Anatoly Uzdensky

Summary

Affiliation: Southern Federal University
Location: Rostov-on-Don, Russia
Summary:
Photodynamic effect on neurons and glial cells
Cell death: necrosis and apoptosis
Signaling
Neuroglial interactions
Ultrastructure

Publications:
1: Komandirov MA, Knyazeva EA, Fedorenko YP, Rudkovskii MV, Stetsurin DA,
Uzdensky AB. On the Role of Phosphatidylinositol 3-Kinase, Protein Kinase B/Akt,
and Glycogen Synthase Kinase-3β in Photodynamic Injury of Crayfish Neurons and
Glial Cells. J Mol Neurosci. 2011 Feb 12. [Epub ahead of print] PubMed PMID:
.


2: Fedorenko GM, Fedorenko YP, Fedorenko AG, Uzdensky AB. Dynamics of
ultrastructural alterations in photosensitized crayfish glial and neuronal cells:
Structures involved in transport processes and neuroglial interactions. J
Neurosci Res. 2011 Mar;89(3):341-51. doi: 10.1002/jnr.22560. Epub 2010 Dec 22.
PubMed PMID: .


3: Fedorenko GM, Fedorenko YP, Fedorenko AG, Uzdensky AB. Dynamics of
ultrastructural alterations in photosensitized crayfish glial and neuronal cells:
Structures involved in transport processes and neuroglial interactions. J
Neurosci Res. 2010 Dec 22. [Epub ahead of print] PubMed PMID: .


4: Fedorenko GM, Uzdensky AB. Cellular structures involved in the transport
processes and neuroglial interactions in the crayfish stretch receptor. J Integr
Neurosci. 2009 Dec;8(4):433-40. PubMed PMID: .


5: Uzdensky AB, Lobanov AV. Elevated activity of the crayfish stretch receptor
neuron increases resistance of surrounding glial cells to apoptosis induced by
photodynamic treatment. Neurosci Lett. 2010 Jan 1;468(1):89-92. Epub 2009 Oct 29.
PubMed PMID: .


6: Fedorenko GM, Uzdensky AB. Ultrastructure of neuroglial contacts in crayfish
stretch receptor. Cell Tissue Res. 2009 Sep;337(3):477-90. Epub 2009 Jul 8.
PubMed PMID: .


7: Lobanov AV, Uzdensky AB. Protection of crayfish glial cells but not neurons
from photodynamic injury by nerve growth factor. J Mol Neurosci. 2009
Sep;39(1-2):308-19. Epub 2009 Apr 18. PubMed PMID: .


8: Fedorenko GM, Uzdensky AB. Dynamics of ultrastructural changes in the isolated
crayfish mechanoreceptor neuron under photodynamic impact. J Neurosci Res. 2008
May 1;86(6):1409-16. PubMed PMID: .


9: Uzdensky A, Lobanov A, Bibov M, Petin Y. Involvement of Ca2+- and cyclic
adenosine monophosphate-mediated signaling pathways in photodynamic injury of
isolated crayfish neuron and satellite glial cells. J Neurosci Res. 2007
Mar;85(4):860-70. PubMed PMID: .


10: Kolosov M, Uzdensky A. Crayfish mechanoreceptor neuron prevents photoinduced
apoptosis of satellite glial cells. Brain Res Bull. 2006 May 15;69(5):495-500.
Epub 2006 Mar 24. PubMed PMID: .


11: Lobanov AV, Uzdensky AB. PDT-induced death of sensory neurons and glial cells
in the isolated crayfish stretch receptor after proteolytic treatment. J Neurosci
Res. 2005 Dec 15;82(6):866-74. PubMed PMID: .


12: Uzdensky A, Kolpakova E, Juzeniene A, Juzenas P, Moan J. The effect of
sub-lethal ALA-PDT on the cytoskeleton and adhesion of cultured human cancer
cells. Biochim Biophys Acta. 2005 Feb 11;1722(1):43-50. Epub 2004 Dec 15. PubMed
PMID: .


