Hae Young Chung

Summary

Affiliation: Pusan National University
Country: Korea

Publications

  1. pmc Age-related inflammation and insulin resistance: a review of their intricate interdependency
    Min Hi Park
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, 609 735, Republic of Korea
    Arch Pharm Res 37:1507-14. 2014
  2. pmc Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
    Yeon Ja Choi
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Korea
    PLoS ONE 7:e43418. 2012
  3. pmc Computational approach to identify enzymes that are potential therapeutic candidates for psoriasis
    Daeui Park
    Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Kumjeong gu, Busan 609 735, Republic of Korea
    Enzyme Res 2011:826784. 2011
  4. pmc Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver
    Dae Hyun Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan 609 735, Korea
    J Ginseng Res 37:54-63. 2013
  5. pmc Molecular study of dietary heptadecane for the anti-inflammatory modulation of NF-kB in the aged kidney
    Dae Hyun Kim
    Department of Pharmacy, College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan, Republic of Korea
    PLoS ONE 8:e59316. 2013
  6. pmc Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-κB signaling
    So Ra Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Republic of Korea
    PLoS ONE 8:e73877. 2013
  7. ncbi request reprint The molecular inflammatory process in aging
    Hae Young Chung
    College of Pharmacy, Pusan National University, Busan, Korea
    Antioxid Redox Signal 8:572-81. 2006
  8. doi request reprint Molecular inflammation as an underlying mechanism of the aging process and age-related diseases
    H Y Chung
    Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609 735, Korea
    J Dent Res 90:830-40. 2011
  9. ncbi request reprint Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction
    Hae Young Chung
    College of Pharmacy, Pusan National University, Pusan 609 735, Korea
    Microsc Res Tech 59:264-72. 2002
  10. pmc Molecular inflammation: underpinnings of aging and age-related diseases
    Hae Young Chung
    Department of Pharmacy, Longevity Science and Technology Institutes, Research Institute for Drug Development, Pusan National University, Geumjeong Gu, Busan 609 735, South Korea
    Ageing Res Rev 8:18-30. 2009

Collaborators

Detail Information

Publications86

  1. pmc Age-related inflammation and insulin resistance: a review of their intricate interdependency
    Min Hi Park
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, 609 735, Republic of Korea
    Arch Pharm Res 37:1507-14. 2014
    ....
  2. pmc Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion
    Yeon Ja Choi
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Korea
    PLoS ONE 7:e43418. 2012
    ..The significance of this study is the finding of a novel inhibitor of autophagy with an mTOR activating effect...
  3. pmc Computational approach to identify enzymes that are potential therapeutic candidates for psoriasis
    Daeui Park
    Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Kumjeong gu, Busan 609 735, Republic of Korea
    Enzyme Res 2011:826784. 2011
    ..We adopted a computational approach to detect potential therapeutic targets; this approach may become an effective strategy for the discovery of new drug targets for psoriasis...
  4. pmc Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver
    Dae Hyun Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan 609 735, Korea
    J Ginseng Res 37:54-63. 2013
    ..Taken together, our results suggest that the anti-inflammatory effects of ginsenoside Rd are due to the down-regulation of NF-κB and the consequent expressional suppressions of iNOS and COX-2...
  5. pmc Molecular study of dietary heptadecane for the anti-inflammatory modulation of NF-kB in the aged kidney
    Dae Hyun Kim
    Department of Pharmacy, College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan, Republic of Korea
    PLoS ONE 8:e59316. 2013
    ..We conclude that heptadecane suppresses age-related increases in pro-inflammatory gene expressions then travel upstream set by step by reducing NF-kB activity by downregulating the NIK/IKK and MAPKs pathways induced by RS...
  6. pmc Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-κB signaling
    So Ra Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Republic of Korea
    PLoS ONE 8:e73877. 2013
    ..Summarizing, caffeic acid, S-allyl cysteine, and uracil inhibited UVB-induced wrinkle formation by modulating MMP via NF-κB signaling. ..
  7. ncbi request reprint The molecular inflammatory process in aging
    Hae Young Chung
    College of Pharmacy, Pusan National University, Busan, Korea
    Antioxid Redox Signal 8:572-81. 2006
    ....
  8. doi request reprint Molecular inflammation as an underlying mechanism of the aging process and age-related diseases
    H Y Chung
    Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609 735, Korea
    J Dent Res 90:830-40. 2011
    ..The final section discusses calorie restriction as an aging-retarding intervention that also exhibits extraordinarily effective anti-inflammatory activity by modulating GSH redox, NF-κB, SIRT1, PPARs, and FOXOs...
