Goksel Sener

Summary

Publications

  1. ncbi request reprint Melatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pineal Res 35:163-8. 2003
  2. ncbi request reprint Melatonin protects against ionizing radiation-induced oxidative damage in corpus cavernosum and urinary bladder in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad 34668 Istanbul, Turkey
    J Pineal Res 37:241-6. 2004
  3. ncbi request reprint Ginkgo biloba extract protects against ionizing radiation-induced oxidative organ damage in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad 34668 Istanbul, Turkey
    Pharmacol Res 53:241-52. 2006
  4. ncbi request reprint Pressure ulcer-induced oxidative organ injury is ameliorated by beta-glucan treatment in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Division of Biochemistry, Tibbiye Cad 34668 Istanbul, Turkey
    Int Immunopharmacol 6:724-32. 2006
  5. ncbi request reprint Ginkgo biloba extract protects against mercury(II)-induced oxidative tissue damage in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Food Chem Toxicol 45:543-50. 2007
  6. ncbi request reprint Melatonin protects against gentamicin-induced nephrotoxicity in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pineal Res 32:231-6. 2002
  7. ncbi request reprint The protective effect of melatonin on renal ischemia-reperfusion injury in the rat
    Goksel Sener
    Department of Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey
    J Pineal Res 32:120-6. 2002
  8. ncbi request reprint Melatonin prevents oxidative kidney damage in a rat model of thermal injury
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    Life Sci 70:2977-85. 2002
  9. ncbi request reprint Melatonin improves oxidative organ damage in a rat model of thermal injury
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Tibbiye Cad, 81010, Istanbul, Turkey
    Burns 28:419-25. 2002
  10. ncbi request reprint Effects of chard (Beta vulgaris L. var. cicla) extract on oxidative injury in the aorta and heart of streptozotocin-diabetic rats
    G Sener
    Department of Pharmacology, Faculty of Pharmacy, Marmara University, 81010, Istanbul, Turkey
    J Med Food 5:37-42. 2002

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Melatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pineal Res 35:163-8. 2003
    ..In conclusion, the results of the present study suggest that the therapeutic value of melatonin as a 'reperfusion injury-limiting' agent must be considered in ACS...
  2. ncbi request reprint Melatonin protects against ionizing radiation-induced oxidative damage in corpus cavernosum and urinary bladder in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad 34668 Istanbul, Turkey
    J Pineal Res 37:241-6. 2004
    ....
  3. ncbi request reprint Ginkgo biloba extract protects against ionizing radiation-induced oxidative organ damage in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad 34668 Istanbul, Turkey
    Pharmacol Res 53:241-52. 2006
    ....
  4. ncbi request reprint Pressure ulcer-induced oxidative organ injury is ameliorated by beta-glucan treatment in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Division of Biochemistry, Tibbiye Cad 34668 Istanbul, Turkey
    Int Immunopharmacol 6:724-32. 2006
    ..Thus, supplementing geriatric and neurologically impaired patients with adjuvant therapy of beta-glucan may have some benefits for successful therapy and improving quality of life...
  5. ncbi request reprint Ginkgo biloba extract protects against mercury(II)-induced oxidative tissue damage in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Food Chem Toxicol 45:543-50. 2007
    ..On the other hand, EGb treatment reversed all these biochemical indices. Our results implicate that mercury-induced oxidative damage in brain, lung, liver, and kidney tissues protected by G. biloba extract, with its antioxidant effects...
  6. ncbi request reprint Melatonin protects against gentamicin-induced nephrotoxicity in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pineal Res 32:231-6. 2002
    ..On the other hand simultaneous melatonin administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by GEN treatment...
  7. ncbi request reprint The protective effect of melatonin on renal ischemia-reperfusion injury in the rat
    Goksel Sener
    Department of Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey
    J Pineal Res 32:120-6. 2002
    ..As melatonin administration reversed these oxidant responses, improved renal function and microscopic damage, it seems likely that melatonin protects kidney tissue against oxidative damage...
  8. ncbi request reprint Melatonin prevents oxidative kidney damage in a rat model of thermal injury
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    Life Sci 70:2977-85. 2002
    ..Treatment of rats with melatonin (10 mg/kg) significantly elevated the reduced GSH levels while it decreased MDA and PO levels as well as MPO activity...
  9. ncbi request reprint Melatonin improves oxidative organ damage in a rat model of thermal injury
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Tibbiye Cad, 81010, Istanbul, Turkey
    Burns 28:419-25. 2002
    ..Treatment of rats with melatonin (10mg/kg) significantly elevated the reduced GSH levels while it decreased MDA and PO levels as well as MPO activity...
