Chukwuemeka S Nworu

Summary

Publications

  1. doi request reprint Activation of murine lymphocytes and modulation of macrophage functions by fractions of Alchornea cordifolia (Euphorbiaceae) leaf extract
    Chukwuemeka S Nworu
    Department of Molecular and Medical Virology, Ruhr University, Bochum, Germany
    Immunopharmacol Immunotoxicol 32:28-36. 2010
  2. pmc Efficacy and safety assessment of T. Angelica herbal tonic, a phytomedicinal product popularly used in Nigeria
    Charles O Esimone
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria
    Evid Based Complement Alternat Med 2011:123036. 2011
  3. doi request reprint Extracts of Ficus exasperata leaf inhibit topical and systemic inflammation in rodents and suppress LPS-induced expression of mediators of inflammation in macrophages
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    J Immunotoxicol 10:302-10. 2013
  4. doi request reprint Inhibition of pro-inflammatory cytokines and inducible nitric oxide by extract of Emilia sonchifolia L. aerial parts
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
    Immunopharmacol Immunotoxicol 34:925-31. 2012
  5. doi request reprint Supplementation with aqueous leaf extract of Morinda lucida enhances immunorestoration and upregulates the expression of cytokines and immunostimulatory markers
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    Immunol Invest 41:799-819. 2012
  6. doi request reprint The leaf extract of Spondias mombin L. displays an anti-inflammatory effect and suppresses inducible formation of tumor necrosis factor-α and nitric oxide (NO)
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    J Immunotoxicol 8:10-6. 2011
  7. doi request reprint Adjuvant properties of AcF1, an immunostimulant fraction of Alchornea cordifolia extract
    C S Nworu
    Department of Molecular and Medical Virology, Ruhr University, Bochum, Germany
    Immunol Invest 39:132-58. 2010
  8. doi request reprint Aqueous extract of Phyllanthus niruri (Euphorbiaceae) enhances the phenotypic and functional maturation of bone marrow-derived dendritic cells and their antigen-presentation function
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    Immunopharmacol Immunotoxicol 32:393-401. 2010
  9. ncbi request reprint Immunomodulatory activities of kolaviron, a mixture of three related biflavonoids of Garcinia kola Heckel
    C S Nworu
    Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Enugu State, Nigeria
    Immunopharmacol Immunotoxicol 30:317-32. 2008
  10. doi request reprint The effects of Phyllanthus niruri aqueous extract on the activation of murine lymphocytes and bone marrow-derived macrophages
    C S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    Immunol Invest 39:245-67. 2010

