Toshio Imanishi

Summary

Affiliation: Wakayama Medical University
Country: Japan

Publications

  1. ncbi request reprint Inflammatory Biomarkers in Peripheral Artery Disease: Diagnosis, Prognosis, and Therapeutic Challenges
    Yuichi Ozaki
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama, 641 8510, Japan
    Curr Med Chem 22:2744-53. 2015
  2. pmc Endothelial progenitor cells dysfunction and senescence: contribution to oxidative stress
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Curr Cardiol Rev 4:275-86. 2008
  3. ncbi request reprint MicroRNAs in peripheral artery disease
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Japan
    Curr Top Med Chem 13:1589-95. 2013
  4. ncbi request reprint Novel strategies to target inflammatory processes in atherosclerosis
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama, Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Curr Pharm Des 19:1616-25. 2013
  5. ncbi request reprint Biomarkers associated with vulnerable atheromatous plaque
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Curr Med Chem 19:2588-96. 2012
  6. ncbi request reprint Evaluation of pharmacological modulation of nitroglycerin-induced impairment of nitric oxide bioavailability by a catheter-type nitric oxide sensor
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 71:1473-9. 2007
  7. doi request reprint Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Hypertension 51:734-41. 2008
  8. doi request reprint Effects of pioglitazone on nitric oxide bioavailability measured using a catheter-type nitric oxide sensor in angiotensin II-infusion rabbit
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Japan
    Hypertens Res 31:117-25. 2008
  9. doi request reprint Endothelial progenitor cell senescence--is there a role for estrogen?
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Ther Adv Cardiovasc Dis 4:55-69. 2010
  10. doi request reprint Effects of angiotensin converting enzyme inhibitor and angiotensin II receptor antagonist combination on nitric oxide bioavailability and atherosclerotic change in Watanabe heritable hyperlipidemic rabbits
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Hypertens Res 31:575-84. 2008

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Inflammatory Biomarkers in Peripheral Artery Disease: Diagnosis, Prognosis, and Therapeutic Challenges
    Yuichi Ozaki
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama, 641 8510, Japan
    Curr Med Chem 22:2744-53. 2015
    ..In this review, inflammatory biomarkers that should be contributory to diagnosis, prognosis, and avenues for therapeutic challenges in PAD are summarized. ..
  2. pmc Endothelial progenitor cells dysfunction and senescence: contribution to oxidative stress
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Curr Cardiol Rev 4:275-86. 2008
    ..In this review, we describe current understanding of the contributions of oxidative stress in cardiovascular disease, focusing on the potential mechanisms of EPCs senescence...
  3. ncbi request reprint MicroRNAs in peripheral artery disease
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Japan
    Curr Top Med Chem 13:1589-95. 2013
    ..Recent evidence has demonstrated that specific miRNAs are involved in the pathological development of PAD. In this review, the roles of specific miRNAs in PAD are summarized...
  4. ncbi request reprint Novel strategies to target inflammatory processes in atherosclerosis
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama, Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Curr Pharm Des 19:1616-25. 2013
    ..Here, the impact of monocytes/macrophages in both early atherogenesis and advanced plaque progression is discussed with a focus on the potential targeting of inflammatory processes in atherosclerosis...
  5. ncbi request reprint Biomarkers associated with vulnerable atheromatous plaque
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Curr Med Chem 19:2588-96. 2012
    ..Furthermore, assays for automated use need to be developed, and cut-off levels need to be defined. Further technological advances will likely facilitate the use of multimarker profiling to identify with coronary vulnerable plaque...
  6. ncbi request reprint Evaluation of pharmacological modulation of nitroglycerin-induced impairment of nitric oxide bioavailability by a catheter-type nitric oxide sensor
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 71:1473-9. 2007
    ..The study also examined whether these effects could be modified by an antioxidant, an angiotensin converting enzyme inhibitor, or an angiotensin II type 1 receptor antagonist (ARB)...
  7. doi request reprint Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Hypertension 51:734-41. 2008
    ..Combined treatment with a selective aldosterone antagonist and an angiotensin-converting enzyme inhibitor has additive protective effects on endothelial function and on atherosclerotic changes via decreased nitrosative stress...
  8. doi request reprint Effects of pioglitazone on nitric oxide bioavailability measured using a catheter-type nitric oxide sensor in angiotensin II-infusion rabbit
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Japan
    Hypertens Res 31:117-25. 2008
    ..In conclusion, the PPARgamma agonist pioglitazone significantly improved NO bioavailability in Ang II-infused rabbits, most likely by attenuating nitrosative stresses...
