Bhupesh S Samant

Summary

Affiliation: Rhodes University
Country: South Africa

Publications

  1. doi Novel naphthoquinone derivatives: synthesis and activity against human African trypanosomiasis
    Bhupesh S Samant
    Natural Product and Medicinal Chemistry Research Group, Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa
    Bioorg Med Chem Lett 23:1420-3. 2013
  2. doi A novel microwave synthesis of quinoline-3-carboxylic acid derivatives for treatment against human African trypanosomiasis
    Bhupesh S Samant
    Natural Product and Medicinal Chemistry Research Group, Division of Pharmaceutical Chemistry, Rhodes University, Grahamstown 6140, South Africa
    Mol Divers 16:685-95. 2012
  3. doi Hydrogenolysis-hydrogenation of aryl ethers: selectivity pattern
    Bhupesh S Samant
    Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa
    Chem Commun (Camb) 48:8658-60. 2012
  4. doi Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis
    Bhupesh S Samant
    Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa
    Bioorg Med Chem Lett 21:1015-8. 2011
  5. doi A novel catalytic process for trifluoromethylation of bromoaromatic compounds
    Bhupesh S Samant
    Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa
    Chem Commun (Camb) 47:7236-8. 2011

Detail Information

Publications5

  1. doi Novel naphthoquinone derivatives: synthesis and activity against human African trypanosomiasis
    Bhupesh S Samant
    Natural Product and Medicinal Chemistry Research Group, Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa
    Bioorg Med Chem Lett 23:1420-3. 2013
    ..Two derivatives of naphthoquinone (9b and 9c) exhibited potent activity against Trypanosoma brucei in vitro with low cytotoxicity...
  2. doi A novel microwave synthesis of quinoline-3-carboxylic acid derivatives for treatment against human African trypanosomiasis
    Bhupesh S Samant
    Natural Product and Medicinal Chemistry Research Group, Division of Pharmaceutical Chemistry, Rhodes University, Grahamstown 6140, South Africa
    Mol Divers 16:685-95. 2012
    ..The combination of electron withdrawing and donating groups in the structure seems to be the crucial factor to inhibit T. brucei...
  3. doi Hydrogenolysis-hydrogenation of aryl ethers: selectivity pattern
    Bhupesh S Samant
    Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa
    Chem Commun (Camb) 48:8658-60. 2012
    ..The selectivity pattern of nickel-catalyzed hydrogenolysis-hydrogenation of aryl ethers has been studied in the micellar media. The micellar conditions selectively formed arenes and alcohols with enhanced yields...
  4. doi Compounds containing 2-substituted imidazole ring for treatment against human African trypanosomiasis
    Bhupesh S Samant
    Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa
    Bioorg Med Chem Lett 21:1015-8. 2011
    ..brucei in vitro with low cytotoxicity and good solubility. The presence of the NO(2) group at the 5-position of the imidazole ring in 2-substituted imidazoles is the crucial factor to inhibit T. brucei...
  5. doi A novel catalytic process for trifluoromethylation of bromoaromatic compounds
    Bhupesh S Samant
    Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa
    Chem Commun (Camb) 47:7236-8. 2011
    ..The micellar conditions result in enhanced yields and are applicable to bromoaromatics with ketone, aldehyde, hydroxyl and amine functionalities...