P Pratheeshkumar

Summary

Publications

  1. doi request reprint Ameliorative action of Vernonia cinerea L. on cyclophosphamide-induced immunosuppression and oxidative stress in mice
    P Pratheeshkumar
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur, 680555 Kerala, India
    Inflammopharmacology 18:197-207. 2010
  2. ncbi request reprint Cardiospermum halicacabum inhibits cyclophosphamide induced immunosupression and oxidative stress in mice and also regulates iNOS and COX-2 gene expression in LPS stimulated macrophages
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Kerala State, India
    Asian Pac J Cancer Prev 11:1245-52. 2010
  3. doi request reprint Antimetastatic potential of vernolide-A, a sesquiterpenoid from Vernonia cinerea L
    P Pratheeshkumar
    Department of Immunology, Amala Cancer Research Centre, Thrissur, Kerala, India
    Hum Exp Toxicol 31:66-80. 2012
  4. doi request reprint Protective role of Vernonia cinerea L. against gamma radiation--induced immunosupression and oxidative stress in mice
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Hum Exp Toxicol 30:1022-38. 2011
  5. ncbi request reprint Vernolide-A inhibits radiation-induced hypoxia-mediated tumor angiogenesis by regulating HIF-1α, MMP-2, MMP-9, and VEGF
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala State, India
    J Environ Pathol Toxicol Oncol 30:139-51. 2011
  6. doi request reprint Modulation of immune response by Vernonia cinerea L. inhibits the proinflammatory cytokine profile, iNOS, and COX-2 expression in LPS-stimulated macrophages
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Immunopharmacol Immunotoxicol 33:73-83. 2011
  7. doi request reprint Effect of vernolide-A, a sesquiterpene lactone from Vernonia cinerea L., on cell-mediated immune response in B16F-10 metastatic melanoma-bearing mice
    P Pratheeshkumar
    Amala Cancer Research Centre, Thrissur, Kerala, India
    Immunopharmacol Immunotoxicol 33:533-8. 2011
  8. ncbi request reprint Protective role of perillic acid against radiation-induced oxidative stress, cytokine profile, DNA damage, and intestinal toxicity in mice
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala State, India
    J Environ Pathol Toxicol Oncol 29:199-212. 2010
  9. doi request reprint Andrographolide induces apoptosis in B16F-10 melanoma cells by inhibiting NF-κB-mediated bcl-2 activation and modulating p53-induced caspase-3 gene expression
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Immunopharmacol Immunotoxicol 34:143-51. 2012
  10. ncbi request reprint Oleanolic acid induces apoptosis by modulating p53, Bax, Bcl-2 and caspase-3 gene expression and regulates the activation of transcription factors and cytokine profile in B16F
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala State, India
    J Environ Pathol Toxicol Oncol 30:21-31. 2011

