Johan M Lorenzen

Summary

Publications

  1. ncbi request reprint Detection and transport mechanisms of circulating microRNAs in neurological, cardiac and kidney diseases
    J M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover, Germany
    Curr Med Chem 20:3623-8. 2013
  2. pmc Circulating microRNAs in patients with Shiga-Toxin-producing E. coli O104:H4 induced hemolytic uremic syndrome
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover, Germany
    PLoS ONE 7:e47215. 2012
  3. doi request reprint Circulating and urinary microRNAs in kidney disease
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS and Department of Medicine, Division of Nephrology and Hypertension, Hanover Medical School, Hannover, Germany
    Clin J Am Soc Nephrol 7:1528-33. 2012
  4. doi request reprint Conversion from conventional in-centre thrice-weekly haemodialysis to short daily home haemodialysis ameliorates uremia-associated clinical parameters
    Johan M Lorenzen
    Department of Medicine Division of Nephrology and Hypertension, Hanover Medical School, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    Int Urol Nephrol 44:883-90. 2012
  5. pmc Achilles tendon suture deteriorates tendon capillary blood flow with sustained tissue oxygen saturation - an animal study
    Robert Kraemer
    Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Orthop Surg Res 4:32. 2009
  6. pmc Acute effects of remote ischemic preconditioning on cutaneous microcirculation--a controlled prospective cohort study
    Robert Kraemer
    Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    BMC Surg 11:32. 2011
  7. doi request reprint Circulating miR-210 predicts survival in critically ill patients with acute kidney injury
    Johan M Lorenzen
    Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Clin J Am Soc Nephrol 6:1540-6. 2011
  8. pmc Epigenetic modifications in cardiovascular disease
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    Basic Res Cardiol 107:245. 2012
  9. doi request reprint Osteopontin in patients with idiopathic pulmonary hypertension
    Johan M Lorenzen
    Department of Nephrology and Hypertension, Centre of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Chest 139:1010-7. 2011
  10. doi request reprint Osteopontin predicts survival in critically ill patients with acute kidney injury
    Johan M Lorenzen
    Department of Medicine, Division of Nephrology and Hypertension, Hanover Medical School, Hannover, Germany
    Nephrol Dial Transplant 26:531-7. 2011

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Detection and transport mechanisms of circulating microRNAs in neurological, cardiac and kidney diseases
    J M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover, Germany
    Curr Med Chem 20:3623-8. 2013
    ..The present article outlines the quantification and biomarker use of microRNAs in various body fluids of patients with cardiac and kidney disease as well as neurological disorders. ..
  2. pmc Circulating microRNAs in patients with Shiga-Toxin-producing E. coli O104:H4 induced hemolytic uremic syndrome
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover, Germany
    PLoS ONE 7:e47215. 2012
    ..MicroRNAs are small ribonucleotides orchestrating gene expression. We tested whether circulating microRNAs in serum of HUS patients during the 2011 epidemics are altered in this patient cohort and related to clinical manifestations...
  3. doi request reprint Circulating and urinary microRNAs in kidney disease
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS and Department of Medicine, Division of Nephrology and Hypertension, Hanover Medical School, Hannover, Germany
    Clin J Am Soc Nephrol 7:1528-33. 2012
    ..The aim of the present article is to give an outline of recent work on circulating and urinary microRNAs as well as their potential paracrine activity in kidney disease...
  4. doi request reprint Conversion from conventional in-centre thrice-weekly haemodialysis to short daily home haemodialysis ameliorates uremia-associated clinical parameters
    Johan M Lorenzen
    Department of Medicine Division of Nephrology and Hypertension, Hanover Medical School, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    Int Urol Nephrol 44:883-90. 2012
    ..Even if considered adequate by current Kt/V-based dose estimates, this unphysiological dose is associated with an unacceptable annual mortality rate of 10-20%. Increasing dialysis dose might ameliorate this mortality rate...
  5. pmc Achilles tendon suture deteriorates tendon capillary blood flow with sustained tissue oxygen saturation - an animal study
    Robert Kraemer
    Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Orthop Surg Res 4:32. 2009
    ..We hypothesize that an experimental Achilles tendon suture in an animal model significantly deteriorates Achilles tendon microcirculation immediately following suturing...
  6. pmc Acute effects of remote ischemic preconditioning on cutaneous microcirculation--a controlled prospective cohort study
    Robert Kraemer
    Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    BMC Surg 11:32. 2011
    ....
