Shaik Mohammad Naushad

Summary

Publications

  1. pmc Population-level diversity in the association of genetic polymorphisms of one-carbon metabolism with breast cancer risk
    Shaik Mohammad Naushad
    Biochemical Genetics, Sandor Life Sciences Pvt Ltd, Banjara Hills, Road No 3, Hyderabad, 500034, India
    J Community Genet 7:279-290. 2016
  2. doi request reprint In silico approaches to identify the potential inhibitors of glutamate carboxypeptidase II (GCPII) for neuroprotection
    Shaik Mohammad Naushad
    Sandor Life Sciences Pvt Ltd, Banjara Hills, Road No 3, Hyderabad 500034, India School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur 613401, India Electronic address
    J Theor Biol 406:137-42. 2016
  3. doi request reprint Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer
    Shaik Mohammad Naushad
    School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur 613401, India Electronic address
    Gene 580:159-68. 2016
  4. doi request reprint Multifactor dimensionality reduction analysis to elucidate the cross-talk between one-carbon and xenobiotic metabolic pathways in multi-disease models
    Shaik Mohammad Naushad
    School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur, 613401, India
    Mol Biol Rep 42:1211-24. 2015
  5. doi request reprint Clinical utility of genetic variants of glutamate carboxypeptidase II in predicting breast cancer and prostate cancer risk
    Shaik Mohammad Naushad
    School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur, India Electronic address
    Cancer Genet 208:552-8. 2015
  6. doi request reprint Adaptive developmental plasticity in methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism limits its frequency in South Indians
    Shaik Mohammad Naushad
    School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur, 613401, India
    Mol Biol Rep 41:3045-50. 2014
  7. doi request reprint Aberrations in folate metabolic pathway and altered susceptibility to autism
    Naushad Shaik Mohammad
    Center for DNA Fingerprinting and Diagnostics, Niloufer Hospital, Hyderabad, India
    Psychiatr Genet 19:171-6. 2009
  8. doi request reprint Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India
    Shaik Mohammad Naushad
    Division of Diagnostic, Center for DNA Fingerprinting and Diagnostics, Hyderabad, India
    J Perinat Med 38:63-9. 2010
  9. doi request reprint GCPII modulates oxidative stress and prostate cancer susceptibility through changes in methylation of RASSF1, BNIP3, GSTP1 and Ec-SOD
    Shree Divyya
    Departments of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences NIMS, Panjagutta, Hyderabad, 500082, India
    Mol Biol Rep 40:5541-50. 2013
  10. doi request reprint Paradoxical role of C1561T glutamate carboxypeptidase II (GCPII) genetic polymorphism in altering disease susceptibility
    Shree Divyya
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Hyderabad, India
    Gene 497:273-9. 2012

Collaborators

  • Damineni Surekha
  • Omar S Al-Attas
  • Ramakrishna Pinjala
  • Vijay Kumar Kutala
  • Nadella Kumudini
  • Addepalli Pavani
  • Shree Divyya
  • Addepally Uma
  • Rukmini Mridula
  • Akella Radha Rama Devi
  • Yedluri Rupasree
  • Konda Kumaraswami
  • Balraj Alex Stanley
  • Rupam Borgohain
  • Nageswara Rao Dunna
  • S V Vijaya Lakshmi
  • Sana Venkata Vijaya Lakshmi
  • Ch Ram Reddy
  • P V L N Murthy
  • Patchva Dorababu
  • Naushad Shaik Mohammad
  • Manoharan Niveditha
  • Govindaraj Swathika Mahalakshmi
  • Rupam Borghain
  • Gunasekaran Sharmila
  • Liza Rajasekhar
  • Ravi Varshaa
  • Krishnan Abinaya
  • Renganathan Gnanambal Kamakshi
  • Malempati Amaresh Rao
  • Satti Vishnupriya
  • Digumarti Raghunadha Rao
  • Cingeetham Anuradha
  • Kagita Sailaja
  • Sugunakar Vuree
  • D Seshagiri Rao
  • Cheruku Apoorva Reddy
  • Damera Seshagiri Rao
  • Kankanala Saumya
  • Srigiridhar Kotamraju
  • Pallu Reddanna
  • Takallapally Ramesh Kumar
  • Sadashivudu Gundeti
  • Sreedhar Amere Subbarao
  • S Rammurti
  • Anthony Addlagatta
  • Narayana Nagesh
  • Vuppala Anusha
  • Ajit Kumar
  • Suryanarayana Raju Gottumukkala
  • Raghunadharao Digumarti
  • Ramesh C Mishra
  • Vijay Gandhi Linga
  • Subhash Kaul
  • Raghunadha Rao Digumarti
  • Amaresh Rao Malempati
  • Jamal Md Nurul Jain
  • Ram Prakash Singh
  • Radha Rama Devi Akella
  • Krishna Prasad Chintakindi
  • Usha Naik

