Gun Il Im

Summary

Affiliation: Dongguk University International Hospital
Country: Korea

Publications

  1. ncbi request reprint Chondrogenic differentiation of mesenchymal stem cells isolated from patients in late adulthood: the optimal conditions of growth factors
    Gun Il Im
    Department of Orthopedics, Dongguk University International Hospital, Goyang, Korea
    Tissue Eng 12:527-36. 2006
  2. ncbi request reprint Adipose stem cells and skeletal repair
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Histol Histopathol 28:557-64. 2013
  3. doi request reprint Epigenetic approaches to regeneration of bone and cartilage from stem cells
    Gun Il Im
    Dongguk University Ilsan Hospital, Department of Orthopaedics, Goyang, Korea 82 31 961 7315 82 31 961 7314
    Expert Opin Biol Ther 15:181-93. 2015
  4. doi request reprint The relationship between osteoarthritis and osteoporosis
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, 410 773, Republic of Korea
    J Bone Miner Metab 32:101-9. 2014
  5. doi request reprint Drug delivery systems for intra-articular treatment of osteoarthritis
    Mi Lan Kang
    Dongguk University Ilsan Hospital, Department of Orthopedics, Goyang 410 773, Korea 82 31 961 7315 82 31 961 7314
    Expert Opin Drug Deliv 11:269-82. 2014
  6. doi request reprint Epigenetics in osteoarthritis and its implication for future therapeutics
    Gun Il Im
    Dongguk University Ilsan Hospital, Department of Orthopaedics, Goyang 410 773, Korea
    Expert Opin Biol Ther 13:713-21. 2013
  7. doi request reprint Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5,-6 and -9) genes
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Siksa dong, Goyang, Republic of Korea
    Biomaterials 32:4385-92. 2011
  8. doi request reprint Wnt inhibitors enhance chondrogenesis of human mesenchymal stem cells in a long-term pellet culture
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, 814 Siksa dong, Goyang 411 773, Republic of Korea
    Biotechnol Lett 33:1061-8. 2011
  9. doi request reprint The effects of Wnt inhibitors on the chondrogenesis of human mesenchymal stem cells
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Tissue Eng Part A 16:2405-13. 2010
  10. doi request reprint Radiological joint space width in the clinically normal hips of a Korean population
    G I Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Osteoarthritis Cartilage 18:61-4. 2010

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Chondrogenic differentiation of mesenchymal stem cells isolated from patients in late adulthood: the optimal conditions of growth factors
    Gun Il Im
    Department of Orthopedics, Dongguk University International Hospital, Goyang, Korea
    Tissue Eng 12:527-36. 2006
    ..This study shows that an effective proliferation and chondrogenesis may be obtained with proper combinations of growth factors and mesenchymal stem cells from aged individuals...
  2. ncbi request reprint Adipose stem cells and skeletal repair
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Histol Histopathol 28:557-64. 2013
    ..In this review, we discuss the definition of ASCs, the induction of osteogenic differentiation from ASCs, scaffolding materials for adipose bone tissue engineering, and in vivo models for future clinical applications...
  3. doi request reprint Epigenetic approaches to regeneration of bone and cartilage from stem cells
    Gun Il Im
    Dongguk University Ilsan Hospital, Department of Orthopaedics, Goyang, Korea 82 31 961 7315 82 31 961 7314
    Expert Opin Biol Ther 15:181-93. 2015
    ..Epigenetic mechanisms play essential roles in stem cell maintenance and differentiation. However, little is known about the epigenetic regulation of osteogenesis and chondrogenesis of stem cells...
  4. doi request reprint The relationship between osteoarthritis and osteoporosis
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, 410 773, Republic of Korea
    J Bone Miner Metab 32:101-9. 2014
    ..Low BMD at the lumbar spine is associated with a lower incidence of knee OA although it does not arrest the progression of knee OA. ..
