Mohammad I Choudhary

Summary

Affiliation: University of Karachi
Country: Pakistan

Publications

  1. ncbi request reprint Synthesis and antiglycation activity of kaempferol-3-O-rutinoside (nicotiflorin)
    Sajan Lal Shyaula
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Med Chem 8:415-20. 2012
  2. pmc A traditional poly herbal medicine "Le Pana Guliya" induces apoptosis in HepG2 and HeLa cells but not in CC1 cells: an in vitro assessment
    Nekadage Don Amal Wageesha
    Department of Biochemistry and Chemistry, Faculty of Medicine, South Asian Institute of Technology and Medicine, Malabe, Sri Lanka Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Chem Cent J 11:2. 2017
  3. pmc Biotransformation of perfumery terpenoids, (-)-ambrox® by a fungal culture Macrophomina phaseolina and a plant cell suspension culture of Peganum harmala
    Syed Ghulam Musharraf
    H, E, J, Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Cent J 6:82. 2012
  4. pmc Biodiesel production from microalgal isolates of southern Pakistan and quantification of FAMEs by GC-MS/MS analysis
    Syed Ghulam Musharraf
    H, E, J, Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Cent J 6:149. 2012
  5. pmc Electrospray tandem mass spectrometric analysis of a dimeric conjugate, salvialeriafone and related compounds
    Syed Ghulam Musharraf
    H, E, J, Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Cent J 6:120. 2012
  6. pmc Antibacterial constituents of three Cameroonian medicinal plants: Garcinia nobilis, Oricia suaveolens and Balsamocitrus camerunensis
    Hugues Fouotsa
    Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon
    BMC Complement Altern Med 13:81. 2013
  7. doi request reprint Biotransformation of clerodane diterpenoids by Rhizopus stolonifer and antibacterial activity of resulting metabolites
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Phytochemistry 90:56-61. 2013
  8. doi request reprint Biotransformation of dehydroepiandrosterone with Macrophomina phaseolina and β-glucuronidase inhibitory activity of transformed products
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    J Enzyme Inhib Med Chem 27:348-55. 2012
  9. doi request reprint Diterpenoids including a novel dimeric conjugate from Salvia leriaefolia
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    Planta Med 78:269-75. 2012
  10. ncbi request reprint Five new peltogynoids from underground parts of Iris bungei: a Mongolian medicinal plant
    M I Choudhary
    HEJ Research Institute of Chemistry, University of Karachi, Pakistan
    Chem Pharm Bull (Tokyo) 49:1295-8. 2001

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Synthesis and antiglycation activity of kaempferol-3-O-rutinoside (nicotiflorin)
    Sajan Lal Shyaula
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Med Chem 8:415-20. 2012
    ..Moreover the cytotoxicity analysis was also performed for these compounds. The Structure-Activity Relationship (SAR) studies showed that sugar derivatives of kaempferol possess a promising antiglycation activity...
  2. pmc A traditional poly herbal medicine "Le Pana Guliya" induces apoptosis in HepG2 and HeLa cells but not in CC1 cells: an in vitro assessment
    Nekadage Don Amal Wageesha
    Department of Biochemistry and Chemistry, Faculty of Medicine, South Asian Institute of Technology and Medicine, Malabe, Sri Lanka Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Chem Cent J 11:2. 2017
    ..Therefore present study provides the scientific proof of the traditional knowledge in using LPG as an anticancer agent...
  3. pmc Biotransformation of perfumery terpenoids, (-)-ambrox® by a fungal culture Macrophomina phaseolina and a plant cell suspension culture of Peganum harmala
    Syed Ghulam Musharraf
    H, E, J, Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Cent J 6:82. 2012
    ..This paper describes the biotransformational studies of ambrox, one of the most important components of natural Ambergris (wale sperm) with fungal and plant cell culture...
  4. pmc Biodiesel production from microalgal isolates of southern Pakistan and quantification of FAMEs by GC-MS/MS analysis
    Syed Ghulam Musharraf
    H, E, J, Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Cent J 6:149. 2012
    ..Anabaena sp., Chlorella sp. and Oscillatoria sp., isolated from fresh and marine water resources of southern Pakistan for biodiesel production and the GC-MS/MS analysis of their fatty acid methyl esters (FAMEs)...