  9. doi request reprint Endothelial progenitor cell senescence--is there a role for estrogen?
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Ther Adv Cardiovasc Dis 4:55-69. 2010
    ..This review describes current understanding of EPC senescence and the role of estrogen in preventing EPC senescence...
  10. doi request reprint Effects of angiotensin converting enzyme inhibitor and angiotensin II receptor antagonist combination on nitric oxide bioavailability and atherosclerotic change in Watanabe heritable hyperlipidemic rabbits
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Hypertens Res 31:575-84. 2008
    ..01). In conclusion, the combined treatment with an ACEI and an ARB may have additive protective effects on endothelial function as well as atherosclerotic change...
  11. doi request reprint Pioglitazone inhibits angiotensin II-induced senescence of endothelial progenitor cell
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Hypertens Res 31:757-65. 2008
    ..In conclusion, pioglitazone inhibited Ang II-induced senescence of EPCs via down-regulation of the expression of AT1R...
  12. doi request reprint Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama City, Wakayama, Japan
    Hypertension 52:563-72. 2008
    ..Furthermore, cotreatment with a direct renin inhibitor and an angiotensin II receptor blocker has additive protective effects on both...
  13. doi request reprint Combined effects of an 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and angiotensin II receptor antagonist on nitric oxide bioavailability and atherosclerotic change in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Hypertens Res 31:1199-208. 2008
    ..In conclusion, the combined treatment with an HMG-CoA reductase inhibitor and an ARB may have additive protective effects on endothelial function as well as atherosclerotic change...
  14. doi request reprint Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama, Japan
    Atherosclerosis 212:628-35. 2010
    ..We examined whether distinct monocyte subsets relate in specific ways to coronary fibrous cap thickness (FCT) in patients with unstable angina pectoris (UAP)...
  15. ncbi request reprint Effects of angiotensin II on NO bioavailability evaluated using a catheter-type NO sensor
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Hypertension 48:1058-65. 2006
    ..Although Ang II stimulates release of NO in the short term, chronic treatment with Ang II elicits the decreased NO bioavailability in the aorta of the Ang II-infusion rabbit model...
  16. ncbi request reprint Angiotensin II potentiates vascular endothelial growth factor-induced proliferation and network formation of endothelial progenitor cells
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Hypertens Res 27:101-8. 2004
    ..In conclusion, our data indicate that Ang II potentiates VEGF-induced human EPCs proliferation and network formation through the up-regulation of KDR...
  17. ncbi request reprint Oxidized low density lipoprotein potentiation of Fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells
    Toshio Imanishi
    Division of Cardiology, Department of Medicine, Wakayama Medical University, Japan
    Circ J 66:1060-4. 2002
    ..The results may provide insights into the pathogenesis of accelerated atherosclerosis in patients with hyperlipidemia...
  18. ncbi request reprint Oxidized low-density lipoprotein inhibits vascular endothelial growth factor-induced endothelial progenitor cell differentiation
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Clin Exp Pharmacol Physiol 30:665-70. 2003
    ..01). 4. Our data indicate that oxLDL inhibits VEGF-induced EPC differentiation through the dephosphorylation of Akt...
  19. ncbi request reprint Effect of estrogen on differentiation and senescence in endothelial progenitor cells derived from bone marrow in spontaneously hypertensive rats
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Hypertens Res 28:763-72. 2005
    ..In addition, the rate of senescence was significantly greater in the BM-EPCs from SHR/Izm than in those from WKY/Izm. Estrogen was shown to augment differentiation and delay the onset of senescence in BM-EPCs from SHR/Izm...
  20. ncbi request reprint Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Clin Exp Pharmacol Physiol 31:407-13. 2004
    ..5. In conclusions, ox-LDL accelerates the onset of EPC senescence, which may be related to telomerase inactivation. Oxidized LDL-induced EPC senescence leads to the impairment of proliferative capacity and network formation...
  21. ncbi request reprint Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    J Hypertens 23:97-104. 2005
    ..We investigated the effect of angiotensin II (Ang II) on EPC senescence, leading to the impairment of proliferative activity...
  22. ncbi request reprint Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimidera, Wakayama City, Wakayama 641 8510, Japan
    J Hypertens 23:1699-706. 2005
    ..Conversely, estrogens have been shown to accelerate recovery of the endothelium after vascular injury...
