Trine Husøy

Summary

Affiliation: Norwegian Institute of Public Health
Country: Norway

Publications

  1. ncbi request reprint Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
    Carcinogenesis 24:643-50. 2003
  2. doi request reprint Reducing added sugar intake in Norway by replacing sugar sweetened beverages with beverages containing intense sweeteners - a risk benefit assessment
    T Husøy
    Department of Food Safety and Nutrition, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Food Chem Toxicol 46:3099-105. 2008
  3. ncbi request reprint Intestinal adenomas of Min-mice lack enterochromaffin cells, and have increased lysozyme production in non-Paneth cells
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 26:1797-802. 2006
  4. doi request reprint Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure
    T Husøy
    Division of Environmental Medicine, Norwegian Institute of Public Health, Nydalen, 0403 Oslo, NO, Norway
    Food Chem Toxicol 46:3697-702. 2008
  5. ncbi request reprint Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Int J Cancer 116:351-8. 2005
  6. ncbi request reprint Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes
    T Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, NO 0403 Oslo, Norway
    Mutat Res 580:111-8. 2005
  7. ncbi request reprint Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Eur J Cancer 40:1599-603. 2004
  8. doi request reprint The impact of commercial rodent diets on the induction of tumours and flat aberrant crypt foci in the intestine of multiple intestinal neoplasia mice
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, PO Box 4404, Nydalen, NO 0403 Oslo, Norway
    Lab Anim 46:207-14. 2012
  9. doi request reprint Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, Nydalen, Oslo, Norway
    Mol Carcinog 51:984-92. 2012
  10. ncbi request reprint 5-Hydroxymethylfurfural and 5-sulfooxymethylfurfural increase adenoma and flat ACF number in the intestine of Min/+ mice
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 29:1921-6. 2009