  5. pmc Electrospray tandem mass spectrometric analysis of a dimeric conjugate, salvialeriafone and related compounds
    Syed Ghulam Musharraf
    H, E, J, Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Cent J 6:120. 2012
    ..Diterpenoids are widely distributed throughout the plant kingdom and posses interesting biological activities...
  6. pmc Antibacterial constituents of three Cameroonian medicinal plants: Garcinia nobilis, Oricia suaveolens and Balsamocitrus camerunensis
    Hugues Fouotsa
    Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon
    BMC Complement Altern Med 13:81. 2013
    ....
  7. doi request reprint Biotransformation of clerodane diterpenoids by Rhizopus stolonifer and antibacterial activity of resulting metabolites
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Phytochemistry 90:56-61. 2013
    ..The metabolites 3-7 showed moderate activities against both Gram-positive and Gram-negative organisms. While metabolite 8 showed a moderate activity against Gram-positive organisms and a good activity against Gram-negative organisms...
  8. doi request reprint Biotransformation of dehydroepiandrosterone with Macrophomina phaseolina and β-glucuronidase inhibitory activity of transformed products
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    J Enzyme Inhib Med Chem 27:348-55. 2012
    ..All the transformed products were screened for enzyme inhibition, among which four were found to inhibit the β-glucuronidase enzyme, while none inhibited the α-chymotrypsin enzyme...
  9. doi request reprint Diterpenoids including a novel dimeric conjugate from Salvia leriaefolia
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    Planta Med 78:269-75. 2012
    ..Compounds 1, 5, 6, and 7 exhibited IN VITRO antiproliferative activity against the human cervical cancer cell line (Hela), while 6 showed cytotoxicity against the human prostate cancer cell line (PC3)...
  10. ncbi request reprint Five new peltogynoids from underground parts of Iris bungei: a Mongolian medicinal plant
    M I Choudhary
    HEJ Research Institute of Chemistry, University of Karachi, Pakistan
    Chem Pharm Bull (Tokyo) 49:1295-8. 2001
    ..The structure of irisoid B (2) was established unambiguously by X-ray diffraction study...
  11. ncbi request reprint New leishmanicidal physalins from Physalis minima
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 21:877-83. 2007
    ..var. indica). Their structures were deduced on the basis of spectroscopic analysis. Both of these compounds have shown potent leishmanicidal activity against the promastigotes of Leishmania major...
  12. ncbi request reprint Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans
    Muhammad Iqbal Choudhary
    HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    Steroids 72:923-9. 2007
    ..Structures of new metabolites 2, 5, and 6 were established by single-crystal X-ray diffraction analysis...
  13. doi request reprint Phenolic and other constituents of fresh water fern Salvinia molesta
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Phytochemistry 69:1018-23. 2008
    ..S. Mitch. These compounds showed a potent antioxidant radical scavenging activity in a non-physiological assay. Their structures were determined by NMR spectroscopic and CID mass spectrometry techniques...
  14. doi request reprint Microbial transformation of oleanolic acid by Fusarium lini and alpha-glucosidase inhibitory activity of its transformed products
    M Iqbal Choudhary
    HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 22:489-94. 2008
    ..Metabolite 3 was found to be a new compound. The structures were characterized on the basis of spectroscopic studies. These metabolites exhibited a potent inhibition of alpha-glucosidase enzyme...
  15. doi request reprint A benzil and isoflavone from Iris tenuifolia
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Phytochemistry 69:1880-5. 2008
    ..Compounds 3, 5 and 7 were also subjected to single-crystal X-ray diffraction analysis and their structures were unambiguously deduced...
  16. doi request reprint Cycloartane triterpenoids from Astragalus bicuspis
    M Iqbal Choudhary
    HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    J Nat Prod 71:1557-60. 2008
    ..Two known cycloartane derivatives, 4 and 5, were also obtained from this plant. Compounds 2-5 were tested for leishmanicidal activity against Leishmania major promastigotes and for cytotoxicity against 3T3 cancer cells...
  17. doi request reprint Microbial oxidation of anabolic steroids
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    Nat Prod Res 22:1289-96. 2008
    ....
  18. doi request reprint Two new antioxidant phenylpropanoids from Lindelofia stylosa
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    Chem Biodivers 5:2676-83. 2008
    ..Compound 2 was found to be most active in all assays with potency nearly similar to that of propyl gallate. Besides 2, compounds 1 and 5 were also found to be active in DPPH radical-scavenging standard assay...