  9. ncbi request reprint Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction
    Hae Young Chung
    College of Pharmacy, Pusan National University, Pusan 609 735, Korea
    Microsc Res Tech 59:264-72. 2002
    ..It was further proposed that CR's major force of the regulation of redox-sensitive inflammation may well be its life-prolonging action...
  10. pmc Molecular inflammation: underpinnings of aging and age-related diseases
    Hae Young Chung
    Department of Pharmacy, Longevity Science and Technology Institutes, Research Institute for Drug Development, Pusan National University, Geumjeong Gu, Busan 609 735, South Korea
    Ageing Res Rev 8:18-30. 2009
    ....
  11. doi request reprint Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway
    Mi Kyung Kim
    Department of Pharmacy, Pusan National University, Busan, South Korea
    Exp Gerontol 45:419-26. 2010
    ....
  12. doi request reprint PPARγ activation by baicalin suppresses NF-κB-mediated inflammation in aged rat kidney
    Hyun Ae Lim
    Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Gumjung gu, Busan, Republic of Korea
    Biogerontology 13:133-45. 2012
    ..These results indicate that baicalin is a novel PPARγ activator and that this agent may have the potential to minimize inflammation...
  13. ncbi request reprint Upregulation of aortic adhesion molecules during aging
    Yani Zou
    College of Pharmacy, Pusan National University, Gumjung gu, Busan 609 735, Korea
    J Gerontol A Biol Sci Med Sci 61:232-44. 2006
    ..Our study documented that aortic upregulated AMs with age are closely related to activation of NIK/IKK/IkappaB/nuclear factor-kappaB pathway brought on by oxidative stress...
  14. doi request reprint Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis
    Tae Gen Son
    Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong Gu, Busan, Korea
    J Neurosci Res 87:2890-7. 2009
    ..Moreover, we found that ERK1/2 activation was involved in the up-regulation of SMP30 in astrocytes. Our results suggest that elevated SMP30 in activated astrocytes plays an important supportive role after brain damage...
  15. ncbi request reprint Short-term feeding of baicalin inhibits age-associated NF-kappaB activation
    Dae Hyun Kim
    Department of Pharmacy, College of Pharmacy, Pusan National University, Gumjung gu, Busan 609 735, Korea
    Mech Ageing Dev 127:719-25. 2006
    ..Thus, the significance of the current study is the new information revealing the anti-oxidative properties of baicalin and the role it plays in the regulation of age-related alterations...
  16. doi request reprint Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity
    Ji Min Kim
    Department of Pharmacy and Molecular Inflammation Research Center for Aging MRCA Intervention, Pusan National University, Busan, Korea
    Free Radic Res 44:454-61. 2010
    ..The significance of the current study is the new revelation that morin may have potential as an effective anti-inflammatory therapeutic agent...
  17. doi request reprint Molecular delineation of gamma-ray-induced NF-kappaB activation and pro-inflammatory genes in SMP30 knockout mice
    Sang Woon Chung
    Department of Pharmacy, Pusan National University, Busan 609 735, South Korea
    Radiat Res 173:629-34. 2010
    ..Furthermore, our data revealed vitamin C may play an important protective role in attenuating the adverse gamma-radiation-induced adverse effects by suppressing adverse oxidative effects and pro-inflammatory mediators...
  18. doi request reprint Allylmethylsulfide Down-Regulates X-Ray Irradiation-Induced Nuclear Factor-kappaB Signaling in C57/BL6 Mouse Kidney
    Eun Kyeong Lee
    Department of Pharmacy, Pusan National University, Busan, Republic of Korea
    J Med Food 12:542-51. 2009
    ..Based on these results, AMS may be a useful radioprotective agent by down-regulating the MAPKs and NF-kappaB signaling pathway that can be induced via X-ray irradiation...
  19. ncbi request reprint Outer membrane protein A of Acinetobacter baumannii induces differentiation of CD4+ T cells toward a Th1 polarizing phenotype through the activation of dendritic cells
    Jun Sik Lee
    Department of Pharmacy, Pusan National University College of Pharmacy, Busan 609 735, South Korea
    Biochem Pharmacol 74:86-97. 2007
    ..Our findings suggest that AbOmpA induces maturation of DCs and drives Th1 polarization, which are important properties for determining the nature of immune response against A. baumannii...
  20. doi request reprint Modulation of FoxO1 phosphorylation/acetylation by baicalin during aging
    Dae Hyun Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan 609 735, Republic of Korea
    J Nutr Biochem 23:1277-84. 2012
    ..Our results further reveal that baicalin regulated FoxO1 phosphorylation via PI3K/Akt by insulin and FoxO1 acetylation by the interaction of CBP and SIRT1, leading to changes in catalase gene expression during aging...