  10. ncbi request reprint Effects of chard (Beta vulgaris L. var. cicla) extract on oxidative injury in the aorta and heart of streptozotocin-diabetic rats
    G Sener
    Department of Pharmacology, Faculty of Pharmacy, Marmara University, 81010, Istanbul, Turkey
    J Med Food 5:37-42. 2002
    ..However, treatment with chard extract reversed the effects of diabetes on blood glucose and tissue lipid peroxidation and glutathione levels...
  11. ncbi request reprint Octreotide improves burn-induced intestinal injury in the rat
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    Peptides 24:123-7. 2003
    ..OCT may have some beneficial therapeutic effects by reducing neutrophil-dependent injury and related lipid peroxidation following burn trauma...
  12. ncbi request reprint Melatonin treatment protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder
    Goksel Sener
    Department of Pharmacology, Marmara University Faculty of Pharmacy, Hayadarpasa, Istanbul, Turkey
    J Pineal Res 34:226-30. 2003
    ..16 +/- 0.07; P < 0.001). Melatonin almost completely reversed the low contractile responses of rat urinary bladder strips to CCh and prevented oxidative tissue damage following I/R...
  13. ncbi request reprint Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion
    Goksel Sener
    School of Pharmacy, Department of Pharmacology, Marmara University, Tibbiye Cad 81010, Istanbul, Turkey
    Life Sci 72:2707-18. 2003
    ..Our findings show that Mel and NAC have beneficial effects against the I/R injury and due to their synergistic effects, when administered in combination, may have a more pronounced protective effects on the liver...
  14. ncbi request reprint Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: a comparative study
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pineal Res 35:61-8. 2003
    ..This may be the result of the higher efficacy of melatonin in scavenging various free radicals and also because of its ability in stimulating the antioxidant enzymes...
  15. ncbi request reprint Octreotide ameliorates alendronate-induced gastric injury
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Haydarpasa, 34668 Istanbul, Turkey
    Peptides 25:115-21. 2004
    ..Therefore, its therapeutic role as a "ulcer healing" agent must be further elucidated in alendronate-induced gastric mucosal injury...
  16. ncbi request reprint Melatonin reverses urinary system and aorta damage in the rat due to chronic nicotine administration
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pharm Pharmacol 56:359-66. 2004
    ..Moreover, melatonin, as an antioxidant, abolished elevation in lipid peroxidation products, and reduction in the endogenous antioxidant glutathione, and protected the tissues from severe damage due to nicotine exposure...
  17. ncbi request reprint L-carnitine ameliorates oxidative damage due to chronic renal failure in rats
    Goksel Sener
    School of Pharmacy, Department of Pharmacology, Marmara University, Istanbul, Turkey
    J Cardiovasc Pharmacol 43:698-705. 2004
    ..These results suggest that L-carnitine supplementation may have some benefit in CRF patients...
  18. ncbi request reprint Melatonin attenuates ifosfamide-induced Fanconi syndrome in rats
    Goksel Sener
    School of Pharmacy and Department of Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey
    J Pineal Res 37:17-25. 2004
    ..These data suggest that melatonin may be of therapeutic use in preventing acquired FS due to IFO toxicity...
  19. ncbi request reprint 2-Mercaptoethane sulfonate (MESNA) protects against burn-induced renal injury in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad 34668 Istanbul, Turkey
    Burns 30:557-64. 2004
    ..Since MESNA reversed the oxidant responses seen in burn injury, it seems likely that MESNA could protect against thermal trauma-induced renal damage...
  20. ncbi request reprint Gastroprotective effect of leukotriene receptor blocker montelukast in alendronat-induced lesions of the rat gastric mucosa
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    Prostaglandins Leukot Essent Fatty Acids 72:1-11. 2005
    ....
  21. ncbi request reprint Aqueous garlic extract alleviates ischaemia-reperfusion-induced oxidative hepatic injury in rats
    Goksel Sener
    Department of Pharmacology, Marmara University School of Pharmacy, Tibbiye Cad 34668 Istanbul, Turkey
    J Pharm Pharmacol 57:145-50. 2005
    ....
  22. ncbi request reprint Protective effects of taurine against nicotine-induced oxidative damage of rat urinary bladder and kidney
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, School of Medicine, Istanbul, Turkey
    Pharmacology 74:37-44. 2005
    ..These data suggest that taurine supplementation effectively counteracts the deleterious effect of chronic nicotine administration on bladder and kidney functions and attenuates oxidative damage possibly by its antioxidant effects...
  23. ncbi request reprint Octreotide ameliorates sepsis-induced pelvic inflammation in female rats by a neutrophil-dependent mechanism
    Goksel Sener
    Faculty of Pharmacy, Department of Pharmacology, Marmara University, 34668 Haydarpasa, Istanbul, Turkey
    Peptides 26:493-9. 2005
    ..Our results suggest that OCT may be of therapeutic value in ameliorating sepsis-associated pelvic inflammation...
