Ramzi A Mothana

Summary

Publications

  1. pmc Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra
    Ramzi A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, Sana a, Yemen
    BMC Complement Altern Med 9:7. 2009
  2. pmc Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats
    Mohammed Al-Yahya
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Evid Based Complement Alternat Med 2013:569037. 2013
  3. pmc Antimicrobial, antioxidant and cytotoxic activities and phytochemical screening of some yemeni medicinal plants
    Ramzi A A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, PO Box 33039, Institute of Pharmacy, College of Medical Science, University of Science and Technology, Sana a, Yemen and Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst Moritz Arndt University, Greifswald, F L Jahn Str 15a, D 17487 Greifswald, Germany
    Evid Based Complement Alternat Med 7:323-30. 2010
  4. pmc Species and tissue-specificity of prokinetic, laxative and spasmodic effects of Fumaria parviflora
    - Najeeb-ur-Rehman
    Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    BMC Complement Altern Med 12:16. 2012
  5. doi request reprint Assessment of selected Yemeni medicinal plants for their in vitro antimicrobial, anticancer, and antioxidant activities
    Ramzi A A Mothana
    Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Pharm Biol 49:200-10. 2011
  6. doi request reprint Chemical analysis and biological activity of the essential oils of two endemic Soqotri Commiphora species
    Ramzi A Mothana
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Molecules 15:689-98. 2010
  7. ncbi request reprint Antimicrobial and cytotoxic abietane diterpenoids from the roots of Meriandera benghalensis (Roxb.) Benth
    R A A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, Yemen
    Pharmazie 64:613-5. 2009
  8. ncbi request reprint Evaluation of the in vitro anticancer, antimicrobial and antioxidant activities of some Yemeni plants used in folk medicine
    R A A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, Sana a, Yemen
    Pharmazie 64:260-8. 2009
  9. ncbi request reprint Study of the anticancer potential of Yemeni plants used in folk medicine
    R A A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, Yemen
    Pharmazie 62:305-7. 2007
  10. doi request reprint Anti-inflammatory, antinociceptive and antioxidant activities of the endemic Soqotraen Boswellia elongata Balf. f. and Jatropha unicostata Balf. f. in different experimental models
    Ramzi A A Mothana
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Food Chem Toxicol 49:2594-9. 2011

Collaborators

  • Louis Maes
  • Nawal M Al-Musayeib
  • Adnan J Al-Rehaily
  • Ulrike Lindequist
  • Mohammed S Al-Dosari
  • Mohamed Farag
  • M F Melzig
  • Sabrin R M Ibrahim
  • Patrick J Bednarski
  • Mansour S al-Said
  • Syed Rafatullah
  • Mohammed Al-Yahya
  • Mohammed Al-Sohaibani
  • Nawal M Al Musayeib
  • Shaza M Al-Massarani
  • Naiyf S Alharbi
  • Ali A El Gamal
  • Mohammed A Al-Yahya
  • Jamal M Khaled
  • Mansour S Alsaid
  • Mohammed O Al-Sohaibani
  • - Najeeb-ur-Rehman
  • A Oleski
  • Khalid E Alzaharni
  • Mansour Alhoshan
  • Shine Kadaikunnan
  • Lawrence Arockiasamy Dass
  • Ahmed S Alobaidi
  • Mohammad K Parvez
  • Ajaz Ahmad
  • Husnu C Baser
  • Mine Kurkcuoglu
  • Abdulrahman Alatar
  • Mohammed M Al-Yahya
  • Mohammad Raish
  • Mahmoud H Assaf
  • Kamal Elddin El-Tahir
  • Mansour Al-Said
  • Mohammad Khalid Parvez
  • Kamaleldin H El Tahir
  • Omer A Basudan
  • Atallah F Ahmed
  • Ali S Al-Blowi
  • Anwar H Gilani
  • Malik Hassan Mehmood