  19. doi request reprint Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Phytother Res 23:1336-9. 2009
    ..Compounds 6, 7 and 10 were found to have significant antiinflammatory activity in a cell-based contemporary assay, whereas compounds 1 and 2 exhibited a potent lipoxygenase inhibition...
  20. doi request reprint Microbial transformation of 18beta-glycyrrhetinic acid by Cunninghamella elegans and Fusarium lini, and lipoxygenase inhibitory activity of transformed products
    Muhammad Iqbal Choudhary
    International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 23:507-13. 2009
    ..Compound 3 exhibited a potent lipoxygenase (LOX) inhibitory activity. The structures of these metabolites were elucidated on the basis of spectroscopic techniques...
  21. doi request reprint Bisbenzylisoquinoline alkaloids from Cocculus pendulus
    - Atta-Ur-Rahman
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 23:1265-73. 2009
    ..The structures for these compounds were deduced by spectroscopic methods. All bisbenzylisoquinoline alkaloids showed inhibitory activities against acetyl- and butyrylcholinesterases...
  22. doi request reprint New oxandrolone derivatives by biotransformation using Rhizopus stolonifer
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    Steroids 74:1040-4. 2009
    ..Compounds 1 and 3 showed a significant beta-glucuronidase inhibitory activity...
  23. doi request reprint Hemiterpene glucosides and other constituents from Spiraea canescens
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Phytochemistry 70:1467-73. 2009
    ..Some of these compounds showed potent radical scavenging activity in relevant non-physiological assays. Their structures were determined by NMR spectroscopic and CID mass spectrometric techniques...
  24. doi request reprint Oxidation of lynestrenol by the fungus Cunninghamella elegans
    M Iqbal Choudhary
    International Center for Chemical Sciences, H E J Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 24:1-6. 2010
    ..Metabolite 4 was identified as a new compound. These metabolites were structurally characterised on the basis of spectroscopic techniques...
  25. doi request reprint Substituted benzenediol Schiff bases as promising new anti-glycation agents
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    J Enzyme Inhib Med Chem 26:98-103. 2011
    ..Some of these compounds have shown a promising anti-glycation potential in vitro...
  26. ncbi request reprint Characterization and antiglycation activity of phenolic constituents from Viscum album (European Mistletoe)
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    Chem Pharm Bull (Tokyo) 58:980-2. 2010
    ..European Mistletoe). These compounds were studied for their anti-glycation and antioxidant properties. The structures of new compounds 1 and 2 were deduced on the basis of spectroscopic evidence...
  27. ncbi request reprint Alkaloidal constituents of Tinospora crispa
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Commun 5:1747-50. 2010
    ..The structure of new compound 1 was deduced on the basis of spectroscopic data...
  28. ncbi request reprint Microbial hydroxylation of pregnenolone derivatives
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan
    Chem Pharm Bull (Tokyo) 53:1455-9. 2005
    ..Fermentation of with R. stolonifer yielded two known metabolites, 11alpha-hydroxypreg-4-ene-3,20-dione and. Compounds were screened for their cholinesterase inhibitory activity in a mechanism-based assay...
  29. ncbi request reprint Isoflavonoid glycosides from the rhizomes of Iris germanica
    - Atta-Ur-Rahman
    HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
    Chem Pharm Bull (Tokyo) 50:1100-2. 2002
    ..These compounds were identified as iriskashmirianin 4'-O-beta-D-glucoside (1), nigricin 4'-O-beta-D-glucoside (2), irilone 4'-O-beta-D-glucoside (3) and iridin (4). Their structures were determined with the help of spectroscopic methods...
  30. ncbi request reprint Triterpene and coumarins from Skimmia laureola
    - Atta-Ur-Rahman
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan
    Nat Prod Lett 16:305-13. 2002
    ..The structures were identified by spectroscopic studies and the stereochemistry at C-2' in compounds 3 and 4 were established by Horeau's procedure...
  31. ncbi request reprint Microbial transformation of (+)-androsta-1 ,4-diene-3,17-dione by Cephalosporium aphidicola
    M Iqbal Choudhary
    HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Lett 16:377-82. 2002
    ..The fermentation of [structure: see text] with Fusarium lini also yielded metabolites [structure: see text]. The structures of these metabolites were elucidated on the basis of spectroscopic techniques...
