E O Farombi

Summary

Affiliation: University of Ibadan
Country: Nigeria

Publications

  1. ncbi request reprint Influence of quercetin on haematological indices and biomarkers of oxidative stress in the serum of rats exposed to atrazine
    S O Abarikwu
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan Nigeria
    Afr J Med Med Sci 39:81-8. 2010
  2. ncbi request reprint Chemoprevention of aflatoxin B1-induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural bioflavonoid of Garcinia kola seeds
    E O Farombi
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Eur J Cancer Prev 14:207-14. 2005
  3. ncbi request reprint Anti-oxidant mechanisms of kolaviron: studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats
    E O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Clin Exp Pharmacol Physiol 32:667-74. 2005
  4. ncbi request reprint Antioxidant and anti-inflammatory activities of Mallotus oppositifolium in model systems
    E O Farombi
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, Faculty of Pharmacy, University of Ibadan, Nigeria
    Afr J Med Med Sci 30:213-5. 2001
  5. ncbi request reprint Antioxidant properties of extracts from Alchornea laxiflora (Benth) Pax and Hoffman
    E Olatunde Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine University of Ibadan, Ibadan, Nigeria
    Phytother Res 17:713-6. 2003
  6. ncbi request reprint Influence of chloramphenicol on rat hepatic microsomal components and biomarkers of oxidative stress: protective role of antioxidants
    E Olatunde Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Pharmacol Toxicol 91:129-34. 2002
  7. ncbi request reprint Antioxidant status and hepatic lipid peroxidation in chloramphenicol-treated rats
    E O Farombi
    Department of Biochemistry, University of Ibadan, Nigeria
    Tohoku J Exp Med 194:91-8. 2001
  8. doi request reprint Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed
    I A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Hum Exp Toxicol 31:506-17. 2012
  9. ncbi request reprint Hibiscus sabdariffa ethanolic extract protects against dyslipidemia and oxidative stress induced by chronic cholesterol administration in rabbits
    M Ekor
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 39:161-70. 2010
  10. ncbi request reprint Hepatoprotective effect of Curcuma longa L. in D-galactosamine induced liver injury in mice: evidence of antioxidant activity
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Nigeria
    Afr J Med Med Sci 39:27-34. 2010

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Influence of quercetin on haematological indices and biomarkers of oxidative stress in the serum of rats exposed to atrazine
    S O Abarikwu
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan Nigeria
    Afr J Med Med Sci 39:81-8. 2010
    ..We suggest that the antioxidant activities of QT at a doses of 10mg/kg could be responsible for its protective effects against ATR-induced oxidative stress and hematological toxicity...
  2. ncbi request reprint Chemoprevention of aflatoxin B1-induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural bioflavonoid of Garcinia kola seeds
    E O Farombi
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Eur J Cancer Prev 14:207-14. 2005
    ..Thus kolaviron may qualify for clinical trial in combating the menace of aflatoxicosis in endemic areas of aflatoxin contamination of foods...
  3. ncbi request reprint Anti-oxidant mechanisms of kolaviron: studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats
    E O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Clin Exp Pharmacol Physiol 32:667-74. 2005
    ....
  4. ncbi request reprint Antioxidant and anti-inflammatory activities of Mallotus oppositifolium in model systems
    E O Farombi
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, Faculty of Pharmacy, University of Ibadan, Nigeria
    Afr J Med Med Sci 30:213-5. 2001
    ..Thin layer chromatographic (TLC) analysis of the crude extract in methanol identified four phenolic spots two of which were flavonoid in nature (UV(254nm, 356nm), FeCl3 and AlCl3 visualization)...
  5. ncbi request reprint Antioxidant properties of extracts from Alchornea laxiflora (Benth) Pax and Hoffman
    E Olatunde Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine University of Ibadan, Ibadan, Nigeria
    Phytother Res 17:713-6. 2003
    ..Our results suggest that A. laxiflora contains potent natural antioxidants and may therefore be relevant in the preservation of lipid food products, which are prone to oxidation and rancidity...
  6. ncbi request reprint Influence of chloramphenicol on rat hepatic microsomal components and biomarkers of oxidative stress: protective role of antioxidants
    E Olatunde Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Pharmacol Toxicol 91:129-34. 2002
    ....