  24. ncbi request reprint Protective effect of taurine against alendronate-induced gastric damage in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Haydarpasa, 34668, Istanbul, Turkey
    Fundam Clin Pharmacol 19:93-100. 2005
    ..Findings of the present study suggest that ALD induces oxidative gastric damage by a local irritant effect, and that TAU ameliorates this damage by its antioxidant and/or membrane-stabilizing effects...
  25. ncbi request reprint Protective effects of MESNA (2-mercaptoethane sulphonate) against acetaminophen-induced hepatorenal oxidative damage in mice
    Goksel Sener
    School of Pharmacy, Department of Pharmacology, Marmara University, Istanbul, Turkey
    J Appl Toxicol 25:20-9. 2005
    ..Therefore, its therapeutic role as a 'tissue injury-limiting agent' must be elucidated further in drug-induced oxidative damage...
  26. ncbi request reprint Taurine treatment protects against chronic nicotine-induced oxidative changes
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    Fundam Clin Pharmacol 19:155-64. 2005
    ..These data suggest that taurine supplementation effectively attenuates the oxidative damage because of chronic nicotine administration possibly by its antioxidant effects...
  27. ncbi request reprint Protective effect of beta-glucan against oxidative organ injury in a rat model of sepsis
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Haydarpasa, Istanbul 34668, Turkey
    Int Immunopharmacol 5:1387-96. 2005
    ..Since beta-glucan administration reversed these oxidant responses, it seems likely that beta-glucan protects against sepsis-induced oxidative organ injury...
  28. ncbi request reprint Chronic nicotine toxicity is prevented by aqueous garlic extract
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    Plant Foods Hum Nutr 60:77-86. 2005
    ..Since AGE administration reversed these oxidant responses, improved renal function and histological damage, it seems likely that AGE protects the tissues against nicotine-induced oxidative damage...
  29. ncbi request reprint Estrogen protects the liver and intestines against sepsis-induced injury in rats
    Goksel Sener
    Marmara University School of Pharmacy, Department of Pharmacology and School of Medicine, Istanbul, Turkey
    J Surg Res 128:70-8. 2005
    ..The aim of this study was to examine the putative protective role of estradiol against sepsis-induced oxidative organ damage...
  30. pmc Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Tlbbiye Cad istanbul 34668, Turkey
    World J Gastroenterol 11:5444-9. 2005
    ..To assess the antioxidant and antifibrotic effects of long-term Ginkgo biloba administration on liver fibrosis induced by biliary obstruction in rats...
  31. ncbi request reprint Protective effects of ginkgo biloba against acetaminophen-induced toxicity in mice
    Goksel Sener
    School of Pharmacy, Department of Pharmacology, Marmara University, Istanbul, Turkey
    Mol Cell Biochem 283:39-45. 2006
    ..The analgesic acetaminophen (AAP) causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. It was reported that these toxic effects of AAP are due to oxidative reactions that take place during its metabolism...
  32. ncbi request reprint Propylthiouracil (PTU)-induced hypothyroidism alleviates burn-induced multiple organ injury
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Burns 32:728-36. 2006
    ....
  33. ncbi request reprint Melatonin prevents neutrophil-mediated oxidative injury in Escherichia coli-induced pyelonephritis in rats
    Goksel Sener
    School of Pharmacy, Department of Pharmacology, Marmara University, Istanbul, Turkey
    J Pineal Res 41:220-7. 2006
    ....
  34. ncbi request reprint Erdosteine prevents colonic inflammation through its antioxidant and free radical scavenging activities
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Tibbiye Cad 34668, Istanbul, Turkey
    Dig Dis Sci 52:2122-32. 2007
    ....
  35. ncbi request reprint Role of garlic in the prevention of ischemia-reperfusion injury
    Goksel Sener
    Marmara University School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Mol Nutr Food Res 51:1345-52. 2007
    ..Future studies should focus on post ischemia reperfusion administration of garlic to explore its rescue potential rather than prophylactic impact. Bench research findings should be translated into clinical use through human studies...
  36. ncbi request reprint Chronic renal failure-induced multiple-organ injury in rats is alleviated by the selective CysLT1 receptor antagonist montelukast
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad, 34668 Istanbul, Turkey
    Prostaglandins Other Lipid Mediat 83:257-67. 2007
    ....
  37. ncbi request reprint Acetaminophen-induced toxicity is prevented by beta-D-glucan treatment in mice
    Hale Z Toklu
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Eur J Pharmacol 543:133-40. 2006
    ..In conclusion, these results suggest that beta-d-glucan exerts cytoprotective effects against oxidative injury through its antioxidant properties and may be of therapeutic use in preventing acetaminophen toxicity...
  38. ncbi request reprint Melatonin protects against pressure ulcer-induced oxidative injury of the skin and remote organs in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pineal Res 40:280-7. 2006
    ..Tissue injury was decreased especially in the locally treated group. Findings of the present study suggest that local and/or systemic melatonin treatment may prove beneficial in the treatment of PU...
