Nikolaos Papageorgiou

Summary

Publications

  1. ncbi request reprint Antioxidant treatment and endothelial dysfunction: is it time for flavonoids?
    Nikolaos Papageorgiou
    Athens University Medical School, Hippokration Hospital, Vasilisis Sofias 114, 115 28 Athens, Greece
    Recent Pat Cardiovasc Drug Discov 8:81-92. 2013
  2. ncbi request reprint Prognostic role of miRNAs in coronary artery disease
    Nikolaos Papageorgiou
    1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 13:1540-7. 2013
  3. ncbi request reprint The role of microRNAs in the initiation and progression of stable atheromatous plaque
    Nikolaos Papageorgiou
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Pharm Des 19:1651-7. 2013
  4. ncbi request reprint The role of microRNAs in cardiovascular disease
    N Papageorgiou
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Med Chem 19:2605-10. 2012
  5. ncbi request reprint Genetic variability of matrix metalloproteinase genes in cardiovascular disease
    Nikolaos Papageorgiou
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Curr Top Med Chem 12:1206-13. 2012
  6. ncbi request reprint Lifestyle factors and endothelial function
    Nikolaos Papageorgiou
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 10:94-106. 2012
  7. ncbi request reprint Inflammation in hypertension: current therapeutic approaches
    Emmanuel Androulakis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Pharm Des 17:4121-31. 2011
  8. ncbi request reprint Potential pathogenic inflammatory mechanisms of endothelial dysfunction induced by type 2 diabetes mellitus
    Anna Maria Kampoli
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Pharm Des 17:4147-58. 2011
  9. doi request reprint Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 149:46-9. 2011
  10. ncbi request reprint Novel therapeutic approaches targeting matrix metalloproteinases in cardiovascular disease
    Alexandros Briasoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Top Med Chem 12:1214-21. 2012

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Antioxidant treatment and endothelial dysfunction: is it time for flavonoids?
    Nikolaos Papageorgiou
    Athens University Medical School, Hippokration Hospital, Vasilisis Sofias 114, 115 28 Athens, Greece
    Recent Pat Cardiovasc Drug Discov 8:81-92. 2013
    ..However, the vascular-protective role of flavonoids and especially their antioxidant properties are still under investigation. ..
  2. ncbi request reprint Prognostic role of miRNAs in coronary artery disease
    Nikolaos Papageorgiou
    1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 13:1540-7. 2013
    ..Therefore, evaluating the role of these molecules may be of great importance in the understanding of atherogenesis providing new evidence for diagnosis and prognosis of CAD. ..
  3. ncbi request reprint The role of microRNAs in the initiation and progression of stable atheromatous plaque
    Nikolaos Papageorgiou
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Pharm Des 19:1651-7. 2013
    ....
  4. ncbi request reprint The role of microRNAs in cardiovascular disease
    N Papageorgiou
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Med Chem 19:2605-10. 2012
    ..Understanding the underlying mechanisms, in which these major regulatory gene families are implicated, will provide novel opportunities for diagnosis and therapy of cardiovascular diseases...
  5. ncbi request reprint Genetic variability of matrix metalloproteinase genes in cardiovascular disease
    Nikolaos Papageorgiou
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Curr Top Med Chem 12:1206-13. 2012
    ..Therefore, further studies are required to evaluate the role of matrix metalloproteinases and especially the associated genetic polymorphisms in cardiovascular disease...
  6. ncbi request reprint Lifestyle factors and endothelial function
    Nikolaos Papageorgiou
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 10:94-106. 2012
    ..However, little is known about how individual's genetic background interacts with environmental influences on vascular health, thereby making the interpretation of the relative importance of lifestyle interventions more complicated...
  7. ncbi request reprint Inflammation in hypertension: current therapeutic approaches
    Emmanuel Androulakis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Pharm Des 17:4121-31. 2011
    ..Although the available data are encouraging, further large scale studies are required to evaluate the reported anti-inflammatory effects in management and treatment of arterial hypertension...
  8. ncbi request reprint Potential pathogenic inflammatory mechanisms of endothelial dysfunction induced by type 2 diabetes mellitus
    Anna Maria Kampoli
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Pharm Des 17:4147-58. 2011
    ....
  9. doi request reprint Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 149:46-9. 2011
    ..We examined the effect of combined therapy with atorvastatin and metformin on glucose-induced variations of inflammatory molecules in patients with newly diagnosed diabetes mellitus type 2 (DM)...
