skeletal muscle-derived progenitor cells to SPARC may explain a shift from myogenesis to adipogenesis
    Katsuyuki Nakamura
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Aging (Albany NY) 4:40-8. 2012
    ..Our data may explain an age-related shift from myogenesis to adipogenesis, associated with sarcopenia...
  3. pmc Expression of aldo-keto reductase family 1 member C1 (AKR1C1) gene in porcine ovary and uterine endometrium during the estrous cycle and pregnancy
    Kyeong Seok Seo
    Animal Biotechnology, Graduate School of Bio and Information Technology, Institute of Genetic Engineering, Hankyong National University, Ansung 456 749, Korea
    Reprod Biol Endocrinol 9:139. 2011
    ..The 20 alpha-hydroxysteroid dehydrogenase (20 alpha-HSD) is a member of AKR family. The aims of this study were to determine its expression in the ovary and uterus endometrium during the estrous cycle and pregnancy...
  4. ncbi request reprint Satellite cell differentiation in goat skeletal muscle single fiber culture
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
    J Reprod Dev 55:252-5. 2009
    ..The present study is the first to describe establishment of a goat skeletal muscle single fiber culture that can be used as a model system for further studies on satellite cell behavior in ruminants...
  5. ncbi request reprint 18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Tokyo, Japan
    Cell Physiol Biochem 20:781-90. 2007
    ..These results indicate that inhibition of connexin function induces phenotypic changes of skeletal muscle cells to enter adipogenesis...
  6. ncbi request reprint Both PPARgamma and C/EBPalpha are sufficient to induce transdifferentiation of goat fetal myoblasts into adipocytes
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Reprod Dev 53:563-72. 2007
    ..These results demonstrate for the first time that primary cultured myoblasts can be transdifferentiated into adipocytes...
  7. ncbi request reprint Myogenic and adipogenic properties of goat skeletal muscle stem cells
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Reprod Dev 53:51-8. 2007
    ..These results clearly demonstrate the presence of both myogenic and adipogenic stem cells in goat skeletal muscle...
  8. ncbi request reprint Analyses of hind leg skeletons in human growth hormone transgenic rats
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Gerontol 39:1179-88. 2004
    ..The results obtained in this study indicate that the transgenic rats could be useful model to gain insight into the complex mechanism leading to osteoporosis with aging...
  9. ncbi request reprint Increased adipogenicity of cells from regenerating skeletal muscle
    Keitaro Yamanouchi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Cell Res 312:2701-11. 2006
    ....
  10. ncbi request reprint Expression of myostatin gene in regenerating skeletal muscle of the rat and its localization
    K Yamanouchi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Biochem Biophys Res Commun 270:510-6. 2000
    ....
  11. ncbi request reprint Molecular analysis of structural protein genes of the Yamagata-1 strain of defective subacute sclerosing panencephalitis virus. IV. Nucleotide sequence of the fusion gene
    K Komase
    Laboratory Animal Research Center, University of Tokyo, Japan
    Virus Genes 4:173-81. 1990
    ..The variations of the C-terminal region of the F protein were observed with two other SSPE viruses, suggesting that this may be a common property of SSPE virus that differs from MV...
  12. ncbi request reprint Molecular analysis of structural protein genes of the Yamagata-1 strain of defective subacute sclerosing panencephalitis virus. III. Nucleotide sequence of the hemagglutinin gene
    K Komase
    Laboratory Animal Research Center, University of Tokyo, Japan
    Virus Genes 4:163-72. 1990
    ..These results suggested that the H protein of the Yamagata-1 strain of defective SSPE virus is structurally and functionally similar to that of the Edmonston strain of MV...
  13. ncbi request reprint Molecular analysis of structural protein genes of the Yamagata-1 strain of defective subacute sclerosing panencephalitis virus. I. Nucleotide sequence of the nucleoprotein gene
    K Komase
    Laboratory Animal Research Center, University of Tokyo, Japan
    Virus Genes 4:137-49. 1990
    ..These results suggest that the NP proteins of SSPE viruses have a common property that is different from MV...