  39. ncbi request reprint Oxytocin alleviates oxidative renal injury in pyelonephritic rats via a neutrophil-dependent mechanism
    Nese Karaaslan Biyikli
    Marmara University, School of Medicine, Department of Pediatric Nephrology, Istanbul, Turkey
    Peptides 27:2249-57. 2006
    ..We investigated the possible therapeutic effects of OT against Escherichia coli induced pyelonephritis in rats both in the acute and chronic setting...
  40. doi request reprint Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury
    Mehmet Ersahin
    Istanbul Medeniyet University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey
    Prostaglandins Other Lipid Mediat 99:131-9. 2012
    ..Moreover, montelukast does not only exert antioxidant and antiapoptotic effects on the spinal cord, but it has a significant impact on the bladder tissue damage secondary to SCI...
  41. ncbi request reprint Leukotriene receptor blocker montelukast protects against burn-induced oxidative injury of the skin and remote organs
    Goksel Sener
    School of Pharmacy, Department of Pharmacology, Marmara University, 34668 Haydarpasa, Istanbul, Turkey
    Burns 31:587-96. 2005
    ..Findings of the present study suggest that montelukast possesses an anti-inflammatory effect on burn-induced damage in remote organs and protects against oxidative organ damage by a neutrophil-dependent mechanism...
  42. ncbi request reprint Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism
    Sevgin Ozlem Iseri
    Department of Physiology, School of Medicine, Marmara University, Haydarpasa, Istanbul 34668, Turkey
    Peptides 26:483-91. 2005
    ..The present work was conducted to assess the possible therapeutic effects of OT against the acetic acid-induced colonic injury in the rat...
  43. ncbi request reprint Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death
    Mustafa Cetiner
    Department of Hematology, School of Medicine, Marmara University, 34668 Haydarpasa, Istanbul, Turkey
    Toxicol Appl Pharmacol 209:39-50. 2005
    ..In conclusion, it appears that taurine protects against methotrexate-induced oxidant organ injury and inhibits leukocyte apoptosis and may be of therapeutic potential in alleviating the systemic side effects of chemotherapeutics...
  44. ncbi request reprint Amelioration of sepsis-induced hepatic and ileal injury in rats by the leukotriene receptor blocker montelukast
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Haydarpasa, Istanbul, Turkey
    Prostaglandins Leukot Essent Fatty Acids 73:453-62. 2005
    ..Sepsis is a generalized inflammatory response, which involves organ systems remote from the locus of the initial infectious insult, involves the release of cytokines and the subsequent formation of reactive oxygen and nitrogen species...
  45. ncbi request reprint Montelukast protects against renal ischemia/reperfusion injury in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad 34668 Istanbul, Turkey
    Pharmacol Res 54:65-71. 2006
    ..Oxygen free radicals are important components involved in the pathophysiological processes observed during ischemia/reperfusion (I/R)...
  46. ncbi request reprint Resveratrol improves ifosfamide-induced Fanconi syndrome in rats
    Ozer Sehirli
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad 34668 Istanbul, Turkey
    Toxicol Appl Pharmacol 222:33-41. 2007
    ..Therefore, its therapeutic role in preventing the development of chemotherapeutic drug-induced major toxicity in the urinary system requires further elucidation...
  47. ncbi request reprint Ginkgo biloba extract ameliorates ischemia reperfusion-induced renal injury in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Tibbiye Cad, 34668 Istanbul, Turkey
    Pharmacol Res 52:216-22. 2005
    ..The findings imply that ROMs play a causal role in I/R-induced renal injury and EGb exerts renoprotective effects probably by the radical scavenging and antioxidant activities...
  48. ncbi request reprint Oxidative renal damage in pyelonephritic rats is ameliorated by montelukast, a selective leukotriene CysLT1 receptor antagonist
    Halil Tugtepe
    Marmara University, School of Medicine, Department of Pediatric Surgery, Istanbul, Turkiye
    Eur J Pharmacol 557:69-75. 2007
    ....
  49. ncbi request reprint Grape seed extract reduces oxidative stress and fibrosis in experimental biliary obstruction
    Ender Dulundu
    Department of Fifth Surgery, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
    J Gastroenterol Hepatol 22:885-92. 2007
    ..The aim of this study was to assess the protective effect of grape seed extract (GSE) against oxidative liver injury and fibrosis induced by biliary obstruction in rats...
  50. ncbi request reprint Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats
    Hale Z Toklu
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pharm Pharmacol 59:1287-95. 2007
    ..It therefore seems likely that PPE, with its antioxidant and antifibrotic properties, may be of potential therapeutic value in protecting the liver from fibrosis and oxidative injury due to biliary obstruction...
