Yvan Devaux

Summary

Country: Luxembourg

Publications

  1. pmc Cardioprotective effects of adenosine within the border and remote areas of myocardial infarction
    Melanie Bousquenaud
    Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, 84 Val Fleuri, Luxembourg L1526, Luxembourg
    EJNMMI Res 3:65. 2013
  2. pmc MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?
    Yvan Devaux
    Laboratory of Cardiovascular Research, Luxembourg Institute of Health, L 1526, Luxembourg, Luxembourg
    Crit Care 19:54. 2015
  3. pmc Identification of candidate long non-coding RNAs in response to myocardial infarction
    Jennifer Zangrando
    Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé CRP Santé, 84 Val Fleuri, Luxembourg L1526, Luxembourg
    BMC Genomics 15:460. 2014
  4. ncbi request reprint Regulation of endothelial progenitor cell function by micrornas
    E Goretti
    Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, CRP Santé Luxembourg, Luxembourg
    Minerva Cardioangiol 61:591-604. 2013
  5. pmc A panel of 4 microRNAs facilitates the prediction of left ventricular contractility after acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg
    PLoS ONE 8:e70644. 2013
  6. doi request reprint MicroRNA-150: a novel marker of left ventricular remodeling after acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg
    Circ Cardiovasc Genet 6:290-8. 2013
  7. doi request reprint Low levels of vascular endothelial growth factor B predict left ventricular remodeling after acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Luxembourg, Luxembourg
    J Card Fail 18:330-7. 2012
  8. doi request reprint Integrated protein network and microarray analysis to identify potential biomarkers after myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, 120 route d Arlon, 1150, Luxembourg, Luxembourg
    Funct Integr Genomics 10:329-37. 2010
  9. pmc Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research Centre de Recherche Public Santé, Luxembourg, L 1150, Luxembourg
    BMC Med Genomics 4:83. 2011
  10. pmc Adenosine stimulates the migration of human endothelial progenitor cells. Role of CXCR4 and microRNA-150
    Magali Rolland-Turner
    Laboratory of Cardiovascular Research, Public Research Centre Health CRP Santé, Luxembourg, Luxembourg
    PLoS ONE 8:e54135. 2013

