Sei Kwang Hahn

Summary

Affiliation: Pohang University of Science and Technology
Country: Korea

Publications

  1. ncbi request reprint Preparation and characterization of biocompatible polyelectrolyte complex multilayer of hyaluronic acid and poly-L-lysine
    Sei Kwang Hahn
    Department of Advanced Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang 790 784, Republic of Korea
    Int J Biol Macromol 37:227-31. 2005
  2. doi request reprint Bioimaging of botulinum toxin and hyaluronate hydrogels using zwitterionic near-infrared fluorophores
    Ki Su Kim
    PHI BIOMED Co, 613, 12 Gangnam daero 65 gil, Seocho Gu, Seoul, 06612 South Korea
    Biomater Res 21:15. 2017
  3. ncbi request reprint Sustained release formulation of erythropoietin using hyaluronic acid hydrogels crosslinked by Michael addition
    Sei Kwang Hahn
    Department of Advanced Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang 790 784, Republic of Korea
    Int J Pharm 322:44-51. 2006
  4. ncbi request reprint Injectable hyaluronic acid microhydrogels for controlled release formulation of erythropoietin
    Sei Kwang Hahn
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, 790 784, Korea
    J Biomed Mater Res A 80:916-24. 2007
  5. ncbi request reprint Synthesis and degradation test of hyaluronic acid hydrogels
    Sei Kwang Hahn
    Preclinical Research Department I, Roche Group, Chugai Pharmaceutical Co, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Int J Biol Macromol 40:374-80. 2007
  6. doi request reprint Target specific systemic delivery of TGF-β siRNA/(PEI-SS)-g-HA complex for the treatment of liver cirrhosis
    Kitae Park
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, San 31 Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Biomaterials 32:4951-8. 2011
  7. doi request reprint Flt1 peptide-hyaluronate conjugate micelle-like nanoparticles encapsulating genistein for the treatment of ocular neovascularization
    Hyemin Kim
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Acta Biomater 8:3932-40. 2012
  8. doi request reprint In situ supramolecular assembly and modular modification of hyaluronic acid hydrogels for 3D cellular engineering
    Kyeng Min Park
    Center for Smart Supramolecules, Department of Chemistry, Division of Advanced Materials Science, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    ACS Nano 6:2960-8. 2012
  9. doi request reprint Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives
    Eun Ju Oh
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang 790 784, Republic of Korea
    J Control Release 141:2-12. 2010
  10. doi request reprint Target-specific gene silencing of layer-by-layer assembled gold-cysteamine/siRNA/PEI/HA nanocomplex
    Min Young Lee
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    ACS Nano 5:6138-47. 2011

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Preparation and characterization of biocompatible polyelectrolyte complex multilayer of hyaluronic acid and poly-L-lysine
    Sei Kwang Hahn
    Department of Advanced Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang 790 784, Republic of Korea
    Int J Biol Macromol 37:227-31. 2005
    ..This nano-scale control of material deposition may be successfully applied for surface modification of various biomaterials...
  2. doi request reprint Bioimaging of botulinum toxin and hyaluronate hydrogels using zwitterionic near-infrared fluorophores
    Ki Su Kim
    PHI BIOMED Co, 613, 12 Gangnam daero 65 gil, Seocho Gu, Seoul, 06612 South Korea
    Biomater Res 21:15. 2017
    ..The biocompatible hydrogels are injected with BTX for effective tissue augmentation. However, it is difficult to determine the interval of injection for effective tissue augmentation...
  3. ncbi request reprint Sustained release formulation of erythropoietin using hyaluronic acid hydrogels crosslinked by Michael addition
    Sei Kwang Hahn
    Department of Advanced Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang 790 784, Republic of Korea
    Int J Pharm 322:44-51. 2006
    ..There was no adverse effect during and after the in vivo tests...
  4. ncbi request reprint Injectable hyaluronic acid microhydrogels for controlled release formulation of erythropoietin
    Sei Kwang Hahn
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, 790 784, Korea
    J Biomed Mater Res A 80:916-24. 2007
    ..1 ng/mL, which is a critical minimal concentration for EPO efficacy, was maintained up to 7 days. There was no adverse effect during and after the in vivo tests...