  7. doi request reprint Circulating miR-210 predicts survival in critically ill patients with acute kidney injury
    Johan M Lorenzen
    Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Clin J Am Soc Nephrol 6:1540-6. 2011
    ..We tested whether circulating miRNAs in the plasma of critically ill patients with acute kidney injury (AKI) at the inception of renal replacement therapy are deregulated and may predict survival...
  8. pmc Epigenetic modifications in cardiovascular disease
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    Basic Res Cardiol 107:245. 2012
    ..In addition, RNA-based mechanisms (e.g., microRNAs and long non-coding RNAs) influence the development of disease. We here outline the recent work pertaining to epigenetic changes in a cardiovascular disease setting...
  9. doi request reprint Osteopontin in patients with idiopathic pulmonary hypertension
    Johan M Lorenzen
    Department of Nephrology and Hypertension, Centre of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Chest 139:1010-7. 2011
    ..OPN plasma levels may be related to disease severity and mortality in patients with PAH...
  10. doi request reprint Osteopontin predicts survival in critically ill patients with acute kidney injury
    Johan M Lorenzen
    Department of Medicine, Division of Nephrology and Hypertension, Hanover Medical School, Hannover, Germany
    Nephrol Dial Transplant 26:531-7. 2011
    ..We have tested the hypothesis that osteopontin levels might serve as a biomarker predicting outcome in critically ill patients requiring renal replacement therapy after acute kidney injury...
  11. doi request reprint Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease
    Johan Lorenzen
    Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Eur J Clin Invest 40:294-300. 2010
    ..Therefore, we assessed the relationship between OPN plasma levels and renal function in patients at different stages of chronic kidney disease (CKD)...
  12. doi request reprint Osteopontin in antineutrophil cytoplasmic autoantibody-associated vasculitis: relation to disease activity, organ manifestation and immunosuppressive therapy
    Johan Lorenzen
    Hannover Medical School, Department of Internal Medicine, Division of Nephrology, 30625 Hannover, Germany
    Ann Rheum Dis 69:1169-71. 2010
    ..Osteopontin may play a role in the pathogenesis of AAV...
  13. doi request reprint Angiotensin II receptor blocker and statins lower elevated levels of osteopontin in essential hypertension--results from the EUTOPIA trial
    Johan M Lorenzen
    Department of Medicine Division of Nephrology and Hypertension, Hanover Medical School, Hannover, Germany
    Atherosclerosis 209:184-8. 2010
    ..We aimed at studying the effect of olmesartan and/or pravastatin on osteopontin plasma levels, and the association between vascular inflammation markers and osteopontin in hypertensive patients...
  14. doi request reprint Effects of arginase inhibitors on the contractile and relaxant responses of isolated human penile erectile tissue
    Johan M Lorenzen
    Department of Urology and Uro Oncology, Hannover Medical School, 30625 Hannover, Germany
    World J Urol 27:805-10. 2009
    ..The aim of the present study was to elucidate the effects of drugs known to inhibit arginase activity on the relaxation of isolated human corpus cavernosum (HCC) and the production of cyclic GMP...
  15. doi request reprint Infection with Mycobacterium genavense in a patient with systemic lupus erythematosus
    Johan Lorenzen
    Department of Internal Medicine, Division of Nephrology, Hanover Medical School, Carl Neuberg Strasse 1, 30625, Hanover, Germany
    Clin Rheumatol 28:S39-41. 2009
    ..To our knowledge, this is the first case involving M. genavense infection in a patient with systemic lupus erythematosus. In contrast to other reports regarding disseminated M. genavense infection, the patient is still alive and well...
  16. doi request reprint Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients
    J M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS Department of Medicine Division of Nephrology and Hypertension, Hannover Medical School, Hanover, Germany
    Am J Transplant 11:2221-7. 2011
    ..The miR-210 levels identify patients with acute rejection and predict long-term kidney function. Urinary miR-210 may thus serve as a novel biomarker of acute kidney rejection...
  17. doi request reprint SDMA is an early marker of change in GFR after living-related kidney donation
    Jan T Kielstein
    Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School Hannover, Germany
    Nephrol Dial Transplant 26:324-8. 2011
    ..It is however unknown how fast SDMA is increasing after reduction in GFR. The aim of our study was therefore to determine the temporal change of SDMA in comparison with cystatin C after a defined reduction in GFR...