  21. doi request reprint Design, synthesis, and evaluation of (E)-N-substituted benzylidene-aniline derivatives as tyrosinase inhibitors
    Sung Jin Bae
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Kumjeong gu, Busan 609 735, Republic of Korea
    Eur J Med Chem 57:383-90. 2012
    ..Therefore, we propose (E)-4-((4-hydroxyphenylimino)methyl)benzene-1,2-diol as a new candidate of potent tyrosinase inhibitors that could be used as therapeutic agent with safe skin-whitening efficiency...
  22. pmc The novel PPAR α/γ dual agonist MHY 966 modulates UVB-induced skin inflammation by inhibiting NF-κB activity
    Min Hi Park
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Korea Laboratory of Biochemistry, Pusan National University, Busan, Korea
    PLoS ONE 8:e76820. 2013
    ..The major finding of this study is that MHY 966 demonstrates potential as an agent against wrinkle formation associated with chronic UVB exposure. ..
  23. doi request reprint A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol
    Jehun Choi
    Department of Pharmacy and Molecular Inflammation Research Center for Aging Intervention MRCA, Pusan National University, Gumjung gu, Busan 609 735, Republic of Korea
    Bioorg Med Chem Lett 20:4882-4. 2010
    ..We propose that 5HNB might have skin-whitening effects as well as therapeutic potential for treating skin pigmentation disorders...
  24. doi request reprint Molecular activation of NF-kappaB, pro-inflammatory mediators, and signal pathways in gamma-irradiated mice
    Young Mi Ha
    Department of Pharmacy, Pusan National University, Busan, 609 735, Korea
    Biotechnol Lett 32:373-8. 2010
    ..Considering the exquisite sensitivity of NF-kappaB and other pro-inflammatory mediators to the redox status, we conclude that the activation of inflammatory processes by irradiation is likely initiated by increased oxidative stress...
  25. ncbi request reprint The anti-apoptotic action of 5-hydroxyindole: protection of mitochondrial integrity
    Sung Jin Bae
    Department of Pharmacy, Pusan National University, Korea
    Biol Pharm Bull 33:550-5. 2010
    ..Our data suggest that 5HI protects cells by attenuating oxidative stress and consequently protects against mitochondrial dysfunction...
  26. ncbi request reprint A novel synthesized tyrosinase inhibitor: (E)-2-((2,4-dihydroxyphenyl)diazenyl)phenyl 4-methylbenzenesulfonate as an azo-resveratrol analog
    Sung Jin Bae
    Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Busan, Republic of Korea
    Biosci Biotechnol Biochem 77:65-72. 2013
    ..Therefore the active compounds (3-5) might be considered excellent candidates for use in the development of therapeutic agents for diseases associated with hyperpigmentation...
  27. doi request reprint Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation
    Young Mi Ha
    College of Pharmacy, Pusan National University, Kumjeong gu, Busan 609 735, Republic of Korea
    Biochim Biophys Acta 1810:612-9. 2011
    ..A series of 5-(substituted benzylidene)hydantoin derivatives 2a-2k were prepared, and their inhibitory activities toward tyrosinase and melanin formation were evaluated...
  28. doi request reprint Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo
    Mohammad Akbar Hossain
    Division of Pharmacy, College of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609 735, Republic of Korea
    Int J Oncol 40:1636-42. 2012
    ..Therefore, the combination of ASA and DOX could be used as a novel combination regimen which provides a strong anticancer synergy in the treatment of hepatocellular carcinoma...
  29. doi request reprint Peroxisome proliferator-activated receptor activation by a short-term feeding of zingerone in aged rats
    Sang Woon Chung
    College of Pharmacy, Pusan National University, Busan, Republic of Korea
    J Med Food 12:345-50. 2009
    ..Collectively, our findings suggest that zingerone exerts its potent anti-inflammatory action by increasing HNF-4 and PPAR activities, while suppressing NF-kappaB activity...
  30. doi request reprint De novo tyrosinase inhibitor: 4-(6,7-dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol (MHY1556)
    June Whan Park
    Molecular Inflammation Research Centre for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Kumjeong gu, Busan 609 735, Republic of Korea
    Bioorg Med Chem Lett 23:4172-6. 2013
    ..The tyrosinase activity assay results with MHY1556 also support its potent inhibitory effects. Therefore, our data strongly suggest MHY1556 suppresses the melanogenesis via a tyrosinase inhibitory effect. ..