Collaborators

Detail Information

Publications41

  1. pmc Cardioprotective effects of adenosine within the border and remote areas of myocardial infarction
    Melanie Bousquenaud
    Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, 84 Val Fleuri, Luxembourg L1526, Luxembourg
    EJNMMI Res 3:65. 2013
    ..We assessed the long-term effects of adenosine after MI using electrocardiogram-triggered 18 F-fluorodeoxyglucose positron emission tomography...
  2. pmc MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?
    Yvan Devaux
    Laboratory of Cardiovascular Research, Luxembourg Institute of Health, L 1526, Luxembourg, Luxembourg
    Crit Care 19:54. 2015
    ..This review highlights the recent discoveries suggesting that microRNAs may be useful both to predict outcome and to treat patients after cardiac arrest. ..
  3. pmc Identification of candidate long non-coding RNAs in response to myocardial infarction
    Jennifer Zangrando
    Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé CRP Santé, 84 Val Fleuri, Luxembourg L1526, Luxembourg
    BMC Genomics 15:460. 2014
    ..LncRNAs regulate gene expression, thus having the possibility to modulate disease progression. In this study, we investigated the changes of lncRNAs expression in the heart after myocardial infarction (MI)...
  4. ncbi request reprint Regulation of endothelial progenitor cell function by micrornas
    E Goretti
    Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, CRP Santé Luxembourg, Luxembourg
    Minerva Cardioangiol 61:591-604. 2013
    ..Then, we will summarize current knowledge on the role of miRNAs in EPC and we will discuss how miRNAs may be used to enhance the capacity of EPC to repair the injured heart. ..
  5. pmc A panel of 4 microRNAs facilitates the prediction of left ventricular contractility after acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg
    PLoS ONE 8:e70644. 2013
    ..Prediction of clinical outcome after acute myocardial infarction (AMI) is challenging and would benefit from new biomarkers. We investigated the prognostic value of 4 circulating microRNAs (miRNAs) after AMI...
  6. doi request reprint MicroRNA-150: a novel marker of left ventricular remodeling after acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg
    Circ Cardiovasc Genet 6:290-8. 2013
    ..MicroRNAs (miRNAs) regulate the expression of several genes involved in LV remodeling. Our aim was to identify miRNAs associated with LV remodeling after acute myocardial infarction...
  7. doi request reprint Low levels of vascular endothelial growth factor B predict left ventricular remodeling after acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Luxembourg, Luxembourg
    J Card Fail 18:330-7. 2012
    ..We recently reported that vascular endothelial growth factor B (VEGFB) may be a potential new biomarker of LV remodeling. This potential biomarker was evaluated in the present study...
  8. doi request reprint Integrated protein network and microarray analysis to identify potential biomarkers after myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, 120 route d Arlon, 1150, Luxembourg, Luxembourg
    Funct Integr Genomics 10:329-37. 2010
    ..In conclusion, a new strategy is described that allows identifying new potential biomarkers. The three specific biomarkers described here remain to be validated in a larger patient population...
  9. pmc Transforming growth factor β receptor 1 is a new candidate prognostic biomarker after acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research Centre de Recherche Public Santé, Luxembourg, L 1150, Luxembourg
    BMC Med Genomics 4:83. 2011
    ..Prediction of left ventricular (LV) remodeling after acute myocardial infarction (MI) is clinically important and would benefit from the discovery of new biomarkers...
  10. pmc Adenosine stimulates the migration of human endothelial progenitor cells. Role of CXCR4 and microRNA-150
    Magali Rolland-Turner
    Laboratory of Cardiovascular Research, Public Research Centre Health CRP Santé, Luxembourg, Luxembourg
    PLoS ONE 8:e54135. 2013
    ..Mobilization and migration of EPC are mainly controlled by stromal cell-derived factor 1α (SDF-1α) and its receptor CXCR4. We hypothesized that adenosine, a cardioprotective molecule, may improve the recruitment of EPC to the heart...
  11. doi request reprint Adenosine reduces cell surface expression of toll-like receptor 4 and inflammation in response to lipopolysaccharide and matrix products
    Benjamin Haas
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, 120 route d Arlon 1150, Luxembourg
    J Cardiovasc Transl Res 4:790-800. 2011
    ..Reduction of TLR4 expression by Ado may therefore represent an important strategy to limit remodeling post-MI...
  12. doi request reprint Adenosine modifies the balance between membrane and soluble forms of Flt-1
    Frédérique Léonard
    Centre de Recherche Public Santé, 120 route d Arlon, L1150 Luxembourg
    J Leukoc Biol 90:199-204. 2011
    ..In conclusion, Ado down-regulates sFlt-1 and up-regulates mFlt-1 production, an effect that indicates that Ado may be used to stimulate angiogenesis in the heart...
  13. doi request reprint Transcriptional networks characterize ventricular dysfunction after myocardial infarction: a proof-of-concept investigation
    Francisco Azuaje
    Laboratory of Cardiovascular Research, Centre de Recherche Public, santé, Luxembourg
    J Biomed Inform 43:812-9. 2010
    ..Furthermore, it may reflect clinically-meaningful synergistic effects that cannot be identified by standard analyses...
