Chung Yeng Looi

Summary

Affiliation: University of Malaya
Country: Malaysia

Publications

  1. doi request reprint Antidiabetic and antioxidant properties of alkaloids from Catharanthus roseus (L.) G. Don
    Soon Huat Tiong
    Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Molecules 18:9770-84. 2013
  2. pmc Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition
    Ismail Adam Arbab
    Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Malaysia
    Evid Based Complement Alternat Med 2012:856029. 2012
  3. pmc Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds
    Chung Yeng Looi
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 8:e56643. 2013
  4. pmc Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways
    Chung Yeng Looi
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    BMC Complement Altern Med 13:166. 2013
  5. pmc Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway
    Elham Rouhollahi
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
    BMC Complement Altern Med 15:15. 2015
  6. doi request reprint Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, β-TC6 and its alleviating role in type 2 diabetic rats
    Aditya Arya
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Ethnopharmacol 144:22-32. 2012
  7. doi request reprint Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-κB and IL-6/STAT3 as potential targets
    Ashok Kumar Pandurangan
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50503 Kuala Lumpur, Malaysia
    Biofactors 42:247-58. 2016
  8. pmc Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell
    Mohadeseh Hasanpourghadi
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia
    J Exp Clin Cancer Res 35:58. 2016
  9. pmc The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats
    Elham Rouhollahi
    Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Drug Des Devel Ther 9:3911-22. 2015
  10. pmc Triclosan Demonstrates Synergic Effect with Amphotericin B and Fluconazole and Induces Apoptosis-Like Cell Death in Cryptococcus neoformans
    Elaheh Movahed
    Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center, Faculty of Medicine, University of Malaya Kuala Lumpur, Malaysia
    Front Microbiol 7:360. 2016