13: Uzdensky A, Kolosov M, Bragin D, Dergacheva O, Vanzha O, Oparina L.
Involvement of adenylate cyclase and tyrosine kinase signaling pathways in
response of crayfish stretch receptor neuron and satellite glia cell to
photodynamic treatment. Glia. 2005 Feb;49(3):339-48. PubMed PMID: .


14: Uzdensky AB, Juzeniene A, Kolpakova E, Hjortland GO, Juzenas P, Moan J.
Photosensitization with protoporphyrin IX inhibits attachment of cancer cells to
a substratum. Biochem Biophys Res Commun. 2004 Sep 17;322(2):452-7. PubMed PMID:
.


15: Uzdensky AB, Dergacheva OY, Zhavoronkova AA, Reshetnikov AV, Ponomarev GV.
Photodynamic effect of novel chlorin e6 derivatives on a single nerve cell. Life
Sci. 2004 Mar 12;74(17):2185-97. PubMed PMID: .


16: Uzdensky A, Juzeniene A, Ma LW, Moan J. Photodynamic inhibition of enzymatic
detachment of human cancer cells from a substratum. Biochim Biophys Acta. 2004
Jan 5;1670(1):1-11. PubMed PMID: .


17: Uzdensky AB, Bragin DE, Kolosov MS, Kubin A, Loew HG, Moan J. Photodynamic
effect of hypericin and a water-soluble derivative on isolated crayfish neuron
and surrounding glial cells. J Photochem Photobiol B. 2003 Dec 5;72(1-3):27-33.
PubMed PMID: .


18: Bragin DE, Kolosov MS, Uzdensky AB. Photodynamic inactivation of isolated
crayfish neuron requires protein kinase C, PI 3-kinase and Ca2+. J Photochem
Photobiol B. 2003 May-Jun;70(2):99-105. PubMed PMID: .


19: Uzdensky A, Bragin D, Kolosov M, Dergacheva O, Fedorenko G, Zhavoronkova A.
Photodynamic inactivation of isolated crayfish mechanoreceptor neuron: different
death modes under different photosensitizer concentrations. Photochem Photobiol.
2002 Oct;76(4):431-7. PubMed PMID: .


20: Uzdensky AB, Iani V, Ma LW, Moan J. Photobleaching of hypericin bound to
human serum albumin, cultured adenocarcinoma cells and nude mice skin. Photochem
Photobiol. 2002 Sep;76(3):320-8. PubMed PMID: .


21: Uzdensky AB, Ma LW, Iani V, Hjortland GO, Steen HB, Moan J. Intracellular
localisation of hypericin in human glioblastoma and carcinoma cell lines. Lasers
Med Sci. 2001;16(4):276-83. PubMed PMID: .


22: Uzdensky AB, Dergacheva OY, Zhavoronkova AA, Ivanov AV, Reshetnikov AV,
Ponomarev GV. Photodynamic effect of deuteroporphyrin IX and hematoporphyrin
derivatives on single neuron. Biochem Biophys Res Commun. 2001 Mar;281(5):1194-9.
PubMed PMID: .


23: Uzdensky AB, Derkacheva VM, Dergacheva OY, Zhavoronkova AA. A single neuron
response to photodynamic effect of various aluminum and zinc phthalocyanines.
Life Sci. 2000 Dec 22;68(5):547-55. PubMed PMID: .