  14. doi request reprint MicroRNA-16 affects key functions of human endothelial progenitor cells
    Emeline Goretti
    Laboratory of Cardiovascular Research, Public Research Centre Health, Luxembourg
    J Leukoc Biol 93:645-55. 2013
    ..In conclusion, miR-16 regulates key biological pathways in EPCs. This may have important implications to enhance the capacity of EPCs to repair injured tissues...
  15. doi request reprint Adenosine up-regulates vascular endothelial growth factor in human macrophages
    Isabelle Ernens
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg
    Biochem Biophys Res Commun 392:351-6. 2010
    ..This study suggests that adenosine is a unique pro-angiogenic molecule that may be used to stimulate cardiac repair...
  16. doi request reprint Use of circulating microRNAs to diagnose acute myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Centre de Recherche Public, santé, Luxembourg
    Clin Chem 58:559-67. 2012
    ..We compared the diagnostic performance of high-sensitivity cardiac troponin T (hs-cTnT) and cardiac enriched microRNAs (miRNAs) in patients with MI...
  17. doi request reprint Acipimox-enhanced ¹⁸F-fluorodeoxyglucose positron emission tomography for characterizing and predicting early remodeling in the rat infarct model
    Melanie Bousquenaud
    Laboratory of Cardiovascular Research Centre de Recherche Public Santé, Luxembourg, Luxembourg
    Int J Cardiovasc Imaging 28:1407-15. 2012
    ..The acipimox-enhanced FDG gated-PET technique provides efficient characterization and prediction of early remodeling in the rat infarct model...
  18. pmc Predictive integration of gene functional similarity and co-expression defines treatment response of endothelial progenitor cells
    Francisco J Azuaje
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, L 1150, Luxembourg
    BMC Syst Biol 5:46. 2011
    ..Specifically, we set out to identify novel biosignatures of Ado-treatment response in EPCs...
  19. doi request reprint Circulating microRNAs after cardiac arrest
    Pascal Stammet
    Department of Anaesthesia and Intensive Care, Centre Hospitalier, Luxembourg, Luxembourg
    Crit Care Med 40:3209-14. 2012
    ..While the potential of circulating microRNAs as biomarkers of acute coronary syndromes is an active field of investigation, it is unknown whether microRNAs are associated with outcome in cardiac arrest patients...
  20. doi request reprint Modeling serum level of s100β and bispectral index to predict outcome after cardiac arrest
    Pascal Stammet
    Department of Anaesthesia and Intensive Care, Centre Hospitalier, Luxembourg, Luxembourg
    J Am Coll Cardiol 62:851-8. 2013
    ..This study was designed to evaluate multimodal prognostication in patients after cardiac arrest (CA)...
  21. doi request reprint Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages
    Emilie Velot
    Laboratory of Cardiovascular Research, CRP Sante, Luxembourg, Luxembourg
    Cardiovasc Res 80:246-54. 2008
    ..We have shown that Ado inhibits the secretion of MMP-9 by human neutrophils. This study investigated the effect of Ado on MMP-9 production by human macrophages...
  22. pmc Drug-target network in myocardial infarction reveals multiple side effects of unrelated drugs
    Francisco J Azuaje
    Laboratory of Cardiovascular Research, Public Research Centre for Health CRP Santé, 120 route d Arlon, L 1150 Luxembourg, Luxembourg
    Sci Rep 1:52. 2011
    ..We provide systemic insights into cardiovascular effects of non-cardiovascular drugs. My-DTome provides the basis for an alternative approach to investigate new targets and multidrug treatment in MI...
  23. doi request reprint Monocyte chemotactic protein 3 is a homing factor for circulating angiogenic cells
    Melanie Bousquenaud
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, 120 route d Arlon, L1150 Luxembourg, Luxembourg
    Cardiovasc Res 94:519-25. 2012
    ..Since the expression of monocyte chemotactic protein 3 (MCP3) is increased in ischaemic hearts, we hypothesized that it may participate in CAC mobilization...
  24. pmc MicroRNAs in patients on chronic hemodialysis (MINOS study)
    Cristina Emilian
    Division of Cardiology, Centre Hospitalier, Luxembourg, Luxembourg
    Clin J Am Soc Nephrol 7:619-23. 2012
    ..Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis...
  25. doi request reprint Proteomic analysis of plasma samples from patients with acute myocardial infarction identifies haptoglobin as a potential prognostic biomarker
    Benjamin Haas
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg, Luxembourg
    J Proteomics 75:229-36. 2011
    ..A plasma level of Hp below 1.4g/L predicted the occurrence of heart failure (NYHA 2, 3, 4) at 1-year with 100% sensitivity...
  26. pmc Information encoded in a network of inflammation proteins predicts clinical outcome after myocardial infarction
    Francisco J Azuaje
    Laboratory of Cardiovascular Research, Public Research Centre for Health, CRP Sante, L 1150, Luxembourg
    BMC Med Genomics 4:59. 2011
    ..We investigated the interplay of inflammation proteins and assessed network-derived knowledge to support clinical decisions after MI. The main focus is the prediction of clinical outcome after MI...
  27. pmc Proof-of-principle investigation of an algorithmic model of adenosine-mediated angiogenesis
    Francisco Azuaje
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé CRP Santé, L 1150 Luxembourg, Luxembourg
    Theor Biol Med Model 8:7. 2011