  31. doi request reprint The anti-inflammatory action of fermented soybean products in kidney of high-fat-fed rats
    Jehun Choi
    Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, San 30, Jangjeon Dong, Geumjeong Gu, Busan, 609 735, Republic of Korea
    J Med Food 14:232-9. 2011
    ..Based on these results, we conclude that Korean traditional soybean fermented products, especially CGJ, suppress the generation of reactive species, NF-κB activity, and NF-κB-related inflammatory genes...
  32. ncbi request reprint 4-(6-Hydroxy-2-naphthyl)-1,3-bezendiol: a potent, new tyrosinase inhibitor
    Young Mi Ha
    Department of Pharmacy, Pusan National University, Kumjeong gu, Busan 609 735, Korea
    Biol Pharm Bull 30:1711-5. 2007
    ..In addition to tyrosinase inhibiting activity, melanin biosynthesis was inhibited by HNB in the B16F10 cells. These data strongly suggest that HNB can suppress the production of melanin via the modulation of tyrosinase activity...
  33. ncbi request reprint Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde
    Dae Hyun Kim
    College of Pharmacy, Pusan National University, San 30, Jangjun dong, Gumjung gu, Busan 609 735, Korea
    Biogerontology 8:545-54. 2007
    ..Thus, the significance of the current study is the new information revealing the anti-inflammatory properties of CNA and the role it plays in the regulation of age-related alterations in signal transduction pathways...
  34. doi request reprint Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors
    Young Mi Ha
    Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Kumjeong gu, Busan 609 735, Republic of Korea
    Biochimie 94:533-40. 2012
    ..Also, 2g effectively inhibited tyrosinase activity and reduced melanin levels in B16 cells treated with α-MSH. These data strongly suggest that 2g can suppress the production of melanin via the inhibition of tyrosinase activity...
  35. doi request reprint Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats
    Dong Su Shin
    College of Pharmacy, Pusan National University, Busan, 609 735, Korea
    Arch Pharm Res 36:626-33. 2013
    ..Sinapic acid may thus have potential as a therapeutic agent for suppressing hepatic inflammation...
  36. doi request reprint Suppression of melanogenesis by a newly synthesized compound, MHY966 via the nitric oxide/protein kinase G signaling pathway in murine skin
    Yeon Ja Choi
    Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Busan 609 735, Republic of Korea
    J Dermatol Sci 68:164-71. 2012
    ..In an attempt to find a novel anti-melanogenic agent, we synthesized a new compound, 2-bromo-4-(5-chloro-benzo[d]thiazol-2-yl) phenol (MHY966)...
  37. ncbi request reprint Betaine modulates age-related NF-kappaB by thiol-enhancing action
    Eun Kyung Go
    Department of Pharmacy, College of Pharmacy, Pusan National University, Gumjung ku, Busan 609 735, Korea
    Biol Pharm Bull 30:2244-9. 2007
    ..Based on both in vivo and in vitro data, we concluded that betaine exerts its efficacy by maintaining thiol status in the regulation of COX-2 and TNFalpha via NF-kappaB activation during aging...
  38. doi request reprint Modulation of NF-κB and FOXOs by baicalein attenuates the radiation-induced inflammatory process in mouse kidney
    Eun Kyeong Lee
    College of Pharmacy, Pusan National University, Busan 609 735, Republic of Korea
    Free Radic Res 45:507-17. 2011
    ..Thus, these findings provide new insights into the molecular mechanism underlying the radioprotective role of baicalein in mice...
  39. ncbi request reprint Induction of endothelial apoptosis by 4-hydroxyhexenal
    Ji Young Lee
    Genetic Engineering Research Institute, Pusan National University, Busan, Korea
    Eur J Biochem 271:1339-47. 2004
    ..During aging, increased lipid peroxidation and its associated production of HHE may exacerbate the weakened redox balance, leading to various chronic degenerative processes including vascular dysfunction...
  40. ncbi request reprint Down-regulation of iNOS and TNF-alpha expression by kaempferol via NF-kappaB inactivation in aged rat gingival tissues
    Hyung Keun Kim
    Department of Oral Pathology, School of Dentistry, Pusan National University, Busan, 602 739, Korea
    Biogerontology 8:399-408. 2007
    ..Kaempferol may inhibit ROS generation via the inhibition of iNOS and TNF-alpha expression in aged gingival tissues, via the modulation of the NF-kappaB and mitogen-activated protein kinase (MAPK) pathways...
  41. ncbi request reprint NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway
    Jeong Hwan Je
    Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609 735, Republic of Korea
    FEBS Lett 566:183-9. 2004
    ..These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 MAPK and ERK activation associated with oxidative stress in endothelial cells...
