Ashu Johri

Summary

Publications

  1. ncbi Mitochondria: prospective targets for neuroprotection in Parkinson's disease
    Anuradha Yadav
    Developmental Toxicology Division, Systems Toxicology Group, CSIR Indian Institute of Toxicology Research CSIR IITR, 80 MG Marg, Lucknow 226001, India
    Curr Pharm Des 20:5558-73. 2014
  2. ncbi Peptide therapeutics in neurodegenerative disorders
    Shashi Kant Tiwari
    Developmental Toxicology Division, Systems Toxicology Group, CSIR Indian Institute of Toxicology Research CSIR IITR, 80 MG Marg, Lucknow 226001, India
    Curr Med Chem 21:2610-31. 2014
  3. doi Mitochondrial diseases of the brain
    Rajnish K Chaturvedi
    CSIR Indian Institute of Toxicology Research, 80 MG Marg, Lucknow 226001, India
    Free Radic Biol Med 63:1-29. 2013
  4. doi Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases
    Rajnish K Chaturvedi
    Developmental Toxicology Division, Systems Toxicology Group, CSIR Indian Institute of Toxicology Research CSIR IITR, 80 MG Marg, Lucknow 226001, India
    Mol Cell Neurosci 55:101-14. 2013
  5. pmc Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease
    Rajnish Kumar Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 21:3474-88. 2012
  6. pmc Impaired PGC-1alpha function in muscle in Huntington's disease
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 18:3048-65. 2009
  7. pmc Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:3190-205. 2010
  8. doi Responsiveness of cerebral and hepatic cytochrome P450s in rat offspring prenatally exposed to lindane
    Ashu Johri
    Developmental Toxicology Division, Indian Institute of Toxicology Research formerly Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226 001, India
    Toxicol Appl Pharmacol 231:10-6. 2008
  9. pmc PGC-1α, mitochondrial dysfunction, and Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Free Radic Biol Med 62:37-46. 2013
  10. pmc Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 21:1124-37. 2012

Collaborators

  • Yoon Seong Kim
  • M Flint Beal
  • Ferdinando Squitieri
  • Anatoly A Starkov
  • Rajnish K Chaturvedi
  • M Flint Beal
  • Abhishek Chandra
  • Shashi Kant Tiwari
  • Noel Y Calingasan
  • Lichuan Yang
  • Anuradha Yadav
  • Swati Agarwal
  • Seema Gollamudi
  • Rajnish Kumar Chaturvedi
  • Thomas Hennessey
  • Sanjay Yadav
  • X William Yang
  • Joshua M White
  • Yevgeniya Shurubor
  • Abhijeet Sharma
  • Divya Mishra
  • Olivier Elemento
  • Jenny Sassone
  • Andrea Ciammola
  • Thomas Hennessy
  • Noel Calingasan
  • Mahmoud Kiaei
  • Shubha Shukla
  • Milena Cannella
  • Peter Adhihetty
  • Prahlad K Seth
  • Alok Dhawan
  • Devendra Parmar

