G H Kang

Summary

Affiliation: Seoul National University
Country: Korea

Publications

  1. doi Improved results of LINE-1 methylation analysis in formalin-fixed, paraffin-embedded tissues with the application of a heating step during the DNA extraction process.
    Xianyu Wen
    Department of Pathology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, South Korea
    Clin Epigenetics 9:1. 2017
  2. pmc Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients
    Duo Chen
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China
    Clin Epigenetics 8:36. 2016
  3. pmc Synchronous mucosal Schwann-cell hamartomas in a young adult suggestive of mucosal Schwann-cell harmatomatosis: a case report
    Jeong Mo Bae
    Department of Pathology, the Armed Forces Capital Hospital, 81, Saemaeul ro 177beon gil, Bundang gu, Seongnam si, Gyeonggi Do, 463 040, South Korea
    BMC Gastroenterol 15:128. 2015
  4. pmc Prognostic influence of body mass index and body weight gain during adjuvant FOLFOX chemotherapy in Korean colorectal cancer patients
    Dae Won Lee
    Department of Internal Medicine, Seoul National University Hospital, 101 Daehang ro, Jongno gu, Seoul, 110 744, South Korea
    BMC Cancer 15:690. 2015
  5. doi Tumoral LINE-1 hypomethylation is associated with poor survival of patients with intrahepatic cholangiocarcinoma
    Seorin Jeong
    Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    BMC Cancer 17:588. 2017
  6. pmc The influence of the treatment response on the impact of resection margin status after preoperative chemoradiotherapy in locally advanced rectal cancer
    Joo Ho Lee
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 13:576. 2013
  7. pmc Methylation profiles of CpG island loci in major types of human cancers
    Seog Yun Park
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 22:311-7. 2007
  8. pmc Identification of novel methylation markers in hepatocellular carcinoma using a methylation array
    So Hyun Shin
    Laboratory of Epigenetics, Cancer Research Institute and Brain Korea 2nd Stage, Seoul National University, Seoul, Korea
    J Korean Med Sci 25:1152-9. 2010
  9. pmc Pharmacological unmasking microarray approach-based discovery of novel DNA methylation markers for hepatocellular carcinoma
    Namhee Jung
    Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 27:594-604. 2012
  10. pmc CpG island hypermethylation in gastric carcinoma and its premalignant lesions
    Gyeong Hoon Kang
    Department of Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Korean J Pathol 46:1-9. 2012

Collaborators

Detail Information

Publications75

  1. doi Improved results of LINE-1 methylation analysis in formalin-fixed, paraffin-embedded tissues with the application of a heating step during the DNA extraction process.
    Xianyu Wen
    Department of Pathology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, South Korea
    Clin Epigenetics 9:1. 2017
    ..The application of prolonged heating of DNA samples improves bisulfite conversion-based measurement of LINE-1 or single gene methylation levels in FFPE tissue samples...
  2. pmc Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients
    Duo Chen
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China
    Clin Epigenetics 8:36. 2016
    ....
  3. pmc Synchronous mucosal Schwann-cell hamartomas in a young adult suggestive of mucosal Schwann-cell harmatomatosis: a case report
    Jeong Mo Bae
    Department of Pathology, the Armed Forces Capital Hospital, 81, Saemaeul ro 177beon gil, Bundang gu, Seongnam si, Gyeonggi Do, 463 040, South Korea
    BMC Gastroenterol 15:128. 2015
    ..Mucosal Schwann-cell hamartoma is a rare mesenchymal polyp that presents in the intestine. Despite lacking ganglion cells, it resembles a gastrointestinal ganglioneuroma...
  4. pmc Prognostic influence of body mass index and body weight gain during adjuvant FOLFOX chemotherapy in Korean colorectal cancer patients
    Dae Won Lee
    Department of Internal Medicine, Seoul National University Hospital, 101 Daehang ro, Jongno gu, Seoul, 110 744, South Korea
    BMC Cancer 15:690. 2015
    ..However, the effect of obesity and body weight gain in Asian colorectal cancer patients treated with adjuvant chemotherapy has not been studied thus far...
  5. doi Tumoral LINE-1 hypomethylation is associated with poor survival of patients with intrahepatic cholangiocarcinoma
    Seorin Jeong
    Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    BMC Cancer 17:588. 2017
    ..However, little information is available regarding LINE-1 hypomethylation and its prognostic implication in intrahepatic cholangiocarcinomas...