Publications

  1. ncbi request reprint Photodynamic effect of deuteroporphyrin IX and hematoporphyrin derivatives on single neuron
    A B Uzdensky
    Rostov State University, Rostov-on-Don, 344090, Russia
    Biochem Biophys Res Commun 281:1194-9. 2001
  2. doi request reprint Dynamics of ultrastructural alterations in photosensitized crayfish glial and neuronal cells: Structures involved in transport processes and neuroglial interactions
    G M Fedorenko
    Southern Federal University, Rostov on Don, Russia
    J Neurosci Res 89:341-51. 2011
  3. ncbi request reprint Cellular structures involved in the transport processes and neuroglial interactions in the crayfish stretch receptor
    Grigoriy M Fedorenko
    Southern Scientific Center RAS, A B Kogan Research Institute for Neurocybernetics, Southern Federal University, 194 1, Stachki ave, Rostov on Don, 344090, Russian Federation
    J Integr Neurosci 8:433-40. 2009
  4. doi request reprint Elevated activity of the crayfish stretch receptor neuron increases resistance of surrounding glial cells to apoptosis induced by photodynamic treatment
    Anatoly B Uzdensky
    Southern Federal University, Rostov on Don, Russia
    Neurosci Lett 468:89-92. 2010
  5. doi request reprint Ultrastructure of neuroglial contacts in crayfish stretch receptor
    Grigory M Fedorenko
    Southern Federal University, Rostov on Don, Russia
    Cell Tissue Res 337:477-90. 2009
  6. doi request reprint Protection of crayfish glial cells but not neurons from photodynamic injury by nerve growth factor
    A V Lobanov
    Institute for Neurocybernetics, Southern Federal University, 194 1 Stachky ave, NII NK, Rostov on Don 344090, Russia
    J Mol Neurosci 39:308-19. 2009
  7. ncbi request reprint A single neuron response to photodynamic effect of various aluminum and zinc phthalocyanines
    A B Uzdensky
    Rostov University, Department of Biophysics, Rostov on Don, Russia
    Life Sci 68:547-55. 2000
  8. ncbi request reprint Dynamics of ultrastructural changes in the isolated crayfish mechanoreceptor neuron under photodynamic impact
    G M Fedorenko
    Institute of Neurocybernetics, South Federal University, Rostov on Don, Russia
    J Neurosci Res 86:1409-16. 2008
  9. ncbi request reprint Involvement of Ca2+- and cyclic adenosine monophosphate-mediated signaling pathways in photodynamic injury of isolated crayfish neuron and satellite glial cells
    Anatoly Uzdensky
    Institute of Neurocybernetics, Rostov State University, Rostov on Don, Russia
    J Neurosci Res 85:860-70. 2007
  10. ncbi request reprint Crayfish mechanoreceptor neuron prevents photoinduced apoptosis of satellite glial cells
    Mikhail Kolosov
    Institute for Neurocybernetics, Rostov State University, Rostov on Don 344090, Russia
    Brain Res Bull 69:495-500. 2006