Detail Information

Publications21

  1. ncbi Mitochondria: prospective targets for neuroprotection in Parkinson's disease
    Anuradha Yadav
    Developmental Toxicology Division, Systems Toxicology Group, CSIR Indian Institute of Toxicology Research CSIR IITR, 80 MG Marg, Lucknow 226001, India
    Curr Pharm Des 20:5558-73. 2014
    ..We also provide a succinct overview of current therapeutic implications of PGC-1α, SIRT, AMPK, and Nrf2-ARE as salutary targets to overcome the deleterious effects posed by mitochondrial dysfunction in the onset and progression of PD. ..
  2. ncbi Peptide therapeutics in neurodegenerative disorders
    Shashi Kant Tiwari
    Developmental Toxicology Division, Systems Toxicology Group, CSIR Indian Institute of Toxicology Research CSIR IITR, 80 MG Marg, Lucknow 226001, India
    Curr Med Chem 21:2610-31. 2014
    ....
  3. doi Mitochondrial diseases of the brain
    Rajnish K Chaturvedi
    CSIR Indian Institute of Toxicology Research, 80 MG Marg, Lucknow 226001, India
    Free Radic Biol Med 63:1-29. 2013
    ..We also discuss clinical trials of bioenergetics agents in neurodegenerative disorders. Lastly, we shed light on PGC-1α, TORC-1, AMP kinase, Nrf2-ARE, and Sirtuins as novel therapeutic targets for neurodegenerative disorders. ..
  4. doi Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases
    Rajnish K Chaturvedi
    Developmental Toxicology Division, Systems Toxicology Group, CSIR Indian Institute of Toxicology Research CSIR IITR, 80 MG Marg, Lucknow 226001, India
    Mol Cell Neurosci 55:101-14. 2013
    ..This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'...
  5. pmc Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease
    Rajnish Kumar Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 21:3474-88. 2012
    ..These findings show that impaired expression and function of TORC1, which results in a reduction in PGC-1α, plays an important role in mitochondrial dysfunction in HD...
  6. pmc Impaired PGC-1alpha function in muscle in Huntington's disease
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 18:3048-65. 2009
    ..Furthermore, muscle may provide a readily accessible tissue in which to monitor therapeutic interventions...
  7. pmc Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:3190-205. 2010
    ....
  8. doi Responsiveness of cerebral and hepatic cytochrome P450s in rat offspring prenatally exposed to lindane
    Ashu Johri
    Developmental Toxicology Division, Indian Institute of Toxicology Research formerly Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226 001, India
    Toxicol Appl Pharmacol 231:10-6. 2008
    ..Our data assume significance as the subtle changes in the expression profiles of hepatic and cerebral CYPs in rat offspring during postnatal development could modify the adult response to a later exposure to xenobiotics...
  9. pmc PGC-1α, mitochondrial dysfunction, and Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Free Radic Biol Med 62:37-46. 2013
    ..Here we have attempted to discuss in a nutshell, the key findings on the role of PGC-1α in mitochondrial dysfunction in HD and its potential as a therapeutic target to cure HD. ..
  10. pmc Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 21:1124-37. 2012
    ..These findings provide strong evidence that treatment with bezafibrate exerts neuroprotective effects which may be beneficial in the treatment of HD...
  11. pmc Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA asj2002 med cornell edu
    Neurodegener Dis 8:496-503. 2011
    ..The N-truncated splice variant of PGC1α (NT-PGC1α) is produced in tissues, but the role of truncated splice variants of PGC1α in HD and in the regulation of mitochondrial gene expression has not been elucidated...
  12. ncbi Persistence in alterations in the ontogeny of cerebral and hepatic cytochrome P450s following prenatal exposure to low doses of lindane
    Ashu Johri
    Developmental Toxicology Division, Industrial Toxicology Research Centre, Lucknow 226 001, Uttar Pradesh, India
    Toxicol Sci 101:331-40. 2008
    ....
  13. ncbi Overexpression of cerebral and hepatic cytochrome P450s alters behavioral activity of rat offspring following prenatal exposure to lindane
    Ashu Johri
    Developmental Toxicology Division, Industrial Toxicology Research Centre, M G Marg, Lucknow 226 001, UP, India
    Toxicol Appl Pharmacol 225:278-92. 2007
    ....
  14. pmc Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease
    Seema Gollamudi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 7:e36191. 2012
    ..The analysis of these networks and pathways may therefore lead to improved understanding of disease pathogenesis, and potential novel therapeutic targets...
  15. pmc Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease
    Abhishek Chandra
    Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Hum Mol Genet 25:2269-2282. 2016
    ....
  16. pmc Mitochondrial dysfunction in neurodegenerative diseases
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    J Pharmacol Exp Ther 342:619-30. 2012
    ..Here, we provide a concise overview of the major findings in recent years highlighting the importance of healthy mitochondria for a healthy neuron...
  17. pmc Antioxidants in Huntington's disease
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Biochim Biophys Acta 1822:664-74. 2012
    ..This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease...
  18. pmc Prospects for neuroprotective therapies in prodromal Huntington's disease
    Abhishek Chandra
    Brain and Mind Research Institute, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York, USA
    Mov Disord 29:285-93. 2014
    ..We review both the earliest detectable clinical and laboratory manifestations of HD, as well as potential neuroprotective therapies that could be utilized in presymptomatic HD...
  19. pmc Hunting-ton for new proteases: MMPs as the new target?
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Neuron 67:171-3. 2010
    ..These findings provide new insights into huntingtin proteolysis and its potential as a therapeutic target...
  20. ncbi Regional specificity in deltamethrin induced cytochrome P450 expression in rat brain
    Sanjay Yadav
    Developmental Toxicology Division, Industrial Toxicology Research Centre, PO Box 80, Mahatma Gandhi Marg, Lucknow 226 001, UP, India
    Toxicol Appl Pharmacol 217:15-24. 2006
    ....
  21. doi Muscling in on PGC-1α for improved quality of life in ALS
    Ashu Johri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Cell Metab 15:567-9. 2012
    ..In this issue, Da Cruz et al. (2012) show improved muscle function, but not survival, with increased PGC-1α activity in muscle in a mouse model of amyotrophic lateral sclerosis...