  51. doi request reprint Resveratrol treatment protects against doxorubicin-induced cardiotoxicity by alleviating oxidative damage
    Elif Tatlidede
    Department of Pharmacology, Marmara University, Istanbul, Turkey
    Free Radic Res 43:195-205. 2009
    ..On the other hand, RVT markedly ameliorated the severity of cardiac dysfunction, while all oxidant responses were prevented; implicating that RVT may be of therapeutic use in preventing oxidative stress due to DOX toxicity...
  52. pmc Neuroprotective effects of alpha-lipoic acid in experimental spinal cord injury in rats
    Hale Z Toklu
    Marmara University School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    J Spinal Cord Med 33:401-9. 2010
    ..Oxidative stress is a mediator of secondary injury to the spinal cord following trauma...
  53. ncbi request reprint Melatonin ameliorates chronic renal failure-induced oxidative organ damage in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pineal Res 36:232-41. 2004
    ..CRF-induced dysfunction of the aorta and corpus cavernosum of rats was reversed by melatonin treatment. Thus, supplementing CRF patients with adjuvant therapy of melatonin may have some benefit...
  54. ncbi request reprint Melatonin protects against oxidative organ injury in a rat model of sepsis
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Haydarpasa, Istanbul, 34668, Turkey
    Surg Today 35:52-9. 2005
    ..Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats...
  55. ncbi request reprint Burn-induced oxidative injury of the gut is ameliorated by the leukotriene receptor blocker montelukast
    Levent Kabasakal
    Department of Pharmacology, School of Pharmacy, Marmara University, 34668 Haydarpasa, Istanbul, Turkey
    Prostaglandins Leukot Essent Fatty Acids 72:431-40. 2005
    ..Findings of the present study suggest that montelukast possesses an anti-inflammatory effect on burn-induced gastrointestinal damage and protects against oxidative injury by a neutrophil-dependent mechanism...
  56. ncbi request reprint The effects of melatonin on ischemia-reperfusion induced changes in rat corpus cavernosum
    Goksel Sener
    Department of Pharmacology, Faculty of Pharmacy and Department of Physiology, School of Medicine, Marmara University, Istanbul, Turkey
    J Urol 167:2624-7. 2002
    ..We determined the change in contractile activity and oxidant damage after ischemia-reperfusion of rat corpus cavernosum and investigated the effects of melatonin (Sigma Chemical Co., St. Louis, Missouri) on these parameters...
  57. ncbi request reprint Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats
    Ender Dulundu
    Department of 5th Surgery, Haydarpasa Numune Educational and Research Hospital, Istanbul, Turkey
    Pharmacology 79:163-70. 2007
    ..To evaluate the protective effect of alpha-lipoic acid in reducing oxidative damage after severe hepatic ischemia/reperfusion (IR) injury...
  58. doi request reprint Alpha lipoic acid alleviates oxidative stress and preserves blood brain permeability in rats with subarachnoid hemorrhage
    Mehmet Ersahin
    Department of Neurosurgery, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
    Neurochem Res 35:418-28. 2010
    ....
  59. doi request reprint Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two-kidney, one-clip hypertensive rats
    Hale Z Toklu
    Department of Pharmacology, Marmara University School of Pharmacy, Istanbul, Turkey
    J Pharm Pharmacol 62:1784-93. 2010
    ..The putative protective effects of resveratrol against oxidative injury in the heart, kidney and brain tissues of rats induced with the two-kidney, one-clip (2K1C) hypertension model were investigated...
  60. ncbi request reprint Melatonin protects against pancreaticobiliary inflammation and associated remote organ injury in rats: role of neutrophils
    Afsar Barlas
    Department of General Surgery, Marmara University School of Medicine, Istanbul, Turkey
    J Pineal Res 37:267-75. 2004
    ..Melatonin, probably because of its free-radical scavenging and antioxidant activity, which involves an inhibitory effect on tissue neutrophil infiltration, protected all the affected tissues...
  61. ncbi request reprint Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats
    Nursal Gedik
    Kasimpasa Military Hospital, Division of Biochemistry, Istanbul, Turkey
    Life Sci 76:2593-606. 2005
    ....
  62. ncbi request reprint Resveratrol reduces renal and lung injury caused by sepsis in rats
    Meltem Kolgazi
    Department of Physiology, School of Medicine, Marmara University, Istanbul, Turkey
    J Surg Res 134:315-21. 2006
    ..The present study was aimed to investigate the possible beneficial activities of resveratrol on lung and kidney damage in a rat model of sepsis...
  63. ncbi request reprint Octreotide: a new approach to the management of acute abdominal hypertension
    Ayhan Kacmaz
    Department of 3rd Surgery, Haydarpasa Numune Hospital, Istanbul, Turkey
    Peptides 24:1381-6. 2003
    ..Therefore, its therapeutic role as a "reperfusion injury-limiting" agent must be further elucidated in IAP-induced abdominal organ injury...