  6. pmc The influence of the treatment response on the impact of resection margin status after preoperative chemoradiotherapy in locally advanced rectal cancer
    Joo Ho Lee
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    BMC Cancer 13:576. 2013
    ..Effect and adequate length of resection margin as well as impact of treatment response after preoperative CRT was evaluated...
  7. pmc Methylation profiles of CpG island loci in major types of human cancers
    Seog Yun Park
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 22:311-7. 2007
    ..The findings indicate that aberrant CpG island hypermethylation is a frequent finding in human cancers of various tissue types, and each tissue type has its own distinct methylation pattern...
  8. pmc Identification of novel methylation markers in hepatocellular carcinoma using a methylation array
    So Hyun Shin
    Laboratory of Epigenetics, Cancer Research Institute and Brain Korea 2nd Stage, Seoul National University, Seoul, Korea
    J Korean Med Sci 25:1152-9. 2010
    ..Further study will be required to elucidate the clinicopathological implications of these newly found DNA methylation markers in hepatocellular carcinoma...
  9. pmc Pharmacological unmasking microarray approach-based discovery of novel DNA methylation markers for hepatocellular carcinoma
    Namhee Jung
    Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 27:594-604. 2012
    ..022 and P = 0.010, respectively). In conclusion, we identified 221 novel DNA methylation markers for HCC. One promising prognostic marker, HIST1H2AE, should be further validated in the prognostication of HCC patients...
  10. pmc CpG island hypermethylation in gastric carcinoma and its premalignant lesions
    Gyeong Hoon Kang
    Department of Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Korean J Pathol 46:1-9. 2012
    ..In this review, a variety of information is summarized regarding CpG island hypermethylation in gastric cancer...
  11. pmc The CpG island methylator phenotype may confer a survival benefit in patients with stage II or III colorectal carcinomas receiving fluoropyrimidine-based adjuvant chemotherapy
    Byung Hoon Min
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    BMC Cancer 11:344. 2011
    ..Identification of CIMP status in CRC is important for proper patient management. In Eastern countries, however, the clinicopathologic and molecular characteristics and prognosis of CRCs with CIMP are still unclear...
  12. ncbi DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis
    Gyeong Hoon Kang
    Department of Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Lab Invest 88:161-70. 2008
    ..Through our large-scale screening of 170 CpG island loci, we found 17 new DNA methylation markers of GC, which may serve as useful markers that may identify a distinct subset of GC...
  13. ncbi Profile of aberrant CpG island methylation along multistep gastric carcinogenesis
    Gyeong Hoon Kang
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Lab Invest 83:519-26. 2003
    ..Our results suggest that tumor-suppressor genes show a gene-type specific methylation profile along the multistep carcinogenesis and that aberrant CpG island methylation tend to accumulate along the multistep carcinogenesis...
  14. ncbi Profile of methylated CpG sites of hMLH1 promoter in primary gastric carcinoma with microsatellite instability
    Gyeong Hoon Kang
    Department of Pathology, Seoul National University College of Medicine and Cancer Research Institute, Seoul, Korea
    Pathol Int 52:764-8. 2002
    ..Our study suggests that methylation of a more upstream region observed in colon cancer cell lines may be an acquired change during cell line establishment and it was not identified in primary gastric carcinomas without MSI...
  15. ncbi Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis
    Gyeong Hoon Kang
    Department of Pathology, Seoul National University College of Medicine and Cancer Research Institute, Seoul, Korea
    Lab Invest 83:635-41. 2003
    ..Our results suggest that tumor suppressor genes show a gene type-specific methylation profile and that aberrant CpG island methylation tends to accumulate along the pathway of multistep carcinogenesis...
  16. pmc Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma
    Gyeong Hoon Kang
    Department of Pathology, Seoul NationalUniversity College of Medicine and Cancer Research Institute, Seoul, Korea
    Am J Pathol 160:787-94. 2002
    ..These results demonstrate a relationship between EBV and aberrant methylation in GC and suggest that aberrant methylation may be an important mechanism of EBV-related gastric carcinogenesis...
