Dae Keun Kim

Summary

Affiliation: Woosuk University
Country: Korea

Publications

  1. ncbi request reprint Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 27:1127-31. 2004
  2. doi request reprint Pentacyclic triterpenoids fromllex macropoda
    Dae Keun Kim
    College of Pharmacy, Woosuk University, 565 701, Samrye, Korea
    Arch Pharm Res 25:617. 2002
  3. ncbi request reprint Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 25:817-9. 2002
  4. ncbi request reprint Acetylcholinesterase inhibitors from the roots of Angelica dahurica
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 25:856-9. 2002
  5. ncbi request reprint Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 26:735-8. 2003
  6. ncbi request reprint Pentacyclic triterpenoids from Ilex macropoda
    Dae Keun Kim
    College of Pharmacy Woosuk University, Samrye, Korea
    Arch Pharm Res 25:617-20. 2002
  7. doi request reprint Effects of isolated compounds from Catalpa ovata on the T cell-mediated immune responses and proliferation of leukemic cells
    Chan Ho Oh
    Department of Food and Biotechnology, Woosuk University, Jeonju, 565 701, Korea
    Arch Pharm Res 33:545-50. 2010
  8. ncbi request reprint Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa
    Sang Un Choi
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 30:151-4. 2007
  9. doi request reprint Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe
    Ju Sin Kim
    College of Pharmacy, Woosuk University, Samrye, Korea
    Arch Pharm Res 31:415-8. 2008
  10. ncbi request reprint Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel
    Jae Hyeok Lee
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 27:53-6. 2004