Collaborators

Detail Information

Publications11

  1. doi request reprint Ameliorative action of Vernonia cinerea L. on cyclophosphamide-induced immunosuppression and oxidative stress in mice
    P Pratheeshkumar
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur, 680555 Kerala, India
    Inflammopharmacology 18:197-207. 2010
    ..Methanolic extract of V. cinerea given intraperitoneally (i.p.) showed a significant chemoprotective activity without compromising the chemotherapeutic efficacy of CTX, indicating its possible use as an adjuvant during chemotherapy...
  2. ncbi request reprint Cardiospermum halicacabum inhibits cyclophosphamide induced immunosupression and oxidative stress in mice and also regulates iNOS and COX-2 gene expression in LPS stimulated macrophages
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Kerala State, India
    Asian Pac J Cancer Prev 11:1245-52. 2010
    ..These studies indicate that C. halicacabum could reduce cyclophosphamide induced oxidative stress and immunosupression through enhancing the antioxidant status and immunomodulation by stem cell proliferation...
  3. doi request reprint Antimetastatic potential of vernolide-A, a sesquiterpenoid from Vernonia cinerea L
    P Pratheeshkumar
    Department of Immunology, Amala Cancer Research Centre, Thrissur, Kerala, India
    Hum Exp Toxicol 31:66-80. 2012
    ..These results indicate that vernolide-A could inhibit the metastatic progression of B16F-10 melanoma cells in mice...
  4. doi request reprint Protective role of Vernonia cinerea L. against gamma radiation--induced immunosupression and oxidative stress in mice
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Hum Exp Toxicol 30:1022-38. 2011
    ..Methanolic extract of V. cinerea given i.p. showed a significant radioprotective activity without compromising the radiotherapeutic efficacy of radiation, indicating its possible use as an adjuvant during radiotherapy...
  5. ncbi request reprint Vernolide-A inhibits radiation-induced hypoxia-mediated tumor angiogenesis by regulating HIF-1α, MMP-2, MMP-9, and VEGF
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala State, India
    J Environ Pathol Toxicol Oncol 30:139-51. 2011
    ..Our results indicate that vernolide-A inhibits radiation-induced tumor angiogenesis by regulating HIF-1α, MMP-2, MMP-9, and VEGF...
  6. doi request reprint Modulation of immune response by Vernonia cinerea L. inhibits the proinflammatory cytokine profile, iNOS, and COX-2 expression in LPS-stimulated macrophages
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Immunopharmacol Immunotoxicol 33:73-83. 2011
    ..Moreover The extract downregulated the inducible NO synthase and cyclooxygenase-2 (COX-2) mRNA expression in LPS-stimulated macrophages. These results indicate the immunomodulatory activity of V. cinerea...
  7. doi request reprint Effect of vernolide-A, a sesquiterpene lactone from Vernonia cinerea L., on cell-mediated immune response in B16F-10 metastatic melanoma-bearing mice
    P Pratheeshkumar
    Amala Cancer Research Centre, Thrissur, Kerala, India
    Immunopharmacol Immunotoxicol 33:533-8. 2011
    ..All these results demonstrate that vernolide-A could enhance the immune response against metastatic progression of B16F-10 melanoma cells in mice...
  8. ncbi request reprint Protective role of perillic acid against radiation-induced oxidative stress, cytokine profile, DNA damage, and intestinal toxicity in mice
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala State, India
    J Environ Pathol Toxicol Oncol 29:199-212. 2010
    ..Agarose gel electrophoresis of DNA isolated from bone marrow of mice exposed to gamma radiation showed heavy damage that was reduced by treatment with perillic acid...
  9. doi request reprint Andrographolide induces apoptosis in B16F-10 melanoma cells by inhibiting NF-κB-mediated bcl-2 activation and modulating p53-induced caspase-3 gene expression
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Immunopharmacol Immunotoxicol 34:143-51. 2012
    ..These results suggest that andrographolide induces apoptosis via inhibiting NF-κB-induced bcl-2-mediated survival signaling and modulating p53-induced caspase-3-mediated proapoptotic signaling...
  10. ncbi request reprint Oleanolic acid induces apoptosis by modulating p53, Bax, Bcl-2 and caspase-3 gene expression and regulates the activation of transcription factors and cytokine profile in B16F
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala State, India
    J Environ Pathol Toxicol Oncol 30:21-31. 2011
    ..These results suggest that OA induces apoptosis through activating the p53-induced caspase mediated proapoptotic pathway and suppression of the NF-κB–nduced Bcl-2–ediated antiapoptotic pathway..
  11. ncbi request reprint Andrographolide inhibits human umbilical vein endothelial cell invasion and migration by regulating MMP-2 and MMP-9 during angiogenesis
    P Pratheeshkumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala State, India
    J Environ Pathol Toxicol Oncol 30:33-41. 2011
    ..All these results demonstrate that andrographolide inhibits in vitro angiogenesis by inhibiting MMP-2 and MMP-9, and also by regulating the nuclear translocation of transcription factors...