  10. ncbi request reprint Novel therapeutic approaches targeting matrix metalloproteinases in cardiovascular disease
    Alexandros Briasoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Top Med Chem 12:1214-21. 2012
    ..This review discusses pharmacological approaches to MMP inhibition...
  11. doi request reprint Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Am J Hypertens 24:936-42. 2011
    ..However, the mechanisms regulating ADMA synthesis in hypertension are unclear...
  12. ncbi request reprint Novel biomarkers assessing endothelial dysfunction: role of microRNAs
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 13:1518-26. 2013
    ..They have been shown to participate in cardiovascular disease pathogenesis including atherosclerosis and endothelial dysfunction and this may have important clinical implications. ..
  13. ncbi request reprint Inflammatory markers in essential hypertension: potential clinical implications
    Elli Stefanadi
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 8:509-16. 2010
    ..However, further randomized studies are required to determine the potential favorable effects of suppression of inflammation in the management of arterial hypertension...
  14. doi request reprint Combined effects of fibrinogen genetic variability on atherosclerosis in patients with or without stable angina pectoris: focus on the coagulation cascade and endothelial function
    Nikolaos Papageorgiou
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Greece
    Int J Cardiol 168:4602-7. 2013
    ..We examined the combined effects of the G455A and the G58A fibrinogen genetic polymorphisms on prothrombotic profile, endothelial function and the risk of CAD in a Caucasian population...
  15. doi request reprint Effects of direct infusion of bone marrow-derived progenitor cells and indirect mobilization of hematopoietic progenitor cells on atherosclerotic plaque and inflammatory process in atherosclerosis
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Greece Electronic address
    Int J Cardiol 168:4769-74. 2013
    ..We sought to investigate the effects of lin-/sca+ cells, endothelial progenitor cells (EPCs) and granulocyte colony-stimulating factor (G-CSF) administration on atherosclerotic plaque progression...
  16. doi request reprint Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches
    Dimitris Tousoulis
    First Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    J Am Coll Cardiol 62:667-76. 2013
    ..The use of specific biomarkers related to vascular function could be a useful therapeutic approach in such patients. ..
  17. ncbi request reprint Targeting myocardial metabolism for the treatment of stable angina
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Greece
    Curr Pharm Des 19:1587-92. 2013
    ..This review summarizes the main aspects of myocardial metabolism and focuses on the therapeutic approaches that could offer clinical benefit in patients with stable angina...
  18. ncbi request reprint Stable angina pectoris: current medical treatment
    Katerina Siama
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Pharm Des 19:1569-80. 2013
    ..These drugs, which are currently approved as second-line treatments, have dynamically entered the clinical practice and their long-term effects are still under investigation...
  19. ncbi request reprint Insight to the pathophysiology of stable angina pectoris
    Dimitris Tousoulis
    1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Greece
    Curr Pharm Des 19:1593-600. 2013
    ..However, several issues with respect to the comprehension of the pathophysiology of the chronic coronary syndrome have not been fully elucidated...
  20. ncbi request reprint Heart rate as a therapeutic target in angina pectoris
    Emmanuel Androulakis
    1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Greece
    Curr Pharm Des 19:1562-8. 2013
    ..However, additional data are now being sought to assess the impact of this approach on clinical practice...
  21. ncbi request reprint Matrix metallopropteinases in heart failure
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 12:1181-91. 2012
    ....
  22. ncbi request reprint Matrix metalloproteinases in acute coronary syndromes: current perspectives
    Anna Maria Kampoli
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 12:1192-205. 2012
    ....
  23. doi request reprint Comparative effects of rosuvastatin and allopurinol on circulating levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with chronic heart failure
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Int J Cardiol 145:438-43. 2010
    ..In the present study, we sought to compare the effects of statins and xanthine oxidase inhibitors on circulating levels of MMPs and TIMPs in patients with chronic HF...
  24. ncbi request reprint Pathophysiology of atherosclerosis: the role of inflammation
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Pharm Des 17:4089-110. 2011
    ..The main drug categories that have been proved to ameliorate the inflammatory state in atherosclerosis are angiotensin converting enzyme inhibitors/angiotensin receptors blockers, statins, and antioxidants...
  25. ncbi request reprint MicroRNAs in the diagnosis and treatment of unstable angina
    George Latsios
    1st Department of Cardiology, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 13:1596-604. 2013
    ..Thus, it will be necessary to further explore their complications, before their use as therapeutic option...