  23. ncbi request reprint Estrogen reduces angiotensin II-induced acceleration of senescence in endothelial progenitor cells
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 8510, Japan
    Hypertens Res 28:263-71. 2005
    ..In conclusion, estrogen reduces Ang II-induced acceleration of senescence in EPCs partially through down-regulation of AT1R expression...
  24. ncbi request reprint Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    J Hypertens 23:1831-7. 2005
    ..Although hypertension is an important coronary risk factor, the influence to the EPCs is not fully understood. We investigated the effect of hypertension on EPC senescence...
  25. ncbi request reprint Inhibition of nuclear translocation of transcription factor nuclear factor-kappa B induces FAS- as well as tumour necrosis factor-alpha-mediated apoptosis through downregulation of a conserved family of inhibitor of apoptosis 1
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Clin Exp Pharmacol Physiol 30:133-9. 2003
    ..4. These findings suggest that c-IAP1 is an important intracellular modulator of Fas as well as TNF-alpha death signalling pathways in hVSMC. The expression of c-IAP1 is regulated by a NF-kappaB-mediated phenomenon...
  26. ncbi request reprint Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris
    Hideyuki Ikejima
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 74:337-45. 2010
    ....
  27. ncbi request reprint Effect of pioglitazone on nitroglycerin-induced impairment of nitric oxide bioavailability by a catheter-type nitric oxide sensor
    Hideyuki Ikejima
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 72:998-1002. 2008
    ..We examined whether nitroglycerin (NTG)-induced impairment of nitric oxide (NO) bioavailability could be modified by a peroxisome proliferator-activated receptor (PPAR) gammaagonist...
  28. doi request reprint Association of monocyte subsets with vulnerability characteristics of coronary plaques as assessed by 64-slice multidetector computed tomography in patients with stable angina pectoris
    Manabu Kashiwagi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Atherosclerosis 212:171-6. 2010
    ..The aim of the present study was to examine the relation between monocyte subsets and the presence, extent, and vulnerability characteristics of non-calcified coronary plaques (NCPs) as assessed by multidetector computed tomography (MDCT)...
  29. doi request reprint The effect of lipid and inflammatory profiles on the morphological changes of lipid-rich plaques in patients with non-ST-segment elevated acute coronary syndrome: follow-up study by optical coherence tomography and intravascular ultrasound
    Shigeho Takarada
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    JACC Cardiovasc Interv 3:766-72. 2010
    ..The aim of this study was to determine the relationship between the morphological changes of nonculprit lipid-rich plaques and several clinical profiles in patients with non-ST-segment elevated acute coronary syndrome (NSTEACS)...
  30. doi request reprint High-sensitivity C-reactive protein and plaque composition in patients with stable angina pectoris: a virtual histology intravascular ultrasound study
    Takashi Kubo
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Coron Artery Dis 20:531-5. 2009
    ..We used virtual histology intravascular ultrasound to evaluate the relationship between serum hs-CRP level and coronary plaque composition in patients with stable angina pectoris...
  31. ncbi request reprint Effect of direct renin inhibitor, aliskiren, on peripheral blood monocyte subsets and myocardial salvage in patients with primary acute myocardial infarction
    Yuichi Ozaki
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 76:1461-8. 2012
    ..We investigated the effects of adding the direct renin inhibitor (DRI), aliskiren, to an ACEI or an ARB on monocyte subsets and myocardial salvage in patients with primary acute myocardial infarction (AMI)...
  32. doi request reprint Impact of attenuated plaque as detected by intravascular ultrasound on the occurrence of microvascular obstruction after percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction
    Yasutsugu Shiono
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    JACC Cardiovasc Interv 6:847-53. 2013
    ....
  33. pmc First evaluation of real-time nitric oxide changes in the coronary circulation in patients with non-ischaemic dilated cardiomyopathy using a catheter-type sensor
    Shigeho Takarada
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Eur Heart J 31:2862-70. 2010
    ..In this study, we evaluated a new method for measuring plasma NO concentration in patients with dilated cardiomyopathy (DCM) and in normal controls using a catheter-type sensor...
  34. doi request reprint Prognostic value of microvascular resistance index immediately after primary percutaneous coronary intervention on left ventricular remodeling in patients with reperfused anterior acute ST-segment elevation myocardial infarction
    Hironori Kitabata
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan Electronic address
    JACC Cardiovasc Interv 6:1046-54. 2013
    ....
  35. doi request reprint Thin-cap fibroatheroma as high-risk plaque for microvascular obstruction in patients with acute coronary syndrome
    Yuichi Ozaki
    Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Circ Cardiovasc Imaging 4:620-7. 2011
    ..The purpose of this study was to investigate whether TCFA was associated with MVO after PCI in patients with ACS...
