Shi Lung Lin

Summary

Publications

  1. doi request reprint microRNAs and Fragile X Syndrome
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, 12145 Mora Drive, STE6, Santa Fe Springs, CA, 90670, USA
    Adv Exp Med Biol 888:107-21. 2015
  2. ncbi request reprint Mechanism and method for generating tumor-free iPS cells using intronic microRNA miR-302 induction
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:295-312. 2013
  3. ncbi request reprint Transgene-like animal models using intronic microRNAs
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:279-94. 2013
  4. ncbi request reprint Isolation and identification of gene-specific microRNAs
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:271-8. 2013
  5. ncbi request reprint Gene silencing in vitro and in vivo using intronic microRNAs
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:209-29. 2013
  6. pmc Regulation of somatic cell reprogramming through inducible mir-302 expression
    Shi Lung Lin
    WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA 90670, USA
    Nucleic Acids Res 39:1054-65. 2011
  7. pmc Concise review: Deciphering the mechanism behind induced pluripotent stem cell generation
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, California, USA
    Stem Cells 29:1645-9. 2011
  8. doi request reprint MicroRNA miR-302 inhibits the tumorigenecity of human pluripotent stem cells by coordinate suppression of the CDK2 and CDK4/6 cell cycle pathways
    Shi Lung Lin
    WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, California 90670, USA
    Cancer Res 70:9473-82. 2010
  9. ncbi request reprint Gene silencing in vitro and in vivo using intronic microRNAs
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:295-312. 2006
  10. ncbi request reprint Transgene-like animal models using intronic microRNAs
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:321-34. 2006