  5. ncbi request reprint Synthesis and degradation test of hyaluronic acid hydrogels
    Sei Kwang Hahn
    Preclinical Research Department I, Roche Group, Chugai Pharmaceutical Co, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Int J Biol Macromol 40:374-80. 2007
    ..Dried HA hydrogel at 37 degrees C for a day resulted in relatively slow degradation compared to the bulk HA hydrogel. There was no adverse effect during the in vivo tests...
  6. doi request reprint Target specific systemic delivery of TGF-β siRNA/(PEI-SS)-g-HA complex for the treatment of liver cirrhosis
    Kitae Park
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, San 31 Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Biomaterials 32:4951-8. 2011
    ..The siRNA/(PEI-SS)-g-HA complex can be exploited for the target specific systemic treatment of various liver diseases...
  7. doi request reprint Flt1 peptide-hyaluronate conjugate micelle-like nanoparticles encapsulating genistein for the treatment of ocular neovascularization
    Hyemin Kim
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Acta Biomater 8:3932-40. 2012
    ..The retinal vascular hyperpermeability was also drastically reduced by the treatment in diabetic retinopathy model rats...
  8. doi request reprint In situ supramolecular assembly and modular modification of hyaluronic acid hydrogels for 3D cellular engineering
    Kyeng Min Park
    Center for Smart Supramolecules, Department of Chemistry, Division of Advanced Materials Science, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    ACS Nano 6:2960-8. 2012
    ..Taken together, CB[6]/DAH-HA hydrogels might be successfully exploited as a 3D artificial extracellular matrix for various tissue engineering applications...
  9. doi request reprint Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives
    Eun Ju Oh
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang 790 784, Republic of Korea
    J Control Release 141:2-12. 2010
    ..This review will give you a peer overview on novel HA derivatives and the latest advances in HA-based drug delivery systems of various biopharmaceuticals for further clinical development...
  10. doi request reprint Target-specific gene silencing of layer-by-layer assembled gold-cysteamine/siRNA/PEI/HA nanocomplex
    Min Young Lee
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    ACS Nano 5:6138-47. 2011
    ..Taken together, AuCM/siRNA/PEI/HA complex was thought to be developed as target-specific siRNA therapeutics for the systemic treatment of various liver diseases...
  11. doi request reprint Self-adjuvanted hyaluronate--antigenic peptide conjugate for transdermal treatment of muscular dystrophy
    Won Ho Kong
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, 77 Cheongam ro, Nam Gu, Pohang, Kyungbuk, 790 784, Republic of Korea
    Biomaterials 81:93-103. 2016
    ..Furthermore, the mdx mice immunized with HA-MstnF conjugates resulted in statistically significant improvement in the biochemical and pathological status of skeletal musculature as well as functional behaviors. ..
  12. doi request reprint In vivo real-time confocal microscopy for target-specific delivery of hyaluronic acid-quantum dot conjugates
    Ki Su Kim
    Department of Materials Science and Engineering, Pohang University of Science and Technology Pohang, Republic of Korea
    Nanomedicine 8:1070-3. 2012
    ....
  13. doi request reprint Hyaluronic acid-gold nanoparticle/interferon α complex for targeted treatment of hepatitis C virus infection
    Min Young Lee
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    ACS Nano 6:9522-31. 2012
    ..Taken together, the target-specific HA-AuNP/IFNα complex was thought to be successfully applied to the systemic treatment of HCV infection...
  14. doi request reprint Self-assembled complex of probe peptide--E. Coli RNA I conjugate and nano graphene oxide for apoptosis diagnosis
    Won Ho Kong
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, Pohang, Kyungbuk, South Korea
    Biomaterials 33:7556-64. 2012
    ..Furthermore, the self-assembled NGO complex was successfully exploited for in vivo diagnosis of apoptosis-related diseases like hypoxic-ischemic encephalopathy (HIE) and liver cirrhosis...
  15. doi request reprint Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine-hyaluronic acid conjugate
    Kitae Park
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Biomaterials 31:5258-65. 2010
    ..Moreover, intra-tumoral injection of vascular endothelial growth factor (VEGF) siRNA/(PEI-SS)-b-HA complex resulted in dramatically inhibited tumor growth with reduced VEGF mRNA and VEGF levels in the tumors...