  36. doi request reprint Multiple coronary lesion instability in patients with acute myocardial infarction as determined by optical coherence tomography
    Takashi Kubo
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Am J Cardiol 105:318-22. 2010
    ..007). In conclusion, the present OCT examination demonstrated multiple lesion instability in the presence of AMI...
  37. doi request reprint Effect of human peripheral monocyte subsets on coronary flow reserve in infarct-related artery in patients with primary anterior acute myocardial infarction
    Hideyuki Ikejima
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Clin Exp Pharmacol Physiol 37:453-9. 2010
    ..4. In conclusion, peak levels of CD14(+)CD16(-) monocytes following primary anterior AMI were closely related to the extent of microvascular injury...
  38. ncbi request reprint Clinical significance of low signal intensity area surrounding stent struts identified by optical coherence tomography
    Kohei Ishibashi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Int Heart J 54:7-10. 2013
    ..37 ± 0.37 mm versus 0.12 ± 0.26 mm, P = 0.048). Our results suggest that LSIA might be involved in excessive neointimal formation, and that the healing response after PES implantation might be different from BMS or SES...
  39. doi request reprint Circulating malondialdehyde-modified low-density lipoprotein levels are associated with the presence of thin-cap fibroatheromas determined by optical coherence tomography in coronary artery disease
    Yoshiki Matsuo
    Division of Cardiology, Social Insurance Kinan Hospital, 46 70 Shinjo cho, Tanabe, Wakayama 646 8588, Japan
    Eur Heart J Cardiovasc Imaging 14:43-50. 2013
    ..We evaluated the relationship between coronary plaque vulnerability assessed by optical coherence tomography (OCT) and circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL)...
  40. doi request reprint Serial angiographic findings and prognosis of stent fracture site without early restenosis after sirolimus-eluting stent implantation
    Yasushi Ino
    Division of Cardiology, Wakayama National Hospital, Wakayama, Japan
    Am Heart J 160:775.e1-9. 2010
    ..The aim of this study is to investigate the risk of late restenosis at the stent fracture site without early restenosis after SES implantation...
  41. doi request reprint Comparison of vascular response after sirolimus-eluting stent implantation between patients with unstable and stable angina pectoris: a serial optical coherence tomography study
    Takashi Kubo
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    JACC Cardiovasc Imaging 1:475-84. 2008
    ....
  42. doi request reprint Coronary microvascular resistance index immediately after primary percutaneous coronary intervention as a predictor of the transmural extent of infarction in patients with ST-segment elevation anterior acute myocardial infarction
    Hironori Kitabata
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    JACC Cardiovasc Imaging 2:263-72. 2009
    ....
  43. doi request reprint Difference in neointimal appearance between early and late restenosis after sirolimus-eluting stent implantation assessed by optical coherence tomography
    Yasushi Ino
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Coron Artery Dis 24:95-101. 2013
    ..The aim of the present study was to compare the neointimal tissue appearance between early ISR (<1 year) and late ISR (>1 year) after sirolimus-eluting stent (SES) implantation using optical coherence tomography (OCT)...
  44. ncbi request reprint Association between circulating monocyte subsets and in-stent restenosis after coronary stent implantation in patients with ST-elevation myocardial infarction
    Yong Liu
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 74:2585-91. 2010
    ..The clinical significance of 2 distinct monocyte subsets as a marker of late in-stent restenosis (ISR) following implantation of bare-metal stents (BMSs) in patients with acute myocardial infarction (AMI) was examined...
  45. ncbi request reprint Assessment by optical coherence tomography of stent struts across side branch. -Comparison of bare-metal stents and drug-elution stents.-
    Yong Liu
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 75:106-12. 2011
    ..Optical coherence tomography (OCT) was performed to compare 3 types of stents placed across side branches...
  46. doi request reprint Prevalence and clinical significance of papillary muscle infarction detected by late gadolinium-enhanced magnetic resonance imaging in patients with ST-segment elevation myocardial infarction
    Takashi Tanimoto
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Circulation 122:2281-7. 2010
    ....
  47. ncbi request reprint Post-reperfusion enhancement of CD14(+)CD16(-) monocytes and microvascular obstruction in ST-segment elevation acute myocardial infarction
    Hiroto Tsujioka
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 74:1175-82. 2010
    ..The aim of the paper was to examine the relationship between distinct monocyte subsets and gadolinium-enhanced cardiovascular magnetic resonance (CMR) characteristics of MVO after STEMI...