  5. doi request reprint Drug delivery systems for intra-articular treatment of osteoarthritis
    Mi Lan Kang
    Dongguk University Ilsan Hospital, Department of Orthopedics, Goyang 410 773, Korea 82 31 961 7315 82 31 961 7314
    Expert Opin Drug Deliv 11:269-82. 2014
    ..Intra-articular (IA) drug delivery is very useful in the treatment of osteoarthritis (OA), the most common chronic joint affliction. However, the therapeutic effect of IA administration depends mostly on the efficacy of drug delivery...
  6. doi request reprint Epigenetics in osteoarthritis and its implication for future therapeutics
    Gun Il Im
    Dongguk University Ilsan Hospital, Department of Orthopaedics, Goyang 410 773, Korea
    Expert Opin Biol Ther 13:713-21. 2013
    ..Changes occurring in the chondrocyte gene that control articular cartilage are important for the onset and progression of osteoarthritis (OA). However, actual development of the disease may be also controlled by changes in epigenome...
  7. doi request reprint Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5,-6 and -9) genes
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Siksa dong, Goyang, Republic of Korea
    Biomaterials 32:4385-92. 2011
    ..Gross and histological findings from the in vivo study showed enhanced cartilage regeneration in ASCs/SOX trio pDNA-incorporated PLGA scaffolds...
  8. doi request reprint Wnt inhibitors enhance chondrogenesis of human mesenchymal stem cells in a long-term pellet culture
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, 814 Siksa dong, Goyang 411 773, Republic of Korea
    Biotechnol Lett 33:1061-8. 2011
    ..05) while SOX-9 and type X collagen protein expression was unaffected. These findings suggest that Wnt inhibitors promote the chondrogenic differentiation of hMSCs when treated for three weeks...
  9. doi request reprint The effects of Wnt inhibitors on the chondrogenesis of human mesenchymal stem cells
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Tissue Eng Part A 16:2405-13. 2010
    ..The overall results of this study suggest that although the inhibitors of Wnt pathway promote early chondrogenesis of MSCs, they do not provide an ultimately enhancing role in the cartilage tissue engineering of MSCs...
  10. doi request reprint Radiological joint space width in the clinically normal hips of a Korean population
    G I Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Osteoarthritis Cartilage 18:61-4. 2010
    ..The purpose of this paper was to investigate the association of the joint space width (JSW) of the hip with radiologically observed hip deformity, the anthropological features and aging in a clinically asymptomatic Korean population...
  11. doi request reprint Electroporation-mediated gene transfer of SOX trio to enhance chondrogenesis in adipose stem cells
    G I Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Republic of Korea
    Osteoarthritis Cartilage 19:449-57. 2011
    ..The aim of the present study was to determine if the electroporation-mediated gene transfer of SOX trio enhances the chondrogenic potential of adipose stem cells (ASCs)...
  12. doi request reprint The relationship between radiological parameters from plain hip radiographs and bone mineral density in a Korean population
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, 814 Siksa dong, Goyang, 411 773, Republic of Korea
    J Bone Miner Metab 30:504-8. 2012
    ..033). In conclusion, of three parameters available from plain radiograph (age, height, BMI), only CTI was significantly associated with BMD. CTI can provide a tool for rapid assessment of osteoporosis from plain hip radiographs...
  13. doi request reprint Proximal hip geometry and hip fracture risk assessment in a Korean population
    G I Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, 814 Siksa dong, Goyang 411 773, Republic of Korea
    Osteoporos Int 22:803-7. 2011
    ..64-fold and 2.32-fold with 1 standard deviation (sd) increase of hip axis length and neck-shaft angle, respectively, while the risk of femur neck fracture 2.03-fold with 1 sd decrease in femoral head offset...
  14. doi request reprint Repair of osteochondral defects with adipose stem cells and a dual growth factor-releasing scaffold in rabbits
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Korea
    J Biomed Mater Res B Appl Biomater 92:552-60. 2010
    ....
  15. doi request reprint Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells
    Hye Joung Kim
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Stem Cells Dev 20:2103-14. 2011
    ....
