Samir Kumar Patra

Summary

Publications

  1. ncbi request reprint Epigenetic DNA-methylation regulation of genes coding for lipid raft-associated components: a role for raft proteins in cell transformation and cancer progression (review)
    Samir K Patra
    Department of Medicina Sperimentale, University of Parma, I 43100 Parma, Italy
    Oncol Rep 17:1279-90. 2007
  2. doi request reprint Ras regulation of DNA-methylation and cancer
    Samir Kumar Patra
    Cancer Epigenetics Research, Kalyani B 7 183, Nadia, West Bengal, India
    Exp Cell Res 314:1193-201. 2008
  3. doi request reprint Interaction of phospholipase C with liposome: A conformation transition of the enzyme is critical and specific to liposome composition for burst hydrolysis and fusion in concert
    Samir Kumar Patra
    Department of Life Science, National Institute of Technology, Rourkela, Orissa, India Electronic address
    Spectrochim Acta A Mol Biomol Spectrosc 173:647-654. 2017
  4. pmc 5-Aza-2'-deoxycytidine stress response and apoptosis in prostate cancer
    Aditi Patra
    Clin Epigenetics 2:339-48. 2011
  5. doi request reprint Dissecting lipid raft facilitated cell signaling pathways in cancer
    Samir Kumar Patra
    Cancer Epigenetics Research, Kalyani B 7 183, Nadia, West Bengal, India 741235
    Biochim Biophys Acta 1785:182-206. 2008
  6. doi request reprint Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development
    Samir Kumar Patra
    Cancer Epigenetics Research, Kalyani B 7 183, Nadia, West Bengal, India
    Cancer Metastasis Rev 27:315-34. 2008
  7. doi request reprint DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FAS ligand and RASSF1A
    Samir K Patra
    Cancer Epigenetics Research, Kalyani, India
    FEBS J 275:5217-35. 2008
  8. ncbi request reprint Epigenetic DNA-(cytosine-5-carbon) modifications: 5-aza-2'-deoxycytidine and DNA-demethylation
    S K Patra
    Division of Biochemistry, Department of Experimental Medicine, University of Parma, Parma, Italy
    Biochemistry (Mosc) 74:613-9. 2009
  9. doi request reprint Epigenetic choreography of stem cells: the DNA demethylation episode of development
    Swayamsiddha Kar
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769008, India
    Cell Mol Life Sci 71:1017-32. 2014
  10. doi request reprint Elucidation of caveolin 1 both as a tumor suppressor and metastasis promoter in light of epigenetic modulators
    Moonmoon Deb
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769008, India
    Tumour Biol 35:12031-47. 2014

Collaborators

  • M Szyf
  • Vedang A Londhe
  • Rajvir Dahiya
  • S Bettuzzi
  • Moonmoon Deb
  • Swayamsiddha Kar
  • Dipta Sengupta
  • Sabnam Parbin
  • Sandip Kumar Rath
  • Arunima Shilpi
  • Nibedita Pradhan
  • Subhendu Roy
  • Aditi Patra
  • Madhumita Rakshit
  • Sujit Kumar Bhutia
  • Vijayalaxmi Kari
  • Goutam Das
  • Sandip K Rath
  • Gautam Das

