Ali Sazci

Summary

Publications

  1. ncbi request reprint Methylenetetrahydrofolate reductase gene polymorphisms in patients with nonalcoholic steatohepatitis (NASH)
    Ali Sazci
    Faculty of Medicine, Department of Medical Biology, University of Kocaeli, Umuttepe, Kocaeli, Turkey
    Cell Biochem Funct 26:291-6. 2008
  2. pmc Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Kocaeli, 41380, Turkey
    J Headache Pain 17:93. 2016
  3. doi request reprint Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41380 Kocaeli, Turkey Electronic address
    Gene 532:272-5. 2013
  4. doi request reprint Gender-specific association of methylenetetrahydrofolate reductase gene polymorphisms with sporadic amyotrophic lateral sclerosis
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey
    Genet Test Mol Biomarkers 16:716-21. 2012
  5. doi request reprint A polymerase chain reaction-restriction fragment length polymorphism method for screening ZNF804A gene polymorphism (rs1344706) in patients with schizophrenia: a significant association
    Ali Sazci
    Department of Medical Biology and Genetics, University of Kocaeli, Kocaeli, Turkey
    Genet Test Mol Biomarkers 16:157-61. 2012
  6. doi request reprint Association of apolipoprotein E polymorphisms in patients with non-alcoholic steatohepatitis
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Umuttepe, Kocaeli, 41380, Turkey
    Dig Dis Sci 53:3218-24. 2008
  7. ncbi request reprint Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Umuttepe, 41380 Kocaeli, Turkey
    Brain Res Bull 71:45-50. 2006
  8. ncbi request reprint Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: association is significant in men but not in women
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, 41900, Kocaeli, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 29:1113-23. 2005
  9. ncbi request reprint Catechol-O-methyltransferase gene Val108/158Met polymorphism, and susceptibility to schizophrenia: association is more significant in women
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, 41900 Kocaeli, Turkey
    Brain Res Mol Brain Res 132:51-6. 2004
  10. ncbi request reprint Catechol-O-methyltransferase Val 108/158 Met polymorphism in premenopausal breast cancer patients
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, 41900 Kocaeli, Turkey
    Toxicology 204:197-202. 2004

Collaborators

  • Cem Aygun
  • Murat Kasap
  • Mustafa Yildiz
  • Kemal Bayulkem
  • Thomas Liehr
  • Nese Tuncer
  • Emel Ergul
  • Mavi Deniz Ozel
  • Eylul Ece Islek
  • Halil Atilla Idrisoglu
  • Ihsan Kara
  • Gensay Sazci
  • Hakan Uzunoglu
  • Ezgi Sonmez
  • Zeynep Ozbek
  • Gamze Kilic
  • Nihal Uren
  • Tugcan Korak
  • N Zafer Utkan
  • Bilgen Sazci
  • Ertugrul Kargi
  • Mehmet Emin Onder
  • Çağri Triyaki
  • Oktay Yirmibesoglu
  • Kristin Mrasek
  • Cem Ismail Kucukali
  • Nurcan Orhan
  • Elif Ozkok
  • Makbule Aydin
  • N Zafer Canturk
  • Guner Kaya
  • Zafer Utkan