  14. ncbi request reprint Molecular analysis of structural protein genes of the Yamagata-1 strain of defective subacute sclerosing panencephalitis virus. II. Nucleotide sequence of a cDNA corresponding to the P plus M dicistronic mRNA
    Y Yoshikawa
    Laboratory Animal Research Center, University of Tokyo, Japan
    Virus Genes 4:151-61. 1990
    ..Thus, the deduced SSPE-virus M protein lacked 50 amino acids at the amino terminal and had 15 extra amino acids at the carboxyl end when compared with the MV M protein...
  15. ncbi request reprint Endometrial expression of cellular protooncogene c-ski and its regulation by estradiol-17beta
    K Yamanouchi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    FEBS Lett 449:273-6. 1999
    ..These results suggest that the c-ski gene plays a role in uterine epithelial cell proliferation and mediates the proliferative action of E2...
  16. doi request reprint Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice
    Y Tanaka
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Neuroscience 250:8-19. 2013
    ....
  17. ncbi request reprint Germinal vesicle materials are not required for the activation of MAP kinase in porcine oocyte maturation
    K Sugiura
    Laboratory of Applied Genetics, Department of Animal Resource Sciences, Graduate School of Agricultural Sciences, University of Tokyo, Tokyo, Japan
    Mol Reprod Dev 59:215-20. 2001
    ....
  18. ncbi request reprint Expression and localization of matrix metalloproteinases (MT1-MMP, MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) during synepitheliochorial placentation of goats (Capra hircus)
    T Uekita
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113 8657, Japan
    Placenta 25:810-9. 2004
    ....
  19. doi request reprint Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice
    Y Tanaka
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Neuroscience 231:49-60. 2013
    ..These results suggest that PGRN is produced in CD68-positive microglia and suppresses excessive inflammatory responses related to activated microglia after TBI in mice...
  20. ncbi request reprint Comparative analysis of HOXC-9 gene expression in murine hemochorial and caprine synepitheliochorial placentae by in situ hybridization
    H Murasawa
    Laboratory of Applied Genetics, Department of Animal Resource Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Anat Rec 259:383-94. 2000
    ....
  21. ncbi request reprint A transgenic mouse model for investigating the response of the upstream region of whey acidic protein (WAP) gene to various steroid hormones
    H Inuzuka
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan
    Exp Anim 50:1-7. 2001
    ..The results showed that the response of 5' region of WAP requires at least some extended development of the mammary gland and that the 2.6 kb upstream region of the exogenous WAP gene contained the element responsive to ovarian hormones...
  22. pmc Skeletal muscle growth defect in human growth hormone transgenic rat is accompanied by phenotypic changes in progenitor cells
    Shingo Shibata
    Department of Veterinary Physiology, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, Tokyo 113 8657, Japan
    Age (Dordr) 32:239-53. 2010
    ....
  23. ncbi request reprint Characterization of mesonephric cells that migrate into the XY gonad during testis differentiation
    K Nishino
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan
    Exp Cell Res 267:225-32. 2001
    ..Thus, our findings provide important information related to the migration and differentiation of migrated mesonephric cells in the XY gonad...
  24. ncbi request reprint Complete nucleotide sequence of the phosphoprotein of the Yamagata-1 strain of a defective subacute sclerosing panencephalitis (SSPE) virus
    K Komase
    Department of Technology, Kitasato Institute, Tokyo, Japan
    Biochim Biophys Acta 1129:342-4. 1992
    ..As a result of the frameshift downstream of the site of G insertion, the cysteine-rich V protein was predicted from the one G-inserted mRNA besides the P and C proteins predicted from the genome-copied mRNA...
  25. ncbi request reprint Activation of ribosomal S6 kinase (RSK) during porcine oocyte maturation
    K Sugiura
    Department of Animal Resource Sciences, Graduate School of Agricultural Sciences, University of Tokyo, Japan
    Zygote 10:31-6. 2002
    ..These results suggest that the activation of RSK is involved in the regulation of meiotic maturation of porcine oocytes...
  26. ncbi request reprint Characterization of temperature-sensitive mutants of measles virus
    Y Morikawa
    Kitasato Institute, Tokyo, Japan
    Kitasato Arch Exp Med 64:15-30. 1991
    ..5 degrees C, and both P333 and F2-104 lacked one epitope of the P protein. The lack of these viral epitopes was shown to correlate with the temperature-sensitivity of the three ts mutants...
