A G Shaikh

Summary

Publications

  1. doi request reprint Motion Illusion-Evidence towards Human Vestibulo-Thalamic Projections
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH, USA
    Cerebellum . 2017
  2. ncbi request reprint Cervical dystonia: a neural integrator disorder
    Aasef G Shaikh
    1 Department of Neurology, Case Western Reserve University, Cleveland, OH, USA 2 Daroff DelOsso Ocular Motility Laboratory, Neurology Service, Louis Stoke VA Medical Center, Cleveland, OH, USA
    Brain 139:2590-2599. 2016
  3. pmc Impaired Motor Learning in a Disorder of the Inferior Olive: Is the Cerebellum Confused?
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, 44110, USA
    Cerebellum 16:158-167. 2017
  4. doi request reprint Opsoclonus in a patient with increased titers of anti-GAD antibody provides proof for the conductance-based model of saccadic oscillations
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH, United States Daroff DelOsso Ocular Motility Laboratory and Neurology Service, Cleveland VA Medical Center, Cleveland, OH, United States Electronic address
    J Neurol Sci 362:169-73. 2016
  5. doi request reprint Misdirected horizontal saccades in pan-cerebellar atrophy
    Aasef G Shaikh
    Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, United States Electronic address
    J Neurol Sci 355:125-30. 2015
  6. pmc Why are voluntary head movements in cervical dystonia slow?
    Aasef G Shaikh
    Department of Neurology, Emory University, Atlanta, GA, USA Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA Electronic address
    Parkinsonism Relat Disord 21:561-6. 2015
  7. pmc Temporal profile of improvement of tardive dystonia after globus pallidus deep brain stimulation
    Aasef G Shaikh
    Department of Neurology, Emory University, Atlanta, GA, USA Electronic address
    Parkinsonism Relat Disord 21:116-9. 2015
  8. pmc Globus pallidus deep brain stimulation for adult-onset axial dystonia
    Aasef G Shaikh
    Department of Neurology, Emory University, Atlanta, GA, USA Electronic address
    Parkinsonism Relat Disord 20:1279-82. 2014
  9. doi request reprint Gaze holding after anterior-inferior temporal lobectomy
    Aasef G Shaikh
    Department of Neurology, Emory University, 1841 Clifton Road, NE, Suite 350, Atlanta, GA, 30329 4021, USA
    Neurol Sci 35:1749-56. 2014
  10. doi request reprint Motion perception without Nystagmus--a novel manifestation of cerebellar stroke
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, Ohio Electronic address
    J Stroke Cerebrovasc Dis 23:1148-56. 2014