Detail Information

Publications31

  1. ncbi request reprint Methylenetetrahydrofolate reductase gene polymorphisms in patients with nonalcoholic steatohepatitis (NASH)
    Ali Sazci
    Faculty of Medicine, Department of Medical Biology, University of Kocaeli, Umuttepe, Kocaeli, Turkey
    Cell Biochem Funct 26:291-6. 2008
    ..037). In conclusion, the MTHFR 1298C allele in all NASH patients, C1298C genotype, C677C/C1298C compound genotype in women NASH patients and C677C/A1298C compound genotype in men NASH patients were genetic risk factors for NASH...
  2. pmc Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Kocaeli, 41380, Turkey
    J Headache Pain 17:93. 2016
    ..Elevated levels of homocysteine in the plasma is produced by the MTHFR gene rs 1801133 and rs 1801131 variants as well as the NNMT gene rs 694539 variant...
  3. doi request reprint Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41380 Kocaeli, Turkey Electronic address
    Gene 532:272-5. 2013
    ..With the polymerase chain reaction restriction fragment length polymorphism method we developed we were able to show the association for the first time. This new finding may provide evidence to understand the mechanism of the disease. ..
  4. doi request reprint Gender-specific association of methylenetetrahydrofolate reductase gene polymorphisms with sporadic amyotrophic lateral sclerosis
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey
    Genet Test Mol Biomarkers 16:716-21. 2012
    ..In conclusion, the evidence we provide here clearly shows that MTHFR C677T and A1298C polymorphisms are genetic risk factors for SALS in women in a gender-specific manner whether they are of spinal or bulbar onset...
  5. doi request reprint A polymerase chain reaction-restriction fragment length polymorphism method for screening ZNF804A gene polymorphism (rs1344706) in patients with schizophrenia: a significant association
    Ali Sazci
    Department of Medical Biology and Genetics, University of Kocaeli, Kocaeli, Turkey
    Genet Test Mol Biomarkers 16:157-61. 2012
    ..Stratification analysis of the population according to the gender showed an association that was statistically significant among overall schizophrenia and male schizophrenia and the risk T allele and TT genotype of the ZNF804A gene...
  6. doi request reprint Association of apolipoprotein E polymorphisms in patients with non-alcoholic steatohepatitis
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Umuttepe, Kocaeli, 41380, Turkey
    Dig Dis Sci 53:3218-24. 2008
    ..741; p=0.008). The APOE3/3 genotype (odds ratio [OR]=7.941; p=0.000) was strongly associated with increased risk for NASH in all NASH patients. Consequently, the APOE3/3 genotype may play a role in the aetiopathogenesis of NASH...
  7. ncbi request reprint Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Umuttepe, 41380 Kocaeli, Turkey
    Brain Res Bull 71:45-50. 2006
    ..In conclusion, the C677T and A1298C polymorphisms of the MTHFR gene are genetic risk factors for hamorrhagic and ischemic stroke respectively, independent of other atherothrombotic risk factors...
  8. ncbi request reprint Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: association is significant in men but not in women
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, 41900, Kocaeli, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 29:1113-23. 2005
    ..In conclusion, the MTHFR 677T allele and T677T, C1298C genotypes, and T677T/A1298A, C677C/C1298C compound genotypes are genetic risk factors for schizophrenia in men but not in women in a gender-specific manner...
  9. ncbi request reprint Catechol-O-methyltransferase gene Val108/158Met polymorphism, and susceptibility to schizophrenia: association is more significant in women
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, 41900 Kocaeli, Turkey
    Brain Res Mol Brain Res 132:51-6. 2004
    ..456; 95% CI=1.287-4.687; chi2=7.710; P=0.005). In conclusion, our results provide strong evidence for a role of the COMT-L allele and LL genotype in the etiopathophysiology of schizophrenia with a sexual difference...
  10. ncbi request reprint Catechol-O-methyltransferase Val 108/158 Met polymorphism in premenopausal breast cancer patients
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, 41900 Kocaeli, Turkey
    Toxicology 204:197-202. 2004
    ..1 and 21.5% in the breast cancer subjects and 26.6, 62.7 and 10.7% in the controls respectively. In conclusion, the COMT-L allele and COMT-LL genotype are genetic risk factors for sporadic breast cancer in premenopausal Turkish women...