  17. ncbi CpG island methylation in premalignant stages of gastric carcinoma
    G H Kang
    Department of Pathology, Seoul National University College of Medicine and Cancer Research Institute, Korea
    Cancer Res 61:2847-51. 2001
    ..001) as well as from premalignant lesions to carcinomas (P = 0.002). These results suggest that CpG island hypermethylation occur early in multistep gastric carcinogenesis and tend to accumulate along the multistep carcinogenesis...
  18. pmc Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation
    Gyeong Hoon Kang
    Department of Pathology and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Am J Pathol 163:1551-6. 2003
    ....
  19. doi Four molecular subtypes of colorectal cancer and their precursor lesions
    Gyeong Hoon Kang
    Department of Pathology, Cancer Research Institute, Brain Korea 2nd Stage, Seoul National University College of Medicine, Korea
    Arch Pathol Lab Med 135:698-703. 2011
    ..There are differences between Western (United States and European Union) and Eastern (Korea and China) populations in the number of CRCs that are MSI+, and in the number of MSI+ CRCs that are CIMP+...
  20. ncbi Methylation of the hMLH1 promoter in multiple gastric carcinomas with microsatellite instability
    H Y Jung
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Pathol Int 51:445-51. 2001
    ..None of the tumors showed hMSH2 hypermethylation. These results suggest that epigenetic changes in the hMLH1 promoter account for the genesis of multiple gastric carcinoma with high frequency MSI...
  21. pmc Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location
    J M Bae
    Department of Pathology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    Br J Cancer 109:1004-12. 2013
    ..However, the differential effects of the CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the clinical outcome according to tumour location are not well-known...
  22. ncbi Correlation of methylation of the hMLH1 promoter with lack of expression of hMLH1 in sporadic gastric carcinomas with replication error
    G H Kang
    Department of Pathology, Ulsan University College of Medicine, Asan Medical Center, Seoul, Korea
    Lab Invest 79:903-9. 1999
    ..These results suggest that hypermethylation of the hMLH1 promoter region may be the principal mechanism of gene inactivation in sporadic gastric carcinomas with a high frequency of MSI...
  23. pmc Prognostic implication of mucinous histology in colorectal cancer patients treated with adjuvant FOLFOX chemotherapy
    D W Lee
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
    Br J Cancer 108:1978-84. 2013
    ..There have been controversies in prognostic impact of mucinous histology on colorectal cancer, and its implication in patients treated with adjuvant 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is unclear...
  24. ncbi Gross type-matched study of clinicopathologic features of advanced gastric carcinoma with replication error
    G H Kang
    Department of Diagnostic Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Pathol Int 49:1053-9. 1999
    ..Most of the previously known clinicopathological features of RER+ AGC were related to Borrmann type 2, except for female sex, older age, expanding pattern, and low DNA index...
  25. ncbi Somatic mutations of the first 14 exons of APC in hamartomatous polyps of the colon
    J C Kim
    Laboratory of Gastrointestinal Cancer Biology and Genetics, Department of Surgery, University of Ulsan College of Medicine and Asan Institute for Life Sciences, 388 1 Poongnap dong, Songpa Ku, Seoul, Korea
    Hum Mutat 14:351-2. 1999
    ..Since all mutations were missense or silent mutations occurred in exons not previously known to have functionally relevant area, their phenotypic implication appeared to be limited...
  26. ncbi Clinicopathologic characteristics of replication error-positive gastric carcinoma
    G H Kang
    Department of Diagnostic Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea
    Mod Pathol 12:15-20. 1999
    ..In conclusion, RER+ gastric carcinomas demonstrated distinct clinicopathologic features, and BAT-26 was a useful marker for assessing the RER status of gastric carcinomas...
  27. ncbi Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas
    Y H Shim
    Department of Diagnostic Pathology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
    Lab Invest 80:689-95. 2000
    ..The relatively high frequency of hypermethylation on p16 and the strong correlation between the immunoreactivity and methylation patterns suggest that methylation is an important mechanism for p16 gene inactivation in GC...
  28. pmc Isolated splenic metastasis from colorectal carcinoma: a case report
    J C Kim
    Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
    J Korean Med Sci 15:355-8. 2000
    ..As all reported cases showed elevated serum CEA at the time of metastasis, isolated splenic metastasis might be associated with CEA in regard to its biological functions of immunosuppression and adhesion...