  64. ncbi request reprint Protective effect of aqueous garlic extract against naphthalene-induced oxidative stress in mice
    Gulden Z Omurtag
    Department of Pharmaceutical Toxicology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pharm Pharmacol 57:623-30. 2005
    ..05-0.001) after AGE treatment. The results demonstrate the role of oxidative mechanisms in naphthalene-induced tissue damage. The antioxidant properties of AGE ameliorated oxidative organ injury due to naphthalene toxicity...
  65. ncbi request reprint Resveratrol improves ischemia/reperfusion-induced oxidative renal injury in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    Arch Med Res 37:822-9. 2006
    ..The present study was designed to examine whether resveratrol, a potent antioxidant, protects against renal ischemia-reperfusion (I/R) injury...
  66. ncbi request reprint The protective effect of oxytocin on renal ischemia/reperfusion injury in rats
    Halil Tugtepe
    Marmara University, School of Medicine, Department of Pediatric Surgery, Istanbul, Turkey
    Regul Pept 140:101-8. 2007
    ..The major objective of the present study was to evaluate the protective role of oxytocin (OT) in protecting the kidney against ischemia/reperfusion (I/R) injury...
  67. doi request reprint Resveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity
    Ayliz Velioglu-Ogunc
    Vocational School of Health Related Professions, Marmara University, Istanbul, Turkey
    Free Radic Res 43:1060-71. 2009
    ..In conclusion, supplementing cancer patients with adjuvant therapy of resveratrol may have some benefit for a more successful radiotherapy...
  68. ncbi request reprint Melatonin treatment protects against sepsis-induced functional and biochemical changes in rat ileum and urinary bladder
    Kübra Paskaloğlu
    Department of Pharmacology, Marmara University, School of Pharmacy, Eczacilik Fakultesi, Tibbiye Cad 34668, Istanbul, Turkey
    Life Sci 74:1093-104. 2004
    ....
  69. ncbi request reprint Oxytocin protects against sepsis-induced multiple organ damage: role of neutrophils
    Sevgin Ozlem Iseri
    Department of Physiology, School of Medicine, Marmara University, Istanbul 34668, Turkey
    J Surg Res 126:73-81. 2005
    ..The neurohypophyseal hormone oxytocin (OT), released during social contact, was recently shown to modulate the immune and inflammatory processes. We investigated the protective role of OT against sepsis-induced pelvic inflammation...
  70. doi request reprint The effect of stinging nettle (Urtica dioica) seed oil on experimental colitis in rats
    Zeynep Genc
    Department of Biochemistry, Marmara University, Istanbul, Turkey
    J Med Food 14:1554-61. 2011
    ..In conclusion, UDO, through its anti-inflammatory and antioxidant actions, merits consideration as a potential agent in ameliorating colonic inflammation...
  71. doi request reprint Grape seed extract treatment reduces hepatic ischemia-reperfusion injury in rats
    Ozer Sehirli
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Phytother Res 22:43-8. 2008
    ..In conclusion, GSE reduced I/R-induced organ injury through its ability to balance the oxidant-antioxidant status, to inhibit neutrophil infiltration and to regulate the release of inflammatory mediators...
  72. doi request reprint Protective effect of resveratrol against naphthalene-induced oxidative stress in mice
    Ozer Sehirli
    Department of Pharmacology, Marmara University School of Pharmacy, Istanbul, Turkey
    Ecotoxicol Environ Saf 71:301-8. 2008
    ..This investigation confirms the role of free radicals in naphthalene-induced toxicity and elucidates the mechanism of resveratrol (RVT)...
  73. doi request reprint Protective potential of montelukast against hepatic ischemia/reperfusion injury in rats
    Erkan Ozkan
    Haydarpasa Numune Education and Research Hospital, Department of 5th Surgery, and School of Pharmacy, Department of Pharmacology, Marmara University, Istanbul, Turkey
    J Surg Res 159:588-94. 2010
    ....
  74. doi request reprint The anti-inflammatory and neuroprotective effects of ghrelin in subarachnoid hemorrhage-induced oxidative brain damage in rats
    Mehmet Ersahin
    Haydarpasa Numune Education and Research Hospital, Department of Neurosurgery, Istanbul, Turkey
    J Neurotrauma 27:1143-55. 2010
    ....
  75. ncbi request reprint Ginkgo biloba extract reduces naphthalene-induced oxidative damage in mice
    Ayfer Tozan
    Department of Pharmaceutical Toxicology, Marmara University School of Pharmacy, Istanbul, Turkey
    Phytother Res 21:72-7. 2007
    ..The results demonstrate that EGb extract, by balancing the oxidant-antioxidant status and inhibiting the generation of proinflammatory cytokines and neutrophil infiltration, protects against naphthalene-induced oxidative organ injury...
  76. ncbi request reprint Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction
    Goksel Sener
    School of Pharmacy, Department of Pharmacology, Marmara University, Tibbiye Cad, 34668, Istanbul, Turkey
    Pediatr Surg Int 23:233-41. 2007
    ....