  48. doi request reprint Relation of microchannel structure identified by optical coherence tomography to plaque vulnerability in patients with coronary artery disease
    Hironori Kitabata
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Am J Cardiol 105:1673-8. 2010
    ..01). In conclusion, a significant relation was found between the presence of microchannels in plaques identified by OCT and plaque vulnerability in patients with coronary artery disease...
  49. ncbi request reprint Endothelial progenitor cell differentiation and senescence in an angiotensin II-infusion rat model
    Katsunobu Kobayashi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Hypertens Res 29:449-55. 2006
    ..In conclusion, Ang II decreased the differentiation and accelerated the senescence of BM-EPCs via AT(1)R...
  50. ncbi request reprint Various types of plaque disruption in culprit coronary artery visualized by optical coherence tomography in a patient with unstable angina
    Takashi Tanimoto
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 73:187-9. 2009
    ..OCT also revealed a small ruptured plaque and an eroded plaque with intraluminal thrombi in a distal site remote from the culprit lesion, neither of which was visualized by IVUS...
  51. doi request reprint Relation of albuminuria to coronary microvascular function in patients with chronic kidney disease
    Sari Imamura
    Department of Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Japan
    Am J Cardiol 113:779-85. 2014
    ..Albuminuria was associated with CFVR impairment in patients with CKD; even in mild-to-moderate CKD, patients with albuminuria showed further reduced coronary vasodilator capacity...
  52. ncbi request reprint Effect of direct renin inhibitor on left ventricular remodeling in patients with primary acute myocardial infarction
    Yuichi Ozaki
    Department of Cardiovascular Medicine, Wakayama Medical University
    Int Heart J 55:17-21. 2014
    ..A low dose of aliskiren may be insufficient to maintain suppression of aldosterone under current standard therapies with an ACEI or an ARB and β-blocker in patients with primary AMI, and results in no attenuation of LVR...
  53. doi request reprint Altered coronary flow velocity reserve and left ventricular wall motion dynamics: a phenomenon in hypertensive patients with ECG strain
    Yu Arita
    Department of Medicine, Wakayama Medical University, Wakayama, Japan
    Echocardiography 30:634-43. 2013
    ..Therefore, the aim of this study is to investigate the association of the ratio of inner- to outer-half layer of the LV myocardial deformation and coronary microvascular function with ECG strain in hypertensive patients...
  54. ncbi request reprint Comparison of contrast media and low-molecular-weight dextran for frequency-domain optical coherence tomography
    Yuichi Ozaki
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 76:922-7. 2012
    ..The aim of the present study was to compare the image quality and quantitative measurements between contrast media and LMD-L for FD-OCT image acquisition in coronary stented lesions...
  55. doi request reprint Advantage of next-generation frequency-domain optical coherence tomography compared with conventional time-domain system in the assessment of coronary lesion
    Shigeho Takarada
    Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Catheter Cardiovasc Interv 75:202-6. 2010
    ..The aim of this study was to evaluate the feasibility and usability of next generation FD-OCT in the assessment of coronary lesions...
  56. doi request reprint Difference of culprit lesion morphologies between ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndrome: an optical coherence tomography study
    Yasushi Ino
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    JACC Cardiovasc Interv 4:76-82. 2011
    ....
  57. doi request reprint Lipid-rich plaque and myocardial perfusion after successful stenting in patients with non-ST-segment elevation acute coronary syndrome: an optical coherence tomography study
    Atsushi Tanaka
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1, Kimiidera Wakayama, Japan
    Eur Heart J 30:1348-55. 2009
    ..The aim of this study was to investigate whether optical coherence tomography (OCT) could predict no-reflow in patients with NSTEACS...
  58. ncbi request reprint Impact of stress hyperglycemia on myocardial salvage following successfully recanalized primary acute myocardial infarction
    Ikuko Teraguchi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 76:2690-6. 2012
    ..Elevated blood glucose on admission may worsen outcome after acute myocardial infarction (AMI). No relationship has been identified between admission blood glucose level and myocardial salvage in patients with AMI...
  59. doi request reprint Implication of plaque color classification for assessing plaque vulnerability: a coronary angioscopy and optical coherence tomography investigation
    Takashi Kubo
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Japan
    JACC Cardiovasc Interv 1:74-80. 2008
    ..The purpose of this study was to assess the relationship between plaque color evaluated by coronary angioscopy and fibrous cap thickness estimated by optical coherence tomography (OCT) in vivo...
