Jesang Ko

Summary

Affiliation: University of Ulsan
Country: Korea

Publications

  1. ncbi Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines
    Jesang Ko
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea
    FASEB J 18:890-2. 2004
  2. ncbi cDNA microarray analysis of the differential gene expression in the neuropathic pain and electroacupuncture treatment models
    Jesang Ko
    Asan Institute for Life Sciences, University of Ulsan College of Medicine 138 736, Korea
    J Biochem Mol Biol 35:420-7. 2002
  3. ncbi Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines
    Sung Wuk Jang
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    J Cell Physiol 211:630-7. 2007
  4. pmc Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration
    Ho Joong Sung
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    Exp Mol Med 40:332-8. 2008
  5. ncbi Proteomic analysis of differential protein expression in neuropathic pain and electroacupuncture treatment models
    Ho Joong Sung
    Asan Institute for Life Sciences, Asan Medical Center, Seoul, South Korea
    Proteomics 4:2805-13. 2004
  6. ncbi Leukotactin-1-induced ERK activation is mediated via Gi/Go protein/PLC/PKC delta/Ras cascades in HOS cells
    In Sik Kim
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388 1 Poongnap dong, Songpa Gu, Seoul 138 736, South Korea
    Life Sci 73:447-59. 2003
  7. ncbi C-reactive protein promotes monocyte chemoattractant protein-1--mediated chemotaxis through upregulating CC chemokine receptor 2 expression in human monocytes
    Ki Hoon Han
    Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Circulation 109:2566-71. 2004
  8. ncbi Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice
    Jesang Ko
    Asan Institute for Life Sciences and Department of Internal Medicine, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Oncogene 23:1950-3. 2004
  9. ncbi Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization
    Jesang Ko
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138 736, South Korea
    Oncogene 22:4679-89. 2003
  10. ncbi HCCR-1-interacting molecule "deleted in polyposis 1" plays a tumor-suppressor role in colon carcinogenesis
    Seung Min Shin
    Molecular Genetic Laboratory, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Gastroenterology 130:2074-86. 2006

