Justo Aznar

Summary

Country: Spain

Publications

  1. ncbi Risk of venous thrombosis in carriers of the prothrombin G20210A variant and factor V Leiden and their interaction with oral contraceptives
    J Aznar
    Department of Clinical Pathology, La Fe University Hospital, Avda Campanar 21, 46009 Valencia, Spain
    Haematologica 85:1271-6. 2000
  2. ncbi Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke
    Justo Aznar
    La Fe University Hospital, Department of Clinical Pathology, Avd Campanar 21, 46009 Valencia, Spain
    Thromb Haemost 91:1031-4. 2004
  3. ncbi Is family history sufficient to identify women with risk of venous thromboembolism before commencing the contraceptive pill?
    Justo Aznar
    Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Appl Thromb Hemost 8:139-41. 2002
  4. ncbi Congenital and acquired thrombotic risk factors in women using oral contraceptives: clinical aspects
    Y Mira
    Department of Clinical Pathology, Hospital La Fe, Valencia, Spain
    Clin Appl Thromb Hemost 6:162-8. 2000
  5. ncbi Thrombophilic risk factors and homocysteine levels in Behçet's disease in eastern Spain and their association with thrombotic events
    Jose Ma Ricart
    Dermatology Service, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 95:618-24. 2006
  6. ncbi Prothrombin G20210A mutation and oral contraceptive use increase upper-extremity deep vein thrombotic risk
    Amparo Vaya
    Thrombosis and Hemostasis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 89:452-7. 2003
  7. ncbi Influence of plasma and erythrocyte factors on red blood cell aggregation in survivors of acute myocardial infarction
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 91:354-9. 2004
  8. ncbi Effect of a hypocaloric diet on lipids and rheological profile in subjects with severe and morbid obesity. A follow-up study
    Eva Sola
    Endocrinology Service, Dr Peset Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 30:419-22. 2004
  9. ncbi Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor and circulating activated protein C levels, and thrombotic risk
    Pilar Medina
    Research Center, La Fe University Hosptial, Valencia, Spain
    Thromb Haemost 91:905-11. 2004
  10. ncbi Effect of atorvastatin upon platelet activation in hypercholesterolemia, evaluated by flow cytometry
    Manuel Labiós
    Department of Internal Medicine, Clinic University Hospital, Valencia, Spain
    Thromb Res 115:263-70. 2005