  42. doi request reprint The anti-inflammatory effect of kaempferol in aged kidney tissues: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinase pathways
    Min Ju Park
    Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, Republic of Korea
    J Med Food 12:351-8. 2009
    ..Based on these results, we concluded that anti-oxidative kaempferol suppressed the activation of inflammatory NF-kappaB transcription factor through NIK/IKK and MAPKs in aged rat kidney...
  43. doi request reprint Inhibitory effects of 6-(3-hydroxyphenyl)-2-naphthol on tyrosinase activity and melanin synthesis
    Sang Woon Chung
    College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan 609 735, Korea
    Arch Pharm Res 32:289-94. 2009
    ..Results show that HPN inhibited tyrosinase activity and reduced melanin in B16 cells. Therefore, our data indicate HPN as a new candidate for depigmentation reagents...
  44. doi request reprint Cytoprotective roles of senescence marker protein 30 against intracellular calcium elevation and oxidative stress
    Tae Gen Son
    Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Busan, Korea
    Arch Pharm Res 31:872-7. 2008
    ..Taken together, our results suggest that external calcium regulation and antioxidant properties are involved in the cytoprotective mechanism of SMP30...
  45. pmc Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice
    Min Hi Park
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan, Korea Laboratory of Biochemistry, Pusan National University, Busan, Korea
    PLoS ONE 8:e78815. 2013
    ....
  46. ncbi request reprint Peroxynitrite scavenging mode of alaternin isolated from Cassia tora
    Tae Hyun Park
    College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan 609 735, Korea
    J Pharm Pharmacol 56:1315-21. 2004
    ..We believe alaternin can be developed as an effective ONOO- scavenger for the prevention of ONOO- -associated diseases...
  47. pmc Inhibition of NF-κB-induced inflammatory responses by angiotensin II antagonists in aged rat kidney
    Ji Min Kim
    Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, Republic of Korea
    Exp Gerontol 46:542-8. 2011
    ..Only losartan lowered levels of 5-lipoxygenase (5-LOX). These findings indicate that enalapril and losartan differentially suppress inflammatory responses via inhibition of oxidative stress-induced NF-κB activation in aged rat kidney...
  48. doi request reprint Evaluation of in vitro and in vivo anti-melanogenic activity of a newly synthesized strong tyrosinase inhibitor (E)-3-(2,4 dihydroxybenzylidene)pyrrolidine-2,5-dione (3-DBP)
    Ki Wung Chung
    MRCA, Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 609 735, Republic of Korea
    Biochim Biophys Acta 1820:962-9. 2012
    ..A search for new agents with strong tyrosinase activity led to the synthesis of the tyrosinase inhibitor (E)-3-(2,4-dihydroxybenzylidene)pyrrolidine-2,5-dione (3-DBP)...
  49. ncbi request reprint Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin
    Ji Young Kim
    College of Pharmacy, Pusan National University, Busan, Korea
    Aging Cell 5:401-11. 2006
    ..The most significant findings of the current study report new information on the use of hesperetin as a potential anti-aging agent...
  50. doi request reprint Ferulate protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in tert-butyl hydroperoxide-induced Caco-2 cells
    Hyun Jung Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, Pusan National University, Busan, Korea
    Phytother Res 27:362-7. 2013
    ..The most significant finding of our study is the demonstration of protective, ferulate-mediated antioxidant effects on barrier integrity, with a particular focus on intracellular molecular mechanisms...
  51. doi request reprint A novel resveratrol analogue, HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells
    Dong Hwan Kim
    Department of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609 735, Republic of Korea
    Int J Oncol 43:1915-24. 2013
    ..Taken together, these results implied that HS-1793, a novel analogue of resveratrol, may be a new potent chemopreventive agent against human prostate cancer cells...
  52. doi request reprint Synthesis and preliminary in vitro biological evaluation of 5-chloro-2-(substituted phenyl)benzo[d]thiazole derivatives designed as novel antimelanogenesis agents
    Young Mi Ha
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Busan 609 735, Republic of Korea
    Appl Biochem Biotechnol 168:1416-33. 2012
    ..These data strongly suggest that the newly synthesized compounds MHY884 and MHY966 could suppress production of melanin via inhibition of tyrosinase activity...
  53. doi request reprint Mechanism of attenuation of pro-inflammatory Ang II-induced NF-κB activation by genistein in the kidneys of male rats during aging
    Ji Min Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Korea
    Biogerontology 12:537-50. 2011
    ..Based on these data, genistein may be an anti-Ang II agent that may be used in anti-inflammatory therapies...
