Bhaskar Lakkakula

Summary

Affiliation: Sri Ramachandra University
Location: Chennai, India
URL: http://lvksbhaskar.blogspot.com/
Summary:
DR. L.V. K. S. Bhaskar
Assistant Professor
Department of Biomedical Sciences
SRI RAMACHANDRA UNIVERSITY
No.1 Ramachandra Nagar, Porur
Chennai - 600 116
email: lvksbhaskar@gmail.com
Phone:+91(0)44-24768027 -33 Extn. :8296 or 8297
Mobile:+91-9940524037
Grants:
1. Identification of susceptibility genes associated with non-syndromic cleft lip with or without cleft palate in Indian Population: ICMR- 25 lakhs (26-10-2009 to 25-10-2012)
2. Evaluation of insulin metabolic gene(s) polymorphisms in the pathogenesis of polycystic ovary syndrome (PCOS). DBT-21 lakhs (20-10-2010 to 20-10-2013)
3. The role of microRNA in metabolic syndrome. India-Taiwan programme of co-operation in science & technology (DST-17 lakhs + 6 Taiwan visits) (1-03-2011 to 28-02-2014)
Publications:
1. RamaLakshmi G., Bandyopadhyay S.S., Bhaskar L.V.K.S., Sharma Madhubala, Rao Raghavendra V. Appraisal of risk factors for diabetes mellitus type 2 in central Indian population: a case control study. Antrocom Online Journal of Anthropology 2011, vol. 7. n. 1- ISSN 1973-2880 (In-press)
2. Lakshmi Balaji, Bhaskar LVKS, K. Balaji Singh, Solomon F.D. Paul. Lack of association between ephx1 genotypes and haplotypes with oral cancer in South Indians. Genetic Testing and Molecular Biomarkers 2011 (Impact factor; 1.158).
3. Saikrishna L., Bhaskar LVKS and Rajasekhar M. Molecular genetics of non-syndromic clefts revisited. International journal of Genetics (In press).
4. Jaya Sanyal, Bhaskar LVKS, Avishek Chatterjee, Biswanath Sarkar, Bidhan Chandra Ray, and VR Rao. Single nucleotide polymorphisms of Parkin gene in ten Indian populations. Antrocom Online Journal of Anthropology 2011, vol. 7. n. 1 - ISSN 1973-2880 (In-press)
5. Pramanik V., Sarkar BN., Kar M., Das G., Barman MK, Khannam SK., Bhaskar LVKS. and Rao VR. A Novel Polymorphism in codon 25 of KRAS Gene Associated with Gallbladder carcinoma Patients of Eastern Part of India. Genetic Testing and Molecular Biomarkers 2011 (Impact factor; 1.158).
6. Bhaskar LVKS, Jyotsna Murthy, G. Venkatesh Babu. Polymorphisms in genes involved in folate metabolism and orofacial clefts. Arch Oral Biol. 2011 Feb 8. (Impact factor: 1.649).
7. Ming-Ying Lu, Bhaskar LVKS, Yi-Chu Liao, Pei-Chien Tsai, Yi-Hsin Yang, Suh-Hang Hank Juo. Lack of association between the IL-10 gene polymorphisms and features of the metabolic syndrome. Journal of Investigative Medicine 2011 Feb;59(2):267-71. (Impact factor: 1.628).
8. M. Gopi Chand, J. Srinath, R. S. Rao, Bhaskar LVKS, Satish Kumar, V. R. Rao. Association between the M268T polymorphism in the Angiotensinogen gene and hypertension in South Indian Population. Biochemical Genetics 2011 Feb 11 (Impact factor: 0.878).
9. Bhaskar LVKS, Thangaraj K, Non AL, Singh L, Rao VR. Population-based case-control study of DRD2 gene polymorphisms and Alcoholism. Journal of Addictive Diseases, 29:475–480, 2010 (Impact Factor: 1.182).
10. Bhaskar LVKS, Thangaraj K, Pardhasaradhi G, Praveen Kumar K, Singh L, Rao VR. Neuropeptide Y Gene Polymorphisms are Not Associated with Obesity in a South Indian Population. European journal of clinical nutrition, 2010; 64(8):868-872 (Impact factor: 2.686).
11. Bhaskar LVKS, Thangaraj K, Non, A.L, Praveen Kumar K, Pardhasaradhi G, Singh L, Rao VR. Neuropeptide Y gene functional polymorphism influences susceptibility to hypertension in Indian population. Journal of Human Hypertension, 2010; 24(9):617-622 (Impact factor; 2.637).
12. Bhaskar LVKS, Thangaraj K, Mulligan CJ, Wasnik S, Nandan A, Sharma VK, Sharma V, Reddy AG, Singh L, Rao VR. Dopamine transporter (DAT1) VNTR polymorphism in 12 Indian populations. Neurol Sci. 2009 Dec;30(6):487-93 (Impact factor; 1.435)
13. Murthy J and Bhaskar LVKS. Current concepts in genetics of Nonsyndromic clefts. Indian J Plast Surg. 2009, 42: 68-81.
14. Mukunda Goswami, Kumarasamy Thangaraj, Binod Chaudhary, L.V.K.S. Bhaskar, Achamveettil Gopalakrishnan, M Joshi, Lalji Singh, Wazir Lakra. Genetic heterogeneity in the Indian stocks of seahorse (Hippocampus kuda and Hippocampus trimaculatus) inferred from mtDNA cytochrome b gene. Hydrobiologia 2009 621:213–221. (Impact factor; 1.449)