Detail Information

Publications28

  1. pmc Population-level diversity in the association of genetic polymorphisms of one-carbon metabolism with breast cancer risk
    Shaik Mohammad Naushad
    Biochemical Genetics, Sandor Life Sciences Pvt Ltd, Banjara Hills, Road No 3, Hyderabad, 500034, India
    J Community Genet 7:279-290. 2016
    ..Dietary patterns and altitudinal variations are the likely risk modulators that are contributing toward ethnic- and population-level variations in genetic associations...
  2. doi request reprint In silico approaches to identify the potential inhibitors of glutamate carboxypeptidase II (GCPII) for neuroprotection
    Shaik Mohammad Naushad
    Sandor Life Sciences Pvt Ltd, Banjara Hills, Road No 3, Hyderabad 500034, India School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur 613401, India Electronic address
    J Theor Biol 406:137-42. 2016
    ..Being a NAAG-analogue, this molecule might confer neuroprotection by inhibiting glutamatergic neurotransmission mediated by N-acetylated alpha-linked acidic dipeptidase (NAALADase), a splice variant of GCPII. ..
  3. doi request reprint Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer
    Shaik Mohammad Naushad
    School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur 613401, India Electronic address
    Gene 580:159-68. 2016
    ..Dietary intake of folate appears to confer protection against breast cancer through its modulating effects on ER and PR expression and methylation of EC-SOD and BRCA1...
  4. doi request reprint Multifactor dimensionality reduction analysis to elucidate the cross-talk between one-carbon and xenobiotic metabolic pathways in multi-disease models
    Shaik Mohammad Naushad
    School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur, 613401, India
    Mol Biol Rep 42:1211-24. 2015
    ..63). Cross-talk between one-carbon and xenobiotic pathways was observed in diseases with female preponderance. Gene-gene interactions within one-carbon metabolic pathway were observed in diseases with male preponderance...
  5. doi request reprint Clinical utility of genetic variants of glutamate carboxypeptidase II in predicting breast cancer and prostate cancer risk
    Shaik Mohammad Naushad
    School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur, India Electronic address
    Cancer Genet 208:552-8. 2015
    ..5% and 86.7% of the variability, respectively. Thus, GCPII variants are potential contributors of risk toward breast cancer and prostate cancer. Risk modulation appeared to be mediated through changes in the expression of FOLH1 and PSMA. ..
  6. doi request reprint Adaptive developmental plasticity in methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism limits its frequency in South Indians
    Shaik Mohammad Naushad
    School of Chemical and Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur, 613401, India
    Mol Biol Rep 41:3045-50. 2014
    ....
  7. doi request reprint Aberrations in folate metabolic pathway and altered susceptibility to autism
    Naushad Shaik Mohammad
    Center for DNA Fingerprinting and Diagnostics, Niloufer Hospital, Hyderabad, India
    Psychiatr Genet 19:171-6. 2009
    ..To investigate whether genetic polymorphisms are the underlying causes for aberrations in folate pathway that was reported in autistic children...
  8. doi request reprint Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India
    Shaik Mohammad Naushad
    Division of Diagnostic, Center for DNA Fingerprinting and Diagnostics, Hyderabad, India
    J Perinat Med 38:63-9. 2010
    ....
  9. doi request reprint GCPII modulates oxidative stress and prostate cancer susceptibility through changes in methylation of RASSF1, BNIP3, GSTP1 and Ec-SOD
    Shree Divyya
    Departments of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences NIMS, Panjagutta, Hyderabad, 500082, India
    Mol Biol Rep 40:5541-50. 2013
    ..R190W variant was found to reduce oxidative stress by increasing glutathione levels. GCPII genetic variants contribute to increased oxidative stress and prostate cancer risk by modulating the CpG island methylation of Ec-SOD...