Collaborators

Detail Information

Publications18

  1. doi request reprint Activation of murine lymphocytes and modulation of macrophage functions by fractions of Alchornea cordifolia (Euphorbiaceae) leaf extract
    Chukwuemeka S Nworu
    Department of Molecular and Medical Virology, Ruhr University, Bochum, Germany
    Immunopharmacol Immunotoxicol 32:28-36. 2010
    ..cordifolia leaf extracts which could explain some of the therapeutic benefits attributed to the plant in traditional medicine and could also be exploited as a source of novel immunoregulating substances...
  2. pmc Efficacy and safety assessment of T. Angelica herbal tonic, a phytomedicinal product popularly used in Nigeria
    Charles O Esimone
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria
    Evid Based Complement Alternat Med 2011:123036. 2011
    ..Generally, the results of this study showed some favorable pharmacological effects of TAHT in animals which may authenticate some of the label claims...
  3. doi request reprint Extracts of Ficus exasperata leaf inhibit topical and systemic inflammation in rodents and suppress LPS-induced expression of mediators of inflammation in macrophages
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    J Immunotoxicol 10:302-10. 2013
    ..The results also show that the extracts may be acting through a suppression of mediators of inflammation, such as IL-1β, TNFα, and iNO. ..
  4. doi request reprint Inhibition of pro-inflammatory cytokines and inducible nitric oxide by extract of Emilia sonchifolia L. aerial parts
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
    Immunopharmacol Immunotoxicol 34:925-31. 2012
    ..The results of these studies suggest that treatment with ES alleviated inflammatory responses possibly through a suppression of pro-inflammatory mediators and cytokines such as IL-1β, TNF-α, and iNO...
  5. doi request reprint Supplementation with aqueous leaf extract of Morinda lucida enhances immunorestoration and upregulates the expression of cytokines and immunostimulatory markers
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    Immunol Invest 41:799-819. 2012
    ....
  6. doi request reprint The leaf extract of Spondias mombin L. displays an anti-inflammatory effect and suppresses inducible formation of tumor necrosis factor-α and nitric oxide (NO)
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    J Immunotoxicol 8:10-6. 2011
    ....
  7. doi request reprint Adjuvant properties of AcF1, an immunostimulant fraction of Alchornea cordifolia extract
    C S Nworu
    Department of Molecular and Medical Virology, Ruhr University, Bochum, Germany
    Immunol Invest 39:132-58. 2010
    ..The results of this study show AcF1 as a potent immunostimulant and a potential adjuvant for further study in combination with other vaccine antigens...
  8. doi request reprint Aqueous extract of Phyllanthus niruri (Euphorbiaceae) enhances the phenotypic and functional maturation of bone marrow-derived dendritic cells and their antigen-presentation function
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    Immunopharmacol Immunotoxicol 32:393-401. 2010
    ..Therefore, PN enhances the structural and functional maturation of BM-DCs and their antigen-presenting function. These effects are relevant in immunodeficient conditions, tumor control, and in infectious diseases...
  9. ncbi request reprint Immunomodulatory activities of kolaviron, a mixture of three related biflavonoids of Garcinia kola Heckel
    C S Nworu
    Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Enugu State, Nigeria
    Immunopharmacol Immunotoxicol 30:317-32. 2008
    ..75 to 15.5 days. This study established the immunomodulatory and immunorestorative properties of KV, which could be harnessed for possible clinical benefits to immunodeficient patients...
  10. doi request reprint The effects of Phyllanthus niruri aqueous extract on the activation of murine lymphocytes and bone marrow-derived macrophages
    C S Nworu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
    Immunol Invest 39:245-67. 2010
    ..These activities suggest that stimulation of the immune system by the extracts of P. niruri could be partly responsible for the ethnomedicinal applications in the management of infectious diseases...
  11. doi request reprint Anti-inflammatory and membrane-stabilizing stigmastane steroids from Alchornea floribunda leaves
    Festus B C Okoye
    Department of Pharmaceutical Chemistry, University of Nigeria, Nsukka, Enugu State, Nigeria
    Planta Med 76:172-7. 2010
    ..This is the first report on the isolation and structure elucidation of these anti-inflammatory steroids from Alchornea floribunda leaves...
  12. doi request reprint Dammarenolic acid, a secodammarane triterpenoid from Aglaia sp. shows potent anti-retroviral activity in vitro
    Charles O Esimone
    Department of Molecular and Medical Virology, Ruhr University Bochum, Germany
    Phytomedicine 17:540-7. 2010
    ..Cell cycle analysis revealed that ignT1 arrests HeLa cells at the S and G2/M phase. These results strongly suggest that dammarenolic acid could be a promising lead compound for the development of novel anti-retrovirals...
  13. doi request reprint Inhibition of inflammatory mediators and reactive oxygen and nitrogen species by some depsidones and diaryl ether derivatives isolated from Corynespora cassiicola, an endophytic fungus of Gongronema latifolium leaves
    Festus Basden C Okoye
    Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
    Immunopharmacol Immunotoxicol 35:662-8. 2013
    ..These chemical scaffolds can serve as suitable lead molecules for further development into novel anti-inflammatory and/or anti-cancer agents...
  14. doi request reprint Anticonvulsant effect of kaurenoic acid isolated from the root bark of Annona senegalensis
    Theophine C Okoye
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria
    Pharmacol Biochem Behav 109:38-43. 2013
    ..The herbal preparations of Annona senegalensis Pers. (Annonaceae) root bark are used in Nigerian ethnomedicine for the treatment of epilepsy and febrile seizures. The scientific evidence for this effect has been reported...
  15. doi request reprint Broad spectrum antiviral fractions from the lichen Ramalina farinacea (L.) Ach
    C O Esimone
    Department of Molecular and Medical Virology, Ruhr University, Bochum, Germany
    Chemotherapy 55:119-26. 2009
    ..We now determined the antiviral activity of ET4 against other wild-type viruses, including the herpes simplex virus type 1 (HSV-1) and the respiratory syncytial virus (RSV)...
  16. doi request reprint Immunomodulatory and immunorestorative activities of β-D-glucan-rich extract and polysaccharide fraction of mushroom, Pleurutus tuberregium
    Chukwuemeka S Nworu
    Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Nigeria
    Pharm Biol 53:1555-66. 2015
    ..Some edible mushrooms are reputed to possess useful medicinal properties which are related to their ability to modulate the protective responses of the immune system...
  17. pmc Acanthus montanus: an experimental evaluation of the antimicrobial, anti-inflammatory and immunological properties of a traditional remedy for furuncles
    Charles O Okoli
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria
    BMC Complement Altern Med 8:27. 2008
    ....
  18. doi request reprint Herb-drug interaction between the extract of Hibiscus sabdariffa L. and hydrochlorothiazide in experimental animals
    Okechukwu O Ndu
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
    J Med Food 14:640-4. 2011
    ..The results of this study reveal a possible herb-drug interaction involving HCT and HSE, used as an ingredient in medicinal or refreshing drinks in many countries...