W Masocha

Summary

Affiliation: Kuwait University
Country: Kuwait

Publications

  1. pmc COL-3, a chemically modified tetracycline, inhibits lipopolysaccharide-induced microglia activation and cytokine expression in the brain
    Rawan Abdulhameed Edan
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, Safat, Kuwait
    PLoS ONE 8:e57827. 2013
  2. pmc The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents
    Dhandapani Thangamani
    Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, P O Box 24923, 13110 Safat, Kuwait
    ScientificWorldJournal 2013:240508. 2013
  3. pmc Gait analysis of C57BL/6 mice with complete Freund's adjuvant-induced arthritis using the CatWalk system
    Subramanian S Parvathy
    Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, Safat, 13110, Kuwait
    BMC Musculoskelet Disord 14:14. 2013
  4. doi Differential invasion of Trypanosoma brucei brucei and lymphocytes into the brain of C57BL/6 and 129Sv/Ev mice
    W Masocha
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Safat, Kuwait
    Scand J Immunol 68:484-91. 2008
  5. doi Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain
    Willias Masocha
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Safat, 13110, Kuwait
    J Neuroimmunol 214:78-82. 2009
  6. doi Assessment of weight bearing changes and pharmacological antinociception in mice with LPS-induced monoarthritis using the Catwalk gait analysis system
    Willias Masocha
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait
    Life Sci 85:462-9. 2009
  7. doi CD200 receptors are differentially expressed and modulated by minocycline in the brain during Trypanosoma brucei infection
    Willias Masocha
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait
    J Neuroimmunol 226:59-65. 2010
  8. pmc Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis
    Ala a Ahmed Abu-Ghefreh
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, P O Box 24923 Safat, 13110 Kuwait
    BMC Musculoskelet Disord 11:276. 2010

Collaborators

Detail Information

Publications8

  1. pmc COL-3, a chemically modified tetracycline, inhibits lipopolysaccharide-induced microglia activation and cytokine expression in the brain
    Rawan Abdulhameed Edan
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, Safat, Kuwait
    PLoS ONE 8:e57827. 2013
    ..Our data show that COL-3 has some antibacterial activity against S. aureus, inhibits LPS-induced neuroinflammation, and displays potential as a therapeutic agent for treatment of conditions involving CNS inflammation...
  2. pmc The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents
    Dhandapani Thangamani
    Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, P O Box 24923, 13110 Safat, Kuwait
    ScientificWorldJournal 2013:240508. 2013
    ..Our results indicate that E139 has antinociceptive activity and attenuates paclitaxel-induced neuropathic pain in rodents. ..
  3. pmc Gait analysis of C57BL/6 mice with complete Freund's adjuvant-induced arthritis using the CatWalk system
    Subramanian S Parvathy
    Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, Safat, 13110, Kuwait
    BMC Musculoskelet Disord 14:14. 2013
    ..However, it has not been used to study static and dynamic gait parameters in mice with complete Freund's adjuvant (CFA). CFA is used extensively to induce arthritis in rodents including mice...
  4. doi Differential invasion of Trypanosoma brucei brucei and lymphocytes into the brain of C57BL/6 and 129Sv/Ev mice
    W Masocha
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Safat, Kuwait
    Scand J Immunol 68:484-91. 2008
    ..b. brucei into the brain parenchyma, which is paralleled by the severity of inflammation in the brain and course of the disease, but not by parasitaemia nor by antibody titres...
  5. doi Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain
    Willias Masocha
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Safat, 13110, Kuwait
    J Neuroimmunol 214:78-82. 2009
    ..Thus, LPS-induced changes in CD200-CD200R equilibrium might keep microglia chronically activated. Minocycline does not effectively inhibit microglia activation induced by high-dose LPS...
  6. doi Assessment of weight bearing changes and pharmacological antinociception in mice with LPS-induced monoarthritis using the Catwalk gait analysis system
    Willias Masocha
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait
    Life Sci 85:462-9. 2009
    ..We evaluated the possibility of using the video-based Catwalk gait analysis method to measure weight bearing changes and for testing pharmacological antinociception in freely moving mice with lipopolysaccharide (LPS)-induced monoarthritis...
  7. doi CD200 receptors are differentially expressed and modulated by minocycline in the brain during Trypanosoma brucei infection
    Willias Masocha
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait
    J Neuroimmunol 226:59-65. 2010
    ..This suggests that CD200RLa might play a role in microglia/macrophage activation during trypanosome infection...
  8. pmc Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis
    Ala a Ahmed Abu-Ghefreh
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, P O Box 24923 Safat, 13110 Kuwait
    BMC Musculoskelet Disord 11:276. 2010
    ..However, there are no reports on whether coadministration of these drugs could potentiate each other's activities in alleviating pain and weight bearing deficits during arthritis...