  54. ncbi request reprint Aging effect on myeloperoxidase in rat kidney and its modulation by calorie restriction
    Tae Gen Son
    Department of Pharmacy, College of Pharmacy, Aging Tissue Bank, Longevity Life Science and Technology Institutes, Pusan National University, Gumjung gu, Busan 609 735, South Korea
    Free Radic Res 39:283-9. 2005
    ..We propose that age-related alterations of MPO, dityrosine, and VCAM were modulated by CR through its anti-inflammatory action...
  55. doi request reprint Characterization of a small molecule inhibitor of melanogenesis that inhibits tyrosinase activity and scavenges nitric oxide (NO)
    Ki Wung Chung
    Department of Pharmacy, Pusan National University, Busan, Republic of Korea
    Biochim Biophys Acta 1830:4752-61. 2013
    ..During our on-going search for new agents with an inhibitory effect on tyrosinase, we synthesized a new type of tyrosinase inhibitor, 4-(thiazolidin-2-yl)benzene-1,2-diol (MHY-794), which directly inhibits mushroom tyrosinase...
  56. doi request reprint Inhibitory action of salicylideneamino-2-thiophenol on NF-κB signaling cascade and cyclooxygenase-2 in HNE-treated endothelial cells
    Seongjoon Park
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Jangjeon Dong, Geumjeong Gu, Busan, 609 735, South Korea
    Arch Pharm Res 36:880-9. 2013
    ..Based on these data, we propose that with its combined effect on strong anti-oxidant and anti-inflammatory action, SAL-2 can be a potent anti-inflammatory agent for treatment of inflammatory-related diseases. ..
  57. doi request reprint 5-Hydroxytrytophan inhibits tert-butylhydroperoxide (t-BHP)-induced oxidative damage via the suppression of reactive species (RS) and nuclear factor-kappaB (NF-kappaB) activation on human fibroblast
    Sung Jin Bae
    Department of Pharmacy, Pusan National University, Busan 609 735, Korea
    J Agric Food Chem 58:6387-94. 2010
    ..Data further showed that the protective mechanisms underlying the actions of 5HTP against oxidative stress-induced damage are associated with RS/ONOO(-) scavenging and the inhibition of lipid peroxidation and GSH depletion...
  58. ncbi request reprint The effect of age and calorie restriction on HIF-1-responsive genes in aged liver
    Min Ju Kang
    College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan, Korea
    Biogerontology 6:27-37. 2005
    ..We propose that age-related HIF-1 binding activity may well be influenced by the increased pro-oxidative conditions of aged animals, which up-regulate HIF-1-dependent gene expression...
  59. doi request reprint Lysophosphatidylcholine enhances oxidative stress via the 5-lipoxygenase pathway in rat aorta during aging
    Yani Zou
    College of Pharmacy, Aging Tissue Bank, Busan, South Korea
    Rejuvenation Res 12:15-24. 2009
    ..LPC may well be an important contributor to age-related oxidative stress in aging aorta...
  60. doi request reprint Anti-melanogenic effect of (Z)-5-(2,4-dihydroxybenzylidene) thiazolidine-2,4-dione, a novel tyrosinase inhibitor
    So Hee Kim
    College of Pharmacy, Pusan National University, Kumjeong gu, Busan, 609 735, Republic of Korea
    Arch Pharm Res 36:1189-97. 2013
    ..These findings suggest that MHY498 could be useful as an antimelanogenic agent for the prevention and treatment of diseases associated with skin pigmentation...
  61. ncbi request reprint Activation mechanisms of endothelial NF-kappaB, IKK, and MAP kinase by tert-butyl hydroperoxide
    Ji Young Lee
    Genetic Engineering Research Institute, Aging Tissue Bank, Pusan National University, Busan 609 735, North Korea
    Free Radic Res 39:399-409. 2005
    ..The t-BHP-induced activation of NF-kappaB and MAPK could be a major player in vascular dysfunctions, as seen in oxidative stressed responses and the vascular inflammatory process...
  62. ncbi request reprint Hydroquinone modulates reactivity of peroxynitrite and nitric oxide production
    Ae Ra Kim
    College of Pharmacy, Pusan National University, Pusan 609 735, South Korea
    J Pharm Pharmacol 57:475-81. 2005
    ..The results suggest that hydroquinone may potently modulate reactivity of ONOO(-) and may therefore be a useful agent against ONOO(-) mediated diseases...
  63. ncbi request reprint 3-methyl-1,2-cyclopentanedione down-regulates age-related NF-kappaB signaling cascade
    Jae Heun Chung
    College of Pharmacy, Pusan National University, Busan 609 735, Korea
    J Agric Food Chem 55:6787-92. 2007
    ..Therefore, 3-MCP is proposed to be an effective anti-inflammatory agent that can be a novel approach for the therapy of inflammation...