  32. ncbi request reprint Leucosceptrine--a novel sesterterpene with prolylendopeptidase inhibitory activity from Leucosceptrum canum
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    J Org Chem 69:2906-9. 2004
    ..The structure was determined by single-crystal X-ray diffraction and spectroscopic techniques. The biosynthesis of leucosceptrine (1) is proposed here. Leucosceptrine (1) exhibited prolylendopeptidase inhibitory activity...
  33. ncbi request reprint Two new isoflavanoids from the rhizomes of Iris soforana
    - Atta-Ur-Rahman
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 18:465-71. 2004
    ....
  34. ncbi request reprint Cholinesterase inhibiting withanolides from Withania somnifera
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Pharm Bull (Tokyo) 52:1358-61. 2004
    ..Compounds 2, 3, 5, and 6 displayed inhibitory potential against butyrylcholinesterase, but only compounds 3, 4, and 6 were found to be active against acetylcholinesterase...
  35. ncbi request reprint Phenolic glyscosides, a new class of human recombinant nucleotide pyrophosphatase phosphodiesterase-1 inhibitors
    Muhammad Iqbal Choudhary
    Dr Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical Sciences, University of Karachi 75270, Pakistan
    Bioorg Med Chem 12:5793-8. 2004
    ..Both compounds were found to be nontoxic up to concentration of 500 microM/mL as >90% cells were viable after 3 h of incubation. These compounds are potential candidates for the therapy of arthritis...
  36. ncbi request reprint Biotransformation of (+)-androst-4-ene-3,17-dione
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 18:529-35. 2004
    ..The structures of these metabolites were elucidated on the basis of spectroscopic techniques. These microbially transformed products were assayed against the clinically important enzymes, tyrosinase and prolyl endopeptidase...
  37. ncbi request reprint Cholinesterase inhibitory pregnane-type steroidal alkaloids from Sarcococca hookeriana
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Steroids 70:295-303. 2005
    ..5 to 148.2 and 0.6 to 100.2 microM, respectively...
  38. ncbi request reprint Microbial transformation of prednisone
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 19:311-7. 2005
    ..Compound 3 was found to be a new metabolite. Their structures were elucidated on the basis of spectroscopic techniques. Compound 3 showed inhibitory activity against lipoxygenase enzyme...
  39. ncbi request reprint Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer's disease therapy
    M Iqbal Choudhary
    Dr Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical Sciences, University of Karachi, Pakistan
    Biochem Biophys Res Commun 332:1171-7. 2005
    ..The cholinesterase inhibitory potential along with calcium-channel blocking activity of compound 1 and safe profile in human neutrophils viable assay could make it a possible drug candidate for Alzheimer's disease...
  40. ncbi request reprint Microbial transformation of mestranol by Cunninghamella elegans
    Muhammad Iqbal Choudhary
    International Center for Chemical Sciences, H E J Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan
    Chem Pharm Bull (Tokyo) 53:1011-3. 2005
    ..Metabolite 3 was found to be a new compound. These metabolites were structurally characterized on the basis of spectroscopic techniques...
  41. ncbi request reprint Bioactive phenolic compounds from a medicinal lichen, Usnea longissima
    Muhammad I Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Phytochemistry 66:2346-50. 2005
    ..Compound 1 was found to possess potent anti-inflammatory activity in a cell-based contemporary assay. Cytotoxicity activity measured by cell viability assay showed 100% viability in the presence of 200 microg/mL conc. of these compounds...
  42. ncbi request reprint Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties
    M Iqbal Choudhary
    Dr Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Biochem Biophys Res Commun 334:276-87. 2005
    ....
  43. ncbi request reprint Microbial transformation of (-)-guaiol and antibacterial activity of its transformed products
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    J Nat Prod 70:849-52. 2007
    ..All metabolites were found to be new compounds as deduced on the basis of spectroscopic techniques. Compounds 1-6 were evaluated for their activity against several bacterial strains...
  44. ncbi request reprint Phenyl polypropanoids from Lindelofia stylosa
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Pakistan
    Chem Pharm Bull (Tokyo) 53:1469-71. 2005
    ..This includes three analogs of lithospermic acid, along with rosmarinic acid and its ester derivatives. Compound 1 was identified as a new natural product. These compounds were studied for their antioxidant properties...