Detail Information

Publications25

  1. doi request reprint Motion Illusion-Evidence towards Human Vestibulo-Thalamic Projections
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH, USA
    Cerebellum . 2017
    ....
  2. ncbi request reprint Cervical dystonia: a neural integrator disorder
    Aasef G Shaikh
    1 Department of Neurology, Case Western Reserve University, Cleveland, OH, USA 2 Daroff DelOsso Ocular Motility Laboratory, Neurology Service, Louis Stoke VA Medical Center, Cleveland, OH, USA
    Brain 139:2590-2599. 2016
    ..We hypothesize that changing the activity in an impaired head neural integrator, by modulating feedback, could treat dystonia...
  3. pmc Impaired Motor Learning in a Disorder of the Inferior Olive: Is the Cerebellum Confused?
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, 44110, USA
    Cerebellum 16:158-167. 2017
    ....
  4. doi request reprint Opsoclonus in a patient with increased titers of anti-GAD antibody provides proof for the conductance-based model of saccadic oscillations
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH, United States Daroff DelOsso Ocular Motility Laboratory and Neurology Service, Cleveland VA Medical Center, Cleveland, OH, United States Electronic address
    J Neurol Sci 362:169-73. 2016
    ..We propose that opsoclonus might be due to increased levels of glutamate and subsequent hyperexcitability of excitatory and inhibitory burst neurons leading to reverberation in their reciprocally innervating circuit. ..
  5. doi request reprint Misdirected horizontal saccades in pan-cerebellar atrophy
    Aasef G Shaikh
    Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, United States Electronic address
    J Neurol Sci 355:125-30. 2015
    ..We speculate that upward drift might result from an imbalance in opposing orthogonal signals at the level of neural integrators. ..
  6. pmc Why are voluntary head movements in cervical dystonia slow?
    Aasef G Shaikh
    Department of Neurology, Emory University, Atlanta, GA, USA Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA Electronic address
    Parkinsonism Relat Disord 21:561-6. 2015
    ..Such slowing is typically measured as an increase in time to complete a movement. The mechanisms responsible for this slowing are poorly understood...
  7. pmc Temporal profile of improvement of tardive dystonia after globus pallidus deep brain stimulation
    Aasef G Shaikh
    Department of Neurology, Emory University, Atlanta, GA, USA Electronic address
    Parkinsonism Relat Disord 21:116-9. 2015
    ..Whether different subtypes or distributions of tardive dystonia are associated with different outcomes remains unknown...
  8. pmc Globus pallidus deep brain stimulation for adult-onset axial dystonia
    Aasef G Shaikh
    Department of Neurology, Emory University, Atlanta, GA, USA Electronic address
    Parkinsonism Relat Disord 20:1279-82. 2014
    ..There is a paucity of investigations probing the impact of DBS on adult-onset axial dystonia. We assessed the efficacy of GPi DBS in four patients with rare adult-onset axial dystonia...
  9. doi request reprint Gaze holding after anterior-inferior temporal lobectomy
    Aasef G Shaikh
    Department of Neurology, Emory University, 1841 Clifton Road, NE, Suite 350, Atlanta, GA, 30329 4021, USA
    Neurol Sci 35:1749-56. 2014
    ..Vision might be used to calibrate such feedback, hence the lack of visual cue further impairs the function of the neural integrator leading to worsening of gaze-holding deficits. ..
  10. doi request reprint Motion perception without Nystagmus--a novel manifestation of cerebellar stroke
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, Ohio Electronic address
    J Stroke Cerebrovasc Dis 23:1148-56. 2014
    ....
  11. doi request reprint Gravity-dependent nystagmus and inner-ear dysfunction suggest anterior and posterior inferior cerebellar artery infarct
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, Ohio Electronic address
    J Stroke Cerebrovasc Dis 23:788-90. 2014
    ..However, the gravity-dependent nystagmus allows prompt identification of acute cerebellar infarct. ..
  12. doi request reprint Effects of 4-aminopyridine on nystagmus and vestibulo-ocular reflex in ataxia-telangiectasia
    Aasef G Shaikh
    Department of Neurology, Emory University School of Medicine, Wesley Woods Health Center, 1841 Clifton Road, NE, Suite 350, Atlanta, GA, 30329 4021, USA
    J Neurol 260:2728-35. 2013
    ..We conclude that in subjects with A-T 4-AP has a prominent effect on the ocular motor and vestibular deficits that are ascribed to the loss of cerebellar Purkinje neurons. ..
  13. pmc Keeping your head on target
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurosci 33:11281-95. 2013
    ....
  14. doi request reprint Acute onset of upbeat nystagmus, exotropia, and internuclear ophthalmoplegia--a tell-tale of ponto-mesencephalic infarct
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH 44110, USA
    J Neurol Sci 332:56-8. 2013
    ..We propose that constellation of acute onset of upbeat nystagmus, INO, and exotropia in patients with vascular risk factors might be unequivocal manifestation of the ponto-mesencephalic stroke. ..
  15. doi request reprint Physiology and pathology of saccades and gaze holding
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH 44106 5040, USA
    NeuroRehabilitation 32:493-505. 2013
    ..Foveation is the fundamental requirement for clear vision. Saccades rapidly shift the gaze to the interesting target while gaze holding ensures foveation of the desired object...
  16. doi request reprint Fosphenytoin induced transient pendular nystagmus
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH, USA
    J Neurol Sci 330:121-2. 2013
    ..Such delays in the feedback between the cerebellum and the oculomotor neural integrator may cause instability of the integrator. An improvement in the conduction delay following post-ictal recovery may resolve the pendular nystagmus...
  17. doi request reprint The floccular syndrome in herpes simplex type 1 encephalitis
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH, United States
    J Neurol Sci 325:154-5. 2013
    ..Cerebrospinal fluid polymerase chain reaction confirmed HSV1 infection. Encephalopathy and downbeat nystagmus gradually improved with acyclovir therapy...
  18. pmc Role of cerebellum in motion perception and vestibulo-ocular reflex-similarities and disparities
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH 44106 5040, USA
    Cerebellum 12:97-107. 2013
    ....
  19. doi request reprint Forskolin induced increase in spontaneous activity of auditory brainstem neurons is comparable to acoustic stimulus evoked responses
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH, United States
    Neurosci Lett 531:69-73. 2012
    ..Forskolin induced increase in spontaneous neural activity was comparable to supra-threshold tone evoke neural responses. These results are viewed in context of hyperexcitability as a correlate of tinnitus...
  20. doi request reprint A trail of artificial vestibular stimulation: electricity, heat, and magnet
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurophysiol 108:1-4. 2012
    ..Here I discuss several implications of this unique and noninvasive way to stimulate the vestibular system in experimental neurophysiology and clinical neurology...
  21. doi request reprint Atypical forms of Guillain-Barré syndrome and H1N1-influenza vaccination
    Aasef G Shaikh
    Department of Neurology, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106 5040, United States
    Vaccine 30:3251-4. 2012
    ..However, epidemiological studies with large cohorts are necessary to confirm excess cases of atypical GBS after H1N1-influenza vaccination...
  22. pmc Irregularity distinguishes limb tremor in cervical dystonia from essential tremor
    A G Shaikh
    Department of Neurology, The Johns Hopkins Hospital, 600 North Wolfe Street, Pathology 2 210, Baltimore, MD 21287, USA
    J Neurol Neurosurg Psychiatry 79:187-9. 2008
    ..Whether a common central mechanism underlies the tremor in these conditions is unknown. We addressed this issue by quantifying limb tremor in 19 patients with CD and 35 patients with ET...
  23. doi request reprint Ataxia telangiectasia: a "disease model" to understand the cerebellar control of vestibular reflexes
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurophysiol 105:3034-41. 2011
    ..It may also be of value to the design of treatment trials as a surrogate biomarker of cerebellar function that does not require controlling for motivation or occult changes in motor strategy on the part of experimental subjects...
  24. doi request reprint Gaze fixation deficits and their implication in ataxia-telangiectasia
    A G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, USA
    J Neurol Neurosurg Psychiatry 80:858-64. 2009
    ..Unstable fixation often leads to difficulty reading and blurred vision. Here we characterise the disturbance of visual fixation in A-T...