  16. doi request reprint Genetically engineered mesenchymal stem cell therapy using self-assembling supramolecular hydrogels
    Byung Woo Hwang
    Department of Materials Science and Engineering, 77 Cheongam ro, Nam Gu, Pohang, Gyeongbuk 790 784, Korea
    J Control Release 220:119-29. 2015
    ..In this review, we describe genetic engineering of MSCs, recent progress of self-assembling supramolecular hydrogels, and their applications to cell therapy for intractable diseases and tissue regeneration...
  17. doi request reprint Cationic solid lipid nanoparticles derived from apolipoprotein-free LDLs for target specific systemic treatment of liver fibrosis
    Won Ho Kong
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, Pohang, Kyungbuk 790 784, Republic of Korea
    Biomaterials 34:542-51. 2013
    ..The bio-distribution study by fluorescence bioimaging and single-photon emission computed tomography (SPECT) confirmed the target specific delivery and accumulation of CSLN/siCTGF complexes to the liver tissues...
  18. doi request reprint Bioimaging of hyaluronic acid derivatives using nanosized carbon dots
    Eun Ji Goh
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, Pohang, Kyungbuk, Korea
    Biomacromolecules 13:2554-61. 2012
    ..Taken together, we could confirm the feasibility of HA derivatives as a target-specific drug delivery carrier for the treatment of liver diseases and Cdots as a promising bioimaging agent...
  19. doi request reprint Target specific hyaluronic acid-interferon alpha conjugate for the treatment of hepatitis C virus infection
    Jeong A Yang
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    Biomaterials 32:8722-9. 2011
    ..After tail-vein injection, HA-IFNα conjugate induced ca. 60% higher expression of 2',5'-oligoadenylate synthetase 1 (OAS 1) for innate immune responses to viral infection in the murine liver tissues than IFNα and PEG-Intron...
  20. doi request reprint Guided bone regeneration by poly(lactic-co-glycolic acid) grafted hyaluronic acid bi-layer films for periodontal barrier applications
    Jung Kyu Park
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Acta Biomater 5:3394-403. 2009
    ..Histological and histomorphometric analyses revealed that HA-PLGA/PLGA film resulted in the most effective bone regeneration compared to other samples with a regenerated bone area of 63.1% covering the bone defect area...
  21. doi request reprint Synchrotron X-ray bioimaging of bone regeneration by artificial bone substitute of MegaGen Synthetic Bone and hyaluronate hydrogels
    Junseok Yeom
    Department of Material Science and Engineering, Pohang University of Science and Technology POSTECH, Nam Gu, Pohang, Korea
    Tissue Eng Part C Methods 16:1059-68. 2010
    ..The clinically feasible artificial bone substitutes of MGSB/HA-CYS hydrogels will be investigated further for various bone tissue engineering applications using the synchrotron X-ray bioimaging systems...
  22. doi request reprint Bioimaging and pulmonary applications of self-assembled Flt1 peptide-hyaluronic acid conjugate nanoparticles
    Hyemin Kim
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Biomaterials 34:8478-90. 2013
    ....
  23. doi request reprint 3D tissue engineered supramolecular hydrogels for controlled chondrogenesis of human mesenchymal stem cells
    Hyuntae Jung
    School of Interdisciplinary Bioscience and Bioengineering, Department of Materials Science and Engineering, and Center for Self Assembly and Complexity, Institute for Basic Science, Department of Chemistry, Division of Advanced Materials Science, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    Biomacromolecules 15:707-14. 2014
    ..Taken together, we could confirm the feasibility of cytocompatible monoCB[6]/DAH-HA hydrogels as a platform scaffold with controlled drug delivery for cartilage regeneration and other various tissue engineering applications. ..
  24. doi request reprint Effect of cross-linking reagents for hyaluronic acid hydrogel dermal fillers on tissue augmentation and regeneration
    Junseok Yeom
    Department of Materials Science and Engineering, Pohang University of Science and Technology, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    Bioconjug Chem 21:240-7. 2010
    ..The HA-HMDA hydrogels will be investigated further as a novel dermal filler for clinical applications...
  25. doi request reprint Photodynamic therapy of melanoma skin cancer using carbon dot - chlorin e6 - hyaluronate conjugate
    Songeun Beack
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, 77 Cheongam ro, Nam Gu, Pohang 790 784, Republic of Korea
    Acta Biomater 26:295-305. 2015
    ..Taken together, we could confirm the feasibility of Cdot-Ce6-HA conjugate for transdermal PDT of melanoma skin cancers...