  7. ncbi request reprint Antioxidant status and hepatic lipid peroxidation in chloramphenicol-treated rats
    E O Farombi
    Department of Biochemistry, University of Ibadan, Nigeria
    Tohoku J Exp Med 194:91-8. 2001
    ..The clinical implications in the detoxification of toxic metabolites of lipid peroxidation caused by chloramphenicol warrant co-administration with antioxidant vitamins in chloramphenicol treatment regimen...
  8. doi request reprint Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed
    I A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Hum Exp Toxicol 31:506-17. 2012
    ..Kolaviron or vitamin E exhibited protective effects against EGEE-induced male reproductive toxicity by enhancement of antioxidant status and improvement in spermatozoa quantity and quality...
  9. ncbi request reprint Hibiscus sabdariffa ethanolic extract protects against dyslipidemia and oxidative stress induced by chronic cholesterol administration in rabbits
    M Ekor
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 39:161-70. 2010
    ..Data from this study demonstrate the hypolipidaemic and antioxidant activities of HSE and suggest its therapeutic potential in disorders of lipid metabolism and cardiovascular events associated with hypercholesterolemia...
  10. ncbi request reprint Hepatoprotective effect of Curcuma longa L. in D-galactosamine induced liver injury in mice: evidence of antioxidant activity
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Nigeria
    Afr J Med Med Sci 39:27-34. 2010
    ..The results suggest that the hepatoprotective effect of CLME in GNH2 induced liver injury may be related to its antioxidant activity...
  11. doi request reprint Hepatoprotective activity of purified fractions from Garcinia kola seeds in mice intoxicated with carbon tetrachloride
    O A Adaramoye
    Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    J Med Food 11:544-50. 2008
    ..These fractions are responsible for the observed antihepatotoxic effect of KV...
  12. doi request reprint Effects of Xylopia aethiopica (Annonaceae) fruit methanol extract on gamma-radiation-induced oxidative stress in brain of adult male Wistar rats
    O A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
    Acta Biol Hung 61:250-61. 2010
    ..Treatment with XA and VC ameliorated the radiation-induced decreases in antioxidant status of the animals. These suggest that XA could have beneficial effect by inhibiting oxidative damage in brain of exposed rats...
  13. doi request reprint Municipal landfill leachate induces hepatotoxicity and oxidative stress in rats
    E O Farombi
    Department of Biochemistry, Drug Metabolism and Toxicology Research Laboratories, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Toxicol Ind Health 28:532-41. 2012
    ..Collectively, the hepatotoxicity of OMLL could be due to the induction of oxidative stress and may suggest possible health hazards in subjects with occupational or environmental exposure...
  14. ncbi request reprint N-acetylcysteine pretreatment ameliorates mercuric chloride-induced oxidative renal damage in rats
    M Ekor
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 39:153-60. 2010
    ....
  15. ncbi request reprint Hepatic drug metabolizing enzyme induction and serum triacylglycerol elevation in rats treated with chlordiazepoxide, griseofulvin, rifampicin and phenytoin
    E O Farombi
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Clin Chim Acta 289:1-10. 1999
    ..001). Our results suggest that induction of hepatic enzymes by the administered drugs may lead to hypertriglyceridaemia as an adverse effect, possibly by inducing the activity of regulatory enzymes in the biosynthesis of triglyceride...
  16. ncbi request reprint Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: modulatory role of vitamin C, vitamin E and quercetin
    E O Farombi
    Department of Biochemistry, Drug Metabolism and Toxicology Research Laboratories, College of Medicine, University of Ibadan, Nigeria
    Hum Exp Toxicol 25:251-9. 2006
    ..The results indicate that dietary antioxidants have protective potential against oxidative stress induced by MSG and, in addition, suggest that active oxygen species may play an important role in its genotoxicity...
  17. ncbi request reprint Influence of amodiaquine treatment on microsomal lipid peroxidation and antioxidant defense systems of rats
    E O Farombi
    Department of Biochemistry, University of Ibadan, Nigeria
    Pharmacol Toxicol 87:249-54. 2000
    ..The relevance of this to continuous exposure to amodiaquine therapy should be considered...