Detail Information

Publications27

  1. pmc Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra
    Ramzi A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, Sana a, Yemen
    BMC Complement Altern Med 9:7. 2009
    ..The aim of this work was to investigate 26 plants belonging to 17 families collected from a unique place in Yemen (Soqotra Island) for their in vitro anticancer, antimicrobial and antioxidant activities...
  2. pmc Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats
    Mohammed Al-Yahya
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Evid Based Complement Alternat Med 2013:569037. 2013
    ..SSH was found to contain phenolic compounds. Additionally, the SSH supplementation restored the hepatocytes viability against 2',7'-dichlorofluorescein (DCF) toxicity in ex vivo test...
  3. pmc Antimicrobial, antioxidant and cytotoxic activities and phytochemical screening of some yemeni medicinal plants
    Ramzi A A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, PO Box 33039, Institute of Pharmacy, College of Medical Science, University of Science and Technology, Sana a, Yemen and Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst Moritz Arndt University, Greifswald, F L Jahn Str 15a, D 17487 Greifswald, Germany
    Evid Based Complement Alternat Med 7:323-30. 2010
    ..fruticosa, Iris albicans, L. citriodora and T. pungens. The phytochemical screening demonstrated the presence of different types of compounds like flavonoids, terpenoids and others, which could be responsible for the obtained activities...
  4. pmc Species and tissue-specificity of prokinetic, laxative and spasmodic effects of Fumaria parviflora
    - Najeeb-ur-Rehman
    Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    BMC Complement Altern Med 12:16. 2012
    ..This study was designed to provide pharmacological basis for the medicinal use of Fumaria parviflora in gut motility disorders...
  5. doi request reprint Assessment of selected Yemeni medicinal plants for their in vitro antimicrobial, anticancer, and antioxidant activities
    Ramzi A A Mothana
    Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Pharm Biol 49:200-10. 2011
    ..The role of natural products as a source for remedies has been recognized since the beginning of mankind. Nevertheless, a minority of folkloricly used medicinal plants have been evaluated for their pharmacological activities...
  6. doi request reprint Chemical analysis and biological activity of the essential oils of two endemic Soqotri Commiphora species
    Ramzi A Mothana
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Molecules 15:689-98. 2010
    ..C. ornifolia oil was the most active. In addition, the DPPH-radical scavenging assay exhibited only weak antioxidant activities for both oils at the high concentration tested...
  7. ncbi request reprint Antimicrobial and cytotoxic abietane diterpenoids from the roots of Meriandera benghalensis (Roxb.) Benth
    R A A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, Yemen
    Pharmazie 64:613-5. 2009
    ..All four abietanes showed potent cytotoxic effect against all cancer cell lines (IC50 between 1 and 8 microM) as well as antibacterial effect against the bacteria tested (MIC values between 33 and 70 microM)...
  8. ncbi request reprint Evaluation of the in vitro anticancer, antimicrobial and antioxidant activities of some Yemeni plants used in folk medicine
    R A A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, Sana a, Yemen
    Pharmazie 64:260-8. 2009
    ..Moreover, the methanolic extracts of Cupressus sempervirens, Meriandera benghalensis, Pulicaria inuloides and Rhus retinorrhaea showed a remarkable radical scavenging effect at low concentrations...
  9. ncbi request reprint Study of the anticancer potential of Yemeni plants used in folk medicine
    R A A Mothana
    Department of Pharmacognosy, Faculty of Pharmacy, Sana a University, Yemen
    Pharmazie 62:305-7. 2007
    ..29 and 5.54 microg/ml. The extracts of Jatropha unicostata and Punica protopunica showed a moderate potency on the most tumor cell lines...
  10. doi request reprint Anti-inflammatory, antinociceptive and antioxidant activities of the endemic Soqotraen Boswellia elongata Balf. f. and Jatropha unicostata Balf. f. in different experimental models
    Ramzi A A Mothana
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Food Chem Toxicol 49:2594-9. 2011
    ..These results clearly confirmed the traditional anti-inflammatory indication of B. elongata and suggest that B. elongata could be a potential source for anti-inflammatory, antinociceptive and antioxidant agents...
  11. doi request reprint Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and α-mangostin, its major xanthone derivative
    Shaza M Al-Massarani
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Molecules 18:10599-608. 2013
    ..This in vitro study endorses that the antiprotozoal and antimicrobial potential of prenylated xanthones is non-conclusive in view of the low level of selectivity...
  12. pmc Citrus medica "Otroj": attenuates oxidative stress and cardiac dysrhythmia in isoproterenol-induced cardiomyopathy in rats
    Mohammed A Al-Yahya
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Nutrients 5:4269-83. 2013
    ..medica alleviates myocardial damage in ISO-induced cardiac injury and demonstrates cardioprotective potential which could be attributed to its potent antioxidant and free radical scavenging activity. ..
  13. doi request reprint Assessment of the in vitro antiprotozoal and cytotoxic potential of 20 selected medicinal plants from the island of Soqotra
    Ramzi A Mothana
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Molecules 17:14349-60. 2012
    ..brucei and T. cruzi (IC₅₀ 3.5 and 8.4 µg/mL). Ballochia atrovirgata, Dendrosicycos socotrana, Dracaena cinnabari and Euphorbia socotrana displayed non-specific inhibition of the parasites related to high cytotoxicity...