Detail Information

Publications21

  1. ncbi request reprint Epigenetic DNA-methylation regulation of genes coding for lipid raft-associated components: a role for raft proteins in cell transformation and cancer progression (review)
    Samir K Patra
    Department of Medicina Sperimentale, University of Parma, I 43100 Parma, Italy
    Oncol Rep 17:1279-90. 2007
    ..The recent research acquisitions on lipid rafts have tremendous implications in understanding the genetic and biochemical bases of metastatic diffusion of cancer...
  2. doi request reprint Ras regulation of DNA-methylation and cancer
    Samir Kumar Patra
    Cancer Epigenetics Research, Kalyani B 7 183, Nadia, West Bengal, India
    Exp Cell Res 314:1193-201. 2008
    ..Control of Ras GTPase signaling might reduce the aberrant methylation and accordingly may reduce the risk of cancer development...
  3. doi request reprint Interaction of phospholipase C with liposome: A conformation transition of the enzyme is critical and specific to liposome composition for burst hydrolysis and fusion in concert
    Samir Kumar Patra
    Department of Life Science, National Institute of Technology, Rourkela, Orissa, India Electronic address
    Spectrochim Acta A Mol Biomol Spectrosc 173:647-654. 2017
    ..These data strongly suggest marked differences in conformation transition induced PLC activation and liposome fusion on the lipid composition...
  4. pmc 5-Aza-2'-deoxycytidine stress response and apoptosis in prostate cancer
    Aditi Patra
    Clin Epigenetics 2:339-48. 2011
    ..Analyses of DNA and anti-, pro-, and apoptotic factors of the affected cells revealed that the molecular events that went on are characteristics of programmed cell death (apoptosis)...
  5. doi request reprint Dissecting lipid raft facilitated cell signaling pathways in cancer
    Samir Kumar Patra
    Cancer Epigenetics Research, Kalyani B 7 183, Nadia, West Bengal, India 741235
    Biochim Biophys Acta 1785:182-206. 2008
    ....
  6. doi request reprint Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development
    Samir Kumar Patra
    Cancer Epigenetics Research, Kalyani B 7 183, Nadia, West Bengal, India
    Cancer Metastasis Rev 27:315-34. 2008
    ..The importance of truly chemically defined direct demethylation of intact DNA in regulation of gene expression, development, cell differentiation and transformation are discussed in this contribution...
  7. doi request reprint DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FAS ligand and RASSF1A
    Samir K Patra
    Cancer Epigenetics Research, Kalyani, India
    FEBS J 275:5217-35. 2008
    ..This review focuses on some of these recent advances and uses lipid-raft-facilitated Ras signaling as a paradigm for understanding DNA methylation, chromatin dynamics and apoptosis...
  8. ncbi request reprint Epigenetic DNA-(cytosine-5-carbon) modifications: 5-aza-2'-deoxycytidine and DNA-demethylation
    S K Patra
    Division of Biochemistry, Department of Experimental Medicine, University of Parma, Parma, Italy
    Biochemistry (Mosc) 74:613-9. 2009
    ..Finally, we would like to suggest that terming/designating AzadC as DNA-demethylating agent is a serious misuse of chemistry and chemical terminology...
  9. doi request reprint Epigenetic choreography of stem cells: the DNA demethylation episode of development
    Swayamsiddha Kar
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769008, India
    Cell Mol Life Sci 71:1017-32. 2014
    ....
  10. doi request reprint Elucidation of caveolin 1 both as a tumor suppressor and metastasis promoter in light of epigenetic modulators
    Moonmoon Deb
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769008, India
    Tumour Biol 35:12031-47. 2014
    ..These observations clearly provide a new scenario regarding the role of CAV1 in cancer and as a possible therapeutic target in breast cancer. ..
  11. doi request reprint Clusterin gene is predominantly regulated by histone modifications in human colon cancer and ectopic expression of the nuclear isoform induces cell death
    Moonmoon Deb
    Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India
    Biochim Biophys Acta 1852:1630-45. 2015
    ..Our findings clearly show that promoter histone H3K9me3 and H3K27me3 marks are elevated in comparison to H3K4me3 and H3K9AcS10P marks in colon cancer cell lines. ..
  12. doi request reprint Mechanisms of DNA methyltransferase-inhibitor interactions: Procyanidin B2 shows new promise for therapeutic intervention of cancer
    Arunima Shilpi
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India
    Chem Biol Interact 233:122-38. 2015
    ..Moreover, the toxic property of procyanidin B2 towards triple negative breast cancer cells to normal cells offers platform for pre-clinical trial and an insight to the treatment of cancer...
  13. doi request reprint Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer
    Sabnam Parbin
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India
    Mol Biosyst 12:48-58. 2016
    ..Finally, the result of a higher cytotoxicity of TQ towards MCF-7 breast cancer cells in comparison to normal cells indicates the potential of TQ to be an anticancer drug. ..
  14. doi request reprint Intricacies of hedgehog signaling pathways: a perspective in tumorigenesis
    Swayamsiddha Kar
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India
    Exp Cell Res 318:1959-72. 2012
    ..Understanding the molecular basis of abnormal HH signaling in cancer will provide an opportunity to inhibit the deregulated pathway in many aggressive and therapeutically challenging cancers where promising options are not available...
  15. doi request reprint Epigenetic drift towards histone modifications regulates CAV1 gene expression in colon cancer
    Moonmoon Deb
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, National Institute of Technology, Rourkela, Odisha 769008, India Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India
    Gene 581:75-84. 2016
    ..The tumor suppressor versus oncogene paradox of CAV1 during tumor development tempted us to investigate the role for the epigenetic drift of CAV1 gene regulation...
  16. ncbi request reprint Silencing of ZRF1 impedes survival of estrogen receptor positive MCF-7 cells and potentiates the effect of curcumin
    Sandip Kumar Rath
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769008, India
    Tumour Biol 37:12535-12546. 2016
    ..This investigation thus shed a new light on the role on ZRF1 in breast cancer cells and hence can be exploited to design better therapeutic intervention...
  17. doi request reprint DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop
    Dipta Sengupta
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India
    Exp Cell Res 346:176-87. 2016
    ..Our data provides novel insights into the regulation mechanism of miRNA and mRNA/protein coding genes and enhances the amplitude of cancer epigenome. ..
  18. pmc Histone deacetylases: a saga of perturbed acetylation homeostasis in cancer
    Sabnam Parbin
    Department of Life Science, National Institute of Technology, Rourkela, Odisha, India SP, SK, As, DS, SKR, SKP
    J Histochem Cytochem 62:11-33. 2014
    ..The present report also describes briefly various assays to detect histone deacetylase activity and discusses the potential role of histone deacetylase inhibitors as emerging epigenetic drugs to cure cancer. ..
  19. doi request reprint Chromatin dynamics: H3K4 methylation and H3 variant replacement during development and in cancer
    Moonmoon Deb
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769008, India
    Cell Mol Life Sci 71:3439-63. 2014
    ..Our focus is to highlight the contribution of H3K4 methylation-histone variant crosstalk in regulating chromatin architecture and subsequently its function...
  20. doi request reprint SOX2 function and Hedgehog signaling pathway are co-conspirators in promoting androgen independent prostate cancer
    Swayamsiddha Kar
    Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India
    Biochim Biophys Acta 1863:253-265. 2017
    ..These findings could provide the basis for a novel therapeutic strategy targeting both the effector i.e. SOX2 and perpetuator i.e. HH pathway of aggressive tumorigenic properties in androgen independent prostate cancer...
  21. doi request reprint Integrin-epigenetics: a system with imperative impact on cancer
    Moonmoon Deb
    Department of Life Science, National Institute of Technology, Rourkela, Orissa, India
    Cancer Metastasis Rev 31:221-34. 2012
    ..In this review, we discuss influences of integrin signaling along with their epigenetic relationship on other signals of a normal functioning cell and its dysregulation in cancer...