  77. ncbi request reprint Taurine ameliorates stress-induced degeneration of the urinary bladder
    Ali Zeybek
    Department of Anatomy, School of Medicine, Kocaeli University, Kocaeli, Turkey
    Acta Histochem 109:208-14. 2007
    ..We conclude that taurine protects against WAS-induced oxidant urinary bladder injury, and thus may be a possible therapeutic agent against interstitial cystitis, the symptoms of which are aggravated by stress conditions...
  78. ncbi request reprint Rosiglitazone, a PPAR-gamma ligand, protects against burn-induced oxidative injury of remote organs
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Burns 33:587-93. 2007
    ..According to the findings of the present study, rosiglitazone possesses a anti-inflammatory effect that prevents burn-induced damage in remote organs and protects against organ damage...
  79. ncbi request reprint Silymarin, the antioxidant component of Silybum marianum, prevents sepsis-induced acute lung and brain injury
    Hale Z Toklu
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Surg Res 145:214-22. 2008
    ..Based on the potent antioxidant effects of silymarin, we investigated the putative protective role of silymarin against sepsis-induced oxidative damage in lung and brain tissues...
  80. doi request reprint Melatonin improves cardiovascular function and ameliorates renal, cardiac and cerebral damage in rats with renovascular hypertension
    Mehmet Ersahin
    Department of Neurosurgery, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
    J Pineal Res 47:97-106. 2009
    ....
  81. ncbi request reprint Protective effects of Ginkgo biloba extract against mercury(II)-induced cardiovascular oxidative damage in rats
    Tugba Tunali-Akbay
    School of Dentistry, Department of Biochemistry, Marmara University, Turkey
    Phytother Res 21:26-31. 2007
    ..Since EGb treatment reversed these responses, it seems likely that Ginkgo biloba extract can protect the cardiovascular tissues against HgCl(2)-induced oxidative damage...
  82. ncbi request reprint Resveratrol alleviates bleomycin-induced lung injury in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Pulm Pharmacol Ther 20:642-9. 2007
    ..Thus, an effective supplement with resveratrol as an adjuvant therapy may be a very promising agent in alleviating the side effects of bleomycin, an effective chemotherapeutic agent...
  83. doi request reprint Melatonin protects against endosulfan-induced oxidative tissue damage in rats
    Gulden Z Omurtag
    Department of Pharmaceutical Toxicology, School of Medicine, Marmara University, School of Pharmacy, Istanbul, Turkey
    J Pineal Res 44:432-8. 2008
    ....
  84. ncbi request reprint The beneficial effect of resveratrol on rat bladder contractility and oxidant damage following ischemia/reperfusion
    Hale Toklu
    Department of Pharmacology, Faculty of Pharmacy, Marmara University, Haydarpasa, Istanbul, Turkey
    Pharmacology 78:44-50. 2006
    ....
  85. ncbi request reprint Montelukast reduces ischaemia/reperfusion-induced bladder dysfunction and oxidant damage in the rat
    Goksel Sener
    Marmara University, Faculty of Pharmacy, Department of Pharmacology, Haydarpasa, 34668, Istanbul, Turkey
    J Pharm Pharmacol 59:837-42. 2007
    ..Treatment with montelukast almost completely reversed the low contractile responses of rat urinary bladder to carbachol and prevented oxidative tissue damage following I/R...
  86. ncbi request reprint Alpha-lipoic acid protects against renal ischaemia-reperfusion injury in rats
    Ozer Sehirli
    School of Pharmacy, Department of Pharmacology, Marmara University, Istanbul, Turkey
    Clin Exp Pharmacol Physiol 35:249-55. 2008
    ..Thus, it seems likely that ALA protects kidney tissues by inhibiting neutrophil infiltration, balancing the oxidant-anti-oxidant status and regulating the generation of inflammatory mediators...
  87. doi request reprint Ghrelin improves burn-induced multiple organ injury by depressing neutrophil infiltration and the release of pro-inflammatory cytokines
    Ozer Sehirli
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Peptides 29:1231-40. 2008
    ..According to the findings of the present study, ghrelin possesses a neutrophil-dependent anti-inflammatory effect that prevents burn-induced damage in skin and remote organs and protects against oxidative organ damage...
  88. doi request reprint Melatonin reduces experimental subarachnoid hemorrhage-induced oxidative brain damage and neurological symptoms
    Mehmet Ersahin
    Department of Neurosurgery, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
    J Pineal Res 46:324-32. 2009
    ..This study suggests that melatonin, which can easily cross BBB, alleviates SAH-induced oxidative stress and exerts neuroprotection by preserving BBB permeability and by reducing brain edema...
  89. doi request reprint Protective and therapeutic effects of resveratrol on acetic acid-induced gastric ulcer
    Ali Solmaz
    Department of General Surgery, Marmara University School of Medicine, Istanbul, Turkey
    Free Radic Res 43:594-603. 2009
    ....