  16. doi request reprint PTHrP promotes chondrogenesis and suppresses hypertrophy from both bone marrow-derived and adipose tissue-derived MSCs
    Young Ju Kim
    Department of Orthopaedics, Dongguk University International Hospital, 814 Siksa dong, Goyang 411 773, Republic of Korea
    Biochem Biophys Res Commun 373:104-8. 2008
    ..In conclusion, PTHrP was found to promote chondrogenesis and suppress hypertrophy during in vitro chondrogenesis from both BMMSCs and ATMSCs, which supports its use for cartilage tissue engineering...
  17. doi request reprint Chondrogenesis using mesenchymal stem cells and PCL scaffolds
    Hye Joung Kim
    Department of Orthopaedics, Dongguk University International Hospital, 814 Siksa dong, Goyang 410 773, Korea
    J Biomed Mater Res A 92:659-66. 2010
    ....
  18. doi request reprint The effects of ERK1/2 inhibitor on the chondrogenesis of bone marrow- and adipose tissue-derived multipotent mesenchymal stromal cells
    Hye Joung Kim
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Tissue Eng Part A 16:851-60. 2010
    ..Our study demonstrated that PD98059 suppressed hypertrophy and promoted chondrogenesis of MSCs, and provides a ground for using them in cartilage tissue engineering...
  19. doi request reprint PTHrP isoforms have differing effect on chondrogenic differentiation and hypertrophy of mesenchymal stem cells
    Jong Min Lee
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang 410 773, Republic of Korea
    Biochem Biophys Res Commun 421:819-24. 2012
    ..05). In conclusion, of several PTHrP isoforms, PTHrP 1-34 most significantly enhanced chondrogenesis and suppressed hypertrophy in MSCs, supporting its use for cartilage tissue engineering...
  20. doi request reprint Controlled delivery of low-dose bone morphogenetic protein-2 using heparin-conjugated fibrin in the posterolateral lumbar fusion of rabbits
    Ki Hyoung Koo
    Department of Orthopaedic Surgery, Dongguk University Ilsan Hospital, Goyang, Korea
    Artif Organs 37:487-94. 2013
    ..The HCF long-term delivery system with the low dose of BMP-2 (10 μg) is ineffective for the induction of lumbar posterolateral fusion in the rabbits...
  21. doi request reprint Combination of transforming growth factor-beta2 and bone morphogenetic protein 7 enhances chondrogenesis from adipose tissue-derived mesenchymal stem cells
    Hye Joung Kim
    Department of Orthopedics, Dongguk University International Hospital, Goyang, Korea
    Tissue Eng Part A 15:1543-51. 2009
    ..The findings of this study suggest that the combination of TGF-beta(2) and BMP-7 potently enhances chondrogenesis from ATMSCs and can be used to overcome the inferior chondrogenic potential of ATMSCs in cartilage tissue engineering...
  22. doi request reprint Is continuous treatment with transforming growth factor-beta necessary to induce chondrogenic differentiation in mesenchymal stem cells?
    Hye Joung Kim
    Department of Orthopaedics, Dongguk University International Hospital, Goyang, South Korea
    Cells Tissues Organs 190:1-10. 2009
    ..This study demonstrated that longer duration of TGF-beta treatment is necessary for effective chondrogenesis in hMSCs from bone marrow...
  23. doi request reprint Electroporation-mediated transfer of Runx2 and Osterix genes to enhance osteogenesis of adipose stem cells
    Jai Sun Lee
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Biomaterials 32:760-8. 2011
    ..Runx2- or Osterix-transfected ASC-PLGA scaffold hybrids promoted bone formation in nude mice after 6 weeks of in vivo implantation...
  24. doi request reprint Chondrogenic and Osteogenic Induction from iPS Cells
    Ji Yun Ko
    Department of Orthopaedics, Dongguk University Ilsan Hospital, 814 Siksa dong, Goyang, 410 773, Korea
    Methods Mol Biol 1357:441-50. 2016
    ..The authors developed protocol to examine the in vitro chondrogenesis and osteogenesis from hiPSCs and in vivo cartilage and bone regeneration using animal models...