  27. ncbi request reprint Glucocorticoid maintains pulsatile aecretion of luteinizing hormone under infectious stress condition
    Takashi Matsuwaki
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo 113 8657, Japan
    Endocrinology 144:3477-82. 2003
    ..In addition, the DMH does not seem to mediate the central action of GC, though it may play an important role in inducing pathophysiological reactions to invasive stress...
  28. ncbi request reprint Glucocorticoid counteracts the suppressive effect of tumor necrosis factor-alpha on the surge of luteinizing hormone secretion in rats
    Takashi Matsuwaki
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo 113 8657, Japan
    J Endocrinol 181:509-13. 2004
    ....
  29. ncbi request reprint Molecular cloning of cDNA for equine follistatin and its gene expression in the reproductive tissues of the mare
    Y Sugawara
    Laboratory of Livestock Biotechnology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan
    J Vet Med Sci 61:201-7. 1999
    ..These results suggest that follistatin acts in the reproductive tissues of the mare in maintaining pregnancy...
  30. ncbi request reprint Adipogenic potential of satellite cells from distinct skeletal muscle origins in the rat
    Erica Yada
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 68:479-86. 2006
    ....
  31. ncbi request reprint In vivo gene transfer of PPAR gamma is insufficient to induce adipogenesis in skeletal muscle
    Ayako Ban
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    J Vet Med Sci 70:761-7. 2008
    ..These results suggested that, in addition to an expression of PPAR gamma, niches that support adipogenesis are required for satellite cells to enter adipogenesis in vivo...
  32. ncbi request reprint Maintenance of gonadotropin secretion by glucocorticoids under stress conditions through the inhibition of prostaglandin synthesis in the brain
    Takashi Matsuwaki
    Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Tokyo 113 8657, Japan
    Endocrinology 147:1087-93. 2006
    ....
  33. doi request reprint Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation
    T Nedachi
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    Neuroscience 185:106-15. 2011
    ..In addition, a GSK3β-specific inhibitor enhanced NPC proliferation. Taken together, our observations indicate that PGRN enhanced NPC proliferation, at least in part, via inducing GSK3β phosphorylation...
  34. ncbi request reprint Molecular analysis of virus-producing and non-producing clones derived from a defective SSPE virus Yamagata-1 strain
    T Haga
    Laboratory Animal Research Center, University of Tokyo, Japan
    Microbiol Immunol 36:257-67. 1992
    ..These results suggest that abundant production of P plus M dicistronic mRNA is responsible for the reduced amount of M protein in the non-productive YA clone...
  35. ncbi request reprint Effect of calyculin-A, phosphatase inhibitor, on 20 alpha-hydroxysteroid dehydrogenase activity in rat luteal cell culture
    K Yamanouchi
    Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Japan
    Endocr J 40:699-704. 1993
    ..These results suggest that a CL-A sensitive phosphatase(s) may be involved in the action of PRL in suppressing the increase in 20 alpha-HSD activity in rat luteal cells...
  36. ncbi request reprint Characterization of antinuclear antibodies induced in rabbits by rinderpest virus infection
    K Imaoka
    Laboratory Animal Research Center, University of Tokyo, Japan
    Arch Virol 102:111-8. 1988
    ..The results indicate that DNA and nucleohistone are the major target antigens for ANAs. In addition, antibodies against nucleoli and extractable nuclear antigens were induced in some rabbits...
  37. ncbi request reprint The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats
    Yoshitake Cho
    Department of Animal Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Endocrinology 147:5374-84. 2006
    ..This novel mechanism explains normalization of plasma glucose levels at least in part in a GH excess model...
  38. ncbi request reprint Involvement of neuropeptide Y in hyperphagia in human growth hormone transgenic rats
    Hiroyuki Hozumi
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 68:959-65. 2006
    ..These results suggest that, in the TG rats, insufficiency in circulating GH stimulates the ghrelin-NPY system with a resultant increase in food intake...
  39. ncbi request reprint Skeletal muscle injury induces hepatocyte growth factor expression in spleen
    Shunichi Suzuki
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 292:709-14. 2002
    ....
  40. doi request reprint Degenerative muscle fiber accelerates adipogenesis of intramuscular cells via RhoA signaling pathway
    Tohru Hosoyama
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Differentiation 77:350-9. 2009
    ..Taken together, the present studies clearly demonstrated that muscle fiber condition affects fat accumulation in skeletal muscle and that is possibly mediated by the RhoA signaling pathway...