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Photodynamic effect of deuteroporphyrin IX and hematoporphyrin derivatives on single neuron
    A B Uzdensky
    Rostov State University, Rostov-on-Don, 344090, Russia
    Biochem Biophys Res Commun 281:1194-9. 2001
    ..Extinction and amphiphilicity were shown to be the most important properties determining photodynamic efficiency of the studied photosensitizers...
  2. doi request reprint Dynamics of ultrastructural alterations in photosensitized crayfish glial and neuronal cells: Structures involved in transport processes and neuroglial interactions
    G M Fedorenko
    Southern Federal University, Rostov on Don, Russia
    J Neurosci Res 89:341-51. 2011
    ....
  3. ncbi request reprint Cellular structures involved in the transport processes and neuroglial interactions in the crayfish stretch receptor
    Grigoriy M Fedorenko
    Southern Scientific Center RAS, A B Kogan Research Institute for Neurocybernetics, Southern Federal University, 194 1, Stachki ave, Rostov on Don, 344090, Russian Federation
    J Integr Neurosci 8:433-40. 2009
    ..The neuroglial transport could also be performed by diffusion across the intercellular space. These data indicate the significant neuroglial exchange with cellular components...
  4. doi request reprint Elevated activity of the crayfish stretch receptor neuron increases resistance of surrounding glial cells to apoptosis induced by photodynamic treatment
    Anatoly B Uzdensky
    Southern Federal University, Rostov on Don, Russia
    Neurosci Lett 468:89-92. 2010
    ..This could be attributed to the depletion of the energetic resources, which are transferred from glia into the neuron to support its firing, or to the neurotrophic neuron-to-glia signaling...
  5. doi request reprint Ultrastructure of neuroglial contacts in crayfish stretch receptor
    Grigory M Fedorenko
    Southern Federal University, Rostov on Don, Russia
    Cell Tissue Res 337:477-90. 2009
    ....
  6. doi request reprint Protection of crayfish glial cells but not neurons from photodynamic injury by nerve growth factor
    A V Lobanov
    Institute for Neurocybernetics, Southern Federal University, 194 1 Stachky ave, NII NK, Rostov on Don 344090, Russia
    J Mol Neurosci 39:308-19. 2009
    ..Thus, intercellular signaling mediated by nerve-growth-factor-like neurotrophin, receptor tyrosine kinase, and JNK may be involved in crayfish glia protection from apoptosis induced by photodynamic treatment...
  7. ncbi request reprint A single neuron response to photodynamic effect of various aluminum and zinc phthalocyanines
    A B Uzdensky
    Rostov University, Department of Biophysics, Rostov on Don, Russia
    Life Sci 68:547-55. 2000
    ..The order of these stages depended on photosensitizer type and concentration. The comparison of the dependencies of neuron lifetime on photosensitizer concentrations showed ZnPcS2 to be the most effective photosensitizer...
  8. ncbi request reprint Dynamics of ultrastructural changes in the isolated crayfish mechanoreceptor neuron under photodynamic impact
    G M Fedorenko
    Institute of Neurocybernetics, South Federal University, Rostov on Don, Russia
    J Neurosci Res 86:1409-16. 2008
    ..Their alteration might underlie functional shifts. These structural changes continued to develop after abolishment of neuronal activity and led to necrosis...
  9. ncbi request reprint Involvement of Ca2+- and cyclic adenosine monophosphate-mediated signaling pathways in photodynamic injury of isolated crayfish neuron and satellite glial cells
    Anatoly Uzdensky
    Institute of Neurocybernetics, Rostov State University, Rostov on Don, Russia
    J Neurosci Res 85:860-70. 2007
    ..Thus, Ca(2+)- and cAMP-mediated signaling pathways were involved in photooxidative injury of neurons and glia. Their pharmacological modulation may differently change the efficacy of photodynamic injury of neurons and glial cells...
  10. ncbi request reprint Crayfish mechanoreceptor neuron prevents photoinduced apoptosis of satellite glial cells
    Mikhail Kolosov
    Institute for Neurocybernetics, Rostov State University, Rostov on Don 344090, Russia
    Brain Res Bull 69:495-500. 2006
    ..Altogether the data indicate that mechanoreceptor neurons release some signaling molecules involved in the prevention of glial apoptosis. This may provide integrity of the stretch receptor organ and its resistance to injurious factors...
  11. ncbi request reprint PDT-induced death of sensory neurons and glial cells in the isolated crayfish stretch receptor after proteolytic treatment
    A V Lobanov
    Institute of Neurocybernetics, Rostov State University, Rostov on Don, Russia
    J Neurosci Res 82:866-74. 2005