Collaborators

Detail Information

Publications26

  1. doi request reprint microRNAs and Fragile X Syndrome
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, 12145 Mora Drive, STE6, Santa Fe Springs, CA, 90670, USA
    Adv Exp Med Biol 888:107-21. 2015
    ....
  2. ncbi request reprint Mechanism and method for generating tumor-free iPS cells using intronic microRNA miR-302 induction
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:295-312. 2013
    ..In this chapter, we reviewed the mechanism underlying miR-302-mediated tumor suppression and then applied this mechanism to generate tumor-free iPSCs. The same strategy can also be used to prevent ESC tumorigenicity...
  3. ncbi request reprint Transgene-like animal models using intronic microRNAs
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:279-94. 2013
    ....
  4. ncbi request reprint Isolation and identification of gene-specific microRNAs
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:271-8. 2013
    ..According to this proven-of-principle method, we now have full knowledge to design pre-miRNA inserts that are more efficient and effective for the intronic miRNA-expressing systems...
  5. ncbi request reprint Gene silencing in vitro and in vivo using intronic microRNAs
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA, USA
    Methods Mol Biol 936:209-29. 2013
    ..These miRNA-mediated animal models provide artificial means to reproduce the mechanisms of miRNA-induced disease in vivo and will shed further light on miRNA-related therapies...
  6. pmc Regulation of somatic cell reprogramming through inducible mir-302 expression
    Shi Lung Lin
    WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, CA 90670, USA
    Nucleic Acids Res 39:1054-65. 2011
    ..As the mechanism of conventional iPS cell induction methods remains largely unknown, understanding this microRNA (miRNA)-mediated SCR mechanism may shed light on the improvements of iPS cell generation...
  7. pmc Concise review: Deciphering the mechanism behind induced pluripotent stem cell generation
    Shi Lung Lin
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, California, USA
    Stem Cells 29:1645-9. 2011
    ....
  8. doi request reprint MicroRNA miR-302 inhibits the tumorigenecity of human pluripotent stem cells by coordinate suppression of the CDK2 and CDK4/6 cell cycle pathways
    Shi Lung Lin
    WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, California 90670, USA
    Cancer Res 70:9473-82. 2010
    ..Overall, our findings indicate that miR-302 inhibits human pluripotent stem cell tumorigenicity by enhancing multiple G1 phase arrest pathways rather than by silencing p21Cip1...
  9. ncbi request reprint Gene silencing in vitro and in vivo using intronic microRNAs
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:295-312. 2006
    ..These miRNA-mediated animal models provide artificial means to reproduce the mechanisms of miRNA-induced disease in vivo and will shed further light on miRNA-related therapies...
  10. ncbi request reprint Transgene-like animal models using intronic microRNAs
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:321-34. 2006
    ....
  11. ncbi request reprint mRNA/cDNA library construction using RNA-polymerase cycling reaction
    Shi Lung Lin
    Epiclone Inc, San Diego, CA, USA
    Methods Mol Biol 221:129-43. 2003
  12. ncbi request reprint The microRNA: overview of the RNA gene that modulates gene functions
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:1-18. 2006
    ..The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented in this chapter, hopefully providing a guideline for further miRNA and gene function studies...
  13. doi request reprint Intron-mediated RNA interference, intronic microRNAs, and applications
    Shao Yao Ying
    Department of Cell, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 629:205-37. 2010
    ..These findings suggest an important miRNA-mediated gene regulatory system, which fine-tunes a variety of cellular and developmental events through the mechanism of RNAi-like gene silencing...
  14. ncbi request reprint Single-cell cDNA library construction using cycling aRNA amplification
    Shi Lung Lin
    Epiclone Inc, San Diego, CA, USA
    Methods Mol Biol 221:117-27. 2003
  15. ncbi request reprint MicroRNA protocols. Perspectives
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:351-8. 2006
    ..This chapter offers some perspective, with emphasis on areas that can be further developed...
  16. ncbi request reprint Single-cell mRNA library analysis by Northern blot hybridization
    Shi Lung Lin
    Epiclone Inc, San Diego, CA, USA
    Methods Mol Biol 221:169-78. 2003
  17. ncbi request reprint Isolation and identification of gene-specific microRNAs
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:313-20. 2006
    ..According to this proof- of-principle method, we now have the knowledge to design pre-miRNA inserts that are more efficient and effective for the intronic miRNA-expressing system...
  18. ncbi request reprint The microRNA (miRNA): overview of the RNA genes that modulate gene function
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, BMT 403, Los Angeles, CA, 90033, USA
    Mol Biotechnol 38:257-68. 2008
    ..The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented, hopefully providing a guideline for further miRNA and gene function studies...
  19. ncbi request reprint Peptide library construction from RNA-PCR-derived RNAs
    Shi Lung Lin
    Epiclone Inc, San Diego, CA, USA
    Methods Mol Biol 221:289-93. 2003
  20. doi request reprint Intron-mediated RNA interference and microRNA biogenesis
    Shao Yao Ying
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 487:387-413. 2009
    ..These findings suggest an intracellular miRNA-mediated gene regulatory system, fine-tuning the degradation of protein-coding messenger RNAs...
  21. ncbi request reprint The MicroRNA
    Shao Yao Ying
    Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 936:1-19. 2013
    ..The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented in this chapter, hopefully providing a guideline for further miRNA and gene function studies...
  22. ncbi request reprint Identify intronic microRNA with bioinformatics
    Chih Hao Kuo
    Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 936:77-82. 2013
    ..This information is critical for studying the gene-gene interaction via miRNA, and facilitates the study of miRNA in gene expression regulation...
  23. pmc Mechanism of repeat-associated microRNAs in fragile X syndrome
    Karen Kelley
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, 12145 Mora Drive, STE6, Santa Fe Springs, CA 90670, USA
    Neural Plast 2012:104796. 2012
    ..Using this novel animal model, we may further dissect the etiological mechanisms of TREDs, with the hope of providing insights into new means for therapeutic intervention...
  24. doi request reprint Induction of somatic cell reprogramming using the microRNA miR-302
    Karen Kelley
    Division of Regenerative Medicine, WJWU and LYNN Institute for Stem Cell Research, Santa Fe Springs, California, USA
    Prog Mol Biol Transl Sci 111:83-107. 2012
    ..Looking forward, the next challenge lies with surmounting senescence, an obstacle that often limits stem cell expansion and prevents researchers from growing the large quantities of iPSCs needed for therapeutic use...
  25. doi request reprint Gene silencing in vitro and in vivo using intronic microRNAs
    Jia Han Deng
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Bishop Medical Teaching and Research Building 401, MCH51A, 1333 San Pablo Street, BMT 301, Los Angeles, CA, 90033, USA
    Methods Mol Biol 1218:321-40. 2015
    ..These miRNA-mediated animal models provide artificial means to reproduce the mechanisms of miRNA-induced disease in vivo and will shed further light on miRNA-related therapies. ..
  26. ncbi request reprint cDNA library construction using in vitro transcriptional amplification
    Shi Lung Lin
    Epiclone Inc, San Diego, CA, USA
    Methods Mol Biol 221:93-101. 2003