    ..We explored its feasibility to test angiogenesis-relevant hypotheses. We illustrated its potential to investigate the role of Ado as an angiogenesis modulator by enhancing VEGF activity and antagonizing sVEGFR-1...
  28. doi request reprint Adenosine stimulates angiogenesis by up-regulating production of thrombospondin-1 by macrophages
    Isabelle Ernens
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg and Division of Cardiology, Centre Hospitalier, Luxembourg
    J Leukoc Biol 97:9-18. 2015
    ..The mechanism involves A2AR and A2BR and is mediated through the cAMP/PKA pathway. This information may be important when designing Ado-based therapies of angiogenesis. ..
  29. doi request reprint Identification of potential targets in biological signalling systems through network perturbation analysis
    Francisco Azuaje
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, 120 route d Arlon, Luxembourg
    Biosystems 100:55-64. 2010
    ..The proposed perturbation assessment methodology may be applied to other systems to gain a deeper understanding of their dynamic operation and to assist the discovery of new therapeutic targets and strategies...
  30. pmc Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network
    Francisco Azuaje
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, L 1150 Luxembourg
    BMC Syst Biol 4:60. 2010
    ..To support these efforts, here we report a global network of protein-protein interactions (PPIs) relevant to HF, which was characterized through integrative bioinformatic analyses of multiple sources of "omic" information...
  31. pmc Integrative pathway-centric modeling of ventricular dysfunction after myocardial infarction
    Francisco Azuaje
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg, Luxembourg
    PLoS ONE 5:e9661. 2010
    ..Within this discovery framework key perturbations and predictive patterns are characterized by the integrated biological activity levels observed in pathways, rather than in individual genes...
  32. pmc Challenges and standards in reporting diagnostic and prognostic biomarker studies
    Francisco Azuaje
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg
    Clin Transl Sci 2:156-61. 2009
    ..The review concludes with a discussion of the challenges and recommendations...
  33. doi request reprint Long noncoding RNAs in cardiac development and ageing
    Yvan Devaux
    Luxembourg Institute of Health, L 1526 Luxembourg, Luxembourg
    Nat Rev Cardiol 12:415-25. 2015
    ..We emphasize the importance of chromatin remodelling in this regulation. Finally, we discuss the therapeutic and biomarker potential of lncRNAs. ..
  34. pmc Identification of candidate long noncoding RNAs associated with left ventricular hypertrophy
    Lu Zhang
    Laboratory of Cardiovascular Research, Public Research Center Health CRP Santé, Luxembourg
    Clin Transl Sci 8:100-6. 2015
    ..Their role in cardiac disease is poorly known. Here, we investigated the association between lncRNAs and left ventricular hypertrophy...
  35. doi request reprint Computational biology for cardiovascular biomarker discovery
    Francisco Azuaje
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg
    Brief Bioinform 10:367-77. 2009
    ..The review will conclude with a discussion of key challenges for computational biology, including perspectives from the biosciences and clinical areas...
  36. pmc An optimized protocol for microarray validation by quantitative PCR using amplified amino allyl labeled RNA
    Céline Jeanty
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, Luxembourg
    BMC Genomics 11:542. 2010
    ..To test this possibility, we used an ongoing study of our laboratory aiming at identifying new biomarkers of graft rejection by the transcriptomic analysis of blood cells from brain-dead organ donors...
  37. doi request reprint miRNAs as biomarkers of myocardial infarction: a step forward towards personalized medicine?
    Emeline Goretti
    Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé CRP Santé, 84 Val Fleuri, L 1526 Luxembourg, Luxembourg
    Trends Mol Med 20:716-25. 2014
    ..In the rapidly evolving era of biomarkers, the potential of miRNAs as promising tools to move personalized medicine a step forward is discussed. ..
  38. doi request reprint Long noncoding RNAs in patients with acute myocardial infarction
    Melanie Vausort
    From the Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg M V, Y D and Division of Cardiology, Centre Hospitalier, Luxembourg, Luxembourg D R W
    Circ Res 115:668-77. 2014
    ..Although recent data suggest that lncRNAs may be associated with cardiac disease, little is known about lncRNAs in the setting of myocardial ischemia...
  39. ncbi request reprint Adenosine inhibits matrix metalloproteinase-9 secretion by neutrophils: implication of A2a receptor and cAMP/PKA/Ca2+ pathway
    Isabelle Ernens
    Laboratory of Cardiovascular Research, CRP Sante, Luxembourg
    Circ Res 99:590-7. 2006
    ..Our results suggest that this effect implies the A2a receptor and is mediated through the cAMP/PKA/Ca(2+) pathway. Therefore, adenosine may represent a new approach to prevent matrix degradation and remodeling after myocardial injury...
  40. pmc Effects of adenosine on lymphangiogenesis
    Bénédicte Lenoir
    Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé CRP Santé, Luxembourg
    PLoS ONE 9:e92715. 2014
    ..Production of adenosine is enhanced in the tumor environment and contributes to tumor progression through stimulation of angiogenesis. In this study, we determined whether adenosine affects lymphangiogenesis...