    ..The involvement of neuron-to-glia signaling interactions in this phenomenon is suggested...
  12. ncbi request reprint The effect of sub-lethal ALA-PDT on the cytoskeleton and adhesion of cultured human cancer cells
    Anatoly Uzdensky
    Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    Biochim Biophys Acta 1722:43-50. 2005
    ..Some signal transduction processes are suggested to be involved in ALA-PDT-induced changes in cytoskeleton, cell shape, and adhesion...
  13. ncbi request reprint Involvement of adenylate cyclase and tyrosine kinase signaling pathways in response of crayfish stretch receptor neuron and satellite glia cell to photodynamic treatment
    Anatoly Uzdensky
    Department of Biophysics and Biocybernetics, Rostov State University, 194 1 Stachky ave, Institute of Neurocybernetics, Rostov on Don 344090, Russia
    Glia 49:339-48. 2005
    ..Adenylate cyclase but not phosphotyrosine signaling pathways modulated glial apoptosis and proliferation under photooxidative stress...
  14. ncbi request reprint Photosensitization with protoporphyrin IX inhibits attachment of cancer cells to a substratum
    A B Uzdensky
    Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    Biochem Biophys Res Commun 322:452-7. 2004
    ..Complex processes, including changes in cellular shape and reorganization of the cytoskeleton, are suggested to participate in the observed ALA-PDT effect on the cell adhesion...
  15. ncbi request reprint Photodynamic effect of novel chlorin e6 derivatives on a single nerve cell
    A B Uzdensky
    Department of Biophysics, Rostov State University, 194 1, Stachky ave, NIINK, Rostov on Don, 344090, Russia
    Life Sci 74:2185-97. 2004
    ..Photodynamic efficiency of sensitizers depended on amphiphilicity influencing their intracellular localization...
  16. ncbi request reprint Photodynamic inhibition of enzymatic detachment of human cancer cells from a substratum
    Anatoly Uzdensky
    Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    Biochim Biophys Acta 1670:1-11. 2004
    ..Photodynamic inhibition of enzymatic cell detachment may be related to PDT-induced inhibition of tumour metastasis...
  17. ncbi request reprint Photodynamic effect of hypericin and a water-soluble derivative on isolated crayfish neuron and surrounding glial cells
    Anatoly B Uzdensky
    Rostov State University, Rostov on Don 344090, Russia
    J Photochem Photobiol B 72:27-33. 2003
    ..A minor fraction of hypericin was found in the neuron perinuclear area rich in cytoplasm organelles. This suggests the potential application of Hyp and Hyp-S for visualization and selective photodynamic treatment of malignant gliomas...
  18. ncbi request reprint Photodynamic inactivation of isolated crayfish neuron requires protein kinase C, PI 3-kinase and Ca2+
    Denis E Bragin
    Department of Biophysics, Institute for Neurocybernetics, Rostov State University, 194 1 Stachky ave, Rostov on Don, 344090, Russia
    J Photochem Photobiol B 70:99-105. 2003
    ..These results showed that PKC, PI 3-kinase and Ca(2+) are involved in PDT-induced neurone inactivation and following death...
  19. ncbi request reprint Photodynamic inactivation of isolated crayfish mechanoreceptor neuron: different death modes under different photosensitizer concentrations
    Anatoly Uzdensky
    Department of Biophysics and Biocybernetics, Rostov State University, Rostov on Don, Russia
    Photochem Photobiol 76:431-7. 2002
    ..The observed electrophysiological neuron responses to photodynamic therapy may be considered as early hallmarks of different modes of forthcoming cell death...
  20. ncbi request reprint Photobleaching of hypericin bound to human serum albumin, cultured adenocarcinoma cells and nude mice skin
    Anatoly B Uzdensky
    Department of Biophysics, Institute for Cancer Research, Montebello, Oslo, Norway
    Photochem Photobiol 76:320-8. 2002
    ..The excitation spectrum of these products resembled that of hypericin. Hypericin appears to be more photostable than most sensitizers used in PDT, including mTHPC and Photofrin...
  21. ncbi request reprint Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines
    A B Uzdensky
    Department of Biophysics and Biocybernetics, Rostov State University, 194 1 Stachky ave, Rostov on Don 344090, Russia
    Lasers Med Sci 16:276-83. 2001
    ..Hypericin concentrations of 10 microM or less were not toxic for WiDr cells in the dark. Orange light (lambda max approximately 600 nm; 6 mW/cm2) killed the cells stained with 1 microM hypericin with LD50 approximately 1 J/cm2...
  22. doi request reprint On the role of phosphatidylinositol 3-kinase, protein kinase b/Akt, and glycogen synthase kinase-3β in photodynamic injury of crayfish neurons and glial cells