  25. doi request reprint Chondrogenic differentiation of adipose tissue-derived mesenchymal stem cells: greater doses of growth factor are necessary
    Hye Joung Kim
    Department of Orthopaedics, Dongguk University International Hospital, 814 Siksa dong, Goyang, 411 773, South of Korea
    J Orthop Res 27:612-9. 2009
    ..These results lend a further support to the application of ATMSCs for cartilage tissue engineering...
  26. pmc The correlations of the radiological parameters of hip dysplasia and proximal femoral deformity in clinically normal hips of a Korean population
    Jeong Min Park
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Korea
    Clin Orthop Surg 3:121-7. 2011
    ..between themselves or with the parameters of the proximal femoral deformity and vice versa? 2) Do the physical parameters have a significant correlation with the radiological parameters of hip dysplasia and proximal femoral deformity?..
  27. doi request reprint A hyaluronate-atelocollagen/beta-tricalcium phosphate-hydroxyapatite biphasic scaffold for the repair of osteochondral defects: a porcine study
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Korea
    Tissue Eng Part A 16:1189-200. 2010
    ....
  28. doi request reprint SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat
    Jong Min Lee
    Department of Orthopaedics, Dongguk University Ilsan Hospital, 814 Siksa dong, Goyang 411 773, Republic of Korea
    Biomaterials 33:2016-24. 2012
    ..ASCs co-transduced with SOX trio significantly promoted the in vivo cartilage healing in osteochondral defect model, and prevented the progression of degenerative changes in surgically-induced osteoarthritis...
  29. doi request reprint Lumbar posterolateral fusion using heparin-conjugated fibrin for sustained delivery of bone morphogenic protein-2 in a rabbit model
    Ki Hyoung Koo
    Department of Orthopaedic Surgery, Dongguk University Ilsan Hospital, Goyang, Korea
    Artif Organs 36:629-34. 2012
    ..Biomechanical testing showed the tensile strength was also significantly higher in the LD group using HCF than in other groups. The HCF system can provide a good option for the delivery of BMP-2 on posterolateral lumbar spine fusion...
  30. doi request reprint SOX trio decrease in the articular cartilage with the advancement of osteoarthritis
    Jai Sun Lee
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Connect Tissue Res 52:496-502. 2011
    ..DNA methylation study of SOX-9 promoter regions revealed no difference in the epigenetic status between the two areas. It is concluded that SOX trio gene and protein decreased with advancement of OA in human articular cartilage...
  31. doi request reprint Apatite-coated collagen sponge for the delivery of bone morphogenetic protein-2 in rabbit posterolateral lumbar fusion
    Ki Hyoung Koo
    Department of Orthopedic Surgery, Dongguk University Ilsan Hospital, Goyang, Korea
    Artif Organs 38:893-9. 2014
    ..032). Denser trabeculations were found in the apatite-coated group compared with the uncoated group. It is concluded that the use of apatite-coated collagen sponges for BMP-2 delivery enhanced bone regeneration. ..
  32. doi request reprint Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage
    Kyung Il Kim
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Korea
    J Bone Miner Res 28:1050-60. 2013
    ..These findings suggest that hip OA is associated with a change in the epigenetic status of SOX-9 promoter, including increased DNA methylation and altered histone modification...
  33. doi request reprint Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis
    Ji Yun Ko
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Biomaterials 34:5359-68. 2013
    ..Intraarticular SFN-PLGA microspheres delayed the progression of surgically-induced osteoarthritis in rats. In conclusion, SFN-PLGA microspheres can be a useful injectable delivery system for treating osteoarthritis...
  34. doi request reprint Mesenchymal stem cells for tissue engineering and regenerative medicine
    Suk Kee Tae
    Department of Orthopaedics, Dongguk University International Hospital, Goyang, Korea
    Biomed Mater 1:63-71. 2006
    ..This paper briefly outlines the current status of MSCs, focusing on their biological characteristics and potential for clinical applications...