  64. doi request reprint Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-kappaB signaling in the inflammatory process and aging
    Kyung Jin Jung
    Department of Pharmacy, College of Pharmacy and Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609 735, Korea
    Free Radic Biol Med 47:983-91. 2009
    ..Thus, our data suggest, for the first time, that the delicate balance between PTK and PTP is disturbed during aging and inflammation, both of which lead to NF-kappaB activation via NIK/IKK and MAPKs...
  65. doi request reprint Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice
    Dong Hwan Kim
    Department of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan, Republic of Korea
    Int J Oncol 43:1652-8. 2013
    ..Our findings suggest that baicalein is one of the candidates for the prevention of inflammation-associated colon carcinogenesis...
  66. doi request reprint Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors
    Young Mi Ha
    Molecular Inflammation Research Center for Aging Intervention MRCA, College of Pharmacy, Pusan National University, Kumjeong gu, Busan, Republic of Korea
    Eur J Med Chem 49:245-52. 2012
    ..These data strongly suggest that compounds 2a and 2f suppress the production of melanin via the inhibition of tyrosinase activity...
  67. ncbi request reprint D-pinitol inhibits Th1 polarization via the suppression of dendritic cells
    Jun Sik Lee
    Department of Pharmacy, Pusan National University College of Pharmacy, Busan, South Korea
    Int Immunopharmacol 7:791-804. 2007
    ....
  68. doi request reprint Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells
    Hye Jung Hwang
    Division of Pharmacy, College of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 609 735, Republic of Korea
    Int J Oncol 41:2057-64. 2012
    ..These results suggest that MHY-449 may be a useful candidate for chemo-prevention and/or treatment of colon cancer...
  69. doi request reprint A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-κB in HCT116 human colon cancer cells
    Mi Kyeong Kim
    Division of Pharmacy, College of Pharmacy, Molecular Inflammation Research Center for Aging Intervention MRCA, Pusan National University, Busan 609 735, Republic of Korea
    Int J Oncol 44:256-64. 2014
    ..These results suggest that MHY218 may be a useful candidate to be used in the chemoprevention and/or treatment of colon cancer...
  70. ncbi request reprint Amelioration of age-related inflammation and oxidative stress by PPARgamma activator: suppression of NF-kappaB by 2,4-thiazolidinedione
    Bokyung Sung
    College of Pharmacy, Pusan National University, Jangjeon Dong, Geumjeong Gu, Busan 609 735, South Korea
    Exp Gerontol 41:590-9. 2006
    ..We propose that 2,4-TZD or other potent PPARgamma activators may be useful in the therapy against age-related inflammation...
  71. ncbi request reprint The redox-sensitive DNA binding sites responsible for age-related downregulation of SMP30 by ERK pathway and reversal by calorie restriction
    Kyung Jin Jung
    Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, Korea
    Antioxid Redox Signal 8:671-80. 2006
    ..Perhaps a more significant finding of the present study is that the downregulation of SMP30 is likely involved in ERK signal pathway...
  72. doi request reprint A new synthetic HDAC inhibitor, MHY218, induces apoptosis or autophagy-related cell death in tamoxifen-resistant MCF-7 breast cancer cells
    Ji Hye Park
    College of Pharmacy and MRC Center, Pusan National University, San 30, Jangjeon Dong, Geumjeong Gu, Busan, 609 735, Republic of Korea
    Invest New Drugs 30:1887-98. 2012
    ..The MHY218-induced autophagic cell death could be a new strategy in the treatment of Tam-resistant human breast cancer...
  73. doi request reprint Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors
    Yu Min Song
    Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Busan 609 735, Republic of Korea
    Bioorg Med Chem Lett 22:7451-5. 2012
    ..Among the synthesized azo compounds, azo-resveratrol (5) showed the most potent mushroom tyrosinase inhibition with an IC(50) value of IC(50)=36.28 ± 0.72 μM, comparable to that of resveratrol, a well-known tyrosinase inhibitor...
  74. ncbi request reprint Modulation of redox-sensitive transcription factors by calorie restriction during aging
    Hyon Jeen Kim
    Department of Pharmacy, College of Pharmacy, Pusan National University, Gumjung gu, Busan 609 735, South Korea
    Mech Ageing Dev 123:1589-95. 2002
    ..Data on cellular regulation provide better molecular insights into the mechanisms underlying cellular redox maintenance, which may be the cross-talk between normal aging and age-associated pathogenic processes...