  18. ncbi request reprint Modulation of carbon tetrachloride-induced lipid peroxidation and xenobiotic-metabolizing enzymes in rats fed browned yam flour diet
    E O Farombi
    Department of Biochemistry, Drug Metabolism and Toxicology Unit, College of Medicine, University of Ibadan, Nigeria
    Afr J Med Med Sci 29:127-32. 2000
    ..The results suggest that browned yam flour diet could protect against chemically-mediated lipid peroxidation and tissue damage possibly by scavenging chemically generated reactive species and enhancing carcinogen-detoxifying system...
  19. doi request reprint Quercetin exacerbates the effects of subacute treatment of atrazine on reproductive tissue antioxidant defence system, lipid peroxidation and sperm quality in rats
    E O Farombi
    Department of Biochemistry, Drug Metabolism and Toxicology Research Laboratories, College of Medicine, University of Ibadan, Ibadan 0024, Nigeria
    Andrologia 45:256-65. 2013
    ..We conclude that quercetin at the investigated dose increases the susceptibility of rat reproductive tissues to atrazine-induced oxidative damage. ..
  20. ncbi request reprint Evaluation of antioxidant properties of Mallotus oppositifolium in in-vitro, in-vivo and ex-vivo model systems
    I A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Nigeria
    Afr J Med Med Sci 39:67-72. 2010
    ..Taken together, this study demonstrates that MEMO exhibits antioxidant, radical scavenging and enhancement of enzymatic antioxidant capacity and as such could intervene in toxicological processes mediated by free radical mechanisms...
  21. pmc Biomarkers of oxidative stress and heavy metal levels as indicators of environmental pollution in African cat fish (Clarias gariepinus) from Nigeria Ogun River
    E O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Int J Environ Res Public Health 4:158-65. 2007
    ..The study therefore provides a rational use of biomarkers of oxidative stress in biomonitoring of aquatic pollution...
  22. ncbi request reprint Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Clin Exp Pharmacol Physiol 32:40-6. 2005
    ..This reduction and the favourable lipid profile indicate a possible anti-atherogenic property of the extract...
  23. ncbi request reprint Effect of three structurally related antimalarial drugs on liver microsomal components and lipid peroxidation in rats
    E O Farombi
    Department of Biochemistry, University of Ibadan, Nigeria
    Comp Biochem Physiol C Toxicol Pharmacol 126:217-24. 2000
    ..The results indicate that the alterations in hepatic microsomal components and lipid peroxidation caused by the antimalarials are related to the structural differences in the compounds...
  24. ncbi request reprint Hypolipidemic and antioxidant effects of ethanolic extract from dried calyx of Hibiscus sabdariffa in alloxan-induced diabetic rats
    E O Farombi
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Fundam Clin Pharmacol 21:601-9. 2007
    ....
  25. pmc Effect of butachlor on antioxidant enzyme status and lipid peroxidation in fresh water African catfish, (Clarias gariepinus)
    E O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry College of Medicine, University of Ibadan, Nigeria
    Int J Environ Res Public Health 5:423-7. 2008
    ....
  26. ncbi request reprint Curcumin attenuates gentamicin-induced renal oxidative damage in rats
    E O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Food Chem Toxicol 44:1443-8. 2006
    ..2 mM H2O2). Our data indicate that the natural antioxidant curcumin can be a potent protective agent against renal oxidative damage mediated by gentamicin...
  27. doi request reprint Chemoprotective effects of kolaviron on ethylene glycol monoethyl ether-induced pituitary-thyroid axis toxicity in male rats
    I A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Andrologia 45:111-9. 2013
    ..This study suggests that kolaviron may prove promising as a chemoprotective agent against endocrine pathology resulting from EGEE exposure...
  28. ncbi request reprint Gross morphometric reduction of rats' cerebellum by gamma irradiation was mitigated by pretreatment with Vernonia amygdalina leaf extract
    O Owoeye
    Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Nigeria
    Rom J Morphol Embryol 52:81-8. 2011
    ..0 Gy gamma irradiation reduced significantly the radiation induced gross morphometry changes in rats' cerebellum, suggesting that M may qualify for consideration as a medicinal radioprotector...
  29. ncbi request reprint Antimalarial drugs exacerbate rat liver microsomal lipid peroxidation in the presence of oxidants
    E O Farombi
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Nigeria
    Biosci Rep 21:353-9. 2001
    ..The results indicate that rat liver microsomal lipid peroxidation could be enhanced by antimalarial drugs in the presence of reactive oxygen species and this effect could be ameliorated by treatment with antioxidants...