  41. ncbi request reprint Role of serum myostatin during the lactation period
    Tohru Hosoyama
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Japan
    J Reprod Dev 52:469-78. 2006
    ..These results demonstrate that myostatin in serum acts on skeletal muscle and negatively regulates early postnatal muscle growth...
  42. ncbi request reprint Auditory brain-stem response in zitter rats with genetic spongiform encephalopathy
    F Ochikubo
    Laboratory Animal Research Center, University of Tokyo, Japan
    Electroencephalogr Clin Neurophysiol 82:145-51. 1992
    ..These findings suggest that at least two mechanisms, one involving hypomyelination and the other causing spongy lesions, are responsible for the brain-stem auditory pathway dysfunction in zitter rats...
  43. ncbi request reprint Wilms' tumor suppressor gene (WT1) as a target gene of SRY function in a mouse ES cell line transfected with SRY
    Y Toyooka
    Developmental Biology Group, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Int J Dev Biol 42:1143-51. 1998
    ..Analysis using an appropriate in vitro system will be essential to understand the molecular mechanisms of SRY action within cells...
  44. ncbi request reprint Regulatory considerations on transgenic livestock in Japan in relation to the Cartagena protocol
    K Yamanouchi
    Nippon Institute for Biological Science, 9 2221 1 Shin machi, Ome, Tokyo, Japan
    Theriogenology 67:185-7. 2007
    ..Field use of transgenic livestock is controlled by the Ministry of Agriculture, Forestry and Fisheries. The author describes risk assessment and management of transgenic livestock by both ministries...
  45. ncbi request reprint Activation of complement in quails bearing Rous sarcoma virus-induced tumors
    C Kai
    Department of Veterinary Microbiology, University of Tokyo, Japan
    J Vet Med Sci 57:1077-80. 1995
    ..C3 deposition was also observed in almost all tumor cells at the tumor developing stage. These findings obtained in vivo suggest that the cells transformed by RSV activated the C3 on their surfaces...
  46. ncbi request reprint Molecular cloning of DNA for inhibin alpha-subunit from equine ovary
    K Yamanouchi
    Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Japan
    J Vet Med Sci 57:905-9. 1995
    ..Northern blot analysis revealed that a single major band at 1.5 kb was present in the RNA samples both from equine follicles and testes...
  47. ncbi request reprint Molecular cloning of cDNA for equine ovarian inhibin/activin beta A subunit
    S Yoshida
    Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Japan
    J Vet Med Sci 57:469-73. 1995
    ..Northern blot analysis revealed that placenta from mare on day 180 of pregnancy contained a 1.5 kb inhibin/activin beta A subunit mRNA...
  48. doi request reprint Negative correlation between neuropeptide Y profile in the cerebrospinal fluid and growth hormone pulses in the peripheral circulation in goats
    Tomohiro Yonezawa
    Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Neuroendocrinology 91:308-17. 2010
    ..The present study was conducted to elucidate the relationship between GH pulses and neuropeptide levels in the cerebrospinal fluid (CSF) of the third ventricle in ovariectomized goats...
  49. ncbi request reprint Relationship between growth hormone (GH) pulses in the peripheral circulation and GH-releasing hormone and somatostatin profiles in the cerebrospinal fluid of goats
    Kazutaka Mogi
    Department of Veterinary Physiology, The University of Tokyo, Japan
    J Vet Med Sci 66:1071-8. 2004
    ..The mechanisms underlying the generation of large GH pulses of 5 hr periodicity remain unknown, while direct action of NPY and/or ghrelin on the pituitary might be involved...
  50. doi request reprint The effect of glucocorticoids on bradykinesia induced by immobilization stress
    Takashi Matsuwaki
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Horm Behav 54:41-6. 2008
    ..These results suggest that glucocorticoids play a role in preventing the detrimental effect of IMO on nigral DA neurons and resulting bradykinesia, and that this effect of IMO involves PG-mediated mechanisms...
  51. ncbi request reprint Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus
    Shuichi Chiba
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo, Japan
    J Reprod Dev 53:297-307. 2007
    ....