  29. doi Helicobacter pylori-infection-associated CpG island hypermethylation in the stomach and its possible association with polycomb repressive marks
    Eun Joo Yoo
    Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    Virchows Arch 452:515-24. 2008
    ..pylori infection strongly induces CGI hypermethylation in gastric epithelial cells and that susceptibility to H. pylori-induced DNA hypermethylation may be determined by Polycomb repressive marks in stem or progenitor cells...
  30. ncbi Hypermethylation of CpG island loci and hypomethylation of LINE-1 and Alu repeats in prostate adenocarcinoma and their relationship to clinicopathological features
    N Y Cho
    Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Pathol 211:269-77. 2007
    ....
  31. ncbi Applicability of carcinoembryonic antigen-specific monoclonal antibodies to radioimmunoguided surgery for human colorectal carcinoma
    J C Kim
    Department of Surgery, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Seoul, Korea
    Cancer Res 60:4825-9. 2000
    ..66-pretreated mice. A study using specific anti-CEA MAbs suggested PR1A3 as an efficient immune probe for RIGS in colorectal carcinoma with a low rate of false-positive detection...
  32. doi Role of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis
    Cheol Min Shin
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Cancer Sci 101:1337-46. 2010
    ..pylori. Aberrant methylation of THBD might provide a link between H. pylori infection and development of GC...
  33. ncbi Distinct clinical features and outcomes of gastric cancers with microsatellite instability
    Hye Seung Lee
    Department of Pathology, Seoul National University College of Medicine, Korea
    Mod Pathol 15:632-40. 2002
    ..046). In conclusion, MSI+ phenotype in gastric cancers was found to have distinct clinicopathologic characteristics and to be predictive of a favorable outcome in advanced carcinoma...
  34. pmc Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    Sun Lee
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Am J Pathol 163:1371-8. 2003
    ..CpG island methylation of E-cadherin or GSTP1 might serve as a potential biomarker for prognostication of HCC patients...
  35. ncbi DNA hypermethylation in gastric cancer
    T Y Kim
    National Research Laboratory for Cancer Epigenetics, Cancer Research Institute, Seoul, Korea
    Aliment Pharmacol Ther 20:131-42. 2004
    ..Many genes involved in the regulation of cell cycle, tissue invasion, DNA repair and apoptosis have been shown to be inactivated by this type of epigenetic mechanism...
  36. ncbi Efficiency of combined colonoscopy and computed tomography for diagnosis of colonic actinomycosis: a retrospective evaluation of eight consecutive patients
    J C Kim
    Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
    Int J Colorectal Dis 15:236-42. 2000
    ..A combination of colonoscopy and CT appears to be important for both diagnosis and management because of their compensatory findings of mucosal and extramucosal lesions, respectively...
  37. ncbi Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia
    Gyeong Hoon Kang
    Department of Pathology and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Pathol 202:233-40. 2004
    ..CpG island methylation is a frequent event, occurs early, and accumulates during multi-step prostatic carcinogenesis. High levels of CpG island hypermethylation might serve as a potential biological marker for aggressive prostate cancer...
  38. ncbi Treatment guidelines for branch duct type intraductal papillary mucinous neoplasms of the pancreas: when can we operate or observe?
    Jin Young Jang
    Department of Surgery, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, South Korea
    Ann Surg Oncol 15:199-205. 2008
    ..However, no definite treatment guideline (with respect to surgery or observation) has been issued on the management of branch duct type IPMN...
  39. doi CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels
    Sun Lee
    Department of Pathology, Kyung Hee University College of Medicine, Seoul, Korea
    Arch Pathol Lab Med 132:1657-65. 2008
    ..Little is known about the clinical outcome or histologic characteristics of CIMP-positive colorectal cancers defined by recently identified CpG island methylator phenotype panels...
  40. doi Clinical and histological features of nonalcoholic fatty liver disease in children
    Jae Sung Ko
    Department of Pediatrics, Seoul National University College of Medicine, Jongrogu, Seoul 110 744, Korea
    Dig Dis Sci 54:2225-30. 2009
    ..Nonalcoholic fatty liver disease (NAFLD) is becoming more frequently diagnosed as the prevalence of obesity in children increases rapidly...