  30. doi request reprint Aflatoxin B₁ and ethanol co-exposure induces hepatic oxidative damage in mice
    I A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Toxicol Ind Health 26:717-24. 2010
    ....
  31. ncbi request reprint Attenuation of indomethacin- and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed
    S B Olaleye
    Department of Physiology, College of Medicine, University of Ibadan, Nigeria
    Phytother Res 20:14-20. 2006
    ..Ranitidine elicited 39% and 50% reduction in MDA following HCl/ethanol and IND treatment. The results indicate the gastroprotective activity of kolaviron, which may be linked to its intrinsic antioxidant properties...
  32. ncbi request reprint The protective effects of methyl jasmonate against adriamycin--induced hepatic and renal toxicities
    A M Kosoko
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, IAMRAT, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 41:117-24. 2012
    ..This study suggests that MJ may play an overall protective effect on ADR-induced toxicities in liver and kidneys and the inhibition of tissue peroxidative damage might contribute to this beneficial effect...
  33. ncbi request reprint Nigerian bonny light crude oil induces irreversible reproductive toxicity in adult male rats
    I A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 41:65-74. 2012
    ..The reversibility of reproductive toxicity induced by the Nigerian Bonny light crude oil (BLCO) was investigated in rats...
  34. doi request reprint Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats
    E O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Andrologia 44:273-84. 2012
    ..Taken together, kolaviron and quercetin inhibited the adverse effects of cadmium on the antioxidant enzymes, markers of oxidative stress, endocrine and testicular structure in rats...
  35. ncbi request reprint The effect of modulation of glutathione levels on markers for aflatoxin B1-induced cell damage
    E O Farombi
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Nigeria
    Afr J Med Med Sci 34:37-43. 2005
    ..Overall, our results suggest that the metabolism of aflatoxin B, by GSH does not lead to the formation of toxic products but rather GSH plays a protective role in AFB1-induced cell damage and GSH pathway is less utilised in mice...
  36. ncbi request reprint Free radical scavenging activities of guava extract in vitro
    A Adesida
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 41:81-90. 2012
    ..Psidium guajava (guava) is used in folk medicine in treating diverse human ailments. The therapeutic benefit of medicinal plants is often attributed to their antioxidant properties...
  37. ncbi request reprint The protective effect of aloe vera juice on lindane induced hepatotoxicity and genotoxicity
    O E Etim
    Department of Biochemistry, Faculty of Basic Medical Sciences University of Uyo, Uyo, Nigeria
    Pak J Pharm Sci 19:337-40. 2006
    ..8%), GOT (by 36.5%), GGT (by 14.3%) and ALP (by 10.7%) induced by 100mg/kg body weight of lindane. The level of polychromatic erythrocytes observed was not statistically significant when compared to control...
  38. doi request reprint 6-Gingerol-rich fraction from Zingiber officinale ameliorates carbendazim-induced endocrine disruption and toxicity in testes and epididymis of rats
    M Salihu
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Andrologia . 2016
    ..Collectively, 6-GRF inhibited the adverse effects of CBZ on the antioxidant defence systems, hormonal balance and histology of the testes and epididymis in rats...
  39. ncbi request reprint Cocoa powder extracts exhibits hypolipidemic potential in cholesterol-fed rats
    S O Nwichi
    Molecular Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 41:39-49. 2012
    ..Hypercholesterolemia and oxidative stress are risk factors of cardiovascular diseases...
  40. ncbi request reprint Endocrine disruption and oxidative stress implications of artemether-lumefantrine combination therapy in the ovary and uterus of rats
    A O Abolaji
    Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Hum Exp Toxicol . 2016
    ..05). The results suggest that in the absence of malarial parasite infection, the drugs induced oxidative stress in the ovary and uterus and disrupt hormonal balance in the rats...
  41. ncbi request reprint Insecticide chlorpyrifos and fungicide carbendazim, common food contaminants mixture, induce hepatic, renal, and splenic oxidative damage in female rats
    A O Abolaji
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Hum Exp Toxicol . 2016
    ....
  42. doi request reprint Artemisinin induces hormonal imbalance and oxidative damage in the erythrocytes and uterus but not in the ovary of rats
    E O Farombi
    Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Hum Exp Toxicol 34:83-92. 2015
    ..05). Thus, these data suggest that in the absence of malarial parasite infection, artemisinin induced hormonal imbalance and oxidative damage in the erythrocytes and uterus but spared the ovary of rats. ..