Collaborators

Detail Information

Publications47

  1. doi request reprint Antidiabetic and antioxidant properties of alkaloids from Catharanthus roseus (L.) G. Don
    Soon Huat Tiong
    Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Molecules 18:9770-84. 2013
    ..III showed the highest antioxidant potential in ORAC and DPPH assays and it also alleviated H₂O₂-induced oxidative damage in β-TC6 cells at 12.5 µg/mL and 25.0 µg/mL...
  2. pmc Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition
    Ismail Adam Arbab
    Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Malaysia
    Evid Based Complement Alternat Med 2012:856029. 2012
    ..Thus, we suggest that dentatin may have therapeutic value in prostate cancer treatment worthy of further development...
  3. pmc Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds
    Chung Yeng Looi
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 8:e56643. 2013
    ..seeds (CACF) by inhibiting tumor necrosis factor-α (TNF-α)-induced growth of human breast cancer cells. However, the active compounds in CACF have not been investigated previously...
  4. pmc Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways
    Chung Yeng Looi
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    BMC Complement Altern Med 13:166. 2013
    ..The present study aims to investigate the anti-cancer effect of Centratherum anthelminticum (L.) seeds chloroform fraction (CACF) on human melanoma cells and to elucidate the molecular mechanism involved...
  5. pmc Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway
    Elham Rouhollahi
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
    BMC Complement Altern Med 15:15. 2015
    ..In the present study, the apoptogenic activity of dichloromethane extract of Curcuma purpurascens BI. rhizome (DECPR) was investigated against HT-29 human colon cancer cells...
  6. doi request reprint Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, β-TC6 and its alleviating role in type 2 diabetic rats
    Aditya Arya
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Ethnopharmacol 144:22-32. 2012
    ..Seeds of Centratherum anthelminticum (Asteraceae) have been popularly used in Ayurvedic medicine to treat diabetes and skin disorders. Folk medicine from Rayalaseema (Andhra Pradesh, India) reported wide spread usage in diabetes...
  7. doi request reprint Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-κB and IL-6/STAT3 as potential targets
    Ashok Kumar Pandurangan
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50503 Kuala Lumpur, Malaysia
    Biofactors 42:247-58. 2016
    ..2016 BioFactors, 42(3):247-258, 2016. ..
  8. pmc Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell
    Mohadeseh Hasanpourghadi
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia
    J Exp Clin Cancer Res 35:58. 2016
    ..The present study, focused on the cytotoxic effects of MBIC against HeLa cervical cancer cells and possible actions on the microtubule assembly...
  9. pmc The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats
    Elham Rouhollahi
    Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Drug Des Devel Ther 9:3911-22. 2015
    ..Taken together, the present data clearly indicate that DECPR significantly inhibits ACF formation in AOM-treated rats and may offer protection against colon cancer development. ..
  10. pmc Triclosan Demonstrates Synergic Effect with Amphotericin B and Fluconazole and Induces Apoptosis-Like Cell Death in Cryptococcus neoformans
    Elaheh Movahed
    Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center, Faculty of Medicine, University of Malaya Kuala Lumpur, Malaysia
    Front Microbiol 7:360. 2016
    ..There is an increasing need for discovery of new anti-cryptococcal drugs due to emergence of resistance cases in recent years. In this study, we aim to elucidate the antifungal effect of triclosan against C. neoformans...
  11. doi request reprint Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function in streptozotocin-nicotinamide induced diabetic rats
    Aditya Arya
    Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia Electronic address
    J Ethnopharmacol 175:229-40. 2015
    ....
  12. ncbi request reprint Synthesis of Apoptotic New Quinazolinone-Based Compound and Identification of its Underlying Mitochondrial Signalling Pathway in Breast Cancer Cells
    Maryam Zahedifard
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, Department of Experimental Hematology, Karolinska University Hospital, SE 141 86 Stockholm, Sweden Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Box 574, SE 75 123, Uppsala, Sweden
    Curr Pharm Des 21:3417-26. 2015
    ..Our results demonstrate a novel role of MMD as an anti-proliferative agent and imply the involvement of mitochondrial intrinsic pathway in the observed apoptosis. ..
  13. pmc Apoptotic effect of novel Schiff based CdCl₂(C₁₄H₂₁N₃O₂) complex is mediated via activation of the mitochondrial pathway in colon cancer cells
    Maryam Hajrezaie
    1 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Institute of Biological Science, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sci Rep 5:9097. 2015
    ..The results suggest that the CdCl2(C14H21N3O2) complex is able to induce the apoptosis of colon cancer cells and is a potential candidate for future cancer studies...
  14. pmc Subditine, a new monoterpenoid indole alkaloid from bark of Nauclea subdita (Korth.) Steud. induces apoptosis in human prostate cancer cells
    Sook Yee Liew
    Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 9:e87286. 2014
    ..Overall, our data demonstrated that the new compound subditine (1) exerts anti-proliferative effect on LNCaP and PC-3 human prostate cancer cells through induction of apoptosis. ..
  15. ncbi request reprint In vitro anti-oxidant and anti-cancer activity of methanolic extract from Sanchezia speciosa leaves
    Mohammadjavad Paydar
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603 Malaysia
    Pak J Biol Sci 16:1212-5. 2013
    ..speciosa leaves as a potential source of natural anti-oxidant. To the best of our knowledge, this is the first report on anti-oxidant and cytotoxic activity of S. speciosa...
  16. pmc Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line
    Kok Hoong Leong
    Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 11:e0152652. 2016
    ..The results show that further development of the cycloartane as an anti-cancer drug is worthwhile. ..