  11. ncbi request reprint Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41900 Derince, Kocaeli, Turkey
    Brain Res Mol Brain Res 117:104-7. 2003
    ..157; 95% CI=1.522-6.545; chi(2)=10.336; P=0.001 and OR=1.744; 95% CI=0.108-28.121; chi(2)=0.158; P=0.691, respectively). The MTHFR T677 allele and T677T and T677T/A1298A genotypes are genetic risk factors for schizophrenia...
  12. ncbi request reprint Genotype and allele frequencies of the polymorphic methylenetetrahydrofolate reductase gene in Turkey
    Ali Sazci
    Department of Medical Biology and Genetics, University of Kocaeli, Faculty of Medicine, Kocaeli, Turkey
    Cell Biochem Funct 23:51-4. 2005
    ..34 and 33.16 %, respectively. The frequency of C677T/A1298C compound heterozygosity is highest in Turkey (21.6 %), as compared to Canada (15 %), the United States (17 %) and The Netherlands (20 %)...
  13. doi request reprint Association of nicotinamide-N-methyltransferase gene rs694539 variant with patients with nonalcoholic steatohepatitis
    Ali Sazci
    1 Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey
    Genet Test Mol Biomarkers 17:849-53. 2013
    ..027-0.691). On the other hand, the A allele was a risk factor for NASH (χ(2)=3.793, p=0.051, OR=1.725, and 95% CI=0.994-2.996). Consequently, the rs694539 variant of NNMT gene is a genetic risk factor for developing NASH. ..
  14. doi request reprint TP53 Arg72Pro polymorphism in Turkish patients with sporadic amyotrophic lateral sclerosis
    Emel Ergul
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Umuttepe, Kocaeli, Turkey
    Neurobiol Aging 32:2107.e1-2. 2011
    ..We did not find any association between overall SALS patients with the TP53 Arg72Pro polymorphism and controls (χ(2) = 2.674; p = 0.263). Consequently the TP53 Arg72Pro polymorphism was not associated with SALS...
  15. doi request reprint Methylenetetrahydrofolate reductase gene polymorphisms in Turkish children with attention-deficit/hyperactivity disorder
    Emel Ergul
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Umuttepe, Kocaeli, Turkey
    Genet Test Mol Biomarkers 16:67-9. 2012
    ..Thus, the MTHFR gene does not seem to play a role in the etiopathogenesis of ADHD in the cohort studied...
  16. ncbi request reprint Apolipoprotein E phylogeny and evolution
    Murat Kasap
    Department of Medical Biology and Genetics, Faculty of Medicine, Kocaeli University, Umuttepe, Kocaeli, Turkey
    Cell Biochem Funct 26:43-50. 2008
    ..It may be suggested that Apo E evolution and very likely the evolution of other apolipoproteins are influenced by the organism's feeding environment and diet...
  17. ncbi request reprint Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in patients with essential tremor in Turkey
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, Kocaeli, Turkey
    Mov Disord 19:1472-6. 2004
    ..In conclusion, the MTHFR 677T, 1298C alleles and MTHFR T677T genotype and T677T/A1298A, and C677C/C1298C compound genotypes are genetic risk factors for essential tremor in Turkey...
  18. ncbi request reprint Polymorphisms in the MTHFR gene are associated with breast cancer
    Emel Ergul
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey
    Tumour Biol 24:286-90. 2003
    ..In conclusion, our data suggest that the MTHFR 677T, 1298C alleles, T677T, C1298C genotypes, and C677C/C1298C and T677T/A1298A compound genotypes are genetic risk factors for premenopausal women with sporadic breast cancer...
  19. doi request reprint Association of Nicotinamide-N-Methyltransferase Gene rs694539 Variant with Epilepsy
    Gensay Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, 41380, Kocaeli, Turkey
    Mol Neurobiol 53:4197-200. 2016
    ..However, the statistical power was only 0.33 in female patients with epilepsy (χ (2) = 5.275, P = 0.072). This finding, for the first time, suggests the involvement of the NNMT gene rs694539 variant in the etiology of epilepsy. ..
  20. doi request reprint Association of rs62063857 variant of the saitohin gene with Parkinson's disease
    Ezgi Sonmez
    Departments of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey
    Cell Mol Neurobiol 35:115-21. 2015
    ..051-fold increased risk for the disease. Consequently, the rs62063857 polymorphism of the saitohin gene is a genetic risk factor for Parkinson's disease. Hence, this polymorphism may play a role in the etiology of Parkinson's disease...
  21. pmc Transcription factor 4 gene rs9960767 polymorphism in bipolar disorder
    Mavi Deniz Ozel
    Department of Medical Biology, International School of Medicine, Istanbul Medipol University, Istanbul 34810, Turkey
    Biomed Rep 5:506-510. 2016