  10. doi request reprint Paradoxical role of C1561T glutamate carboxypeptidase II (GCPII) genetic polymorphism in altering disease susceptibility
    Shree Divyya
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Hyderabad, India
    Gene 497:273-9. 2012
    ..70, p<0.05). To conclude, our data suggests that GCPII H475Y variant shows inverse association with autism and cancer while showing positive association with CAD and miscarriages...
  11. doi request reprint Association of aberrations in one-carbon metabolism with molecular phenotype and grade of breast cancer
    Shaik Mohammad Naushad
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Panjagutta, Hyderabad, Andhra Pradesh, India
    Mol Carcinog 51:E32-41. 2012
    ..72, 95% CI: 0.58-0.87, P = 0.008). To conclude, aberrations in one-carbon metabolism predict the subtype of breast cancer and disease progression...
  12. doi request reprint Oxidative stress in coronary artery disease: epigenetic perspective
    Sana Venkata Vijaya Lakshmi
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Panjagutta, Hyderabad, 500082, Andhra Pradesh, India
    Mol Cell Biochem 374:203-11. 2013
    ....
  13. doi request reprint Oxidative stress is associated with genetic polymorphisms in one-carbon metabolism in coronary artery disease
    S V Vijaya Lakshmi
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Panjagutta, Hyderabad, 500082, Andhra Pradesh, India
    Cell Biochem Biophys 67:353-61. 2013
    ..28, P = 0.03). Influence of dietary folate status was not observed. Overall, this study revealed elevated oxidative stress that was associated with the aberrations in one-carbon metabolism which could possibly influence the CAD risk. ..
  14. doi request reprint Impact of hyperhomocysteinemia on breast cancer initiation and progression: epigenetic perspective
    Shaik Mohammad Naushad
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences NIMS, Panjagutta, Hyderabad, 500082, Andhra Pradesh, India
    Cell Biochem Biophys 68:397-406. 2014
    ..To conclude, elevated homocysteine influences methionine dependency phenotype of breast cancer cells and is associated with breast cancer progression by epigenetic modulation of RASSF1 and BRCA1...
  15. doi request reprint Molecular insights into the association of obesity with breast cancer risk: relevance to xenobiotic metabolism and CpG island methylation of tumor suppressor genes
    Shaik Mohammad Naushad
    School of Chemical and Biotechnology, SASTRA University, Thanjavur, 613401, India
    Mol Cell Biochem 392:273-80. 2014
    ....
  16. doi request reprint Comparative analysis of four disease prediction models of Parkinson's disease
    Nadella Kumudini
    Department of Biotechnology, Jawaharlal Nehru Technological University Hyderabad, Hyderabad, India
    Mol Cell Biochem 411:127-34. 2016
    ..6% cases of sporadic PD. To conclude, the ANN model developed using SNPs in folate, xenobiotic, and dopamine pathways along with SNCA has higher clinical utility in predicting PD risk compared to other models...
  17. doi request reprint Sexual dimorphism in xenobiotic genetic variants-mediated risk for Parkinson's disease
    Nadella Kumudini
    Centre for Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, India
    Neurol Sci 35:897-903. 2014
    ..05). To conclude, CYP1A1 m1, COMT p.H108L polymorphisms were associated with PD risk, and sexual dimorphism was observed in these associations...
  18. ncbi request reprint Glutamate carboxypeptidase II (GCPII) genetic variants as determinants of hyperhomocysteinemia: implications in stroke susceptibility
    Shree Divyya
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Hyderabad, India
    Indian J Biochem Biophys 49:356-62. 2012
    ..This model explained 36% variability in plasma homocysteine levels. To conclude, GCPII haplotypes influenced susceptibility to stroke by influencing homocysteine levels...
  19. ncbi request reprint Relationship between methionine synthase, methionine synthase reductase genetic polymorphisms and deep vein thrombosis among South Indians
    Shaik Mohammad Naushad