  35. doi request reprint Influence of chondrocytes on the chondrogenic differentiation of adipose stem cells
    Jai Sun Lee
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Tissue Eng Part A 16:3569-77. 2010
    ..This work may present a simple and innovative method for generating cartilaginous tissue from ASCs and shed a new light in cartilage tissue engineering from ASCs...
  36. pmc In vivo tracking of mesechymal stem cells using fluorescent nanoparticles in an osteochondral repair model
    Jong Min Lee
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Korea
    Mol Ther 20:1434-42. 2012
    ..IOMTS can provide a useful tool to examine the effect of growth factors or chemokines on endogenous cartilage repair...
  37. doi request reprint Effects of BMP-2 and vitamin D3 on the osteogenic differentiation of adipose stem cells
    Insun Song
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Biochem Biophys Res Commun 408:126-31. 2011
    ..In conclusion, BMP-2 and vitamin D(3) promote osteogenic differentiation of ASCs, and can work synergistically. These results can be used to induce effective and economical osteogenic induction of ASCs for bone tissue engineering...
  38. doi request reprint Gene Transfer Strategies to Promote Chondrogenesis and Cartilage Regeneration
    Gun Il Im
    Department of Orthopedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Tissue Eng Part B Rev 22:136-48. 2016
    ..On the other hand, efficiency has been greatly improved in nonviral delivery. This review summarizes the history and recent update on the gene transfer to enhance chondrogenesis from stem cells or articular chondrocytes. ..
  39. ncbi request reprint Wiring through cannulated screws for the fixation of greater trochanter in arthroplasties performed for peritrochanteric fractures
    Gun Il Im
    Department of Orthopaedics, Dongguk University International Hospital, Goyang, South Korea
    J Arthroplasty 21:449-51. 2006
    ..The authors propose a new technique using cannulated screws and wires passed through the screws to fix the greater trochanter in arthroplasties performed for peritrochanteric fractures...
  40. doi request reprint Endogenous Cartilage Repair by Recruitment of Stem Cells
    Gun Il Im
    Department of Orthopedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Tissue Eng Part B Rev 22:160-71. 2016
    ....
  41. doi request reprint Adhesive barrier/directional controlled release for cartilage repair by endogenous progenitor cell recruitment
    Jong Min Lee
    College of Medicine, Dongguk University, Goyang, Republic of Korea Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Biomaterials 39:173-81. 2015
    ..This CHI-C barrier is expected to make a significant contribution in cartilage tissue engineering without cell transplantation as well as application for other tissue engineering. ..
  42. doi request reprint The expressions of the SOX trio, PTHrP (parathyroid hormone-related peptide)/IHH (Indian hedgehog protein) in surgically induced osteoarthritis of the rat
    So Young Kim
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, South Korea
    Cell Biol Int 35:529-35. 2011
    ....
  43. pmc Difficulties in removing ACE tibial intramedullary nail
    Gun Il Im
    Department of Orthopaedics, Hallym University Hospital, 896 Pyongchon Dong, Anyang, Korea
    Int Orthop 27:355-8. 2003
    ..Younger age of the patient was significantly associated with the difficulty in nail removal...
  44. ncbi request reprint Changes in the production and the effect of nitric oxide with aging in articular cartilage: an experimental study in rabbits
    Gun Il Im
    Department of Orthopaedics, Hallym University Hospital, Chunchon, Korea
    Acta Orthop Scand 73:6-10. 2002
    ..Immunohistochemistry showed that older rabbits had fewer eNOS positive chondrocytes. Our findings imply that the age-related change in NO in articular cartilage does not have a relevance to increased NO production in osteoarthrosis...
  45. doi request reprint Relationship between knee alignment and radiographic markers of osteoarthritis: a cross-sectional study from a Korean population
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Korea
    Int J Rheum Dis 19:178-83. 2016
    ..The purpose of this paper was to investigate the relationship between static varus knee alignment and the radiographic markers of knee osteoarthritis (OA), including joint space narrowing (JSN) and Kellgren-Lawrence (K-L) grading scale...