  26. doi request reprint Nanographene oxide-hyaluronic acid conjugate for photothermal ablation therapy of skin cancer
    Ho Sang Jung
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    ACS Nano 8:260-8. 2014
    ..Taken together, we could confirm the feasibility of transdermal NGO-HA for photothermal ablation therapy of melanoma skin cancers. ..
  27. doi request reprint Reducible hyaluronic acid-siRNA conjugate for target specific gene silencing
    Kitae Park
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology POSTECH, San 31 Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    Bioconjug Chem 24:1201-9. 2013
    ..The HA-siRNA conjugate can be effectively applied as a model system to the treatment of liver diseases using various siRNAs and relatively nontoxic polycations. ..
  28. doi request reprint Transdermal delivery of hyaluronic acid -- human growth hormone conjugate
    Jeong A Yang
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Biomaterials 33:5947-54. 2012
    ..This work confirms the feasibility of using the HA-hGH conjugate as a model system for the receptor mediated transdermal delivery of protein drugs and their further exploitation for various cosmetic and tissue engineering applications...
  29. ncbi request reprint Control of the molecular degradation of hyaluronic acid hydrogels for tissue augmentation
    Eun Ju Oh
    Department of Material Science and Engineering, Pohang University of Science and Technology POSTECH, Pohang, Kyungbuk 790 784, Korea
    J Biomed Mater Res A 86:685-93. 2008
    ..There was no adverse effect during and after in vivo degradation tests. All of the HA hydrogel samples appeared to be biocompatible, according to the histological analysis with hematoxylin-eosin and Alcian blue...
  30. doi request reprint In vivo real-time bioimaging of hyaluronic acid derivatives using quantum dots
    Jiseok Kim
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang 790 784, Republic of Korea
    Biopolymers 89:1144-53. 2008
    ..The results are well matched with the fact that HA receptors are abundantly present in the liver with a high specificity to HA molecules...
  31. doi request reprint Long acting hyaluronate--exendin 4 conjugate for the treatment of type 2 diabetes
    Ji Hyun Kong
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, Pohang, Kyungbuk, Republic of Korea
    Biomaterials 31:4121-8. 2010
    ..The HA - exendin 4 conjugates will be investigated further as a twice a week injection dosage form for clinical applications...
  32. doi request reprint Two-photon microscopy of a Flt1 peptide-hyaluronate conjugate
    Songeun Beack
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, 77 Cheongam ro, Nam Gu, Pohang 790 784, Korea
    Nanomedicine (Lond) 10:2315-24. 2015
    ..Two-photon microscopy was performed to visualize ocular distribution of Flt1 peptide-hyaluronate (HA) conjugate micelles for eye drop treatment of corneal neovascularization...
  33. doi request reprint Three-dimensional bioprinting of multilayered constructs containing human mesenchymal stromal cells for osteochondral tissue regeneration in the rabbit knee joint
    Jin Hyung Shim
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, Pohang, Kyungbuk, Korea Department of Mechanical Engineering, Korea Polytechnic University, Siheung si, Gyeonggi Do, Korea
    Biofabrication 8:014102. 2016
    ..We believe that this 3D printing-based platform technology can be effectively exploited for regeneration of various heterogeneous tissues as well as osteochondral tissue. ..
  34. doi request reprint Hyaluronic acid-tumor necrosis factor-related apoptosis-inducing ligand conjugate for targeted treatment of liver fibrosis
    Jeong A Yang
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Acta Biomater 12:174-82. 2015
    ..Finally, we could confirm the antifibrotic effect of HA-TRAIL conjugate in an N-nitrosodimethylamine-induced liver fibrosis model SD rats. ..
  35. doi request reprint Supramolecular hydrogels for long-term bioengineered stem cell therapy
    Junseok Yeom
    Department of Materials Science and Engineering, 77 Cheongam ro, Nam Gu, Pohang, 790 784, Republic of Korea
    Adv Healthc Mater 4:237-44. 2015
    ..Taken together, these findings confirm the feasibility of supramolecular HA hydrogels as 3D artificial ECMs for cell therapies and tissue engineering applications...