  18. doi request reprint TLR-4+ peripheral blood monocytes and cardiovascular events in patients with chronic kidney disease--a prospective follow-up study
    Johan M Lorenzen
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 26:1421-4. 2011
    ..Atherosclerosis is an inflammatory process mediated by circulating immune cells, including monocytes. There is accumulating evidence for the involvement of Toll-like receptor 4 (TLR-4) as a mediator of atherogenesis...
  19. doi request reprint Circulating long noncoding RNATapSaki is a predictor of mortality in critically ill patients with acute kidney injury
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS and Department of Medicine Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Clin Chem 61:191-201. 2015
    ..We tested whether circulating lncRNAs in plasma of critically ill patients with acute kidney injury (AKI) at inception of renal replacement therapy were deregulated and might predict survival...
  20. pmc Fetuin, matrix-Gla protein and osteopontin in calcification of renal allografts
    Johan M Lorenzen
    Department of Medicine, Division of Nephrology and Hypertension, Hanover Medical School, Hannover, Germany
    PLoS ONE 7:e52039. 2012
    ..Aim of this study is to examine the role of the anti-calcifying/calcifying factors in the pathophysiology of renal allograft calcification...
  21. doi request reprint Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome
    Christian Widera
    Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany
    J Mol Cell Cardiol 51:872-5. 2011
    ..The present study tempers speculations about the potential usefulness of cardiomyocyte-enriched microRNAs as diagnostic or prognostic markers in ACS...
  22. doi request reprint Long Noncoding RNAs in Urine Are Detectable and May Enable Early Detection of Acute T Cell-Mediated Rejection of Renal Allografts
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies and Department of Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Clin Chem 61:1505-14. 2015
    ..They are detectable in the blood of patients with acute kidney injury. We tested whether lncRNAs are present in urine and may serve as new predictors of outcome in renal transplant patients with acute rejection...
  23. doi request reprint Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines
    Seema Dangwal
    From the Institute of Molecular and Translational Therapeutic Strategies IMTTS S D, C B, J M L, R K, J F, T T, Integrated Research and Treatment Center Transplantation, IFB Tx J M L, C S F, T T, and Institute of Transplant Immunology C S F, Hannover Medical School, Hannover, Germany Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, Germany B S, D T IZKF Laboratory for Microarray Applications, University Hospital of Wuerzburg, Wuerzburg, Germany C J S and National Heart and Lung Institute, Imperial College London, London, United Kingdom T T
    Arterioscler Thromb Vasc Biol 35:1480-8. 2015
    ..Here, we investigated influence of impaired wound healing on the plasma miRNA signature and their functional importance in patients with type 2 diabetes mellitus...
  24. doi request reprint Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease
    Christian Wolf
    Institut für Molekulare und Translationale Therapiestrategien IMTTS, Medizinische Hochschule, Hannover, Germany
    Int J Cardiol 156:289-94. 2012
    ..Unlike circulating ADMA, very little is known about urinary ADMA and DMA concentrations and a predictive value in CAD patients...
  25. doi request reprint Role of microRNAs in immunity and organ transplantation
    Janine C Spiegel
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    Expert Rev Mol Med 13:e37. 2011
    ..We also focus on the molecular mechanisms and therapeutic implications of the use of miRNA-based therapeutic strategies to improve long-term allograft survival...
  26. pmc Pharmacokinetics of ampicillin/sulbactam in critically ill patients with acute kidney injury undergoing extended dialysis
    Johan M Lorenzen
    Division of Nephrology and Hypertension, Department of Internal Medicine, Hannover Medical School, Germany
    Clin J Am Soc Nephrol 7:385-90. 2012
    ..The aims of this study were to evaluate the pharmacokinetics of ampicillin/sulbactam in critically ill patients with AKI undergoing extended dialysis (ED) and to establish a dosing recommendation for this treatment method...
  27. pmc Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Eur Heart J 36:2184-96. 2015
    ..Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are powerful regulators of gene expression and thus might mediate this process...
  28. pmc Cotrimoxazole plasma levels, dialyzer clearance and total removal by extended dialysis in a patient with acute kidney injury: risk of under-dosing using current dosing recommendations
    Christian Clajus
    Department of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany
    BMC Pharmacol Toxicol 14:19. 2013
    ..Cotrimoxazole, a combination of trimethoprim (TMP) and sulfamethoxazole (SMX) is frequently used in the treatment of several infections including Pneumocystis jirovecii pneumonia (PCP)...
