A A Krayevsky

Summary

Affiliation: Engelhardt Institute of Molecular Biology
Country: Russia

Publications

  1. ncbi Should the asymmetry of enzymatic active centers always correlate with the asymmetry of their substrates?
    A A Krayevsky
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    J Biomol Struct Dyn 14:225-30. 1996
  2. ncbi Terminal deoxynucleotidyl transferase. catalysis of DNA (oligodeoxynucleotide) phosphorylation
    A A Krayevsky
    Department of Chemical and Biological Analysis, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Str, Moscow, Russia
    Pharmacol Ther 85:165-73. 2000
  3. ncbi dNTP modified at triphosphate residues: substrate properties towards DNA polymerases and stability in human serum
    A Krayevsky
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    Nucleosides Nucleotides 17:681-93. 1998
  4. ncbi Purine arabinonucleoside 5'-triphosphates with substituents at 2' position as substrates for DNA polymerases
    Y A Sharkin
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    Biochem Mol Biol Int 35:1041-8. 1995
  5. ncbi Effect of triphosphate modifications in 2'-deoxynucleoside 5'-triphosphates on their specificity towards various DNA polymerases
    B I Martynov
    State Research Institute of Organic Chemistry and Technology, Moscow, Russia
    FEBS Lett 410:423-7. 1997
  6. pmc Formation of phosphonester bonds catalyzed by DNA polymerase
    L S Victorova
    Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow, Russia
    Nucleic Acids Res 20:783-9. 1992
  7. ncbi Modified nucleoside 5'-triphosphates containing 2',3'-fused three-membered rings as substrates for different DNA polymerases
    D G Semizarov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    FEBS Lett 327:45-8. 1993
  8. ncbi Selectivity of DNA polymerases toward alpha and beta nucleotide substrates of D and L series
    D G Semizarov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    FEBS Lett 354:187-90. 1994
  9. ncbi New modified substrates for discriminating between human DNA polymerases alpha and epsilon
    M V Jasko
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    FEBS Lett 357:23-6. 1995
  10. pmc 2'-Deoxynucleoside 5'-triphosphates modified at alpha-, beta- and gamma-phosphates as substrates for DNA polymerases
    L A Alexandrova
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Str, Moscow 117984, Russia
    Nucleic Acids Res 26:778-86. 1998

Collaborators

  • L S Victorova
  • M V Jasko
  • L A Alexandrova
  • A V Shipitsyn
  • D G Semizarov
  • E A Shirokova
  • B I Martynov
  • J S Skoblov
  • Y A Sharkin
  • M K Kukhanova
  • N B Tarussova
  • A Y Skoblov
  • - Mozzherin DJu
  • M D Frank-Kamenetskaya
  • N B Dyatkina
  • D N Chernov
  • E V Kuznetsova
  • M von Janta-Lipinski
  • A M Atrazhev

Detail Information

Publications12

  1. ncbi Should the asymmetry of enzymatic active centers always correlate with the asymmetry of their substrates?
    A A Krayevsky
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    J Biomol Struct Dyn 14:225-30. 1996
    ..As a result, the hypothesis is proposed that when the chiral part of the substrate molecule does not interact specifically with the enzyme, substitution of natural D enantiomers by L compounds is possible...
  2. ncbi Terminal deoxynucleotidyl transferase. catalysis of DNA (oligodeoxynucleotide) phosphorylation
    A A Krayevsky
    Department of Chemical and Biological Analysis, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Str, Moscow, Russia
    Pharmacol Ther 85:165-73. 2000
    ..It has also been shown that TDT catalyzes primer extension with dinucleoside 5',5'-tetraphosphates as substrates...
  3. ncbi dNTP modified at triphosphate residues: substrate properties towards DNA polymerases and stability in human serum
    A Krayevsky
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    Nucleosides Nucleotides 17:681-93. 1998
    ..In some cases hydrophobicity of these compounds was markedly enhanced...
  4. ncbi Purine arabinonucleoside 5'-triphosphates with substituents at 2' position as substrates for DNA polymerases
    Y A Sharkin
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    Biochem Mol Biol Int 35:1041-8. 1995
    ..This is a reliable distinction of these enzymes from cellular DNA polymerases...
  5. ncbi Effect of triphosphate modifications in 2'-deoxynucleoside 5'-triphosphates on their specificity towards various DNA polymerases
    B I Martynov
    State Research Institute of Organic Chemistry and Technology, Moscow, Russia
    FEBS Lett 410:423-7. 1997
    ..It is interesting to mention that beta,gamma-CBr2 substituted dTTP is neither a substrate nor an inhibitor of DNA polymerase beta. This specificity distinguishes DNA polymerase beta from other DNA polymerases studied...
  6. pmc Formation of phosphonester bonds catalyzed by DNA polymerase
    L S Victorova
    Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow, Russia
    Nucleic Acids Res 20:783-9. 1992
    ..The 3'----5'-exonuclease activity of DNA polymerase I, Klenow fragment, hydrolyzed DNA fragments containing phosphonomethyl internucleoside groups, while such DNA fragments were resistant to the E. coli exonuclease III...
  7. ncbi Modified nucleoside 5'-triphosphates containing 2',3'-fused three-membered rings as substrates for different DNA polymerases
    D G Semizarov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    FEBS Lett 327:45-8. 1993
    ..Furthermore, Vmax values for modified substrates are only 2-3 times lower than Vmax for dTTP. The evidence favours the hypothesis of high affinity of modified nucleotides with a flattened furanosyl ring for DNA polymerase active sites...
  8. ncbi Selectivity of DNA polymerases toward alpha and beta nucleotide substrates of D and L series
    D G Semizarov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    FEBS Lett 354:187-90. 1994
    ..A hypothesis for binding of nucleotides to the DNA polymerase active center was proposed...
  9. ncbi New modified substrates for discriminating between human DNA polymerases alpha and epsilon
    M V Jasko
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    FEBS Lett 357:23-6. 1995
    ..Meanwhile, they were not recognized by DNA polymerase epsilon and beta of the same origin as well as by reverse transcriptases from human immunodeficiency virus and avian myeloblastosis virus...
  10. pmc 2'-Deoxynucleoside 5'-triphosphates modified at alpha-, beta- and gamma-phosphates as substrates for DNA polymerases
    L A Alexandrova
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Str, Moscow 117984, Russia
    Nucleic Acids Res 26:778-86. 1998
    ..HIV reverse transcriptase utilized these compounds 1 order of magnitude less efficiently than AMV reverse transcriptase; terminal deoxynucleotidyl transferase did not recognize them at all...
  11. ncbi Modified nucleotides as substrates and inhibitors of adenylate kinase from different sources
    J S Skoblov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    FEBS Lett 395:283-5. 1996
    ..3'-Azido-2',3'-dideoxythymidine and its phosphorus derivatives did not inhibit the adenylate kinase reaction...
  12. ncbi Synthesis of [bis(inosine-5')]-tetraphosphate and [bis(inosine-5')]-pentaphosphate analogues bearing the residues of methylenediphosphonic acid
    A V Shipitsyn
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    Nucleosides Nucleotides Nucleic Acids 19:881-9. 2000
    ..Phosphonate analogues of Ip4I and Ip5I are prepared...