Vladislav Khrustalev

Summary

Affiliation: Belarussian State Medical University
Location: Minsk, Belarus

Publications

  1. doi The part of a long beta hairpin from the scrapie form of the human prion protein is reconstructed in the synthetic CC36 protein
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarusian State Medical University, Dzerzinskogo, 83, Minsk, Belarus
    Proteins 84:1462-79. 2016
  2. doi Magnesium and manganese binding sites on proteins have the same predominant motif of secondary structure
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarusian State Medical University, Dzerzinskogo, 83, Minsk, Belarus Electronic address
    J Theor Biol 395:174-85. 2016
  3. doi Intragenic isochores (intrachores) in the platelet phosphofructokinase gene of Passeriform birds
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarusian State Medical University, Dzerzinskogo 83, Minsk, Belarus Electronic address
    Gene 546:16-24. 2014
  4. pmc A blueprint for a mutationist theory of replicative strand asymmetries formation
    Vladislav V Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Belarus, Minsk, Dzerzinskogo, 83, Russia
    Curr Genomics 13:55-64. 2012
  5. doi Random coil structures in bacterial proteins. Relationships of their amino acid compositions to flanking structures and corresponding genic base compositions
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Dzerzinskogo, 83, Minsk, Belarus
    Biochimie 95:1745-54. 2013
  6. doi Stabilization of secondary structure elements by specific combinations of hydrophilic and hydrophobic amino acid residues is more important for proteins encoded by GC-poor genes
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk 220029, Dzerzinskogo 83, Belarus
    Biochimie 94:2706-15. 2012
  7. doi "Protoisochores" in certain archaeal species are formed by replication-associated mutational pressure
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Dzerzinskogo, 83, 220116 Minsk, Belarus
    Biochimie 93:160-7. 2011
  8. doi Percent of highly immunogenic amino acid residues forming B-cell epitopes is higher in homologous proteins encoded by GC-rich genes
    Vladislav V Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Belarus, Minsk 220022, Dzerzinskogo 83, Belarus
    J Theor Biol 282:71-9. 2011
  9. ncbi Unusual nucleotide content of Rubella virus genome as a consequence of biased RNA-editing: comparison with Alphaviruses
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk 220000, Belarus
    Int J Bioinform Res Appl 7:82-100. 2011
  10. doi An in-silico study of alphaherpesviruses ICP0 genes: positive selection or strong mutational GC-pressure?
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk, Belarus
    IUBMB Life 60:456-60. 2008