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 27:1127-31. 2004
    ..These compounds inhibited acetylcholinesterase activity in a dose-dependent manner, and the IC50 values of compounds 1-4 were 89.0, 16.1, 5.8, and 3.3 microM, respectively...
  2. doi request reprint Pentacyclic triterpenoids fromllex macropoda
    Dae Keun Kim
    College of Pharmacy, Woosuk University, 565 701, Samrye, Korea
    Arch Pharm Res 25:617. 2002
    ..Among them, lupeol, betulone, erythrodiol and 11-oxo-erythrodiol were isolated for the first time from this plant. ..
  3. ncbi request reprint Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 25:817-9. 2002
    ..Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 microM. The AChE inhibitory activity of corynoline was reversible and noncompetitive...
  4. ncbi request reprint Acetylcholinesterase inhibitors from the roots of Angelica dahurica
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 25:856-9. 2002
    ..These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds 1-3 were 74.6, 63.7 and 89.1 microM, respectively...
  5. ncbi request reprint Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 26:735-8. 2003
    ..This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of trans-N-p-coumaroyl tyramine was 34.5 microg/mL (122 microM)...
  6. ncbi request reprint Pentacyclic triterpenoids from Ilex macropoda
    Dae Keun Kim
    College of Pharmacy Woosuk University, Samrye, Korea
    Arch Pharm Res 25:617-20. 2002
    ..Among them, lupeol, betulone, erythrodiol and 11-oxo-erythrodiol were isolated for the first time from this plant...
  7. doi request reprint Effects of isolated compounds from Catalpa ovata on the T cell-mediated immune responses and proliferation of leukemic cells
    Chan Ho Oh
    Department of Food and Biotechnology, Woosuk University, Jeonju, 565 701, Korea
    Arch Pharm Res 33:545-50. 2010
    ..Compound 3 enhanced gene expressions of p53 and IL-4, but decreased IL-2 and IFN-Gamma genes in Molt-4 cell. Our findings indicate that compound 3 may enhance T cell-mediated immune responses and anticancer properties...
  8. ncbi request reprint Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa
    Sang Un Choi
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 30:151-4. 2007
    ..Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells...
  9. doi request reprint Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe
    Ju Sin Kim
    College of Pharmacy, Woosuk University, Samrye, Korea
    Arch Pharm Res 31:415-8. 2008
    ..6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2)...
  10. ncbi request reprint Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel
    Jae Hyeok Lee
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 27:53-6. 2004
    ..These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds 1 and 2 were 33.6 (79 microM) and 10.0 (52 microM) microg/mL, respectively...
  11. doi request reprint The effects of ketorolac tromethamine and baicalein on the levels of inflammatory factors in human synoviocytes
    Jae Heon Yang
    Department of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 31:1517-23. 2008
    ..The production of oxygen species (ROS) was inhibited by KTBE in FLS cells. KTBE appears to regulate the levels of mRNA that are important for regulating RA progression...
  12. doi request reprint Phlomis umbrosa root inhibits mast cell-dependent allergic reactions and inflammatory cytokine secretion
    Tae Yong Shin
    College of Pharmacy, Woosuk University, Jeonju, Jeonbuk 565 701, Republic of Korea
    Phytother Res 22:153-8. 2008
    ..PUAE (1 mg/mL) inhibited the gene expression and production of the main inflammatory cytokine, TNF-alpha, in HMC-1 cells. These results provide evidence that PUAE may be beneficial in the treatment of allergic diseases...
  13. ncbi request reprint Anti-inflammatory effects by transdermal application of triamcinolone acetonide gel using phonophoresis in rats
    Jae Heon Yang
    Department of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Int J Pharm 302:39-46. 2005
    ..These effects were considerably higher in the phonophoresis group than in the other three groups. Overall, a TA gel using phonophoresis might be used as a new transdermal delivery technique providing enhanced anti-inflammatory effects...
  14. ncbi request reprint Preparation and evaluation of ketorolac tromethamine gel containing genipin for periodontal diseases
    Jeon Heon Yang
    College of Pharmacy, Woosuk University, Wanju 565 701, Korea
    Arch Pharm Res 30:871-5. 2007
    ..The KTG gel appears to be effective against gingivitis in the periodontal pocket through its increased anti-inflammatory activity and the crosslinking of genipin with the biological tissue...
  15. ncbi request reprint Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera
    Mi Kyeong Moon
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 30:299-302. 2007
    ..This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells...
  16. ncbi request reprint Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics
    Young Ee Kwon
    College of Pharmacy, Woosuk University, Jeonbuk, Republic of Korea
    Bioorg Med Chem 15:6596-607. 2007
    ..Because the benzyhydryl moiety of 12 covered the peripheral site of AChE in a funnel-like shape, 12 showed good inhibitory potency against AChE and could inhibit AChE-induced Abeta(1-42) peptide aggregation...
  17. ncbi request reprint Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase
    Hyun Mi Oh
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 29:64-6. 2006
    ..This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of 6-O-angeloylprenolin was 18.8 microM...
  18. ncbi request reprint Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda
    Kyung Ran Im
    College of Pharmacy, Woosuk University, Samrye, Korea
    Arch Pharm Res 29:191-4. 2006
    ..Compounds 1 and 2 were shown to inhibit the activity of hACAT-1 and hACAT-2 in a dose-dependent manner, and compounds 1 and 2 inhibited hACAT-1 with IC50 values of 48 and 83 microM, respectively...