    Maxim A Komandirov
    Department of Biophysics and Biocybernetics, Institute of Neurocybernetics, Southern Federal University, 194 1 Stachky ave, NII NK, Rostov on Don 344090, Russia
    J Mol Neurosci 45:229-35. 2011
    ..The obtained results may be used for the search of pharmacological agents selectively modulating death and survival of normal neurons and glial cells during photodynamic therapy of brain tumors...
  23. doi request reprint Involvement of nitric oxide in photodynamic injury of neurons and glial cells
    Vera Kovaleva
    Southern Federal University, Rostov on Don, Russia
    Nitric Oxide 29:46-52. 2013
    ..The proapoptotic effect of NO on glial cells could be mediated by protein kinase G, which is activated by NO-dependent production of cGMP, because it inhibition reduced the PDT-induced glial apoptosis...
  24. ncbi request reprint Protein Profile and Morphological Alterations in Penumbra after Focal Photothrombotic Infarction in the Rat Cerebral Cortex
    Anatoly Uzdensky
    Laboratory of Molecular Neurobiology, Academy of Biology and Biotechnology, Southern Federal University, 194 1 Stachky pr, Rostov on Don, 344090, Russia
    Mol Neurobiol . 2016
    ..These data provide the integral view on the penumbra response to photothrombotic infarct. Some of these proteins can be potential targets for ischemic stroke therapy...
  25. doi request reprint Protection of the Crayfish Mechanoreceptor Neuron and Glial Cells from Photooxidative Injury by Modulators of Diverse Signal Transduction Pathways
    Anatoly Uzdensky
    Academy of Biology and Biotechnology, Southern Federal University, 194 1 Stachky ave, Rostov on Don, 344090, Russia
    Mol Neurobiol 52:811-25. 2015
    ..Inhibitors or activators of some signaling pathways may be used as potential protectors of neurons and glia from photooxidative stress and following death...
  26. doi request reprint Expression of neuronal and signaling proteins in penumbra around a photothrombotic infarction core in rat cerebral cortex
    S V Demyanenko
    Academy of Biology and Biotechnology, Southern Federal University, Rostov on Don, 344090, Russia
    Biochemistry (Mosc) 80:790-9. 2015
    ..These changes in expression of some neuronal proteins were directed mainly to protection and tissue recovery in the penumbra. Some upregulated proteins might serve as markers of protection processes in a penumbra. ..
  27. doi request reprint Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin
    Anatoly Uzdensky
    Department of Biophysics and Biocybernetics, Southern Federal University, 194 1, Stachky ave, NII NK, Stachky prospect, Rostov on Don, 344090, Russia
    Tumour Biol 35:8225-33. 2014
    ..The observed changes in the peritumoral skin may indicate the epigenetic pre-tuning in this zone possibly involved in malignant transformation. These results can be potentially useful for melanoma diagnostics and targeted therapy...
  28. ncbi request reprint Signal transduction in human cutaneous melanoma and target drugs
    Anatoly B Uzdensky
    194 1 Stachky ave, NII NK, Rostov on Don, 344090, Russia
    Curr Cancer Drug Targets 13:843-66. 2013
    ..Inhibitors of these pathways may serve as promising tools for anti-melanoma targeted therapy. Some novel anti-melanoma target drugs are characterized. ..
  29. doi request reprint Protection effect of GDNF and neurturin on photosensitized crayfish neurons and glial cells
    Anatoly Uzdensky
    Department of Biophysics and Biocybernetics, Institute of Neurocybernetics, Southern Federal University, 194 1 Stachky ave, NII NK, Rostov on Don, 344090, Russia
    J Mol Neurosci 49:480-90. 2013
    ..GDNF-mediated maintenance of metabolism and ultrastructure of photosensitized neurons and glial cells may be the basis of its neuro- and glia protective effects...
  30. doi request reprint Dynamics of signaling, cytoskeleton and cell cycle regulation proteins in glioblastoma cells after sub-lethal photodynamic treatment: antibody microarray study
    Anatoly Uzdensky
    Department of Biophysics, Southern Federal University, Stachky 194 1, 344090, Rostov on Don, Russia
    Biochim Biophys Acta 1820:795-803. 2012
    ..To characterize early molecular events in photosensitized glioblastoma cells, we studied expression of 224 proteins after sublethal PDT that doesn't kill but wounds cells...
  31. doi request reprint Neuron and gliocyte death induced by photodynamic treatment: signal processes and neuron-glial interactions
    A B Uzdenskii
    A B Kogan institute of Neurocybernetics, Southern Federal University, Rostov on Don, Russia
    Neurosci Behav Physiol 38:727-35. 2008
    ..Pharmacological modulation may alter the selectivity of PD neuron and gliocyte damage and the efficacy of PD treatment...