  14. pmc GC and GC/MS analysis of essential oil composition of the endemic Soqotraen Leucas virgata Balf.f. and its antimicrobial and antioxidant activities
    Ramzi A Mothana
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Int J Mol Sci 14:23129-39. 2013
    ..coli. No activity was found against P. aeruginosa and C. albicans. Moreover, the DPPH-radical scavenging assay exhibited only a moderate antioxidant activity (31%) for the oil at the highest concentration tested (1 mg/mL). ..
  15. doi request reprint Edible oils for liver protection: hepatoprotective potentiality of Moringa oleifera seed oil against chemical-induced hepatitis in rats
    Mansour S al-Said
    Dept of Pharmacognosy, College of Pharmacy, King Saud Univ, PO Box 2457, Riyadh 11451, Saudi Arabia
    J Food Sci 77:T124-30. 2012
    ..Consequently, BO can be used as a therapeutic regime in treatment of some hepatic disorders...
  16. doi request reprint In vitro antiprotozoal activity of triterpenoid constituents of Kleinia odora growing in Saudi Arabia
    Nawal M Al Musayeib
    Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Molecules 18:9207-18. 2013
    ..This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum, L. infantum, T. cruzi, and T. brucei. ..
  17. pmc In vitro antiprotozoal activity of abietane diterpenoids isolated from Plectranthus barbatus Andr
    Ramzi A Mothana
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Int J Mol Sci 15:8360-71. 2014
    ..falciparum (IC50 9.2 µM, SI 10.4) and T. brucei (IC50 1.9 µM, SI 50.5). Compounds (3)-(5) exhibited non-specific antiprotozoal activity due to high cytotoxicity. Compound (1) dehydroabietane showed no antiprotozoal potential. ..
  18. pmc In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region
    Nawal M Al-Musayeib
    Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    BMC Complement Altern Med 12:49. 2012
    ..Thus the present study investigated the in vitro antiprotozoal activity of twenty-five plants collected from the Arabian Peninsula...
  19. pmc GC-MS Analysis: In Vivo Hepatoprotective and Antioxidant Activities of the Essential Oil of Achillea biebersteinii Afan. Growing in Saudi Arabia
    Mansour S al-Said
    Department of Pharmacognosy, and Medicinal, Aromatic and Poisonous Plants Research Center MAPPRC, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Evid Based Complement Alternat Med 2016:1867048. 2016
    ..Histopathological study further confirmed these findings. In addition, ABEO showed mild antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and β-carotene-linoleic acid assays. ..
  20. doi request reprint 'Ajwa' dates (Phoenix dactylifera L.) extract ameliorates isoproterenol-induced cardiomyopathy through downregulation of oxidative, inflammatory and apoptotic molecules in rodent model
    Mohammed Al-Yahya
    Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia Center for Medicinal, Aromatic and Poisonous Plants Research, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Phytomedicine 23:1240-8. 2016
    ..its cardioprotective potential remains elusive. We therefore, investigated the cardioprotective effect of lyophilized Ajwa extract (AJLE) ex vivo as well as in vivo...
  21. doi request reprint Klodorone A and klodorol A: new triterpenes from Kleinia odora
    Nawal M Al Musayeib
    a Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Nat Prod Res 28:1142-6. 2014
    ..Their structures were determined by using extensive 1D ((1)H, (13)C and DEPT) and 2D ((1)H-(1)H COSY, HMQC and HMBC) NMR and mass spectral measurements in addition to comparison of their data with the literature...
  22. ncbi request reprint Study of the in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of medicinal plants from Saudi Arabia
    Nawal M Al-Musayeib
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Molecules 17:11379-90. 2012
    ..Activity against T. brucei was obtained in Prosopis juliflora. Cytotoxicity (MRC-5 IC₅₀ < 10 μg/mL) and hence non-specific activities were observed for Conocarpus lancifolius...
  23. doi request reprint Ameliorative effect of Grewia tenax (Forssk) fiori fruit extract on CCl(4)-induced oxidative stress and hepatotoxicity in rats
    Mansour S al-Said
    Dept of Pharmacognosy and Medicinal, Aromatic and Poisonous Plants Research Center MAPPRC, College of Pharmacy, P O Box 2457, King Saud Univ, Riyadh 11451, Saudi Arabia
    J Food Sci 76:T200-6. 2011
    ..tenax extract, which may provide a new drug to be used for fighting liver diseases and it validates its folkloric use in anemic and other conditions...
  24. doi request reprint Effects of Piper cubeba L. essential oil on methicillin-resistant Staphylococcus aureus: an AFM and TEM study
    Naiyf S Alharbi
    Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, KSA, 11451, Saudi Arabia
    J Mol Recognit 30:. 2017
    ..Our results indicate that the extract has a good biological activity against methicillin- and oxacillin-resistant S aureus and that it acts on the cell wall and plasma (cytoplasmic) membrane...
  25. doi request reprint Phytochemical analysis and in vitro antimicrobial and free-radical-scavenging activities of the essential oils from Euryops arabicus and Laggera decurrens
    Ramzi A Mothana
    Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Molecules 16:5149-58. 2011
    ..Both essential oils showed antimicrobial activity with MIC-values between 0.13-5.25 mg/mL. Furthermore, only the essential oil of L. decurrens exhibited a strong antioxidant activity (91%) at 500 µg/mL...
  26. ncbi request reprint Screening of selected Arabian medicinal plant extracts for inhibitory activity against peptidases
    A Oleski
    Institute of Pharmacy, Free University Berlin, Germany
    Pharmazie 61:359-61. 2006
    ..The most active extract was prepared from Kalanchoe farinacea characterized by low IC50 values especially for NEP and APN...