15. Bhaskar LVKS, K. Thangaraj, Pallavi Subramanian, P.S Dandapani, Solomon F. D. Paul. Molecular genetic analysis of Neuropeptide Y (NPY) gene in patients with cardiac arrhythmia. Sri Ramachandra Journal of medicine, August 2008, 8-13.
16. Bhaskar LVKS, K. Thangaraj, C.J. Mulligan, A. Papa Rao, G. Pardhasaradhi, K. Praveen Kumar, Anish M. Shah, B. Sabeera, A.G. Reddy, Lalji Singh, V.R. Rao. Allelic Variation and Haplotype Structure of the Dopamine Receptor Gene DRD2 in Nine Indian Populations. Genetic Testing. March 1, 2008, 12(1): 153-160. (Impact factor; 1.158)
17. Kumarasamy Thangaraj, Gyaneshwer Chaubey, Toomas Kivisild, Vijay Kumar Singh, Selvi-Rani Deepa, Thanseem Ismail, Denise Carvalho-Silva, Mait Metspalu, Bhaskar LVKS, Sharat Chandra, Niharika Adarsh, Abhilasha Verma, Inaganti Amara Jyothi, Chandana Basu Mallick, Nidhi Shrivastava, Ragala Devasena, Babita Kumari, Amit Kumar Singh, Shailendra Kumar Dhar Diwedi, Shefali Singh, Geeta Rao, Pranav Gupta, Kavita Kumari, Afsar Basha, K. R Bhargavi, Albert Lalremruata, Aravind Kumar Gupta, K. K. Reddy. A. Papa Rao, Alla G. Reddy, Richard Villems, Chris Tyler-Smith, Lalji Singh. “Maternal Footprints of Southeast Asians in North India”. Hum Hered 2008;66:1-9 (DOI:10.1159/). (2008 impact factor; 3.226)
18. Bhaskar LVKS, K. Thangaraj, Michael Osier, A.G. Reddy, A. Papa Rao, Lalji Singh and V. R. Rao. Single Nucleotide Polymorphisms of ALDH2 gene in six Indian populations. Annals of Human Biology, 34(6): 607-619; 2007. (Impact factor; 1.009)
19. B. Mohan Reddy, A.N. Srikar Reddy, T. Nagaraju, Bhaskar LVKS, H.P. Singh, V. M. Naidu, K. Thangaraj, A.Govardhan Reddy, A. Nirmala, Lalji Singh. Anthropological Perspective of the Single Nucleotide Polymorphisms in the NPY and DRD2 Genes among the Socio-Economically Stratified Populations of Andhra Pradesh, India. International Journal of Human Genetics, 07(4): 277-284; 2007
20. Bhaskar LVKS, K. Thangaraj, Anish M. Shah. G. Pardhasaradhi, K. Praveen Kumar, A.G. Reddy, A. Papa Rao, C. J. Mulligan, Lalji Singh and V. R. Rao. Allelic variation at the NPY gene in 14 Indian populations. Journal of Human Genetics, 52:592–598; 2007. (Impact factor; 2.431)
21. V. R. Rao, Bhaskar LVKS, Ch. Annapurna, A. G. Reddy, K. Thangaraj A. Papa Rao and Lalji Singh. Single Nucleotide Polymorphisms in Alcohol Dehydrogenase (ADH) genes among Some Indian populations. American Journal of Human Biology, 2007: 19-338-344. (Impact factor; 1.976)
22. B. M. Reddy, A. N. S. Reddy, T. Nagaraja, Bhaskar LVKS, K. Thangaraj, A. G. Reddy and L. Singh. Single Nucleotide polymorphisms of the Alcohol Dehydrogenase Genes among the 28 caste and Tribal Populations of India. International Journal of Human Genetics, 2006. 6(4): 309-316.
23. Ismail Thanseem, Kumarasamy Thangaraj, Gyaneshwer Chaubey, Vijay K Singh, Bhaskar LVKS, Mohan B Reddy, Alla G Reddy and Lalji Singh. Genetic Affinities among the Lower Castes and Tribal Groups of India: Inference from Y Chromosome and Mitochondrial DNA. BMC Genetics, 2006, 7: 42 (http://www.biomedcentral.com/1471-2156/7/42) (Impact factor; 2.35)
24. Bhaskar LVKS. Moult-modulating effect of serotonin in the crab Oziotelphusa senex senex (FABRICIUS). Bio-Science Research Bulletin. 2006, 22 (2), 105-109.
25. Bhaskar LVKS. Effects of biogenic amines on the regulation of ovarian development in the freshwater prawn, Macrobrachium rosenbergii (DE MAN, 1879). Bulletin of Pure & Applied Sciences. 2006, 25A (2), 135-143.
26. Venkatrayulu Ch, Komali M, Bhaskar LVKS, Kalarani V and Reddy D.C. “Hepatogonal changes in the female freshwater field crab, Oziotelphusa senex senex(Fabricius) in response to cadmium toxicity” Proc. of AP Akademi of Sciences, 2005. 9 (1) 29-34.
27. Bhaskar LVKS and Rajeswara Rao M. “Inhibition of rat brain nitric oxide synthase activity by phosalone in vitro” Bulletin of pure and applied science, 2000. 19A (2) 117-119.
28. Leela siva parvathi M, Bhaskar LVKS. and Chandra Sekhara Reddy D. “Impact of phosalone on long term exposure and recovery of ammonia and urea excretion in fresh water fish, Tilapia mossambica (PETERS)” Journal of Ecotoxicology and Environmental Monitoring, 1999. Vol.9 (4) 221-224.