  46. doi request reprint Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis
    Mi Lan Kang
    Department of Orthopedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Acta Biomater 39:65-78. 2016
    ..These results suggest that the thermo-responsive nanospheres provide dual-function therapeutics possessing anti-inflammatory and chondroprotective effects which can be enhanced by cold treatment...
  47. doi request reprint Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration
    Mi Lan Kang
    Department of Orthopedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Biomaterials 35:9984-94. 2014
    ..In conclusion, CHI-KGN NPs or CHI-KGN MPs can be useful polymer-drug conjugates as an IA drug delivery system to treat OA...
  48. doi request reprint Osteogenesis from human induced pluripotent stem cells: an in vitro and in vivo comparison with mesenchymal stem cells
    Ji Yun Ko
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Stem Cells Dev 23:1788-97. 2014
    ..In conclusion, despite delayed in vitro osteogenesis, hiPSCs have an in vivo osteogenic potential as good as hBMMSCs. ..
  49. doi request reprint Osteogenic differentiation and angiogenesis with cocultured adipose-derived stromal cells and bone marrow stromal cells
    Kyung Il Kim
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Biomaterials 35:4792-804. 2014
    ..In conclusion, ASCs added to BMSCs promoted osteogenesis and angiogenesis at the optimal ASC/BMSC ratio of 0.5/1...
  50. pmc PD98059-impregnated functional PLGA scaffold for direct tissue engineering promotes chondrogenesis and prevents hypertrophy from mesenchymal stem cells
    Jong Min Lee
    1 Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Tissue Eng Part A 20:982-91. 2014
    ..These results suggest that the use of the PD98059-impregnated scaffold leads to AC regeneration of better quality and prevents hypertrophy when implanted in the osteochondral defects. ..
  51. doi request reprint In vitro chondrogenesis and in vivo repair of osteochondral defect with human induced pluripotent stem cells
    Ji Yun Ko
    Department of Orthopaedics, Dongguk University Ilsan Hospital, 814 Siksa dong, Goyang 411 773, Republic of Korea
    Biomaterials 35:3571-81. 2014
    ..The defects implanted with chondro-induced hiPSCs showed a significantly better quality of cartilage repair than the control defects, and the majority of cells in the regenerated cartilage consisted of implanted hiPSCs. ..
  52. ncbi request reprint Concave microwell plate facilitates chondrogenesis from mesenchymal stem cells
    Ji Yun Ko
    Department of Orthopedics, Dongguk University Ilsan Hospital, 814 Siksa dong, Goyang, 411 773, Republic of Korea
    Biotechnol Lett 38:1967-1974. 2016
    ..To compare in vitro chondrogenesis from bone marrow-derived mesenchymal stem cells using concave microwell plates with those obtained using culture tubes...
  53. doi request reprint Stem cell responses to nanotopography
    Siyeon Park
    Department of Orthopaedics, Dongguk University, Ilsan Hospital, Korea
    J Biomed Mater Res A 103:1238-45. 2015
    ....
  54. doi request reprint Embryonic stem cells and induced pluripotent stem cells for skeletal regeneration
    Siyeon Park
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
    Tissue Eng Part B Rev 20:381-91. 2014
    ..The purpose of this review was to summarize the current knowledge of osteogenic and chondrogenic induction from ESCs and iPSCs and to provide a perspective on the application of iPSCs for skeletal regeneration. ..
  55. doi request reprint Nonviral gene transfer strategies to promote bone regeneration
    Gun Il Im
    Department of Orthopaedics, Dongguk University Ilsan Hospital, Korea
    J Biomed Mater Res A 101:3009-18. 2013
    ....
  56. ncbi request reprint Distal metaphyseal fractures of tibia: a prospective randomized trial of closed reduction and intramedullary nail versus open reduction and plate and screws fixation
    Gun Il Im
    Department of Orthopaedics, Dongguk University International Hospital, Goyang, Korea
    J Trauma 59:1219-23; discussion 1223. 2005
    ....