  17. doi request reprint Temporal proteomic profiling of Chlamydia trachomatis-infected HeLa-229 human cervical epithelial cells
    Grace Min Yi Tan
    Department of Medical Microbiology, Tropical Infectious Disease Research and Education Centre, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Proteomics 16:1347-60. 2016
    ..trachomatis infection. In summary, intense modifications of proteome profile in C. trachomatis-infected HeLa-229 cells indicate complex host-pathogen interactions at early phase of chlamydial infection. ..
  18. doi request reprint The artificial loss of Runx1 reduces the expression of quiescence-associated transcription factors in CD4(+) T lymphocytes
    Won Fen Wong
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan Electronic address
    Mol Immunol 68:223-33. 2015
    ..Therefore, we suggest that Runx1 may activate, directly or indirectly, the expression of quiescence-associated molecules and thereby contribute to the maintenance of quiescence in CD4(+) T cells. ..
  19. pmc Evaluation of acute toxicity and gastroprotective activity of curcuma purpurascens BI. rhizome against ethanol-induced gastric mucosal injury in rats
    Elham Rouhollahi
    Department of Pharmacology, Pharmacogenomics Laboratory, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    BMC Complement Altern Med 14:378. 2014
    ..The aim of the present study is to investigate the gastroprotective activity of C. purpurascens rhizome hexane extract (CPRHE) against ethanol- induced gastric ulcers in rats...
  20. doi request reprint Natural indole butyrylcholinesterase inhibitors from Nauclea officinalis
    Sook Yee Liew
    Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Phytomedicine 22:45-8. 2015
    ..Kinetic study of angustidine (2) on BChE suggested a mixed inhibition mode with an inhibition constant (Ki) of 6.12 μM. ..
  21. pmc Unraveling the cytotoxicity and metabolic pathways of binary natural deep eutectic solvent systems
    Yves Paul Mbous
    University of Malaya Centre for Ionic Liquids UMCiL, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sci Rep 7:41257. 2017
    ..This infers that they can serve as tools for increasing our understanding of cell physiology and metabolism. It is likely that we only have begun to comprehend the nature of NADESs...
  22. ncbi request reprint Phytometabolites Targeting Warburg Effect in Cancer Cells: A Mechanistic Review
    Mohadeseh Hasanpourghadi
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
    Curr Drug Targets . 2016
    ..In this review, we discuss about phytometabolites that target Warburg effect and the underlying molecular mechanism that leads to tumor growth suppression...
  23. pmc Natural deep eutectic solvents: cytotoxic profile
    Maan Hayyan
    University of Malaya Centre for Ionic Liquids UMCiL, University of Malaya, 50603 Kuala Lumpur, Malaysia Department of Civil Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Springerplus 5:913. 2016
    ..Nevertheless, NADESs in general seem to possess relatively less acute toxicity profiles than their DESs parents. This opens the door for future large scale utilization of these mixtures. ..
  24. doi request reprint Applications of deep eutectic solvents in biotechnology and bioengineering-Promises and challenges
    Yves Paul Mbous
    University of Malaya Centre for Ionic Liquids UMCiL, University of Malaya, Kuala Lumpur 50603, Malaysia Department of Chemical Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia
    Biotechnol Adv . 2016
    ..Second, it provides an overview of the breakthroughs that have occurred and the foreseeable prospects of the use of DESs in various biotechnological and biological applications...
  25. pmc (6E,10E) Isopolycerasoidol and (6E,10E) Isopolycerasoidol Methyl Ester, Prenylated Benzopyran Derivatives from Pseuduvaria monticola Induce Mitochondrial-Mediated Apoptosis in Human Breast Adenocarcinoma Cells
    Hairin Taha
    Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 10:e0126126. 2015
    ..Taken together, our data demonstrate that (1) and (2) induce intrinsic mitochondrial-mediated apoptosis in human breast cancer cells, which provides the first pharmacological evidence for their future development as anticancer agents. ..
  26. pmc Prevalence of plasmid-bearing and plasmid-free Chlamydia trachomatis infection among women who visited obstetrics and gynecology clinics in Malaysia
    Tee Cian Yeow
    Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
    BMC Microbiol 16:45. 2016
    ..trachomatis cryptic plasmid in causing various clinical manifestations; including infertility, reproductive tract disintegrity, menstrual disorder, and polycystic ovarian syndrome (PCOS) among genital C. trachomatis-infected patients...
  27. pmc Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo
    Suresh Kumar Ananda Sadagopan
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia
    J Exp Clin Cancer Res 34:147. 2015
    ..The aim of this work was to gain an insight into the underlying anticancer mechanism of vernodalin using in vitro and in vivo model...
  28. doi request reprint Upregulation of insulin secretion and downregulation of pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats by Pseuduvaria monticola bark extract
    Hairin Taha
    Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Food Chem Toxicol 66:295-306. 2014
    ..Therefore, we conclude that PMm may be developed as an antidiabetic agent for the treatment of type 2 diabetes-associated conditions. ..
  29. doi request reprint β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo
    Suvitha Syam
    UPM MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia Electronic address
    J Ethnopharmacol 153:435-45. 2014
    ..Hence, this study aims to investigate the in vitro and in vivo anti-inflammatory effect of β mangostin (βM), a major compound present in Garcinia mangostana...
  30. pmc Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models
    Mohammadjavad Paydar
    Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia
    Drug Des Devel Ther 8:719-33. 2014
    ..Moreover, intraperitoneal injection of boldine (50 or 100 mg/kg) significantly reduced tumor size in an animal model of breast cancer. Our results suggest that boldine is a potentially useful agent for the treatment of breast cancer...
  31. doi request reprint The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats
    Aditya Arya
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Food Chem Toxicol 50:4209-20. 2012
    ....
  32. doi request reprint Acylphenols and dimeric acylphenols from Myristica maxima Warb