Detail Information

Publications19

  1. doi The part of a long beta hairpin from the scrapie form of the human prion protein is reconstructed in the synthetic CC36 protein
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarusian State Medical University, Dzerzinskogo, 83, Minsk, Belarus
    Proteins 84:1462-79. 2016
    ..Analogs of the CC36 peptide may be considered as antigens for the future development of a vaccine against PrPSc. Proteins 2016; 84:1462-1479. © 2016 Wiley Periodicals, Inc. ..
  2. doi Magnesium and manganese binding sites on proteins have the same predominant motif of secondary structure
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarusian State Medical University, Dzerzinskogo, 83, Minsk, Belarus Electronic address
    J Theor Biol 395:174-85. 2016
    ....
  3. doi Intragenic isochores (intrachores) in the platelet phosphofructokinase gene of Passeriform birds
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarusian State Medical University, Dzerzinskogo 83, Minsk, Belarus Electronic address
    Gene 546:16-24. 2014
    ..Transcription-associated mutational pressure existing during those periods may cause the increase in rates of AT to GC mutations in those genes which are transcribed...
  4. pmc A blueprint for a mutationist theory of replicative strand asymmetries formation
    Vladislav V Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Belarus, Minsk, Dzerzinskogo, 83, Russia
    Curr Genomics 13:55-64. 2012
    ..Homogenized" and "inversed" replicative strand asymmetries in archaeal genomes can be used as retrospective indexes for detection of OriC translocations and large inversions...
  5. doi Random coil structures in bacterial proteins. Relationships of their amino acid compositions to flanking structures and corresponding genic base compositions
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Dzerzinskogo, 83, Minsk, Belarus
    Biochimie 95:1745-54. 2013
    ..Possible causes and consequences of the described differences in amino acid content distribution between different types of random coil have been discussed. ..
  6. doi Stabilization of secondary structure elements by specific combinations of hydrophilic and hydrophobic amino acid residues is more important for proteins encoded by GC-poor genes
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk 220029, Dzerzinskogo 83, Belarus
    Biochimie 94:2706-15. 2012
    ..Possible causes of the described fact that importance of alpha helix and coil stabilization by specific combinations of hydrophobic and hydrophilic amino acids is growing with the decrease of genomic GC-content have been discussed...
  7. doi "Protoisochores" in certain archaeal species are formed by replication-associated mutational pressure
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Dzerzinskogo, 83, 220116 Minsk, Belarus
    Biochimie 93:160-7. 2011
    ....
  8. doi Percent of highly immunogenic amino acid residues forming B-cell epitopes is higher in homologous proteins encoded by GC-rich genes
    Vladislav V Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Belarus, Minsk 220022, Dzerzinskogo 83, Belarus
    J Theor Biol 282:71-9. 2011
    ..The weaker the negative selection on amino acid substitutions caused by symmetric mutational pressure, the higher the slope of direct dependence of the percent of highly immunogenic amino acids included in B-cell epitopes on G+C...
  9. ncbi Unusual nucleotide content of Rubella virus genome as a consequence of biased RNA-editing: comparison with Alphaviruses
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk 220000, Belarus
    Int J Bioinform Res Appl 7:82-100. 2011
    ....
  10. doi An in-silico study of alphaherpesviruses ICP0 genes: positive selection or strong mutational GC-pressure?
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk, Belarus
    IUBMB Life 60:456-60. 2008
    ..In this case, GC-pressure has a substrate for nucleotide substitutions only in first and second codon positions, where most substitutions are nonsynonymous...
  11. doi Levels of HIV1 gp120 3D B-cell epitopes mutability and variability: searching for possible vaccine epitopes
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk 220000, Belarus
    Immunol Invest 39:551-69. 2010
    ..Indeed, the less mutable predicted B-cell epitope is the less variable one. MEGA4 (standard PAM matrix) was used for the alignments and "VVK Consensus" algorithm (http://www.barkovsky.hotmail.ru) was used for the calculations...
  12. doi The probability of nonsense mutation caused by replication-associated mutational pressure is much higher for bacterial genes from lagging than from leading strands
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk, Dzerzinskogo, Belarus
    Genomics 96:173-80. 2010
    ..This circumstance can be an explanation of the lower percent of ORFs in lagging strands of bacterial replichores than in leading strands...
  13. doi The level of cytosine is usually much higher than the level of guanine in two-fold degenerated sites from third codon positions of genes from Simplex- and Varicelloviruses with G+C higher than 50%
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Communisticheskaya 7 24, Dzerzinskogo 83, Minsk 220029, Belarus
    J Theor Biol 266:88-98. 2010
    ..3%). This difference may be caused by transcription-associated mutational pressure...
  14. pmc Study of completed archaeal genomes and proteomes: hypothesis of strong mutational AT pressure existed in their common predecessor
    Vladislav V Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk 220116, Belarus
    Genomics Proteomics Bioinformatics 8:22-32. 2010
    ..Numerous genomic and proteomic biases observed can be explained by the hypothesis of previously existed strong mutational AT pressure in the common predecessor of all archaea...
  15. doi Mutational pressure makes HIV1 gp120 linear B-cell epitopes shorter and may lead to their disappearance
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, 83 Dzerzinskogo Prospect, Minsk 220000, Belarus
    Mol Immunol 47:1635-9. 2010
    ..Moreover, single transition of C to U direction leading to amino acid replacement inside an epitope will cause partial or complete destruction of this epitope at a probability of 98%...
  16. ncbi HIV1 V3 loop hypermutability is enhanced by the guanine usage bias in the part of env gene coding for it
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk 220000, Belarus
    In Silico Biol 9:255-69. 2009
    ..All calculations have been performed by our algorithms "VVK In length", "VVK Dinucleotides" and "VVK Consensus" (www.barkovsky.hotmail.ru)...
  17. ncbi Can mutational GC-pressure create new linear B-cell epitopes in herpes simplex virus type 1 glycoprotein B?
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, Minsk, Belarus
    Immunol Invest 38:613-23. 2009
    ..The calculations of GC-content and amino acid content have been performed by CodonChanges algorithm ( www.barkovsky.hotmail.ru )...
  18. doi Mutational pressure is a cause of inter- and intragenomic differences in GC-content of simplex and varicello viruses
    Vladislav Victorovich Khrustalev
    Department of General Chemistry, Belarussian State Medical University, 83 Dzerzinskogo Prospect, Minsk 220000, Belarus
    Comput Biol Chem 33:295-302. 2009
    ..Indeed, in the potential secondary structure formed by singlestranded genomic DNA of alphaherpesviruses only joined inverted repeats should be doublestranded...