  19. ncbi request reprint Open channel block of hKv1.5 by psoralen from Heracleum moellendorffii Hance
    Jae Soon Eun
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 28:269-73. 2005
    ..Taken together, the present results strongly suggest that psoralen may be an ideal antiarrhythmic drug for atrial fibrillation...
  20. doi request reprint Apoptosis-inducing effect of akebia saponin D from the roots of Dipsacus asper Wall in U937 cells
    Seung Il Jeong
    Department of Food and Biotechnology, Woosuk University, Jeonju 565 701, Korea
    Arch Pharm Res 31:1399-404. 2008
    ..These data provide scientific evidence that Dipsacus asper Wall can be useful as a chemopreventive agent...
  21. doi request reprint Inhibitory activities of anthraquinones from Rubia akane on phosphatase regenerating liver-3
    Mi Kyeong Moon
    Woosuk University, Samrye, Korea
    Arch Pharm Res 33:1747-51. 2010
    ..These compounds inhibited PRL-3 in a dose-dependent manner with IC₅₀ values of 5.2 and 1.3 μg/mL, respectively...
  22. ncbi request reprint Phytochemical constituents from Diodia teres
    Jae Hyeok Lee
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 27:40-3. 2004
    ....
  23. ncbi request reprint Antitumor and antiinflammatory constituents from Celtis sinensis
    Dae Keun Kim
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 28:39-43. 2005
    ....
  24. doi request reprint Anti-metastatic properties of the leaves of Eriobotrya japonica
    Dong Seok Cha
    College of Pharmacy, Woosuk University, Chonbuk, Korea
    Arch Pharm Res 34:425-36. 2011
    ..The present results demonstrate that LEJ may be used as valuable antimetastatic agent for the treatment of cancer metastasis...
  25. ncbi request reprint Synthesis of psoralen derivatives and their blocking effect of hKv1.5 channel
    Jae Soon Eun
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 30:155-60. 2007
    ..5 channel as an open channel blocker and is much more potent than psoralen in blocking hKv1.5 channel. If further studies were done, compound 9 might be an ideal antiarrhythmic drug for atrial fibrillation...
  26. ncbi request reprint Guaiane sesquiterpenoids from Torilis japonica and their cytotoxic effects on human cancer cell lines
    Hye Won Park
    College of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 29:131-4. 2006
    ..Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells...
  27. ncbi request reprint Free radical scavengers from the heartwood of Juniperus chinensis
    Jong Pil Lim
    College of Pharmacy, Woosuk University, Samrye, Korea
    Arch Pharm Res 25:449-52. 2002
    ..Quercetin, naringenin, taxifolin, aromadendrin and isoquercitrin were isolated from the n-BuOH fraction. Their structures were elucidated by physico-chemical and spectroscopic studies...
  28. ncbi request reprint Protective effects of a novel herbal decoction on focal cerebral ischemia in a rodent model
    Myung Gyou Kim
    College of Pharmacy, Woosuk University, Wanju 565 701, Korea
    Neurol Res 29:S16-22. 2007
    ..Herbs have been used to treat stroke and coma patient in traditional Korean medicine (TKM). The novel decoction, Guhpoongchungsimhwan (GCH), was developed on the basis of clinical data and TKM theory...
  29. doi request reprint Prostaglandin E2-mediated dysregulation of proinflammatory cytokine production in pristane-induced lupus mice
    Byeong Suk Chae
    College of Pharmacy, Woosuk University, Wanju, Jeonbuk, Korea
    Arch Pharm Res 31:503-10. 2008
    ..Therefore, our findings suggest that endogenous PGE(2) may mediate dysregulation of production of proinflammatory cytokines, such as IL-6, IL-10, and IFN-gamma, and NO in pristane-induced lupus mice...
  30. ncbi request reprint Effects of oxypeucedanin on hKv1.5 and action potential duration
    Jae Soon Eun
    College of Pharmacy, Woosuk University, Samrye, Korea
    Biol Pharm Bull 28:657-60. 2005
    ..These results suggest that oxypeucedanin is a kind of open-channel blocker of the hKv1.5 channel and it prolongs the APD; therefore, it is an excellent candidate as an antiarrhythmic drug for atrial fibrillation...
  31. doi request reprint Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans
    Yong Seong Kim
    College of Pharmacy, Woosuk University, Jeonbuk, 565 701, Republic of Korea
    Arch Pharm Res 37:245-52. 2014
    ..In addition, PCA-treated aged worms showed increased body movement compared to untreated controls suggesting PCA could enhance healthspan as well as lifespan. ..
  32. ncbi request reprint Transdermal delivery system of triamcinolone acetonide from a gel using phonophoresis
    Jae Heon Yang
    Department of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 29:412-7. 2006
    ..0, 3.0 MHz), intensity (1.0, 2.5 W/cm2), and duty cycle (continuous, pulse mode) using a 0.5% TA gel. The highest permeation was observed under the ultrasound treatment conditions of low frequency, high intensity, and in continuous mode...
  33. ncbi request reprint A new cytotoxic prenylated chalcone from Sophora flavescens
    Jae Hyeok Lee
    Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, Korea
    Arch Pharm Res 30:408-11. 2007
    ..Compound 1 exhibited potent cytotoxicity against human acute promyelocytic (HL60), mouse lymphocytic (L1210) and human histiocytic (U937) leukemia cells...
  34. ncbi request reprint Torilin from Torilis japonica (Houtt.) DC. blocks hKv1.5 channel current
    Yong Geun Kwak
    Department of Pharmacology, Chonbuk National University Medical School, Chonju, 561 756, Korea
    Arch Pharm Res 29:834-9. 2006
    ..5 current, resulting in a tail crossover phenomenon. Additionally, torilin inhibited the hKv1.5 current in a use-dependent manner. These results strongly suggest that torilin is a type of open-channel blocker of the hKv1.5 channel...
  35. ncbi request reprint Inhibitory activity of isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase
    Hyun Mi Oh
    Korea Research Institute of Bioscience and Biotechnology, KIST, Taejeon 305 333, Korea
    Arch Pharm Res 28:169-71. 2005
    ..This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of isorhamnetin was 37.5 microM...