  90. ncbi request reprint Resveratrol protects against methotrexate-induced hepatic injury in rats
    Tugba Tunali-Akbay
    Marmara University School of Dentistry, Department of Biochemistry, Istanbul, Turkey
    J Pharm Pharm Sci 13:303-10. 2010
    ..We hypothesized that resveratrol has a potential to decrease the oxidant damage in MTX-induced hepatic injury...
  91. ncbi request reprint Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury
    Hale Z Toklu
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad, 34668 Istanbul, Turkey
    Burns 33:908-16. 2007
    ..Major thermal injury induces the activation of an inflammatory cascade resulting in local tissue damage, to contribute to the development of subsequent damage of multiple organs distant from the original burn wound...
  92. doi request reprint The protective effect of alpha lipoic acid against traumatic brain injury in rats
    Hale Z Toklu
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Free Radic Res 43:658-67. 2009
    ..These findings suggest that LA exerts neuroprotection by preserving BBB permeability and by reducing brain oedema probably by its anti-inflammatory and antioxidant properties in the TBI model...
  93. doi request reprint Betulinic acid protects against ischemia/reperfusion-induced renal damage and inhibits leukocyte apoptosis
    Emel Eksioglu-Demiralp
    Marmara University, School of Medicine, Department of Hematology and Immunology, Istanbul, Turkey
    Phytother Res 24:325-32. 2010
    ..In conclusion, these data suggest that betulinic acid attenuates I/R-induced oxidant responses, improved microscopic damage and renal function by regulating the apoptotic function of leukocytes and inhibiting neutrophil infiltration...
  94. doi request reprint Protective effects of pycnogenol against ischemia reperfusion-induced oxidative renal injury in rats
    Ahmet Ozer Sehirli
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Ren Fail 31:690-7. 2009
    ..Oxygen free radicals are involved in pathophysiology of ischemia/reperfusion (I/R) injury. This study was designed to assess the possible protective effect of pycnogenol (PYC) against I/R-induced oxidative renal damage...
  95. ncbi request reprint Protective effect of MESNA (2-mercaptoethane sulfonate) against hepatic ischemia/reperfusion injury in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Tibbiye Cad, 34668 Istanbul, Turkey
    Surg Today 35:575-80. 2005
    ..We evaluated the possible protective effect of 2-mercaptoethane sulfonate (MESNA) on hepatic ischemia/reperfusion (I/R) injury...
  96. ncbi request reprint Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats
    Sevgin Ozlem Iseri
    Marmara University, School of Medicine, Department of Physiology, Haydarpasa, Istanbul 34668, Turkey
    Regul Pept 146:73-9. 2008
    ..Reactive oxygen species and oxidative stress are implicated in hepatic stellate cell activation and liver fibrosis, which are initiated by recruitment of inflammatory cells and by activation of cytokines...
  97. doi request reprint Allopurinol improves endothelial function and reduces oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome
    Omer Yiginer
    Gumussuyu Military Hospital, Istanbul, Turkey
    Clin Res Cardiol 97:334-40. 2008
    ....
  98. doi request reprint Antioxidative and lipid lowering effects of 7,8-dihydroxy-3- (4-methylphenyl) coumarin in hyperlipidemic rats
    Basak Yuce
    Marmara University, Faculty of Science and Letters, Department of Chemistry, Goztepe, Istanbul, Turkey
    Arzneimittelforschung 59:129-34. 2009
    ..As a conclusion DHMPC displayed both antioxidant and lipid lowering effects and can be a candidate drug for further studies...
  99. ncbi request reprint Antioxidant effect of alpha-lipoic acid against ethanol-induced gastric mucosal erosion in rats
    Ozer Sehirli
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    Pharmacology 81:173-80. 2008
    ..This investigation elucidates the role of free radicals in ethanol-induced gastric mucosal erosion and the protective effect of lipoic acid...
  100. doi request reprint Oxytocin treatment alleviates stress-aggravated colitis by a receptor-dependent mechanism
    Sule Cetinel
    Marmara University, School of Medicine, Department of Histology and Embryology, Istanbul, Turkey
    Regul Pept 160:146-52. 2010
    ..Thus, the results showed that the anxiolytic and antioxidant effects of OT are mediated via its receptors, since atosiban reversed the protective impact of OT on colonic injury while blocking its stress-relieving effect...
  101. ncbi request reprint Protective effect of melatonin and omeprazole against alendronat-induced gastric damage
    Goksel Sener
    School of Pharmacy, Department of Pharmacology, Marmara University, Haydarpasa, Istanbul, Turkey
    Dig Dis Sci 50:1506-12. 2005
    ..Findings of the present study suggest that alendronate induces oxidative gastric damage by a local irritant effect and that melatonin and omeprazole are protective against this damage due to their antioxidant properties...