    Diagnostic Division, Center for DNA Fingerprinting and Diagnostics, Hyderabad, Andhra Pradesh, India
    Clin Chem Lab Med 46:73-9. 2008
    ....
  20. doi request reprint Application of Various Statistical Models to Explore Gene-Gene Interactions in Folate, Xenobiotic, Toll-Like Receptor and STAT4 Pathways that Modulate Susceptibility to Systemic Lupus Erythematosus
    Yedluri Rupasree
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Hyderabad, 500082, India
    Mol Diagn Ther 20:83-95. 2016
    ....
  21. doi request reprint Mechanistic insights into the effect of CYP2C9*2 and CYP2C9*3 variants on the 7-hydroxylation of warfarin
    Addepalli Pavani
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Punjagutta, Hyderabad, India
    Pharmacogenomics 16:393-400. 2015
    ..To evaluate the impact of CYP2C9*2 and CYP2C9*3 variants on binding and hydroxylation of warfarin...
  22. doi request reprint Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL
    Patchva Dorababu
    Department of Medical Oncology, Nizam s Institute of Medical Sciences, Panjagutta, Hyderabad, Andhra Pradesh, PIN 500082, India
    Pharmacogenomics 13:1001-8. 2012
    ....
  23. doi request reprint Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) expression is epigenetically regulated by one-carbon metabolism in invasive duct cell carcinoma of breast
    Shaik Mohammad Naushad
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Panjagutta, Hyderabad, Andhra Pradesh, India
    Mol Cell Biochem 361:189-95. 2012
    ..The linear association between BNIP3 and 8-oxodG substantiates the role of BNIP3 as redox sensor as well as prognostic marker in breast cancer...
  24. doi request reprint Methodological issues in the development of a pharmacogenomic algorithm for warfarin dosing: comparison of two regression approaches
    Addepalli Pavani
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Punjagutta, Hyderabad, 500082, India
    Pharmacogenomics 15:1125-32. 2014
    ..To ascertain whether multiple polynomial regression (MPR) has any advantage over multiple linear regression (MLR) in developing pharmacogenomic algorithms...
  25. doi request reprint Retrospective evidence for clinical validity of expanded genetic model in warfarin dose optimization in a South Indian population
    Addepalli Pavani
    Departments of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Hyderabad, India
    Pharmacogenomics 13:869-78. 2012
    ..The aim of the current study is to develop an expanded genetic model that can explain greater percentage of warfarin variability and that has clinical validity...
  26. doi request reprint Association of seven functional polymorphisms of one-carbon metabolic pathway with total plasma homocysteine levels and susceptibility to Parkinson's disease among South Indians
    Nadella Kumudini
    Centre for Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, India
    Neurosci Lett 568:1-5. 2014
    ..To conclude, PD cases exhibited hyperhomocysteinemia and MTRR 66 A>G and cSHMT 1420 C>T gene variants were shown to modulate PD risk by altering the homocysteine levels...
  27. doi request reprint Targeted exome sequencing for the identification of complementation groups in methylmalonic aciduria: A south Indian experience
    Akella Radha Rama Devi
    Rainbow Children Hospital and Perinatal Centre, Hyderabad, India Sandor Life Sciences Pvt Ltd, Banjara Hills, Road No 3, Hyderabad, India Electronic address
    Clin Biochem 50:68-72. 2017
    ..In view of high incidence of methylmalonic aciduria (MMA) among South Indians, we have performed clinical, biochemical and molecular genetic evaluation of fifteen patients...
  28. ncbi request reprint Association of thymidylate synthase 5'-UTR 28bp tandem repeat and serine hydroxymethyltransfarase C1420T polymorphisms with susceptibility to acute leukemia
    Nageswara Rao Dunna
    School of Chemical and Biotechnology, SASTRA University, Thanjavur, India E mail
    Asian Pac J Cancer Prev 15:1719-23. 2014
    ..To conclude, the TYMS 5'-UTR 28bp tandem repeat reduces risk for ALL while cSHMT C1420T reduces risk for both ALL and AML. Both also influence disease progression in ALL...