  41. ncbi Methylation profiles of multiple CpG island loci in extrahepatic cholangiocarcinoma versus those of intrahepatic cholangiocarcinomas
    Baek Hee Kim
    Department of Pathology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744 South Korea
    Arch Pathol Lab Med 131:923-30. 2007
    ..Extrahepatic cholangiocarcinoma has been poorly investigated with respect to CpG island hypermethylation, and the number of genes known to be methylated in extrahepatic cholangiocarcinomas is fewer than 20...
  42. doi Genomic hypomethylation and CpG island hypermethylation in prostatic intraepithelial neoplasm
    Nam Yun Cho
    Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    Virchows Arch 454:17-23. 2009
    ..020, 0.073, 0.033, respectively). These results suggest that genomic hypomethylation and CpG island hypermethylation, common among PCas, are early events in prostate carcinogenesis and may be implicated in the development of PIN...
  43. doi CpG island hypermethylation and repetitive DNA hypomethylation in premalignant lesion of extrahepatic cholangiocarcinoma
    Baek Hui Kim
    Department of Pathology, Korea University Medical School, Seoul, South Korea
    Virchows Arch 455:343-51. 2009
    ..These findings suggest that most of cancer-specific CpG island hypermethylation occur in the stage of BilIN and that CpG island hypermethylation seems to occur earlier than repetitive DNA element hypomethylation...
  44. doi Influence of IL1B polymorphism on CpG island hypermethylation in Helicobacter pylori-infected gastric cancer
    Eun Joo Yoo
    Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    Virchows Arch 456:647-52. 2010
    ..pylori infection and IL1B-511T/T allele...
  45. doi DNA methylation changes in ex-adenoma carcinoma of the large intestine
    Hyeong Ju Kwon
    Department of Pathology, Seoul National University College of Medicine, Chongno Gu, Seoul 110 744, South Korea
    Virchows Arch 457:433-41. 2010
    ....
  46. ncbi Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia
    Sun Lee
    Department of Pathology, National Cancer Center, Goyang, Gyeonggi, Korea
    Lab Invest 84:884-93. 2004
    ..It appears that CpG island methylation plays a more important role in proximal colon cancer development than in distal colon cancer development...
  47. doi Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer
    S H Song
    Cancer Genomics Research Laboratory, Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
    Oncogene . 2017
    ..Oncogene advance online publication, 6 November 2017; doi:10.1038/onc.2017.397...
  48. ncbi A spindle cell tumor of unknown origin and diffuse bone marrow involvement in a patient with hypercalcemia
    J J Yim
    Department of Internal Medicine and Cancer Research Center, Seoul National University College of Medicine, Korea
    Tumori 85:526-9. 1999
    ..CONCLUSIONS: We have documented a rare case of spindle cell tumor involving bone marrow without evidence of the tumor's primary site...
  49. ncbi Source of errors in the evaluation of early rectal cancer by endoluminal ultrasonography
    J C Kim
    Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
    Dis Colon Rectum 44:1302-9. 2001
    ..1 percent) of the 28 errors might have been avoided. Therefore, a clear image by endoluminal sonography can effectively distinguish mucosal from submucosal lesions in early rectal cancer...
  50. pmc Papillary immature metaplasia of the uterine cervix: a report of 5 cases with an emphasis on the differential diagnosis from reactive squamous metaplasia, high-grade squamous intraepithelial lesion and papillary squamous cell carcinoma
    G H Kang
    Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Korean Med Sci 16:762-8. 2001
    ..There were no significant differences of Ki-67 labeling index and mitotic index between PIM and SM. The expression of p53 varied among the groups and thus it was not helpful for the differential diagnosis...
  51. ncbi Panels of immunohistochemical markers help determine primary sites of metastatic adenocarcinoma
    Seog Yun Park
    Department of Pathology, Seoul National University College of Medicine and Cancer Research Institute, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Arch Pathol Lab Med 131:1561-7. 2007
    ..Because none of the individual immunohistochemical markers used for tissue identification are both site specific and site sensitive, multiple markers are needed to improve the prediction of primary sites...
  52. ncbi Histology of gastroesophageal junction in fetal and pediatric autopsy
    Young S Park
    Department of Pathology, Seoul National University College of Medicine and Seoul National University Hospital Clinical Research Institute, Seoul, Korea
    Arch Pathol Lab Med 127:451-5. 2003
    ..In one group, it was observed that cardiac mucosa was present in all pediatric autopsies. On the contrary, another group concluded that pure cardiac mucosa was absent in 56% of their autopsy cases...
