Young Jae Lee

Summary

Affiliation: Gachon Medical School
Country: Korea

Publications

  1. pmc Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development
    Young Jae Lee
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Dev Biol 347:195-203. 2010
  2. pmc Clinical and genetic analyses of three Korean families with hereditary hemorrhagic telangiectasia
    Mi Jung Kim
    Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea
    BMC Med Genet 12:130. 2011
  3. pmc Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension
    Kwon Ho Hong
    Department of Physiology and Functional Genomics, Shands Cancer Center, University of Florida College of Medicine, Gainesville, USA
    Circulation 118:722-30. 2008
  4. pmc Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia
    Sung Ok Park
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, 1376 Mowry Road, Room 456, Gainesville, Florida 32610, USA
    J Clin Invest 119:3487-96. 2009
  5. ncbi Generation of activin receptor type IIB isoform-specific hypomorphic alleles
    Young Jae Lee
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610, USA
    Genesis 44:487-94. 2006
  6. pmc TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development
    Ha Long Nguyen
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, USA
    Lab Invest 91:1554-63. 2011
  7. pmc Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2
    Eun Jung Choi
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 8:e63138. 2013
  8. pmc VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2
    Chul Han
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, P O Box 100274, Gainesville, FL, 32610, USA
    Angiogenesis 17:823-30. 2014
  9. ncbi Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3
    Rahul N Kanadia
    Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, University of Florida, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610 0267, USA
    Gene Expr Patterns 3:459-62. 2003
  10. doi Generation of mice with a conditional and reporter allele for Tmem100
    Eun Hye Moon
    Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Yunsu Gu, Incheon, Republic of Korea
    Genesis 48:673-8. 2010

Collaborators

  • Brian S Sorg
  • Yong Hwan Kim
  • Ho Jae Lee
  • Glenn Walter
  • Jeffrey K Harrison
  • Hideyuki Beppu
  • Jeong Hoon Joo
  • Seh Hoon Oh
  • Ji Won Yoon
  • Sung Ok Park
  • Kwon Ho Hong
  • Se Woon Choe
  • Chul Han
  • Eun Jung Choi
  • Mi Jung Kim
  • Ha Long Nguyen
  • Jiyoung Seo
  • Eun Hye Moon
  • Eunji Lee
  • Mohan K Raizada
  • Naime Fliess
  • Sung O Park
  • En Li
  • Tsugio Seki
  • Sean Park
  • Rahul N Kanadia
  • Benjamin G Keselowsky
  • Abhinav P Acharya
  • Myron Chang
  • Eva M Garrido-Martin
  • Yu Gyoung Tak
  • Jaekyung Shin
  • Jae Bom Lee
  • Seon Tae Kim
  • Kyu Yong Lee
  • Joseph H McCarty
  • Keum Soun Ko
  • Mamta Wankhede
  • Xiaofang Wu
  • Kenneth D Bloch
  • Zhigang Jiang
  • Beth L Roman
  • Vesa Kaartinen
  • Alice Park
  • In Kyung Lim
  • Joonil Park
  • Seong Jin Kim
  • Valerie J Crusselle
  • Maurice S Swanson
  • Defang Luo
  • Carl R Urbinati

Detail Information

Publications13

  1. pmc Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development
    Young Jae Lee
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Dev Biol 347:195-203. 2010
    ....
  2. pmc Clinical and genetic analyses of three Korean families with hereditary hemorrhagic telangiectasia
    Mi Jung Kim
    Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea
    BMC Med Genet 12:130. 2011
    ..Endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1; ALK1), receptors for transforming growth factor-β (TGF-β) superfamily, have been identified as the principal HHT-causing genes...
  3. pmc Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension
    Kwon Ho Hong
    Department of Physiology and Functional Genomics, Shands Cancer Center, University of Florida College of Medicine, Gainesville, USA
    Circulation 118:722-30. 2008
    ..The present study was designed to investigate whether endothelial Bmpr2 deletion can predispose to PAH...
  4. pmc Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia
    Sung Ok Park
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, 1376 Mowry Road, Room 456, Gainesville, Florida 32610, USA
    J Clin Invest 119:3487-96. 2009
    ..We believe our data provide novel insights into the pathogenetic mechanisms of HHT and potential therapeutic approaches...
  5. ncbi Generation of activin receptor type IIB isoform-specific hypomorphic alleles
    Young Jae Lee
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610, USA
    Genesis 44:487-94. 2006
    ..In this study, we demonstrate that this phenomenon is most likely due to the reduction in the expressed Acvr2b(4) levels rather than to the functional deficiency of the Acvr2b(4) isoform itself...
  6. pmc TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development
    Ha Long Nguyen
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, USA
    Lab Invest 91:1554-63. 2011
    ..These data reveal for the first time that αvβ8 integrin-activated TGF-βs regulate angiogenesis in the developing brain via paracrine signaling to ECs...
  7. pmc Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2
    Eun Jung Choi
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 8:e63138. 2013
    ..We also demonstrated in vivo that Alk1-deficient ECs exhibited high migratory and invasive properties. Taken together, these data suggest that enhanced responses to angiogenic cues in ALK1-deficient ECs underlie the pathogenesis of HHT2...
  8. pmc VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2
    Chul Han
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, P O Box 100274, Gainesville, FL, 32610, USA
    Angiogenesis 17:823-30. 2014
    ..Taken together, the presented experimental model is an invaluable system for precise molecular mechanism of action of VEGF blockades as well as for preclinical screening of drug candidates for epistaxis and gastrointestinal bleedings...
  9. ncbi Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3
    Rahul N Kanadia
    Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, University of Florida, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610 0267, USA
    Gene Expr Patterns 3:459-62. 2003
    ..Our studies reveal a striking overlap between the expression of Dmpk and the muscleblind genes during development of the limbs, nervous system and various muscles, including the diaphragm and tongue...
  10. doi Generation of mice with a conditional and reporter allele for Tmem100
    Eun Hye Moon
    Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Yunsu Gu, Incheon, Republic of Korea
    Genesis 48:673-8. 2010
    ..We found that Tmem100 was predominantly expressed in arterial endothelial cells of developing embryos. The conditional and reporter allele will be a useful resource to investigate the in vivo role of Tmem100, especially in angiogenesis...
  11. ncbi Role of Pinin in neural crest, dorsal dermis, and axial skeleton development and its involvement in the regulation of Tcf/Lef activity in mice
    Jeong Hoon Joo
    Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Dev Dyn 236:2147-58. 2007
    ..Taken together, the data suggest that Pnn plays important roles during mouse development through its involvement in regulation of Tcf/Lef activity...
  12. pmc ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2
    Sung O Park
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Shands Cancer Center, Gainesville 32610, USA
    Blood 111:633-42. 2008
    ..These data indicate that neither ALK5 nor TGFBR2 is required for ALK1 signaling pertinent to the pathogenesis of HHT and suggest that HHT might not be a TGF-beta subfamily disease...
  13. pmc B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling
    Sean Park
    Department of Physiology and Functional Genomics, University of Florida, 1600 SW Archer Rd, Room D533d, Gainesville, FL 32610, USA
    Mol Cell Biol 24:10256-62. 2004
    ..In view of the genetic evidence that reduced BMP signaling causes posteriorization of the vertebral pattern, we propose that the observed vertebral phenotype in Btg2-null mice is due to attenuated BMP signaling...