Publications

  1. doi request reprint Lack of association between the IL-10 gene polymorphisms and features of the metabolic syndrome
    Ming Ying Lu
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Investig Med 59:267-71. 2011
  2. pmc HLA class II SNP interactions and the association with type 1 diabetes mellitus in Bengali speaking patients of Eastern India
    Oindrila Raha
    Anthropological Survey of India, Kolkata, West Bengal 700016, India
    J Biomed Sci 20:12. 2013
  3. pmc Significant association of MTHFD1 1958G>A single nucleotide polymorphism with nonsyndromic cleft lip and palate in Indian population
    Jyotsna Murthy
    Department of Biomedical Sciences, Sri Ramachandra University, No 1 Ramachandra Nagar, Porur, Chennai 600 116
    Med Oral Patol Oral Cir Bucal 19:e616-21. 2014
  4. doi request reprint TCF7L2 rs7903146 polymorphism and diabetic nephropathy association is not independent of type 2 diabetes--a study in a south Indian population and meta-analysis
    Hajarah Hussain
    Endokrynol Pol 65:298-305. 2014
  5. pmc CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians
    Lakshmi Balaji
    Department of Endodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra University, Chennai, India
    Genet Mol Biol 35:407-12. 2012
  6. ncbi request reprint Role of renin-angiotensin-aldosterone system gene polymorphisms and hypertension-induced end-stage renal disease in autosomal dominant polycystic kidney disease
    Gnanasambandan Ramanathan
    Department of Biomedical Sciences, Sri Ramachandra University, Chennai Sickle Cell Institute Chhattisgarh, Raipur, India
    Iran J Kidney Dis 8:265-77. 2014
  7. pmc Genetic variants associated with insulin signaling and glucose homeostasis in the pathogenesis of insulin resistance in polycystic ovary syndrome: a systematic review
    Bhaskar Venkata Kameswara Subrahmanya Lakkakula
    Department of Biomedical Sciences, Sri Ramachandra University, No 1 Ramachandra Nagar, Porur, Chennai 600 116, India
    J Assist Reprod Genet 30:883-95. 2013
  8. doi request reprint Polymorphisms in genes involved in folate metabolism and orofacial clefts
    L V K S Bhaskar
    Department of Biomedical Sciences, Sri Ramachandra University, No 1 Ramachandra Nagar, Porur, Chennai 600116, India
    Arch Oral Biol 56:723-37. 2011
  9. ncbi request reprint Genetic polymorphisms of the CYP2E1 gene do not contribute to oral cancer susceptibility in south Indians
    Lakshmi Balaji
    Department of Endodontics, Sri Ramachandra Medical College and Hospital, and Department of Biomedical Sciences, Sri Ramachandra University, Chennai, India
    Asian Pac J Cancer Prev 12:1523-7. 2011