  53. ncbi Pelioid-type hepatocellular carcinoma masquerading as a hepatic hemangioma on technetium-99m red blood cell scintigraphy
    E K Ji
    Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Clin Nucl Med 26:33-5. 2001
    ..Pathologic examination showed that the portion of the hepatocellular carcinoma that showed increased uptake on Tc-99m RBC scintigraphy had peliosis, which is the likely cause of the radiotracer avidity...
  54. doi Prognostic implications of and relationship between CpG island hypermethylation and repetitive DNA hypomethylation in hepatocellular carcinoma
    Hwan Seok Lee
    Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Clin Cancer Res 15:812-20. 2009
    ..The association of DNA methylation changes with clinicopathologic factors and the chronological ordering of DNA methylation changes along multistep hepatocarcinogenesis were also assessed...
  55. pmc Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma
    Sun Lee
    Department of Pathology, Seoul National University College of Medicine, Yongondong, Chongno Gu, Korea
    Am J Pathol 161:1015-22. 2002
    ....
  56. doi Feasibility of endoscopic papillectomy in early stage ampulla of Vater cancer
    Sang Myung Woo
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 24:120-4. 2009
    ..The present study was designed to assess the factors that predict malignancy and lymph node metastasis and to suggest potential indications for endoscopic papillectomy by analyzing clinicopathological data...
  57. pmc Hepatocyte expressions in hepatocellular carcinomas, gastrointestinal neoplasms, and non-neoplastic gastrointestinal mucosa: its role as a diagnostic marker
    Hye Seung Lee
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 18:842-8. 2003
    ..CD10 was detected in 46.7% (35/75) of HCCs, and canalicular staining pattern was predominant in HCCs. In conclusion, the expression of Hep and CD10 may help to distinguish HCCs from non-HCCs...
  58. ncbi Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma
    Sang Myung Woo
    Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, 28 Yeongeon dong, Jongno gu, Seoul, Korea ROK
    Ann Surg Oncol 14:3195-201. 2007
    ..Ampullary carcinoma is often considered to have a better prognosis than distal extrahepatic cholangiocarcinoma. However, studies that directly compare the recurrence and histopathological features between the two groups are rare...
  59. doi Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers
    Jung Ho Kim
    Department of Pathology, Seoul National University College of Medicine, 28 Yongon Dong, Jongno gu, Seoul, 110 744, South Korea
    Virchows Arch 455:485-94. 2009
    ..In conclusion, the CIMP+/MSI- subtype tends to present with distinct clinicopathological and molecular features and shows the worst clinical outcome among the four molecular subtypes of CRCs...
  60. doi Differential protein immunoexpression profiles in appendiceal mucinous neoplasms: a special reference to classification and predictive factors
    Sun Och Yoon
    Department of Pathology, Seoul National University Boramae Hospital, Seoul, Korea
    Mod Pathol 22:1102-12. 2009
    ..Five and more altered protein markers, p53 overexpression, NF-kappaB positivity, and beta-catenin loss were predictive factors of adverse clinical outcomes in appendiceal mucinous adenocarcinomas...
  61. ncbi BRAF and KRAS mutations in prostatic adenocarcinoma
    Nam Yun Cho
    Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Int J Cancer 119:1858-62. 2006
    ..Although BRAF and KRAS are members of the same RAS/ERK signaling pathway, prostate adenocarcinomas with a BRAF mutation showed clinicopathologic features that differed from those of prostate adenocarcinoma with a KRAS mutation...
  62. ncbi Association of promoter hypermethylation of the RASSF1A gene with prognostic parameters in endometrial cancer
    Hoenil Jo
    Department of Obstetrics and Gynecology, Seoul National University, Seoul, Korea
    Oncol Res 16:205-9. 2006
    ..8% and 97.0% at 5 years for methylated and unmethylated patients, respectively, p = 0.039). Our results suggest that RASSF1A hypermethylation might be a useful indicator of tumor aggressiveness in endometrial cancer patients...
  63. ncbi Synovial sarcoma of the kidney with rhabdoid features: report of three cases
    Sun Young Jun
    Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Am J Surg Pathol 28:634-7. 2004
    ..A subset of adult rhabdoid tumors may be a rhabdoid variant of synovial sarcoma, and molecular studies to detect SYT-SSX fusion transcripts are recommended for an accurate diagnosis...