  43. pmc AN INVESTIGATION INTO THE ANTIMALARIAL EFFECT OF METHANOLIC EXTRACT OF PAULLINIA PINNATA LEAVES IN PLASMODIUM BERGHEI INFECTED MICE AND COURSE OF INFECTION
    O A Adeyemo-Salami
    Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 43:93-100. 2014
    ..The aim of this study was to investigate the antimalarial activity of methanolic leaves extract of Paullinia pinnata on chloroquine-sensitive Plasmodium berghei NK 65 infected mice...
  44. doi request reprint 6-Gingerol-rich fraction prevents disruption of histomorphometry and marker enzymes of testicular function in carbendazim-treated rats
    M Salihu
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Andrologia . 2017
    ..Conclusively, 6-GRF enhances key functional enzymes involve in spermatogenesis and maintains histo-architecture of testes and epididymis in CBZ-treated rats...
  45. ncbi request reprint In Vitro Antioxidant Properties of Methanolic Leaf Extract of Vernonia Amygdalina Del
    O A Adesanoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan
    Niger J Physiol Sci 29:91-101. 2014
    ..The assay methods correlates very well and could therefore be employed for investigating and understanding antioxidant properties and scavenging activities of plant materials. ..
  46. doi request reprint Sperm characteristics, antioxidant status and hormonal profile in rats treated with artemisinin
    E O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Andrologia 46:893-901. 2014
    ..Overall, induction of oxidative stress in the epididymis, but not in the testes, could cause reproductive deficits in individuals unduly undergoing artemisinin therapy...
  47. doi request reprint Kolaviron protects against ethylene glycol monoethyl ether-induced toxicity in boar spermatozoa
    I A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Andrologia 46:399-407. 2014
    ..Taken together, EGEE exhibited its spermatotoxicity via induction of oxidative stress. The protective effects by kolaviron and vitamin C against EGEE-induced oxidative damage may be due to their intrinsic antioxidative potentials. ..
  48. doi request reprint Kolaviron prevents carbendazim-induced steroidogenic dysfunction and apoptosis in testes of rats
    I A Adedara
    Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605014, India
    Environ Toxicol Pharmacol 35:444-53. 2013
    ..Kolaviron may prove useful in combating carbendazim-induced reproductive toxicity...
  49. doi request reprint The protective effects of quercetin on the cytotoxicity of atrazine on rat Sertoli-germ cell co-culture
    S O Abarikwu
    Department of Chemical Sciences, College of Natural Sciences, Redeemer s University, Redemption City, Ogun State, Nigeria
    Int J Androl 35:590-600. 2012
    ..QT might block these molecular events-induced by ATZ thereby protecting testicular Sertoli-germ cells from ATZ-induced toxicity...
  50. ncbi request reprint Genotoxicity of chloroquine in rat liver cells: protective role of free radical scavengers
    E O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Cell Biol Toxicol 22:159-67. 2006
    ..The results indicate that the genotoxicity of CQ in rat liver cells might involve ROS and that free radical scavengers may elicit protective effects in these cells...
  51. ncbi request reprint Ex-vivo and in vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress in human lymphocytes and rat liver cells
    E Olatunde Farombi
    Institute of Food Safety and Nutrition, Division of Biochemical and Molecular Toxicology, 2860 Søborg, Denmark
    Cell Biol Toxicol 20:71-82. 2004
    ..Kolaviron may therefore be relevant in the chemoprevention of oxidant-induced genotoxicity and possibly human carcinogenesis...
  52. ncbi request reprint Influence of chloroquine treatment and Plasmodium falciparum malaria infection on some enzymatic and non-enzymatic antioxidant defense indices in humans
    E Olatunde Farombi
    Department of Biochemistry, Drug Metabolism and Toxicology, Research Laboratories, College of Medicine, University of Ibadan, Nigeria
    Drug Chem Toxicol 26:59-71. 2003
    ..This has been proved by the efficacy of some antimalarial drugs that are known to act via generation of ROS when administered clinically or experimentally...
  53. ncbi request reprint Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1
    E Olatunde Farombi
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Food Chem Toxicol 46:1279-87. 2008
    ..Taken together, these findings suggest that curcumin protects against DMN-induced hepatotoxicity, at least in part, through ARE-driven induction of HO-1 expression...