  36. doi request reprint Hyaluronate-gold nanoparticle/tocilizumab complex for the treatment of rheumatoid arthritis
    Hwiwon Lee
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, 77 Cheongam ro, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    ACS Nano 8:4790-8. 2014
    ..The therapeutic effect of HA-AuNP/TCZ complex on RA was confirmed in collagen-induced arthritis (CIA) model mice by ELISA, histological, and Western blot analyses. ..
  37. doi request reprint Target specific intracellular delivery of siRNA/PEI-HA complex by receptor mediated endocytosis
    Ge Jiang
    Department of Materials Science and Engineering, Pohang University of Science and Technology, Kyungbuk 790 784, Korea
    Mol Pharm 6:727-37. 2009
    ....
  38. doi request reprint Synthesis, characterization, and preliminary assessment of anti-Flt1 peptide-hyaluronate conjugate for the treatment of corneal neovascularization
    Eun Ju Oh
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, Pohang, Kyungbuk, South Korea
    Biomaterials 30:6026-34. 2009
    ..The water-soluble anti-Flt1 peptide-HA conjugate was thought to have a potential to be developed as anti-angiogenic therapeutics for the treatment of corneal neovascularization...
  39. doi request reprint Bioimaging for targeted delivery of hyaluronic Acid derivatives to the livers in cirrhotic mice using quantum dots
    Ki Su Kim
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    ACS Nano 4:3005-14. 2010
    ..The results were thought to reflect the feasibility of HA derivatives as novel drug delivery carriers for the treatment of various chronic liver diseases including hepatitis, liver cirrhosis, and liver cancer...
  40. doi request reprint Real-time, step-wise, electrical detection of protein molecules using dielectrophoretically aligned SWNT-film FET aptasensors
    Taechang An
    Department of Mechanical Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk, 790 784, Korea
    Lab Chip 10:2052-6. 2010
    ..Thrombin aptamer immobilized SWNT-film FET biosensor resulted in a real-time, label-free, and electrical detection of thrombin molecules down to a concentration of ca. 7 pM with a step-wise rapid response time of several seconds...
  41. doi request reprint Anti-Flt1 peptide - hyaluronate conjugate for the treatment of retinal neovascularization and diabetic retinopathy
    Eun Ju Oh
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Biomaterials 32:3115-23. 2011
    ..Pharmacokinetic analysis confirmed the increased mean residence time of anti-Flt1 peptide after conjugation to HA longer than 2 weeks...
  42. ncbi request reprint Selectively crosslinked hyaluronic acid hydrogels for sustained release formulation of erythropoietin
    Keiko Motokawa
    Preclinical Research Department, Roche Group, Chugai Pharmaceutical, Gotemba, Shizuoka, 412 8513, Japan
    J Biomed Mater Res A 78:459-65. 2006
    ..1 ng/mL could be maintained from 7 days up to 18 days depending on the preparation methods of HA-ADH hydrogels. There was no adverse effect during and after HA-ADH hydrogel implantation...
  43. doi request reprint Theranostic systems assembled in situ on demand by host-guest chemistry
    Hyuntae Jung
    National Creative Research Initiative Center for Smart Supramolecules, Department of Chemistry, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Biomaterials 32:7687-94. 2011
    ..The on-demand theranostic platform technology using host-guest chemistry can be exploited for various bioimaging, biosensing, drug delivery, and tissue engineering applications...
  44. ncbi request reprint Hyaluronate-Epidermal Growth Factor Conjugate for Skin Wound Healing and Regeneration
    Hyemin Kim
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, 77 Cheongam ro, Nam Gu, Pohang, Kyungbuk 790 784, Republic of Korea
    Biomacromolecules 17:3694-3705. 2016
    ..Furthermore, in vivo transdermal delivery of HA-EGF conjugate in the patch-type HA film resulted in significantly improved regeneration of skin tissues even into hypodermis...
  45. doi request reprint Electrical detection of VEGFs for cancer diagnoses using anti-vascular endotherial growth factor aptamer-modified Si nanowire FETs
    Hyun Seung Lee
    Department of Materials Science and Engineering, Pohang University of Science and Technology, Pohang, Gyungbuk, Republic of Korea
    Biosens Bioelectron 24:1801-5. 2009
    ..The detection limit for VEGFs in this study was determined as 1.04nM and 104pM for the cases of n-type and p-type SiNW-FETs, respectively...