  64. ncbi Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old
    Jae Hee Suh
    Department of Pathology, University of Ulsan College of Medicine, Seoul, Korea
    Dis Colon Rectum 45:219-28. 2002
    ....
  65. ncbi Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma
    Ji Woong Choi
    Department of Biochemistry and Molecular Biology, Cancer Research Institute, Seoul, South Korea
    Cancer Res 64:35-9. 2004
    ..In this study, we provide the first molecular evidence that Nur77 activated by HIF under hypoxic conditions regulates production of the peptide hormone precursor POMC...
  66. ncbi Multiphase contrast-enhanced CT imaging in hepatocellular carcinoma correlation with immunohistochemical angiogenic activities
    Young Il Kim
    Department of Radiology, Research Institute and Hospital, National Cancer Center, Seoul National University College of Medicine, 28, Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Acad Radiol 14:1084-91. 2007
    ....
  67. ncbi Nested PCR for diagnosis of tuberculous lymphadenitis and PCR-SSCP for identification of rifampicin resistance in fine-needle aspirates
    Gyungyub Gong
    Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Diagn Cytopathol 26:228-31. 2002
    ..In 7/22 (31.8%), rpoB mutation was observed. In conclusion, PCR is more sensitive in the detection of M. tuberculosis in FNA than Z-N. PCR-SSCP could also be used in FNA in the prediction of multidrug resistance...
  68. pmc CpG methylation in exon 1 of transcription factor 4 increases with age in normal gastric mucosa and is associated with gene silencing in intestinal-type gastric cancers
    Seung Kyoon Kim
    Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Department of Functional Genomics, University of Science and Technology, 52 Eoeun dong, Yuseong Gu, Daejeon 305 806, Republic of Korea
    Carcinogenesis 29:1623-31. 2008
    ..Based on these results, we propose that the observed frequent epigenetic-mediated TCF4 silencing plays a role in tumor formation and progression...
  69. doi Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion
    Mirang Kim
    Medical Genomics Research Center, KRIBB, Daejeon 305 806, Korea
    Carcinogenesis 29:629-37. 2008
    ..Based on these results, we propose that PKD1 is frequently silenced by epigenetic regulation, which plays a role in cell migration and metastasis in gastric cancer...
  70. ncbi Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma
    Bomsoo Cho
    Cancer Genomics Division, In2Gen Company, 110 799, Seoul, Republic of Korea
    Biochem Biophys Res Commun 307:52-63. 2003
    ....
  71. ncbi Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma
    Tai Young Kim
    National Research Laboratory for Cancer Epigenetics, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Lab Invest 84:479-84. 2004
    ..In conclusion, RUNX3 methylation is frequently found in human cancers, including gastric cancer, and is mostly cancer specific, with the exception of the stomach, and thus, might be useful as a potential diagnostic biomarker of cancer...
  72. ncbi Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer
    Sokbom Kang
    Department of Obstetrics and Gynecology, Seoul National University, 28 Yungun Dong, Chongno Ku, Seoul, 110 744, South Korea
    Gynecol Oncol 96:173-80. 2005
    ..This study was conducted to explore the association between the CpG island hypermethylation of tumor-associated genes and the polymorphisms of methyl group metabolizing enzymes in uterine cervical cancer...
  73. ncbi Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma
    Sokbom Kang
    Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Republic of Korea
    Int J Cancer 118:2168-71. 2006
    ..0% vs. 33.3%, p = 0.001). In conclusion, the existence of these unique methylation patterns in these cancers suggests that their tumorigenesis may involve different epigenetic mechanisms...
  74. ncbi CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Nat Genet 38:787-93. 2006
    ..Sporadic cases of mismatch repair deficiency occur almost exclusively as a consequence of CIMP-associated methylation of MLH1 . We propose a robust new marker panel to classify CIMP+ tumors...
  75. ncbi DNA hypomethylation of CAGE promotors in squamous cell carcinoma of uterine cervix
    Taek Sang Lee
    Department of Obstetrics and Gynecology and Cancer Research Institute, College of Medicine, Seoul National University, 28 Yungun Dong, Chongno Ku, Seoul 110 744, South Korea
    Ann N Y Acad Sci 1091:218-24. 2006
    ..It also provides a clue concerning the molecular mechanisms of carcinogenesis in cervical squamous cell carcinoma...