Collaborators

Detail Information

Publications74

  1. ncbi Risk of venous thrombosis in carriers of the prothrombin G20210A variant and factor V Leiden and their interaction with oral contraceptives
    J Aznar
    Department of Clinical Pathology, La Fe University Hospital, Avda Campanar 21, 46009 Valencia, Spain
    Haematologica 85:1271-6. 2000
    ..Moreover, the influence of oral contraceptives (OC) on thrombotic events in patients with the prothrombin G20210A variant has not been well established. In this study we evaluate both circumstances...
  2. ncbi Factor V Leiden and prothrombin G20210A mutations in young adults with cryptogenic ischemic stroke
    Justo Aznar
    La Fe University Hospital, Department of Clinical Pathology, Avd Campanar 21, 46009 Valencia, Spain
    Thromb Haemost 91:1031-4. 2004
    ..OC use is also a significant risk factor for cryptogenic stroke, which is increased in women with some genetic thrombotic risk factor...
  3. ncbi Is family history sufficient to identify women with risk of venous thromboembolism before commencing the contraceptive pill?
    Justo Aznar
    Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Appl Thromb Hemost 8:139-41. 2002
    ..Only 16% of these women had family history which is why in our opinion, it is not a sufficient safeguard to recommending the use of OCs...
  4. ncbi Congenital and acquired thrombotic risk factors in women using oral contraceptives: clinical aspects
    Y Mira
    Department of Clinical Pathology, Hospital La Fe, Valencia, Spain
    Clin Appl Thromb Hemost 6:162-8. 2000
    ..Moreover, if a patient develops a thrombotic complication while taking OC, an evaluation to search for a thrombophilic defect is warranted, and at the same time, alternative methods of contraception should be considered...
  5. ncbi Thrombophilic risk factors and homocysteine levels in Behçet's disease in eastern Spain and their association with thrombotic events
    Jose Ma Ricart
    Dermatology Service, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 95:618-24. 2006
    ..When studies from Turkey were excluded from the meta-analysis, only the prothrombin G20210A mutation was associated with thrombosis...
  6. ncbi Prothrombin G20210A mutation and oral contraceptive use increase upper-extremity deep vein thrombotic risk
    Amparo Vaya
    Thrombosis and Hemostasis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 89:452-7. 2003
    ....
  7. ncbi Influence of plasma and erythrocyte factors on red blood cell aggregation in survivors of acute myocardial infarction
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 91:354-9. 2004
    ..Our results suggest that plasma lipids, predominantly triglycerides, and fibrinogen may not only enhance the development of ischaemic events by their recognized atherogenic mechanisms, but also by increasing EA...
  8. ncbi Effect of a hypocaloric diet on lipids and rheological profile in subjects with severe and morbid obesity. A follow-up study
    Eva Sola
    Endocrinology Service, Dr Peset Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 30:419-22. 2004
    ..However a LCD alone does not produce a further decrease in weight and both lipids and erythrocyte aggregation return to the basal situation at three months...
  9. ncbi Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor and circulating activated protein C levels, and thrombotic risk
    Pilar Medina
    Research Center, La Fe University Hosptial, Valencia, Spain
    Thromb Haemost 91:905-11. 2004
    ....
  10. ncbi Effect of atorvastatin upon platelet activation in hypercholesterolemia, evaluated by flow cytometry
    Manuel Labiós
    Department of Internal Medicine, Clinic University Hospital, Valencia, Spain
    Thromb Res 115:263-70. 2005
    ..65+/-6.43% to 75.84+/-4.89%, p<0.01). A significant correlation can be seen between such normalization and the decrease in plasma levels of total and LDL cholesterol...
  11. ncbi Plasminogen activator inhibitor-1 4G/5G polymorphism in breast cancer patients and its association with tissue PAI-1 levels and tumor severity
    Remedios Castello
    Hospital Universitario La Fe, Centro de Investigación Avda Campanar 21, 46009 Valencia, Spain
    Thromb Res 117:487-92. 2006
    ..In this study, we analyzed the influence of the PAI-1 4G/5G polymorphism on tissue PAI-1 levels and its association with tumor severity in women with breast cancer...
  12. ncbi Activated protein C levels in Behçet's disease and risk of venous thrombosis
    Silvia Navarro
    Research Centre, Hospital Universitario La Fe, Valencia, Spain
    Br J Haematol 126:550-6. 2004
    ..1; 95% confidence interval = 1.1-23.4). These results show that reduced APC levels are associated with the high incidence of VTE in Behçet's disease...
  13. ncbi Sialic acid is an inflammation marker associated with a history of deep vein thrombosis
    Edelmiro Reganon
    Research Centre, La Fe University Hospital, Avenida Campanar 21, 46009 Valencia, Spain
    Thromb Res 119:73-8. 2007
    ..The aim of this study was to investigate whether or not increased levels of TSA are associated with a history of DVT and with inflammation and coagulation markers, as well as with the lipid profile...
  14. ncbi Haemorheological alterations in Behçet's disease are not related to a tendency for venous thrombosis
    Jose Ma Ricart
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Thromb Res 115:399-404. 2005
    ..Alterations in blood rheology, particularly increased erythrocyte aggregation, might play a role in the development of such thrombotic events...