    ..An improved approach would be better to evaluate the TCF4 gene in a pathway specific manner due to its role as a transcription factor...
  22. doi request reprint Genetic variants in the PNPLA3 gene are associated with nonalcoholic steatohepatitis
    Eylul Ece Islek
    1 Department of Medical Biology and Genetics, University of Kocaeli, Kocaeli, Turkey
    Genet Test Mol Biomarkers 18:489-96. 2014
    ..Our findings confirm the findings of the recent case-control and genome-wide association studies carried out in different populations around the world. Thus, the three variants in PNPLA3 gene may be a genetic risk factor for NASH. ..
  23. doi request reprint Evidence for the presence of full-length PARK2 mRNA and Parkin protein in human blood
    Murat Kasap
    Kocaeli University, Department of Medical Biology, Turkey
    Neurosci Lett 460:196-200. 2009
    ..The results of this study showed a simple way for routine amplification of PARK2 cDNA from human blood and may become a useful diagnostic tool in the future...
  24. ncbi request reprint Molecular phylogenetic analysis of methylenetetrahydrofolate reductase family of proteins
    Murat Kasap
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Umuttepe, 41380 Kocaeli, Turkey
    Mol Phylogenet Evol 42:838-46. 2007
    ..On a phylogenetic tree built, eukaryotic MTHFR proteins formed a clear cluster separated from prokaryotic and archeal relatives. The sequence identities among the eukaryotic MTHFRs were less divergent than the bacterial MTHFRs...
  25. doi request reprint The comparison of VEGFR-1-binding domain of VEGF-A with modelled VEGF-C sheds light on receptor specificity
    Murat Kasap
    Department of Medical Biology, Faculty of Medicine, Kocaeli University, Umuttepe, 41380 Kocaeli, Turkey
    J Theor Biol 253:446-51. 2008
    ..Mapping the electrostatic surface potentials to the protein surfaces revealed noteworthy number of dissimilarities between VEGF-A and VEGF-C, indicating that overall both proteins differ in their folding properties and stability...
  26. ncbi request reprint Male factor infertility associated with a familial translocation t(1;13)(q24;q10)
    Ali Sazci
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Derince, Turkey
    Fertil Steril 83:1548-50. 2005
    ..It is possible that the APOE and MTHFR genotypes and lower folate status may also be responsible for the above mentioned translocation...
  27. pmc Association of the nibrin gene (NBN) variants with breast cancer
    Hakan Uzunoglu
    Department of General Surgery, Faculty of Medicine, University of Kocaeli, Kocaeli 41380, Turkey
    Biomed Rep 4:369-373. 2016
    ..570) or the NBN gene 30537 G>C variant (χ2=4.301, P=0.116). In conclusion, the NBN gene 924 T>C variant may be a genetic risk factor for breast cancer development in women with breast cancer...
  28. doi request reprint A de novo complex chromosome rearrangement involving three chromosomes (2, 13, and 18) in an oligospermic male
    Emel Ergul
    Department of Medical Biology and Genetics, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey
    Fertil Steril 92:391.e9-391.e12. 2009
    ..To determine an unusual complex chromosome rearrangement found in a man with oligospermia with a normal phenotype...
  29. doi request reprint Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives
    Zeynep Ozbek
    Department of Biochemistry, Eyup State Hospital, Istanbul, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 32:1331-7. 2008
    ..Patients and relatives carrying TT and/or AA and AC genotypes had elevated tHcy and reduced folate and B12 levels. High tHcy but low folate and vitamin B12 levels may be a risk factor for development of bipolar disorder...
  30. ncbi request reprint Evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of ischaemic stroke
    Nese Tuncer
    Deparment of Neurology, Marmara University School of Medicine, 36 Ada Ata 2 5 Daire 110, 34750 Ataşehir, Istanbul, Turkey
    J Clin Neurosci 13:224-7. 2006
    ..827; df = 3; p = 0.185). Our data supports lack of association between DD genotype and/or D allele and ischemic stroke or subtypes of ischaemic stroke in the Turkish population...
  31. ncbi request reprint Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk
    Ihsan Kara
    Department of Neurological Sciences, Institute for Medical Research, Istanbul University, 34280 Istanbul, Turkey
    Brain Res Mol Brain Res 111:84-90. 2003
    ..444; 95% CI=1.503-36.863); P=0.005). Patients with C1298C and C677C/C1298C genotypes may also predispose to tension-type headache (OR=8.375; 95% CI=0.685-102.458); P=0.049)...