  46. doi request reprint Targeted systemic mesenchymal stem cell delivery using hyaluronate - wheat germ agglutinin conjugate
    Yun Seop Kim
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk 790 784, Korea
    Biomaterials 106:217-27. 2016
    ..This new strategy for targeted delivery of MSCs using HA-WGA conjugate might be successfully exploited for various regenerative medicines including cell therapy. ..
  47. doi request reprint Smart Microbubble Eluting Theranostic Stent for Noninvasive Ultrasound Imaging and Prevention of Restenosis
    Do Hee Keum
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, 77 Cheongam ro, Nam Gu, Pohang, 790 784, South Korea
    Small . 2016
    ..This smart theranostic stent can be effectively applied to facilitate noninvasive monitoring and prevent restenosis after stent implantation...
  48. doi request reprint Signal transduction of hyaluronic acid-peptide conjugate for formyl peptide receptor like 1 receptor
    Eun Ju Oh
    Department of Materials Science and Engineering, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, Korea
    Bioconjug Chem 19:2401-8. 2008
    ..The partially decreased biological activity of HA-peptide conjugates by the steric hindrance of HA was recovered after its degradation by hyaluronidase treatment...
  49. ncbi request reprint Application of microstereolithography in the development of three-dimensional cartilage regeneration scaffolds
    Seung Jae Lee
    Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Kyungbuk, 790 784, South Korea
    Biomed Microdevices 10:233-41. 2008
    ..These 3-D scaffolds could eventually lead to optimally designed constructs for the regeneration of various tissues, such as cartilage and bone...
  50. doi request reprint Hyaluronate-Death Receptor 5 Antibody Conjugates for Targeted Treatment of Liver Metastasis
    Hwiwon Lee
    R and D Center, NovMetaPharma Co, Ltd, Jigokdong, Nam Gu, Pohang, 790 834, Korea
    Biomacromolecules 17:3085-93. 2016
    ..Remarkably, according to in vivo bioimaging study, HA-DR5 Ab conjugate appeared to be highly accumulated in the liver and dramatically effective in inhibiting the tumor growth in liver metastasis model mice. ..
  51. doi request reprint Microneedle biosensor for real-time electrical detection of nitric oxide for in situ cancer diagnosis during endomicroscopy
    Do Hee Keum
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Kyungbuk, 790 784, Korea
    Adv Healthc Mater 4:1153-8. 2015
    ..The dual-diagnostic system can be a new platform for facile, precise, rapid, and accurate detection of cancers in various biomedical applications. ..
  52. doi request reprint Surface modification of multipass caliber-rolled Ti alloy with dexamethasone-loaded graphene for dental applications
    Ho Sang Jung
    Department of Materials Science and Engineering, Pohang University of Science and Technology POSTECH, 77 Cheongam ro, Nam Gu, Pohang, Kyungbuk, 790 784, Korea
    ACS Appl Mater Interfaces 7:9598-607. 2015
    ..Moreover, we could confirm the feasibility of Dex/RGO-MPCR-TNZ from the implantation test of a prototype of a dental implant to an artificial bone block for clinical dental applications. ..
  53. ncbi request reprint Effect of hyaluronic acid molecular weight on the morphology of quantum dot-hyaluronic acid conjugates
    Jiseok Kim
    Department of Materials Science and Engineering, Pohang University of Science and Technology, San 31, Hyoja Dong, Nam Gu, Pohang 790 784, Korea
    Int J Biol Macromol 42:41-5. 2008
    ..QDot-HA conjugate could be successfully used for real-time bio-imaging of HA derivatives in nude mice. The novel QDot-HA conjugate will be further used to investigate the biological roles of HA with a different MW in the body...
  54. ncbi request reprint Characterization and in vivo study of sustained-release formulation of human growth hormone using sodium hyaluronate
    Sei Kwang Hahn
    Biotech Group, LG Life Sciences Co, Yusong gu, Taejon, 305 380, Korea
    Pharm Res 21:1374-81. 2004
    ....
  55. ncbi request reprint Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles
    Sun Jin Kim
    Biotech Group, LG Life Sciences Co, 104 1, Moonji dong, Yusong gu, Daejeon, 305 380, South Korea
    J Control Release 104:323-35. 2005
    ..The bioavailability of both formulations was comparable to that of hGH daily injection formulation. Finally, toxicity studies revealed no evidence of adverse effect in both cynomolgus monkeys and beagle dogs...