Collaborators

Detail Information

Publications35

  1. ncbi Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines
    Jesang Ko
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea
    FASEB J 18:890-2. 2004
    ....
  2. ncbi cDNA microarray analysis of the differential gene expression in the neuropathic pain and electroacupuncture treatment models
    Jesang Ko
    Asan Institute for Life Sciences, University of Ulsan College of Medicine 138 736, Korea
    J Biochem Mol Biol 35:420-7. 2002
    ....
  3. ncbi Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines
    Sung Wuk Jang
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    J Cell Physiol 211:630-7. 2007
    ..These data indicate that LZIP functions as a positive regulator in the NF-kappaB activation pathway that is triggered by Lkn-1 without affecting the transcriptional activation of NF-kappaB induced by other CCR1-dependent chemokines...
  4. pmc Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration
    Ho Joong Sung
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    Exp Mol Med 40:332-8. 2008
    ..LZIP also enhanced the chemotactic activities of monocyte chemoattractant protein-1/CCL2 and Lkn-1. These results suggest that LZIP regulates expression of chemokine receptors that are involved in monocyte migration...
  5. ncbi Proteomic analysis of differential protein expression in neuropathic pain and electroacupuncture treatment models
    Ho Joong Sung
    Asan Institute for Life Sciences, Asan Medical Center, Seoul, South Korea
    Proteomics 4:2805-13. 2004
    ..Potential applications of our results include the identification and characterization of signaling pathways involved in EA treatment and further exploration of the role of selected identified proteins in the animal model...
  6. ncbi Leukotactin-1-induced ERK activation is mediated via Gi/Go protein/PLC/PKC delta/Ras cascades in HOS cells
    In Sik Kim
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388 1 Poongnap dong, Songpa Gu, Seoul 138 736, South Korea
    Life Sci 73:447-59. 2003
    ....
  7. ncbi C-reactive protein promotes monocyte chemoattractant protein-1--mediated chemotaxis through upregulating CC chemokine receptor 2 expression in human monocytes
    Ki Hoon Han
    Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Circulation 109:2566-71. 2004
    ..In addition, recent data suggest that CRP may directly promote atherogenesis. In this study, we investigated whether CRP can directly activate human circulating monocytes...
  8. ncbi Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice
    Jesang Ko
    Asan Institute for Life Sciences and Department of Internal Medicine, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Oncogene 23:1950-3. 2004
    ..These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor...
  9. ncbi Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization
    Jesang Ko
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138 736, South Korea
    Oncogene 22:4679-89. 2003
    ..These results indicate that HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor...
  10. ncbi HCCR-1-interacting molecule "deleted in polyposis 1" plays a tumor-suppressor role in colon carcinogenesis
    Seung Min Shin
    Molecular Genetic Laboratory, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Gastroenterology 130:2074-86. 2006
    ..We identified the HCCR-1 binding protein deleted in polyposis 1 (DP1) and accessed the role of HCCR-1 and DP1 in colon tumorigenesis...
  11. ncbi HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo
    Ki Hoon Han
    Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
    Circulation 111:1439-47. 2005
    ..The present study investigated whether 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition affects CCR2 gene expression and CCR2-dependent monocyte recruitment...
  12. ncbi Overexpression of uncoupling protein 2 in THP1 monocytes inhibits beta2 integrin-mediated firm adhesion and transendothelial migration
    Je Won Ryu
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Arterioscler Thromb Vasc Biol 24:864-70. 2004
    ..Here we investigated whether UCP2 regulates expression of genes involved in monocyte recruitment...
  13. doi Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression
    Yoonseo Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    Cell Physiol Biochem 28:175-84. 2011
    ..In this study, we investigated the effect of celastrol on the migration and invasion of human breast carcinoma cells...
  14. ncbi Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer
    Jesang Ko
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, 138 736, Korea
    Exp Cell Res 280:280-7. 2002
    ..These results indicate that the hsFRP gene probably functions as a tumor suppressor in normal cervical epithelium and down-regulation of hsFRP contributes to development of cervical cancer...
  15. ncbi Expression and purification of enzymatically active forms of the human lysyl oxidase-like protein 4
    Moon Suk Kim
    Genome Research Center for Birth Defects and Genetic Diseases, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138 736, Korea
    J Biol Chem 278:52071-4. 2003
    ....
  16. ncbi PKCdelta-dependent cleavage and nuclear translocation of annexin A1 by phorbol 12-myristate 13-acetate
    Yoon S Kim
    Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea
    Eur J Biochem 270:4089-94. 2003
    ..We propose a novel mechanism of PMA-induced translocation of ANX-1 to the nucleus that may participate in the regulation of cell proliferation and differentiation...
  17. pmc Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages
    Geun Hyang Kim
    Department of Pharmacology, University of Ulsan College of Medicine, Seoul, Korea
    Mol Endocrinol 23:966-74. 2009
    ....
  18. ncbi p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells
    Jesang Ko
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Exp Mol Med 39:129-38. 2007
    ..Therefore, our results demonstrate that 9CRA transduces the signal through p38 MAPK and ERK1/2 for CCR1 and CCR2 up-regulation, and may regulate the pro-inflammatory process through the p38 MAPK and ERK-dependent signaling pathways...
  19. ncbi Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1
    Sung Wuk Jang
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    J Biol Chem 282:11092-100. 2007
    ..Our findings suggest that transcription factor NF-kappaB plays an important role in regulation of LZIP expression, and LZIP expression regulates the monocyte cell migration induced by Lkn-1...
  20. pmc Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras
    Soon Young Shin
    Division of Molecular and Life Science, College of Science and Technology, Hanyang University, Ansan, Korea
    EMBO J 25:1093-103. 2006
    ..Our findings suggest a novel signaling mechanism by which prolonged activation of oncogenic H-Ras can trigger the loss of tumor suppressor Egr-1 through the PI3K pathway in NIH3T3 fibroblast model cell lines...
  21. ncbi Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells
    In Sik Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    FEBS Lett 579:6044-8. 2005
    ..These results indicate that HCC-4 transduces signals differently from other CCR1-dependent chemokines and may play different roles in the immune response...
  22. ncbi Human CC chemokine CCL23, a ligand for CCR1, induces endothelial cell migration and promotes angiogenesis
    Jungsu Hwang
    Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin 449 701, Republic of Korea
    Cytokine 30:254-63. 2005
    ..CCL23 didn't promote the migration of HT1080 human fibrosarcoma cells that did not express CCR1. Our results suggest a role of CCL23 in angiogenesis in vitro as well as in vivo...
  23. ncbi Lysophosphatidylcholine up-regulates CXCR4 chemokine receptor expression in human CD4 T cells
    Ki Hoon Han
    College of Medicine, Asan Medical Center, 388 1 Pungnap 2 dong, Songpa Gu 138 736, Seoul, South Korea
    J Leukoc Biol 76:195-202. 2004
    ..The data suggest that the presence of lysoPC and SDF-1 in atherosclerotic lesions may trigger inflammatory responses mediated by CD4 T cells, which may play an important role in progression of atherosclerosis...
  24. ncbi Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation
    Soon Young Shin
    Division of Molecular and Life Science, College of Science and Technology, Hanyang University, Ansan 426 791, South Korea
    J Mol Biol 340:681-93. 2004
    ..Our data reveal a novel mechanism whereby PKC delta gene is regulated at the transcriptional and post-transcriptional level in the L1210 leukemia cell line...
  25. ncbi Angiogenic activity of human CC chemokine CCL15 in vitro and in vivo
    Jungsu Hwang
    Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin 449 701, South Korea
    FEBS Lett 570:47-51. 2004
    ..Our findings demonstrate that CCL15(25-92) has in vitro and in vivo angiogenic activity, and suggest roles of the chemokine in angiogenesis...
  26. ncbi Leukotactin-1/CCL15-induced chemotaxis signaling through CCR1 in HOS cells
    Jesang Ko
    Immunomodulation Research Center, University of Ulsan, 680 749, Ulsan, South Korea
    FEBS Lett 515:159-64. 2002
    ..DNA binding activity of NF-kappaB was also enhanced by Lkn-1 stimulation. These results suggest that Lkn-1 transduces the signal through G(i)/G(o) protein, PLC, PKCdelta, NF-kappaB and newly synthesized proteins for chemotaxis...
  27. ncbi PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells
    Sang Min Lee
    Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin, Kyunggi do 449 701, Republic of Korea
    Biochem Biophys Res Commun 324:768-72. 2004
    ..Overexpression of PLP2/A4 stimulated a twofold increase in the agonist-induced migration of HOS/CCR1 cells, implicating a functional role for PLP2/A4 in the chemotactic processes via CCR1...
  28. ncbi Differential regulation of CC chemokine receptors by 9-cis retinoic acid in the human mast cell line, HMC-1
    Jesang Ko
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    Life Sci 79:1293-300. 2006
    ..9CRA decreased spontaneous homotype clustering. Therefore, our results demonstrate that 9CRA differentially decreases both CCR2 expression and chemotactic ability of HMC-1 cells, and may regulate the inflammatory effects of mast cells...
  29. ncbi Clozapine, a neuroleptic agent, inhibits Akt by counteracting Ca2+/calmodulin in PTEN-negative U-87MG human glioblastoma cells
    Soon Young Shin
    Division of Molecular and Life Science, College of Science and Technology, Hanyang University, Ansan, South Korea
    Cell Signal 18:1876-86. 2006
    ..These results suggest that the antipsychotic drug CZP modulates the PI3K/Akt/GSK-3beta pathway by counteracting Ca(2+)/CaM in PTEN-negative U-87MG glioblastoma cells...
  30. ncbi Role of 14-3-3 eta as a positive regulator of the glucocorticoid receptor transcriptional activation
    Yoon Suk Kim
    School of Life Sciences and Biotechnology, Korea University, 5 1 Anam dong, Sungbuk Gu, Seoul 136 701, South Korea
    Endocrinology 146:3133-40. 2005
    ..These results suggest that 14-3-3eta functions as a positive regulator in the glucocorticoid signal pathway by blocking the degradation of GR and inducing an elevation of GR, thus enhancing the transcriptional activity of GR...
  31. ncbi Negative regulatory role of annexin-A1 in 14-3-3eta-mediated glucocorticoid receptor transcriptional activation
    Ho Joong Sung
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    Biochem Biophys Res Commun 339:1208-11. 2006
    ..Our results indicate that ANX-1 functions as a negative regulator of GR transcriptional activation by inhibiting 14-3-3eta-induced up-regulation of GR...
  32. ncbi The HCCR oncoprotein as a biomarker for human breast cancer
    Sang Seol Jung
    Department of Surgery, The Catholic University of Korea, Seoul
    Clin Cancer Res 11:7700-8. 2005
    ..Mice transgenic for HCCR developed breast cancers. The objective of this study was to validate the HCCR oncoprotein as a candidate biomarker for breast cancer...
  33. doi The role of calpains in ligand-induced degradation of the glucocorticoid receptor
    Yoon Suk Kim
    Department of Biomedical Laboratory Science, College of Health Science, Yonsei University, Wonju 222 701, South Korea
    Biochem Biophys Res Commun 374:373-7. 2008
    ..These results indicate that calpain is involved in ligand-dependent degradation of GR, thus causing reduced hormone responsiveness...
  34. ncbi Negative regulatory role of overexpression of PLC gamma 1 in the expression of early growth response 1 gene in rat 3Y1 fibroblasts
    Soon Young Shin
    Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, Korea 705 717
    FASEB J 16:1504-14. 2002
    ..Our results demonstrated that overexpression of PLCgamma1 functions as a negative modulator of the tumor suppressor Egr-1 gene expression, possibly through inhibition of Elk-1-dependent transcriptional activity...
  35. ncbi Differential effects of 9-cis retinoic acid on expression of CC chemokine receptors in human monocytes
    In Sik Kim
    Department of Clinical Laboratory Science, School of Medicine, Eulji University, Daejun 301 832, South Korea
    Biochem Pharmacol 68:611-20. 2004
    ....