  26. doi request reprint Genetic predisposition to left ventricular hypertrophy and the potential involvement of cystatin-C in untreated hypertension
    Dimitris Tousoulis
    First Cardiology Department, Athens University Medical School, Athens, Greece
    Am J Hypertens 26:683-90. 2013
    ..We examined whether these variants determined both echocardiography indices and the potential associated underlying mechanisms, including cystatin-C and vascular inflammation...
  27. ncbi request reprint The role of matrix metalloproteinases in essential hypertension
    Emmanuel Androulakis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 12:1149-58. 2012
    ..However, the relationship between extracellular matrix metabolism and the effects of therapy in hypertensive patients needs to be further explored in larger trials over a longer period of time...
  28. doi request reprint Conflicting effects of nitric oxide and oxidative stress in chronic heart failure: potential therapeutic strategies
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Athens, Greece
    Heart Fail Rev 17:65-79. 2012
    ..Approaches using more-effective antioxidants or targeting myocardial oxidant-producing enzymes and oxidative or nitrosative stress might be promising strategies in the future...
  29. doi request reprint Oxidative stress and early atherosclerosis: novel antioxidant treatment
    Dimitris Tousoulis
    Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Cardiovasc Drugs Ther 29:75-88. 2015
    ..Indeed, further research is required to establish the impact of the proposed new therapeutic strategies in atherosclerosis. ..
  30. ncbi request reprint Oxidative stress and endothelial function: therapeutic interventions
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Vasilissis Sofias, Greece
    Recent Pat Cardiovasc Drug Discov 6:103-14. 2011
    ..However, the discussion of recent patents with the novel antioxidant strategies are required to clarify the role of antioxidant intervention in vascular diseases...
  31. doi request reprint Infusion of lin-/sca-1+ and endothelial progenitor cells improves proinflammatory and oxidative stress markers in atherosclerotic mice
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Greece
    Int J Cardiol 167:1900-5. 2013
    ....
  32. ncbi request reprint Novel anti-platelet agents for the treatment of stable angina pectoris
    Alexandros Briasoulis
    1st Cardiology Unit, Athens University Medical School, Greece
    Curr Pharm Des 19:1581-6. 2013
    ..The current review presents traditional and novel antiplatelet treatment options and discusses the indications for aggressive antiplatelet management in patients with stable angina pectoris...
  33. ncbi request reprint The failure of immunomodulation therapy in heart failure: does the statins "paradigm" prove the rule?
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 8:114-21. 2010
    ..Thus, more large scale clinical trials are required to evaluate the impact of statins on immune imbalance and its restoration in patients with CHF...
  34. ncbi request reprint Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches
    Dimitris Tousoulis
    Vasilissis Sofias 114, TK 115 28, Hippokration Hospital, Athens, Greece
    Curr Med Chem 22:2871-901. 2015
    ....
  35. doi request reprint Genetic testing and antiplatelet treatment: Still way to go?
    Evangelos Oikonomou
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Int J Cardiol 187:63-5. 2015
    ....
  36. doi request reprint Genetic variability on adiponectin gene affects myocardial infarction risk: the role of endothelial dysfunction
    Alexios S Antonopoulos
    1st Cardiology Department, Hippokration Hospital, Athens Medical School, Greece
    Int J Cardiol 168:326-30. 2013
    ..We examined the impact of rs2241766 and rs1501299 on circulating adiponectin levels, endothelial function and cardiovascular disease risk...
  37. doi request reprint Is there a role for erythropoietin in cardiovascular disease?
    Georgia Vogiatzi
    Athens University Medical School, Hippokration Hospital, First Cardiology Unit, Vasilissis Sofias 114, 115 28, Athens, Greece
    Expert Opin Biol Ther 10:251-64. 2010
    ..The development of novel laboratory technologies over the last decade has led to substantial progress in bringing new therapies to the bedside...
  38. ncbi request reprint The role of nitric oxide on endothelial function
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 10:4-18. 2012
    ..In the present review we will discuss the important role of nitric oxide in physiological endothelium and we will pinpoint the significance of this molecule in pathological states altering the endothelial function...
  39. ncbi request reprint Endothelial dysfunction and atherosclerosis: focus on novel therapeutic approaches
    Alexandros Briasoulis
    1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Greece
    Recent Pat Cardiovasc Drug Discov 7:21-32. 2012
    ....
  40. doi request reprint Acute effects of different types of oil consumption on endothelial function, oxidative stress status and vascular inflammation in healthy volunteers
    Dimitris Tousoulis
    Hippokration Hospital, Athens University Medical School, Athens, Greece
    Br J Nutr 103:43-9. 2010
    ..However, all types of oils did not affect inflammatory process and systemic oxidative stress, suggesting that their effect on endothelial function may not be mediated by free radicals bioavailability...
