B K Kubata

Summary

Affiliation: Kenya Medical Research Institute
Country: Kenya

Publications

  1. ncbi request reprint Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei
    B K Kubata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Int J Parasitol 35:91-103. 2005
  2. ncbi request reprint Structural and mutational analysis of Trypanosoma brucei prostaglandin H2 reductase provides insight into the catalytic mechanism of aldo-ketoreductases
    Kubata Bruno Kilunga
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 280:26371-82. 2005
  3. pmc Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei
    B K Kubata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Exp Med 192:1327-38. 2000
  4. ncbi request reprint Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form
    K Figarella
    Interfakultäres Institut für Biochemie, Universitat Tubingen, Germany
    Cell Death Differ 12:335-46. 2005
  5. ncbi request reprint Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress
    K Figarella
    Interfaculty Institute of Biochemistry, University of Tuebingen, Germany
    Cell Death Differ 13:1802-14. 2006

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei
    B K Kubata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Int J Parasitol 35:91-103. 2005
    ..This new anti-trypanosomal compound should be further studied to determine its efficacy and suitability as an anti-trypanosomal drug and may be used as a tool to define novel specific drug targets in BF trypanosomes...
  2. ncbi request reprint Structural and mutational analysis of Trypanosoma brucei prostaglandin H2 reductase provides insight into the catalytic mechanism of aldo-ketoreductases
    Kubata Bruno Kilunga
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 280:26371-82. 2005
    ..We also show Tyr52 acts as the general acid catalyst for 9,10-PQ reduction, and thus we not only elucidate the catalytic mechanism of a PGH2 reductase but also provide an insight into the catalytic specificity of AKRs...
  3. pmc Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei
    B K Kubata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Exp Med 192:1327-38. 2000
    ..The characterization of TbPGFS and its gene in T. brucei provides a basis for the molecular analysis of the role of parasite-derived PGF(2alpha) in the physiology of the parasite and the pathogenesis of African trypanosomiasis...
  4. ncbi request reprint Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form
    K Figarella
    Interfakultäres Institut für Biochemie, Universitat Tubingen, Germany
    Cell Death Differ 12:335-46. 2005
    ..Based on these results, we suggest that PGD2-induced programmed cell death is part of the population density regulation as observed in infected animals...
  5. ncbi request reprint Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress
    K Figarella
    Interfaculty Institute of Biochemistry, University of Tuebingen, Germany
    Cell Death Differ 13:1802-14. 2006
    ..We conclude that PGJ(2) and Delta(12)PGJ(2) formation within the serum represents a mechanism to amplify PGD(2)-induced PCD in trypanosomes via ROS production...