  60. doi request reprint Head to head comparison between the conventional balloon occlusion method and the non-occlusion method for optical coherence tomography
    Hideaki Kataiwa
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Int J Cardiol 146:186-90. 2011
    ..The current OCT system, however, has a serious limitation in that the image acquisition method requires a soft balloon occlusion to avoid signal scattering from red blood cells...
  61. doi request reprint Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction
    Hiroto Tsujioka
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama, Japan
    J Am Coll Cardiol 54:130-8. 2009
    ..We examined whether distinct monocyte subsets contribute in specific ways to myocardial salvage in patients with acute myocardial infarction (AMI)...
  62. ncbi request reprint Assessment of circumferential endocardial extent of myocardial edema and infarction in patients with reperfused acute myocardial infarction: a cardiovascular magnetic resonance study
    Shingo Ota
    Department of Cardiovascular Medicine, Wakayama Medical University
    Int Heart J 55:234-8. 2014
    ..99, P < 0.01). There is a strong correlation between the circumferential extent of edema and infarction in reperfused AMI. Thus, T2 weighted imaging can be skipped to quantify the amount of AAR...
  63. ncbi request reprint The effect of endothelial progenitor cells on the development of collateral formation in patients with coronary artery disease
    Yoshiki Matsuo
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Intern Med 47:127-34. 2008
    ..In this study, we investigated whether or not the number and function of EPCs were associated with the development of collateral formation in patients with single-vessel coronary artery disease of chronic total occlusion (CTO)...
  64. doi request reprint Coronary superficial and spotty calcium deposits in culprit coronary lesions of acute coronary syndrome as determined by optical coherence tomography
    Masato Mizukoshi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Am J Cardiol 112:34-40. 2013
    ..219, p = 0.003). In conclusion, calcium was very spotty and more superficial in the culprit lesions of AMI and UAP. These characteristics of calcium might play an important role in the pathogenesis of plaque vulnerability...
  65. ncbi request reprint Circulating CD14+CD16+ monocyte subsets as biomarkers of the severity of coronary artery disease in patients with stable angina pectoris
    Yuichi Ozaki
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 76:2412-8. 2012
    ..We investigated the relationship between the monocyte subsets and the severity of CAD assessed by coronary angiography (CAG) in patients with stable angina pectoris (SAP)...
  66. doi request reprint Effect of strut thickness on neointimal atherosclerotic change over an extended follow-up period (≥ 4 years) after bare-metal stent implantation: intracoronary optical coherence tomography examination
    Hironori Kitabata
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Japan
    Am Heart J 163:608-16. 2012
    ..We sought to investigate whether strut thickness may impact on the atherosclerotic change in neointima 4 years or more after BMS implantation using optical coherence tomography...
  67. ncbi request reprint Hyperglycemia accelerated endothelial progenitor cell senescence via the activation of p38 mitogen-activated protein kinase
    Shintaro Kuki
    Department of Cardiovascular Medicine, Wakayama Medical University, Japan
    Circ J 70:1076-81. 2006
    ..Both the number and function of bone marrow-derived endothelial progenitor cells (EPCs) have been shown to be impaired in patients with diabetes mellitus. Therefore, we investigated the effect of glucose on the senescence of EPCs...
  68. doi request reprint Effect of statin therapy on coronary fibrous-cap thickness in patients with acute coronary syndrome: assessment by optical coherence tomography study
    Shigeho Takarada
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Atherosclerosis 202:491-7. 2009
    ..Recently, optical coherence tomography (OCT) has been proposed as an effective histology-resolution imaging modality for assessing such micro-structural changes...
  69. doi request reprint Advantage of right ventricular outflow tract pacing on cardiac function and coronary circulation in comparison with right ventricular apex pacing
    Takahshi Yamano
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    J Am Soc Echocardiogr 23:1177-82. 2010
    ..The purpose of this study was to investigate the acute effect of right ventricular outflow tract (RVOT) pacing and right ventricular apex (RVA) pacing on synchronous ventricular activation and coronary flow dynamics...
  70. ncbi request reprint Sirolimus accelerates senescence of endothelial progenitor cells through telomerase inactivation
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Atherosclerosis 189:288-96. 2006
    ..On the other hand, circulating endothelial progenitor cells (EPCs) play a significant role in the maintenance of endothelial integrity...