  45. ncbi request reprint Hydroxylation of the sesterterpene leucosceptrine by the fungus Rhizopus stolonifer
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Phytochemistry 67:439-43. 2006
    ..The microbial transformation of leucosceptrine (1), the first member of class leucosesterterpenes, by Rhizopus stolonifer afforded two metabolites, 1alpha-hydroxyleucosceptrine (2), and 8alpha-hydroxyleucosceptrine (3)...
  46. ncbi request reprint Biotransformation of physalin H and leishmanicidal activity of its transformed products
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
    Chem Pharm Bull (Tokyo) 54:927-30. 2006
    ..Their structures were elucidated by spectroscopic analysis. All of these compounds have shown potent leishmanicidal activity with IC50 values in the range of 6.03-13.80 microM...
  47. ncbi request reprint Inhibition of respiratory burst in human neutrophils and lipoxygenase enzyme by compounds from Haloxylon griffithii
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270 Pakistan
    Phytother Res 20:840-3. 2006
    ..Compound 5 was found to be the most potent inhibitory activity against respiratory burst in human neutrophils among all the compounds as well as exhibited moderate lipoxygenase inhibitory activity from this plant...
  48. ncbi request reprint Cinnamate derivatives of fructo-oligosaccharides from Lindelofia stylosa
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Carbohydr Res 341:2398-405. 2006
    ..Compounds 1-4 belong to sucrose derivatives, while compounds 5-6 and 7-8 belong to 1-kestose- and nystose-type oligosaccharides, respectively. The fructo-oligosaccharides have been obtained from L. stylosa for the first time...
  49. ncbi request reprint New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities
    Muhammad Iqbal Choudhary
    Dr Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi 75270, Pakistan
    Bioorg Med Chem 14:8066-72. 2006
    ..Compounds 1, 3, 4, 6, 7, 17, 26, and 30 were found to be non-competitive and non-cytotoxic upto a concentration of 200 microg/mL as evident by less than 10% cell death after 3 h of incubation...
  50. ncbi request reprint Microbial transformation and butyrylcholinesterase inhibitory activity of (-)-caryophyllene oxide and its derivatives
    Muhammad Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    J Nat Prod 69:1429-34. 2006
    ..Compounds 1-10 were evaluated for butyrylcholinesterase inhibitory activity, and compound 5 exhibited an IC50 value of 10.9 +/- 0.2 microM...
  51. ncbi request reprint Microbial transformations of gelomulide G: a member of the rare class of diterpene lactones
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Biodivers 2:1401-8. 2005
    ..The structures of the transformed products 2-5 were deduced to be new on the basis of MS and NMR data...
  52. ncbi request reprint Microbial transformation of mesterolone
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Biodivers 2:392-400. 2005
    ..The structures of these metabolites were characterized on the basis of spectroscopic studies, and the structure of 5 was also determined by single-crystal X-ray-diffraction analysis...
  53. ncbi request reprint Fungal metabolites of (E)-guggulsterone and their antibacterial and radical-scavenging activities
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Biodivers 2:516-24. 2005
    ..Compounds 4-11 have not been described yet. Some of these novel hydroxylated metabolites, as well as acetylated derivatives thereof, exhibited significant antibacterial and radical-scavenging activities (Table 3)...
  54. ncbi request reprint Structure elucidation and antibacterial activity of new fungal metabolites of sclareol
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Chem Biodivers 3:54-61. 2006
    ..Fermentation of 1 with Fusarium lini afforded (1beta)-1-hydroxysclareol (6) and (12S)-12-hydroxysclareol (7). Compounds 4-7 were identified as new compounds, and some of them were active against Bacillus subtilis (Table 3)...
  55. pmc Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis
    Sajjad Hussain
    School of Chemistry, Biology and Health Sciences, Manchester Metropolitan University, Chester St, Manchester, UK
    BMC Cell Biol 10:30. 2009
    ..In all cases the concentration of compound 1 which caused 50% inhibition (IC50) was determined. The effect of compound 1 on EGF and VEGF-induced proliferation was also investigated...
  56. pmc Cheiradone: a vascular endothelial cell growth factor receptor antagonist
    Sajjad Hussain
    School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Chester St, Manchester M1 5GD, UK
    BMC Cell Biol 9:7. 2008
    ..In all cases, the concentration of cheiradone which caused 50% inhibition (IC50) was determined. The effect of cheiradone on the binding of growth factors to their receptors was also investigated...