  52. ncbi request reprint Modulation of growth hormone pulsatility by sex steroids in female goats
    Tomohiro Yonezawa
    Department of Veterinary Physiology and Animal Resource Science Center, Veterinary Medical Science, The University of Tokyo, Tokyo 113 8657, Japan
    Endocrinology 146:2736-43. 2005
    ..These results suggest that the pulsatile pattern of GH secretion in goats varies with sex steroid levels and thereby affects IGF-I secretion and lipolysis during the estrous cycle...
  53. ncbi request reprint Generation of transgenic rats expressing enhanced green fluorescent protein in gonadotropin-releasing hormone neurons
    Hitomi Fujioka
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Japan
    J Reprod Dev 49:523-9. 2003
    ..The mean percentage of EGFP-positive cells in the GnRH-positive cells was 76.3%. The GnRH-EGFP transgenic rats generated in the present study will enable characterization of properties of individual GnRH neurons...
  54. ncbi request reprint The Effects of GABA on embryonic gonadotropin-releasing hormone neurons in rat hypothalamic primary culture
    Hitomi Fujioka
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo, Japan
    J Reprod Dev 53:323-31. 2007
    ..These results suggest that GABA plays a role in stimulating GnRH gene expression through GABA-A receptors in embryonic GnRH neurons in late gestational stages...
  55. ncbi request reprint Expression and possible role of 20alpha-hydroxysteroid dehydrogenase in the placenta of the goat
    Walimuni Samantha Nilanthi Jayasekara
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Japan
    J Reprod Dev 51:265-72. 2005
    ..These results support the notion that 20alpha-HSD protects the fetus from the cytotoxic effects of progesterone, and thereby maintains the normal development of the fetus...
  56. ncbi request reprint Involvement of endogenous vasopressin in high plasma osmolality-induced anorexia via V1 receptor-mediated mechanism
    Ryota Ikemura
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Japan
    J Vet Med Sci 66:951-5. 2004
    ..These results suggest that vasopressin participates in the suppression of food intake during high plasma osmolality, the action of which is mediated by V(1) receptors in the brain...
  57. ncbi request reprint Molecular cloning of goat 20alpha-hydroxysteroid dehydrogenase cDNA
    Walimuni Samantha Nilanthi Jayasekara
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Japan
    J Reprod Dev 50:323-31. 2004
    ..The present study suggests that goat 20alpha-HSD is another member of the aldo-keto reductase superfamily and that it plays a role in the placenta during pregnancy...
  58. ncbi request reprint Expression of ski in the granulosa cells of atretic follicles in the rat ovary
    Hyun Kim
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Japan
    J Reprod Dev 52:715-21. 2006
    ..These results indicate that Ski is profoundly expressed in the granulosa cells of atretic follicles, but not in growing follicles, and suggests that Ski plays a role in apoptosis of granulosa cells during follicular atresia...
  59. pmc Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene
    Keiji Hirabayashi
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem J 382:975-80. 2004
    ....
  60. ncbi request reprint Expression analyses of sex steroid-regulated genes in neonatal rat hypothalamus
    Keisuke Yonehara
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Japan
    J Reprod Dev 49:547-52. 2003
    ..These results suggest that these four genes are involved in sexual differentiation of the rat brain, and that androgen per se as well as estrogen may take part in the processes...
  61. ncbi request reprint Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice
    Jae hyek Choi
    Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo, Japan
    J Reprod Dev 54:408-12. 2008
    ..These results suggest that both maternal and fetal 20alpha-HSD play a role in maintaining normal pregnancy at least partially by reducing progesterone concentrations in fetuses...
  62. ncbi request reprint Expression of the gene of interest fused to the EGFP-expressing gene in transgenic mice derived from selected transgenic embryos
    Jun Kubo
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Exp Zool 293:712-8. 2002
    ..The present cassette gene construct is a useful example for circumventing the routine analyses of DNA and RNA required for the generation and maintenance of transgenic lines...
  63. ncbi request reprint Long term adrenal insufficiency induces skeletal muscle atrophy and increases the serum levels of active form myostatin in rat serum
    Tohru Hosoyama
    Department of Biology, Faculty of Science, Graduate School of Science and Technology, Chiba University, Japan
    Zoolog Sci 22:229-36. 2005
    ....
  64. ncbi request reprint Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene
    Maho Ishida
    Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
    J Reprod Dev 53:499-508. 2007
    ..These findings suggest that the role of 20alpha-HSD in functional luteolysis is relatively minor but that it is involved in the survival of newborn mice...