    Muhamad Aqmal Othman
    Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
    Fitoterapia 111:12-7. 2016
    ..Compounds 1, 4, 5, 7 and 8 exhibited potent DPPH free radical scavenging activity. This is the first report on their free radical scavenging capacity. ..
  33. pmc Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44(+)/CD24(-/low)): an in vitro study
    Fatemeh Ahmadipour
    Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Drug Des Devel Ther 9:1193-208. 2015
    ..The aims of this work were to evaluate the efficacy of koenimbin, isolated from Murraya koenigii (L) Spreng, in the inhibition of MCF7 breast cancer cells and to target MCF7 breast cancer stem cells through apoptosis in vitro...
  34. doi request reprint Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: a mechanistic study
    Aditya Arya
    Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia Electronic address
    Food Chem Toxicol 71:183-96. 2014
    ....
  35. pmc Nickel(II) complex of polyhydroxybenzaldehyde N4-thiosemicarbazone exhibits anti-inflammatory activity by inhibiting NF-κB transactivation
    Hana Bashir Shawish
    Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 9:e100933. 2014
    ..In this study, we incorporated nickel(II) ions into thiosemicarbazone with N4-substitution groups H3L (H; H3L1, CH3; H3L2, C6H5; H3L3 and C2H5; H3L4) and examined its potential anti-inflammatory activity...
  36. doi request reprint Prevalence of nitrite and nitrate contents and its effect on edible bird nest's color
    Mohammadjavad Paydar
    Dept of Pharmacology, Faculty of Medicine, Univ of Malaya, Kuala Lumpur, 50603, Malaysia
    J Food Sci 78:T1940-7. 2013
    ..Together, our study suggested that the color of EBNs was associated with the prevalence of the nitrite and nitrate contents...
  37. pmc Genome-Wide Transcription Study of Cryptococcus neoformans H99 Clinical Strain versus Environmental Strains
    Elaheh Movahed
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 10:e0137457. 2015
    ..We suggest that the genes and pathways identified may possibly play crucial roles in the fungal pathogenesis. ..
  38. pmc Cinnamomum cassia Suppresses Caspase-9 through Stimulation of AKT1 in MCF-7 Cells but Not in MDA-MB-231 Cells
    Sima Kianpour Rad
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 10:e0145216. 2015
    ..In the present study, particular differences in the mechanism of the anti-proliferative property of C. cassia on two breast cancer cell lines, MCF-7 and MDA-MB-231, were elucidated...
  39. pmc Prevalence, antimicrobial susceptibility and virulotyping of Listeria species and Listeria monocytogenes isolated from open-air fish markets
    Hossein Jamali
    Biohealth Science Program, Institute of Biological Science, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
    BMC Microbiol 15:144. 2015
    ..Eight hundred and sixty two samples including raw fish and fish market environments (samples from workers' hands, workers' knives, containers and work surface) were collected from the open-air fish markets in the Northern region of Iran...
  40. pmc A cell-based screening system for anti-influenza A virus agents
    Wan Ying Wong
    Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sci Rep 5:8672. 2015
    ..Moreover, NiPT5 prevents activation of NF-κB, and IRF3 in response to IAV infection. These results demonstrate that NiPT5 is a potent antiviral agent that inhibits the early phase of IAV replication. ..
  41. pmc A Schiff base-derived copper (II) complex is a potent inducer of apoptosis in colon cancer cells by activating the intrinsic pathway
    Maryam Hajrezaie
    Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia Faculty of Science, Institute of Biological Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    ScientificWorldJournal 2014:540463. 2014
    ..Taken together, these results imply that the Cu(BrHAP)2 compound is a potential candidate for further in vivo and clinical colon cancer studies to develop novel chemotherapeutic agents derived from metal-based agents...
  42. pmc An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer
    Sanaz Koosha
    Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Int J Med Sci 13:374-85. 2016
    ..Some flavonoids have the potential to be an effective alternative to chemotherapeutic drugs in the treatment of colon cancer; well-controlled clinical studies should, however, be conducted to support this proposal. ..
  43. doi request reprint Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells
    Yuan Seng Wu
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia University of Malaya Cancer Research Institute, University of Malaya, Kuala Lumpur 50603, Malaysia
    Biochim Biophys Acta 1861:296-306. 2017
    ..To study the mechanism of PDAC progression to metastasis, we investigated the role of PSC-secreted IL-6 in activating EMT and the involvement of Nrf2 in this process...
  44. pmc Cytotoxic constituents from the rhizomes of Curcuma zedoaria
    Omer Abdalla Ahmed Hamdi
    Center for Natural Products and Drugs Discovery CENAR, University of Malaya, 50603 Kuala Lumpur, Malaysia Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    ScientificWorldJournal 2014:321943. 2014
    ..Thus, the present study provides basis for the ethnomedical application of Curcuma zedoaria in the treatment of breast cancer...
  45. pmc Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways
    Mouna Achoui
    Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Drug Des Devel Ther 8:1993-2007. 2014
    ..In conclusion, the present results further support the anti-inflammatory potential of AA in different models of inflammation. ..
  46. pmc In Vitro and In Vivo toxicity profiling of ammonium-based deep eutectic solvents
    Maan Hayyan
    Department of Civil Engineering, University of Malaya, Kuala Lumpur, Malaysia University of Malaya Centre for Ionic Liquids UMCiL, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 10:e0117934. 2015
    ....
  47. doi request reprint T-cell receptor signaling induces proximal Runx1 transactivation via a calcineurin-NFAT pathway
    Won Fen Wong
    Faculty of Medicine, Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia Department of Molecular Immunology, Institute for Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Eur J Immunol 44:894-904. 2014
    ..Together, these results demonstrate that the calcineurin-NFAT pathway regulates proximal Runx1 transcription upon TCR stimulation. ..