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
    Carcinogenesis 24:643-50. 2003
    ..Reduction in GJIC and Cx43 level in IMCE cells may be caused by reduced Cx43 transport as a result of alterations in microtubule function...
  2. doi request reprint Reducing added sugar intake in Norway by replacing sugar sweetened beverages with beverages containing intense sweeteners - a risk benefit assessment
    T Husøy
    Department of Food Safety and Nutrition, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Food Chem Toxicol 46:3099-105. 2008
    ..The highest intake of benzoic acid was observed for 1- to 2-year-old children, and benzoic acid intake in Norwegian children is therefore considered to be of special concern...
  3. ncbi request reprint Intestinal adenomas of Min-mice lack enterochromaffin cells, and have increased lysozyme production in non-Paneth cells
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 26:1797-802. 2006
    ..Paneth and enterochromaffin cells were studied in the intestine and intestinal adenomas from Min-mice with heterozygote and homozygote mutations in Apc, respectively...
  4. doi request reprint Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure
    T Husøy
    Division of Environmental Medicine, Norwegian Institute of Public Health, Nydalen, 0403 Oslo, NO, Norway
    Food Chem Toxicol 46:3697-702. 2008
    ..In spite of this there was a significant correlation (r=0.57, P<0.001) between the estimated HMF intake and urinary HMFA. Further studies are needed to reveal alternative sources for HMF exposure...
  5. ncbi request reprint Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Int J Cancer 116:351-8. 2005
    ..We hypothesise that gap junctions may be of importance in the transfer of signals between epithelium and stroma...
  6. ncbi request reprint Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes
    T Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, NO 0403 Oslo, Norway
    Mutat Res 580:111-8. 2005
    ..We conclude that Min-mice are less sensitive than wt-mice to MN induction by PhIP that forms bulky DNA adducts, while Min-mice and wt-mice are equally sensitive to MN induction by acrylamide and glycidamide that form DNA base adducts...
  7. ncbi request reprint Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Eur J Cancer 40:1599-603. 2004
    ..Absence of matrilysin in Min mice reduces adenoma development. Reduced Cx32 and increased matrilysin secretion from Paneth cells could be important to neoplastic development in the intestine...
  8. doi request reprint The impact of commercial rodent diets on the induction of tumours and flat aberrant crypt foci in the intestine of multiple intestinal neoplasia mice
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, PO Box 4404, Nydalen, NO 0403 Oslo, Norway
    Lab Anim 46:207-14. 2012
    ..These findings show the importance of defining the type of diet used in experimental intestinal carcinogenesis studies, and that the diet should be taken into consideration when comparing results from different studies with Min mice...
  9. doi request reprint Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, Nydalen, Oslo, Norway
    Mol Carcinog 51:984-92. 2012
    ..4-1.3 per animal). Thus, intestinal expression of human SULT1A1 and 1A2 might increase the susceptibility to compounds bioactivated via this pathway implying that humans might be more susceptible than conventional rodent models...
  10. ncbi request reprint 5-Hydroxymethylfurfural and 5-sulfooxymethylfurfural increase adenoma and flat ACF number in the intestine of Min/+ mice
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 29:1921-6. 2009
    ....
  11. ncbi request reprint Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice
    Helle K Knutsen
    Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Anticancer Res 25:3781-9. 2005
    ..ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not...
  12. ncbi request reprint The min mouse on FVB background: susceptibility to spontaneous and carcinogen-induced intestinal tumourigenesis
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 31:785-8. 2011
    ..Treatment with PhIP significantly increased both the number and incidence of tumours in the small intestine, and gave a non-significant increase of tumours and flat ACF in the colon...
  13. pmc Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay
    Anja Hortemo Høie
    Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
    Environ Mol Mutagen 56:709-14. 2015
    ..DMF was not found to be genotoxic. The observation of increased DNA damage in hSULT mice compared with wt mice supports the role of human SULTs in the bioactivation of N-hydroxy-PhIP and HMF in vivo...
  14. pmc An in vitro study on the genotoxic effect of substituted furans in cells transfected with human metabolizing enzymes: 2,5-dimethylfuran and furfuryl alcohol
    Minor P Huffman
    Department of Food, Water and Cosmetics, Norwegian Institute of Public Health NIPH, NO 0403 Oslo, Norway
    Mutagenesis 31:597-602. 2016
    ..The results suggest that DNA damage in V79 cells from exposure to DMF detected by the alkaline SCGE assay is independent of human CYP2E1 and SULT1A1, and the genotoxic effect of FFA, as assessed by SCGE, is minimal in V79 cells. ..
  15. doi request reprint DNA adducts induced by food mutagen PhIP in a mouse model expressing human sulfotransferases 1A1 and 1A2
    Anja Hortemo Høie
    Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, 0456 Oslo, Norway
    Toxicol Lett 248:34-8. 2016
    ..The liver was the least affected organ in wild-type mice, whereas it was the most affected organ in hSULT mice with a 14-fold higher adduct level...
  16. ncbi request reprint Intestinal Tumor Development in C57BL/6J-ApcMin/+ Mice Expressing Human Sulphotransferases 1A1 and 1A2 After Oral Exposure to 2,5-Dimethylfuran
    Anja Hortemo Høie
    Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
    Anticancer Res 36:545-53. 2016
    ..Following side chain hydroxylation, DMF could be a substrate for human sulphotransferases (SULTs), which may lead to formation of a DNA reactive electrophile. Only few conflicting in vitro and no in vivo studies on DMF currently exist...
  17. ncbi request reprint The detection of hamster connexins: a comparison of expression profiles with wild-type mouse and the cancer-prone Min mouse
    Véronique Cruciani
    Department of Environmental and Occupational Cancer, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Cell Commun Adhes 11:155-71. 2004
    ..In contrast, there were minimal differences in expression profiles between wild type and Min mice. Species-specific expression profiles should be considered in attempts to make animal models of human connexin-associated diseases...
  18. doi request reprint The food processing contaminant glyoxal promotes tumour growth in the multiple intestinal neoplasia (Min) mouse model
    Camilla Svendsen
    Department of Toxicology and Risk Assessment, Domain for Infection Control and Environmental Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403 Oslo, Norway Electronic address
    Food Chem Toxicol 94:197-202. 2016
    ..This study suggests that glyoxal has tumour growth promoting properties in the small intestine in Min mice. ..
  19. pmc Formation of DNA adducts in wild-type and transgenic mice expressing human sulfotransferases 1A1 and 1A2 after oral exposure to furfuryl alcohol
    Anja Hortemo Høie
    Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, 0456 Oslo, Norway, Research Group Genotoxic Food Contaminants, German Institute of Human Nutrition DIfE Potsdam Rehbrucke, 14558 Nuthetal, Germany, Department of Exposure and Risk Assessment, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway, Department of Nutritional Toxicology, German Institute of Human Nutrition DIfE Potsdam Rehbrucke, Nuthetal, Germany Present address Department of Food Safety, German Federal Institute for Risk Assessment BfR, 10589 Berlin, Germany
    Mutagenesis 30:643-9. 2015
    ..These different results between wt and transgenic mice may be attributed to the fact that human SULT1A1, but not the orthologous mouse enzyme, is strongly expressed in the small intestine...
  20. ncbi request reprint Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells
    Anita Solhaug
    Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N 0403 Oslo, Norway
    Carcinogenesis 25:809-19. 2004
    ..In conclusion, B[a]P and the CP-PAH induced apoptotic as well as anti-apoptotic signals in Hepa1c1c7 cells...