A M A Nasirudeen

Summary

Affiliation: National University of Singapore
Country: Singapore

Publications

  1. ncbi request reprint Cell death and human intestinal protozoa: a brief overview
    A M A Nasirudeen
    Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597
    Curr Issues Intest Microbiol 6:77-82. 2005
  2. pmc RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection
    A M A Nasirudeen
    Institute of Molecular and Cell Biology, Singapore, Singapore
    PLoS Negl Trop Dis 5:e926. 2011
  3. ncbi request reprint Protozoan programmed cell death--insights from Blastocystis deathstyles
    Kevin S W Tan
    Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597
    Trends Parasitol 21:547-50. 2005
  4. doi request reprint Gene expression profiling by microarray analysis reveals an important role for caspase-1 in dengue virus-induced p53-mediated apoptosis
    A M A Nasirudeen
    Institute of Molecular and Cell Biology, Proteos, Singapore, Singapore
    J Med Virol 81:1069-81. 2009
  5. ncbi request reprint Caspase-3-like protease influences but is not essential for DNA fragmentation in Blastocystis undergoing apoptosis
    A M A Nasirudeen
    Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore
    Eur J Cell Biol 83:477-82. 2004
  6. ncbi request reprint Programmed cell death in Blastocystis hominis occurs independently of caspase and mitochondrial pathways
    A M A Nasirudeen
    Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore
    Biochimie 87:489-97. 2005
  7. doi request reprint Induction of p53-dependent and mitochondria-mediated cell death pathway by dengue virus infection of human and animal cells
    A M A Nasirudeen
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos 138673, Singapore
    Microbes Infect 10:1124-32. 2008
  8. ncbi request reprint Isolation and characterization of the mitochondrion-like organelle from Blastocystis hominis
    A M A Nasirudeen
    Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, 117597 Singapore
    J Microbiol Methods 58:101-9. 2004
  9. ncbi request reprint Metronidazole induces programmed cell death in the protozoan parasite Blastocystis hominis
    A M A Nasirudeen
    Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597
    Microbiology 150:33-43. 2004

Detail Information

Publications9

  1. ncbi request reprint Cell death and human intestinal protozoa: a brief overview
    A M A Nasirudeen
    Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597
    Curr Issues Intest Microbiol 6:77-82. 2005
    ..Understanding conserved cell death pathways in the intestinal protozoa and their host-parasite PCD relationship may lead to drug targets which can be used for a broad range of parasitic diseases...
  2. pmc RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection
    A M A Nasirudeen
    Institute of Molecular and Cell Biology, Singapore, Singapore
    PLoS Negl Trop Dis 5:e926. 2011
    ..Collectively, our studies demonstrate that the intracellular RNA virus sensors (RIG-I, MDA5 and TLR3) are activated upon DV infection and are essential for host defense against the virus...
  3. ncbi request reprint Protozoan programmed cell death--insights from Blastocystis deathstyles
    Kevin S W Tan
    Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597
    Trends Parasitol 21:547-50. 2005
    ..Recent observations of PCD pathways in Blastocystis suggest that this protozoan, as is the case with its multicellular counterparts, possesses complex cell-death mechanisms...
  4. doi request reprint Gene expression profiling by microarray analysis reveals an important role for caspase-1 in dengue virus-induced p53-mediated apoptosis
    A M A Nasirudeen
    Institute of Molecular and Cell Biology, Proteos, Singapore, Singapore
    J Med Virol 81:1069-81. 2009
    ..Gene silencing of caspase-1 or inhibition of caspase-1 activity led to reduction in dengue virus-induced apoptosis with minimal effect on virus replication...
  5. ncbi request reprint Caspase-3-like protease influences but is not essential for DNA fragmentation in Blastocystis undergoing apoptosis
    A M A Nasirudeen
    Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore
    Eur J Cell Biol 83:477-82. 2004
    ..hominis is not wholly dependent on caspase-3-like protease activity and is associated with mitochondrial dysregulation. This is the first report showing evidence for complex apoptotic pathways in a unicellular parasite...
  6. ncbi request reprint Programmed cell death in Blastocystis hominis occurs independently of caspase and mitochondrial pathways
    A M A Nasirudeen
    Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore
    Biochimie 87:489-97. 2005
    ..This study sheds new light on the conserved nature of PCD pathways in parasitic protozoa and is also the first report describing caspase- and mitochondria-independent cell death pathways in a protozoan parasite...
  7. doi request reprint Induction of p53-dependent and mitochondria-mediated cell death pathway by dengue virus infection of human and animal cells
    A M A Nasirudeen
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos 138673, Singapore
    Microbes Infect 10:1124-32. 2008
    ....
  8. ncbi request reprint Isolation and characterization of the mitochondrion-like organelle from Blastocystis hominis
    A M A Nasirudeen
    Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, 117597 Singapore
    J Microbiol Methods 58:101-9. 2004
    ..The role of MLO in this anaerobic protozoan can be widely investigated using this protocol...
  9. ncbi request reprint Metronidazole induces programmed cell death in the protozoan parasite Blastocystis hominis
    A M A Nasirudeen
    Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597
    Microbiology 150:33-43. 2004
    ..hominis central vacuole in PCD; it acts as a repository where apoptotic bodies are stored before being released into the extracellular space. The implications and possible roles of PCD in B. hominis are discussed...