  41. doi request reprint Fibrinogen and cardiovascular disease: genetics and biomarkers
    Dimitris Tousoulis
    Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Blood Rev 25:239-45. 2011
    ....
  42. doi request reprint Impact of 6 weeks of treatment with low-dose metformin and atorvastatin on glucose-induced changes of endothelial function in adults with newly diagnosed type 2 diabetes mellitus: A single-blind study
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Greece
    Clin Ther 32:1720-8. 2010
    ..Endothelium-dependent dilation (EDD) measured by gauge-strain plethysmography in the forearm is considered to be a reliable marker of endothelial function in forearm resistance vessels...
  43. doi request reprint Novel therapeutic strategies in the management of arterial hypertension
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Pharmacol Ther 135:168-75. 2012
    ..However, continued efforts must progress in these areas and the effects of therapeutic strategies in hypertensive patients need to be further explored in larger trials over a longer period of time...
  44. doi request reprint From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 115 28 Athens, Greece
    Trends Cardiovasc Med 20:153-64. 2010
    ..Whether specific agents target the CD40/CD40L system as well as its pathogenic role in ACS remains to be elucidated by large-scale studies in the future...
  45. doi request reprint Homoarginine in the shadow of asymmetric dimethylarginine: from nitric oxide to cardiovascular disease
    Nikolaos Papageorgiou
    1st Cardiology Department, Athens University Medical School, Vasilisis Sofias 114, Athens, Greece
    Amino Acids 47:1741-50. 2015
    ..In this article, we review the available literature regarding the role of ADMA and hArg in endothelial dysfunction and in cardiovascular disease as well as the possible associations between these endogenous Arg derivatives...
  46. doi request reprint Impact of arterial hypertension on the eye
    Vasiliki Katsi
    Cardiology Department, Hippokration Hospital, Athens, Greece
    Curr Hypertens Rep 14:581-90. 2012
    ..It also gives evidence-based clinical data for the therapeutic approach of eye disease in hypertensive patients...
  47. doi request reprint Novel therapeutic strategies targeting vascular endothelium in essential hypertension
    Dimitris Tousoulis
    Athens University Medical School, Hippokration Hospital, First Cardiology Unit, Athens, Greece
    Expert Opin Investig Drugs 19:1395-412. 2010
    ....
  48. doi request reprint The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment
    Evangelos K Economou
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Atherosclerosis 241:624-33. 2015
    ..Finally we evaluate the therapeutic and preventive opportunities that arise from the study of miRNAs in coronary artery disease and especially in myocardial infarction. ..
  49. doi request reprint White-coat hypertension and cardiovascular events: a meta-analysis
    Alexandros Briasoulis
    aDivision of Cardiology, Wayne State University Detroit Medical Center, Detroit, Michigan, USA bJohn Radcliffe Hospital, University of Oxford, Oxford cBarts Heart Centre, St Bartholomew s Hospital, London, UK dDepartment of Cardiology, Hippokration Hospital, University of Athens, Athens, Greece
    J Hypertens 34:593-9. 2016
    ..White-coat hypertension (WCH) is a frequent condition particularly in children and elderly individuals. The prognostic significance of WCH is still a matter of debate...
  50. doi request reprint High platelet reactivity is associated with vascular function in patients after percutaneous coronary intervention receiving clopidogrel
    Gerasimos Siasos
    1st Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece Department of Biological Chemistry, University of Athens Medical School, Athens, Greece
    Int J Cardiol 177:192-6. 2014
    ..In the present study, we evaluated the association of platelet reactivity with vascular function in patients after percutaneous coronary intervention receiving clopidogrel treatment...
  51. doi request reprint Recent therapeutic approaches to platelet activation in coronary artery disease
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Pharmacol Ther 127:108-20. 2010
    ..Presently, antiplatelet intervention remains an important therapeutic modality, with novel antiplatelet therapies, such as prasugrel and ticagrelor under clinical investigation...
  52. doi request reprint Essential hypertension: is there a role for inflammatory mechanisms?
    Emmanuel S Androulakis
    First Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Cardiol Rev 17:216-21. 2009
    ..These data may have great impact on future therapeutic strategies...
  53. ncbi request reprint The impact of diabetes mellitus on coronary artery disease: new therapeutic approaches
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Curr Pharm Des 15:2037-48. 2009
    ....