  75. ncbi request reprint Effect of short-term, low dose aspirin supplementation on the activation of pro-inflammatory NF-kappaB in aged rats
    Kyung Jin Jung
    Department of Pharmacy, College of Pharmacy, Aging Tissue Bank, Pusan National University, Gumjung gu, Busan 609 735, Republic of Korea
    Mech Ageing Dev 127:223-30. 2006
    ..These findings showed for the first time that in aged rat short-term low dose dietary aspirin feeding modulates the molecular signal transduction involved in the inflammatory process...
  76. ncbi request reprint Suppression of apoptosis by calorie restriction in aged kidney
    Ji Hyeon Lee
    Department of Pharmacy, Aging Tissue Bank, Pusan National University, Gumjung ku, Busan 609 735, South Korea
    Exp Gerontol 39:1361-8. 2004
    ..Thus, our present data strongly suggest that the apoptotic activity observed in the aged kidney is likely modulated by the age-related oxidative status, and reversed by CR as a result of its anti-oxidative and anti-aging actions...
  77. ncbi request reprint Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process
    Kyung Jin Jung
    Department of Pharmacy, Aging Tissue Bank, Pusan National University, Gumjung ku, Busan 609 735, Republic of South Korea
    Exp Gerontol 39:1169-77. 2004
    ..The potent anti-aging and anti-oxidative action of CR effectively suppressed the age-related down-regulation of SMP-30 by ROS reduction...
  78. ncbi request reprint cDNA representational difference analysis used in the identification of genes related to the aging process in rat kidney
    Bokyung Sung
    College of Pharmacy, Aging Tissue Bank, Pusan National University, Jangjeon Dong, Geumjeong ku, Busan 609 735, South Korea
    Mech Ageing Dev 126:882-91. 2005
    ..These data suggested that the inflammatory process is a plausible cause of the aging process...
  79. ncbi request reprint Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction
    Yani Zou
    College of Pharmacy, Pusan National University, Busan 609 735, Korea
    FASEB J 18:320-2. 2004
    ..These findings suggest that the altered expressions of sAMs may be due to increased oxidative stress with advanced age and that these increases were prevented by CR through its antioxidative action...
  80. ncbi request reprint Betaine suppresses proinflammatory signaling during aging: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinases
    Eun Kyung Go
    Department of Pharmacy, College of Pharmacy, Pusan National University, Jang Jun dong, Gumjung ku, Busan, Korea
    J Gerontol A Biol Sci Med Sci 60:1252-64. 2005
    ..Thus, betaine might be useful as a preventive agent against the activation of NF-kappaB induced during inflammation and aging...
  81. ncbi request reprint Proteomic analysis of post-mitochondrial fractions of young and old rat kidney
    Chul Hong Kim
    Interdisciplinary Research Program of Bioinformatics, Pusan National University, Gumjung ku, Busan 609 735, South Korea
    Exp Gerontol 39:1155-68. 2004
    ..Thus, our results demonstrated that proteomic analysis can be effectively applied to the assessment of the age status of protein expression, and thereby provide valuable information on age-related changes of proteome...
  82. ncbi request reprint Influence of aging and calorie restriction on MAPKs activity in rat kidney
    Hyon Jeen Kim
    Department of Pharmacy, College of Pharmacy, Pusan National University, Gumjung ku, Pusan 609 735, South Korea
    Exp Gerontol 37:1041-53. 2002
    ..Based on these data, we concluded that an age-related increase in MAPK activity is associated with increased ROS, which was effectively suppressed by the anti-oxidative action of CR...
  83. ncbi request reprint Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process
    Chong Gun Cho
    Department of Molecular Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Exp Gerontol 38:539-48. 2003
    ..Our conclusion is that a redox imbalance occurs during aging and that redox changes are minimized through the anti-oxidative action of CR...
  84. ncbi request reprint Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise
    Zsolt Radak
    Laboratory of Exercise Physiology, School of Sport Science, Semmelweis University, Budapest, Hungary
    FASEB J 18:749-50. 2004
    ....
  85. ncbi request reprint SMP30 deficiency causes increased oxidative stress in brain
    Tae Gen Son
    Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong Gu, Busan, South Korea
    Mech Ageing Dev 127:451-7. 2006
    ..Our results documented that brain SMP30 has a protective action against oxidative damage, without influencing antioxidant enzyme status...
  86. ncbi request reprint Hesperetin: a potent antioxidant against peroxynitrite
    Ji Young Kim
    College of Pharmacy, Aging Tissue Bank, Pusan National University, Gumjung gu, Busan 609 735, South Korea
    Free Radic Res 38:761-9. 2004
    ..The present study suggests that hesperetin is a powerful ONOO- scavenger and promotes cellular defense activity in the protection against ONOO- involved diseases...