  29. pmc Aromatase inhibition attenuates desflurane-induced preconditioning against acute myocardial infarction in male mouse heart in vivo
    Virginija Jazbutyte
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, MHH, Hannover, Germany
    PLoS ONE 7:e42032. 2012
    ....
  30. doi request reprint MicroRNAs as mediators and therapeutic targets in chronic kidney disease
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Rev Nephrol 7:286-94. 2011
    ..The therapeutic potential of miRNA-based treatment strategies in CKD are discussed...
  31. doi request reprint Mitochondrial long noncoding RNAs as blood based biomarkers for cardiac remodeling in patients with hypertrophic cardiomyopathy
    Janina Kitow
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, IFB Tx, Hannover Medical School, Hannover, Germany
    Am J Physiol Heart Circ Physiol 311:H707-12. 2016
    ..4 and uc022bqu.1 were upregulated in patients with HOCM and they were also able to identify HOCM and could be developed as useful clinical biomarkers in the future. ..
  32. doi request reprint Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study
    Julia Osipova
    Institute of Molecular and Translational Therapeutic Strategies J O, S D, I V, K S, J M L, T T, IFB Tx, Department of Cardiology C W, Department of Paediatric Kidney, Liver, and Metabolic Diseases D H, Hannover Medical School, 30625 Hannover, Germany Department of Paediatrics D C F, C S, U J, M H, University Hospital Rostock, 18051 Rostock, Germany and National Heart and Lung Institute T T, Imperial College London, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 99:E1661-5. 2014
    ..Circulating microRNAs (miRNAs/miRs) are used as novel biomarkers for diseases. miR-21, miR-126, and miR-210 are known to be deregulated in vivo or in vitro under diabetic conditions...
  33. doi request reprint Pathologic endothelial response and impaired function of circulating angiogenic cells in patients with Fabry disease
    Johan M Lorenzen
    Hannover Medical School, Institute of Molecular and Translational Therapeutic Strategies, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Basic Res Cardiol 108:311. 2013
    ..Fabry patients show a dysfunction of CAC and a pathologic endothelial response. ERT improves CAC and endothelial function and thus may attenuate development of cardiovascular disease in the long term in this patient population...
  34. doi request reprint Long noncoding RNAs in kidney and cardiovascular diseases
    Johan M Lorenzen
    Department of Nephrology, Hannover Medical School, Carl Neuberg Strase 1, 30625 Hannover, Germany
    Nat Rev Nephrol 12:360-73. 2016
    ..This Review outlines our current understanding of the role and function of lncRNAs in kidney and cardiovascular disease as novel important regulators and potential therapeutic entry points of disease progression. ..
  35. doi request reprint Vascular importance of the miR-212/132 cluster
    Regalla Kumarswamy
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany
    Eur Heart J 35:3224-31. 2014
    ..Many processes in endothelial cells including angiogenic responses are regulated by microRNAs. However, there is limited information available about their complex cross-talk in regulating certain endothelial functions...
  36. doi request reprint Regulation of cardiac and renal ischemia-reperfusion injury by microRNAs
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies, Germany
    Free Radic Biol Med 64:78-84. 2013
    ..This review highlights the latest developments regarding the role of microRNAs in cardiac and renal I/R injury. ..
  37. pmc Endothelial progenitor cells and cardiovascular events in patients with chronic kidney disease--a prospective follow-up study
    Johan Lorenzen
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    PLoS ONE 5:e11477. 2010
    ..Endothelial progenitor cells (EPCs) mediate vascular repair and regeneration. Their number in peripheral blood is related to cardiovascular events in individuals with normal renal function...
  38. doi request reprint Risk of underdosing of ampicillin/sulbactam in patients with acute kidney injury undergoing extended daily dialysis--a single case
    Jan T Kielstein
    Division of Nephrology and Hypertension, Department of Internal Medicine, Medical School Hannover, Hannover, Germany
    Nephrol Dial Transplant 24:2283-5. 2009
    ..5 h, indicating that the current dosing regimen for haemodialysis outpatients (ampicillin/sulbactam 2.0/1.0 g/day) would result in a significant underdosing for patients undergoing EDD...