  71. doi request reprint Clinical classification and plaque morphology determined by optical coherence tomography in unstable angina pectoris
    Masato Mizukoshi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Am J Cardiol 106:323-8. 2010
    ..Plaque vulnerability, progressive stenosis, and vasoconstriction may be related to the cause of the distinct presentations...
  72. doi request reprint Occlusion of left main coronary artery during percutaneous coronary intervention for chronic total occlusion of left circumflex artery with retrograde approach
    Yasushi Ino
    Division of Cardiology, Wakayama National Hospital, 1138 Wada, Mihama cho, Hidaka gun, Wakayama, Japan
    Cardiovasc Interv Ther 28:81-6. 2013
    ..We could perform bail-out stenting for LMCA. In PCI for CTO in the proximal site of left coronary artery with retrograde approach, we should keep in mind a backward dissection to LMCA formed by retrograde wire...
  73. doi request reprint Differential expression of Toll-like receptor 4 and human monocyte subsets in acute myocardial infarction
    Manabu Kashiwagi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Atherosclerosis 221:249-53. 2012
    ..Recent studies have shown that TLR4 is involved in monocyte activation of patients with accelerated forms of atherosclerosis...
  74. doi request reprint Electrocardiographic strain and endomyocardial radial strain in hypertensive patients
    Nobuo Nakamura
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Int J Cardiol 150:319-24. 2011
    ..However, it remains unclear whether the ratio of Endo-RS to Epi-RS alters in hypertensive patients, especially in those with ECGS...
  75. ncbi request reprint Branch segment occlusion with acute myocardial infarction is a risk for left ventricular free wall rupture
    Yasushi Ino
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 73:1473-8. 2009
    ..A first MI with preserved cardiac function is a risk factor for left ventricular free wall rupture (LVFWR), so the aim of this study was to investigate the possible relationship between AMI with branch segment occlusion and LVFWR...
  76. doi request reprint Morphology of exertion-triggered plaque rupture in patients with acute coronary syndrome: an optical coherence tomography study
    Atsushi Tanaka
    Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Circulation 118:2368-73. 2008
    ..The aim of the present study was to use optical coherence tomography to investigate the relationship in patients with ACS between the morphology of a ruptured plaque and the patient's activity at the onset of ACS...
  77. doi request reprint Myocardial salvage for ST-elevation myocardial infarction with terminal QRS distortion and restoration of brisk epicardial coronary flow
    Nobuo Nakamura
    Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Heart Vessels 24:96-102. 2009
    ..15, P = 0.033). Myocardial damage could not be reduced in patients experiencing STEMI with QRSDIS, even when TIMI grade 3 flow could be achieved by primary PCI, as much as in patients experiencing STEMI without QRSDIS...
  78. ncbi request reprint Relationship between coronary arterial remodeling, fibrous cap thickness and high-sensitivity C-reactive protein levels in patients with acute coronary syndrome
    Manabu Kashiwagi
    Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Circ J 73:1291-5. 2009
    ..The aim of this study was to evaluate the relationship between coronary arterial remodeling, fibrous cap thickness and high-sensitivity C-reactive protein (hs-CRP) concentration in patients with ACS...
  79. ncbi request reprint Predictors and prognosis of stent fracture after sirolimus-eluting stent implantation
    Yasushi Ino
    Division of Cardiology, Wakayama National Hospital, Wakayama, Japan
    Circ J 73:2036-41. 2009
    ..Stent fracture is a cause of in-stent restenosis (ISR) after sirolimus-eluting stent (SES) implantation, so this study investigated the incidence, predictors and prognosis of stent fracture...
  80. pmc Optical coherence tomography analysis of attenuated plaques detected by intravascular ultrasound in patients with acute coronary syndromes
    Takashi Kubo
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 8510, Japan
    Cardiol Res Pract 2011:687515. 2011
    ..Conclusions. IVUS-detected attenuated plaque has many characteristics of unstable coronary lesion. The presence of attended plaque might be an important marker of lesion instability...
  81. ncbi request reprint [Acceleration of cellular senescence]
    Toshio Imanishi
    Department of Cardiovascular Medicine, Wakayama Medical University
    Nihon Rinsho 64:70-4. 2006
  82. ncbi request reprint Effects of plasma adiponectin levels on the number and function of endothelial progenitor cells in patients with coronary artery disease
    Yoshiki Matsuo
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 71:1376-82. 2007
    ..It is not known whether plasma adiponectin levels are associated with the number and function of endothelial progenitor cells (EPCs) in patients with coronary artery disease (CAD)...