Collaborators

  • Lakshmi Balaji
  • Gnanasambandan Ramanathan
  • Jyotsna Murthy
  • L V K S Bhaskar
  • Hajarah Hussain
  • Venkatesh Babu Gurramkonda
  • Oindrila Raha
  • Krishna Balaji Singh
  • Ming Ying Lu
  • Teena Sajan
  • Ramprasad Elumalai
  • Samathmika Ravi
  • Kiruthiha Ehambaram
  • Lakkakula Venkata Bhaskar
  • Soundararajan Periyasamy
  • Vinu Ramachandran
  • Raghavendra Rao Vadlamudi
  • Veerraju Pasumarthy
  • Biswanath Sarkar
  • Sudhakar Godi
  • Pradip Raychaudhuri
  • Subhankar Chowdhury
  • Lakkakula V K S Bhaskar
  • G Venkatesh Babu
  • Yi Hsin Yang
  • Pei Chien Tsai
  • Yi Chu Liao
  • Suh Hang Hank Juo

Detail Information

Publications10

  1. doi request reprint Lack of association between the IL-10 gene polymorphisms and features of the metabolic syndrome
    Ming Ying Lu
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Investig Med 59:267-71. 2011
    ..We conducted a case-control study to investigate the association between the IL-10 polymorphisms and the metabolic syndrome...
  2. pmc HLA class II SNP interactions and the association with type 1 diabetes mellitus in Bengali speaking patients of Eastern India
    Oindrila Raha
    Anthropological Survey of India, Kolkata, West Bengal 700016, India
    J Biomed Sci 20:12. 2013
    ..To assess the frequency of HLA class II (DPA1, DPB1, DQA1, DQB1 and DRB1) associated to susceptibility or protection toT1DM in a Bengali population of India with diabetes...
  3. pmc Significant association of MTHFD1 1958G>A single nucleotide polymorphism with nonsyndromic cleft lip and palate in Indian population
    Jyotsna Murthy
    Department of Biomedical Sciences, Sri Ramachandra University, No 1 Ramachandra Nagar, Porur, Chennai 600 116
    Med Oral Patol Oral Cir Bucal 19:e616-21. 2014
    ..Given the key role of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) in folate metabolism, it would be of significant interest to assess its role in NSCLP etiology...
  4. doi request reprint TCF7L2 rs7903146 polymorphism and diabetic nephropathy association is not independent of type 2 diabetes--a study in a south Indian population and meta-analysis
    Hajarah Hussain
    Endokrynol Pol 65:298-305. 2014
    ..Pooled meta-analysis of studies on rs7903146 and T2DM confirmed that rs7903146 is significantly associated with susceptibility to T2DM in Indian populations...
  5. pmc CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians
    Lakshmi Balaji
    Department of Endodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra University, Chennai, India
    Genet Mol Biol 35:407-12. 2012
    ..Hence, CYP1A1 SNPs can be considered as not being associated with oral cancer at either the genotype or haplotype levels in the population studied...
  6. ncbi request reprint Role of renin-angiotensin-aldosterone system gene polymorphisms and hypertension-induced end-stage renal disease in autosomal dominant polycystic kidney disease
    Gnanasambandan Ramanathan
    Department of Biomedical Sciences, Sri Ramachandra University, Chennai Sickle Cell Institute Chhattisgarh, Raipur, India
    Iran J Kidney Dis 8:265-77. 2014
    ..In lieu of applying next generation sequencing technologies to study complex diseases, it is also possible to apply the same to unravel the complexity of ESRD in ADPKD. ..
  7. pmc Genetic variants associated with insulin signaling and glucose homeostasis in the pathogenesis of insulin resistance in polycystic ovary syndrome: a systematic review
    Bhaskar Venkata Kameswara Subrahmanya Lakkakula
    Department of Biomedical Sciences, Sri Ramachandra University, No 1 Ramachandra Nagar, Porur, Chennai 600 116, India
    J Assist Reprod Genet 30:883-95. 2013
    ..PCOS and insulin resistance are interlinked, as approximately 40 % of women with PCOS are insulin resistant. However, the detailed molecular basis for insulin resistance that is coupled with PCOS remains poorly understood...
  8. doi request reprint Polymorphisms in genes involved in folate metabolism and orofacial clefts
    L V K S Bhaskar
    Department of Biomedical Sciences, Sri Ramachandra University, No 1 Ramachandra Nagar, Porur, Chennai 600116, India
    Arch Oral Biol 56:723-37. 2011
    ..The association between folate intake and risk of OFCs however is inconsistent...
  9. ncbi request reprint Genetic polymorphisms of the CYP2E1 gene do not contribute to oral cancer susceptibility in south Indians
    Lakshmi Balaji
    Department of Endodontics, Sri Ramachandra Medical College and Hospital, and Department of Biomedical Sciences, Sri Ramachandra University, Chennai, India
    Asian Pac J Cancer Prev 12:1523-7. 2011
    ..None of the haplotypes showed a significant association with oral cancer. Our results suggest that CYP2E1 is not a major or independent determinant in the pathogenesis of oral cancer in south Indians...