  83. ncbi request reprint Feasibility of noninvasive assessment of thin-cap fibroatheroma by multidetector computed tomography
    Manabu Kashiwagi
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    JACC Cardiovasc Imaging 2:1412-9. 2009
    ..CONCLUSIONS: MDCT can identify differences in plaque morphologies between TCFA and non-TCFA. From our results, MDCT may provide for the noninvasive assessment of vulnerable plaque...
  84. ncbi request reprint Virtual histology intravascular ultrasound compared with optical coherence tomography for identification of thin-cap fibroatheroma
    Takashi Kubo
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Int Heart J 52:175-9. 2011
    ..Our results suggest a potential role for VH-IVUS to exclude high risk lesions for future coronary events...
  85. doi request reprint Distribution and frequency of thin-capped fibroatheromas and ruptured plaques in the entire culprit coronary artery in patients with acute coronary syndrome as determined by optical coherence tomography
    Atsushi Tanaka
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Am J Cardiol 102:975-9. 2008
    ..018). In conclusion, the use of optical coherence tomography to look for TCFAs and identify their distribution when combined with C-reactive protein may contribute to forming a strategy for preventing impending coronary events...
  86. doi request reprint Bedside assessment of myocardial viability using transmural strain profile in patients with ST elevation myocardial infarction: comparison with cardiac magnetic resonance imaging
    Takashi Tanimoto
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    J Am Soc Echocardiogr 22:1015-21. 2009
    ..The aim of this study was to determine whether strain profile could identify myocardial viability confirmed by contrast-enhanced magnetic resonance imaging in patients with acute STEMI...
  87. doi request reprint Pathophysiology of acute coronary syndrome assessed by optical coherence tomography
    Takashi Akasaka
    Department of Cardiovascular Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    J Cardiol 56:8-14. 2010
    ....
  88. ncbi request reprint Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy
    Takashi Kubo
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    J Am Coll Cardiol 50:933-9. 2007
    ....
  89. ncbi request reprint Safety and usefulness of non-occlusion image acquisition technique for optical coherence tomography
    Hideaki Kataiwa
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
    Circ J 72:1536-7. 2008
    ..Because optical coherence tomography (OCT) requires balloon-occlusion to overcome image attenuation by blood, the present study investigated the safety and usefulness of a new non-occlusive technique...
  90. ncbi request reprint Oxidized low-density lipoprotein sensitizes human vascular smooth muscle cells to FAS (CD95)-mediated apoptosis
    Shigeho Takarada
    Department of Cardiovascular Medicine, Wakayama Medical University, Japan
    Clin Exp Pharmacol Physiol 30:289-94. 2003
    ..4. One of the mechanisms proposed by which oxLDL upregulates cell surface Fas is by inhibiting the degradation of Fas through the ubiquitin-proteasome pathway...
  91. ncbi request reprint Non-invasive assessment of plaque rupture by 64-slice multidetector computed tomography--comparison with intravascular ultrasound
    Atsushi Tanaka
    Wakayama Medical University, Department of Cardiovascular Medicine, Wakayama, Japan
    Circ J 72:1276-81. 2008
    ..In this study, we investigated whether 64-slice MDCT could non-invasively detect a plaque rupture in patients with de novo angina...
  92. ncbi request reprint The effect of senescence of endothelial progenitor cells on in-stent restenosis in patients undergoing coronary stenting
    Yoshiki Matsuo
    Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama
    Intern Med 45:581-7. 2006
    ..The objective of this study is to elucidate the relevance of endothelial progenitor cells (EPCs) in the development of in-stent restenosis in patients undergoing stent implantation...
  93. ncbi request reprint Apoptosis of vascular smooth muscle cells is induced by Fas ligand derived from monocytes/macrophage
    Toshio Imanishi
    Division of Cardiology, Department of Medicine, Wakayama Medical College, 811 1, Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Atherosclerosis 161:143-51. 2002
    ..These data suggest that Fas/FasL pathway can be employed by monocytes/macrophages to induce VSMC apoptosis in the atherosclerotic lesions...
  94. doi request reprint Effects of telmisartan, a unique angiotensin receptor blocker with selective peroxisome proliferator-activated receptor-gamma-modulating activity, on nitric oxide bioavailability and atherosclerotic change
    Hideyuki Ikejima
    Department of Cardiovascular Medicine, Wakayama Medical University Japan
    J Hypertens 26:964-72. 2008
    ..We therefore investigated the effects of telmisartan on endothelial function and atherosclerotic change in genetically hyperlipidemic rabbits, compared with candesartan, an ARB without PPAR gamma activity...