  15. pmc Aspirin therapy for inhibition of platelet reactivity in the presence of erythrocytes in patients with vascular disease
    M Teresa Santos
    Research Center, Hospital Universitario La Fe, Valencia, Spain
    J Lab Clin Med 147:220-7. 2006
    ....
  16. ncbi Effect of doxazosin gastrointestinal therapeutic system on platelet degranulation and platelet-leukocyte microaggregate formation induced by physiologic shear stress in hypertension
    Manuel Labiós
    Flow Cytometry Unit, Clinical Pathology Department, La Fe University Hospital, Avda Campanar 21, 46009 Valencia, Spain
    Thromb Res 118:447-53. 2006
    ..In this prospective, ex vivo, single-blind study, the effect of doxazosin on platelet function was studied in patients with hypertension...
  17. ncbi Partial inhibition of platelet thromboxane A2 synthesis by aspirin is associated with myonecrosis in patients with ST-segment elevation myocardial infarction
    Juana Valles
    Research Center, University Hospital La Fe, Valencia, Spain
    Am J Cardiol 99:19-25. 2007
    ..This study describes, for the first time, the association of partial platelet TXA(2) inhibition with myonecrosis...
  18. ncbi Do hemorheological alterations play any role in the development of thrombotic events in Behçet's disease?
    Amparo Vaya
    Thrombosis and Hemorheology Unit, La Fe University Hospital, Department of Clinical Pathology, Valencia, Spain
    Clin Hemorheol Microcirc 30:411-4. 2004
    ..Our results suggest that rheological alterations do not seem to play any role in the development of thrombotic events in patients with Behçet's disease...
  19. ncbi Rheological profile in severe and morbid obesity. Preliminary results
    Eva Sola
    Endocrinology Service, Dr Peset Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 30:415-8. 2004
    ....
  20. ncbi Hyperlipidaemia and venous thromboembolism in patients lacking thrombophilic risk factors
    Amparo Vaya
    Thrombosis and Hemostasis Unit, Department of Clinical Pathology, Thrombosis Research Center, La Fe University Hospital, Valencia, Spain
    Br J Haematol 118:255-9. 2002
    ..In addition, cholesterolaemia levels of >or= 5.69 mmol/l constitute an independent risk factor for idiopathic DVT...
  21. ncbi Effect of eprosartan on cytoplasmic free calcium mobilization, platelet activation, and microparticle formation in hypertension
    Manuel Labiós
    Hypertension Unit, Valencia University Clinic Hospital, Valencia, Spain
    Am J Hypertens 17:757-63. 2004
    ..This study evaluated whether eprosartan can protect against undesirable platelet activation...
  22. ncbi Regulation of cytosolic PlA2 activity by PP1/PP2A serine/threonine phosphatases in human platelets
    Antonio Moscardo
    Research Center, University Hospital La Fe, Valencia, Spain
    Platelets 17:405-15. 2006
    ..Moreover, PP1/PP2A regulation of [Ca2+]i and tyrosine phosphorylation may be important for other calcium-dependent processes and/or signal transduction mechanisms in platelets...
  23. ncbi Association between inflammation and hemostatic markers in atherothrombotic stroke
    Edelmiro Reganon
    Research Center, La Fe University Hospital, Valencia, Spain
    Thromb Res 112:217-21. 2003
    ..The aim of this study was to evaluate the association of thrombogenic and inflammatory profiles in patients who have suffered a stroke...
  24. ncbi Erythrocyte aggregation in Behçet's disease determined with the Sefam and Myrenne aggregometer. Lack of association with thrombosis and uveitis
    Jose M Ricart
    Dermatology Service, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 33:389-96. 2005
    ..05). These results reinforce previous findings of our group, suggesting that EA does not seem to be involved in thrombotic events or in uveitis in BD patients...
  25. ncbi Influence of plasmatic lipids on the hemorheological profile in healthy adults
    Teresa Contreras
    Thrombosis and Hemorheology Unit, La Fe University Hospital, Department of Clinical Pathology, Valencia, Spain
    Clin Hemorheol Microcirc 30:423-5. 2004
    ....
  26. ncbi Menopause, hormone replacement therapy and hemorheology
    Amparo Vaya
    Thrombosis and Hemorheology Unit, La Fe University Hospital, Department of Clinical Pathology, Valencia, Spain
    Clin Hemorheol Microcirc 30:277-81. 2004
  27. ncbi Influence of fibrinogen levels on erythrocyte aggregation determined with the Myrenne aggregometer and the Sefam erythro-aggregometer
    Cristina Falco
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 33:145-51. 2005
    ....
  28. ncbi Thrombin-activatable fibrinolysis inhibitor in young patients with myocardial infarction and its relationship with the fibrinolytic function and the protein C system
    Esther Zorio
    Service of Cardiology, Research Centre and Department of Clinical Pathology, Hospital Universitario La Fe, Valencia, Spain
    Br J Haematol 122:958-65. 2003
    ..Patients have high TAFI Act with low TAFI Ag levels, probably because of an increased stability of TAFI related to a fibrinolytic hypofunction...
  29. ncbi PAI-1 promoter 4G/5G genotype as an additional risk factor for venous thrombosis in subjects with genetic thrombophilic defects
    R Segui
    The Research Centre, La Fe University Hospital, Valencia, Spain
    Br J Haematol 111:122-8. 2000
    ..In conclusion, the PAI-1 promoter polymorphism was found to have an influence on PAI-1 levels in DVT patients and on the risk of venous thrombosis in subjects with other genetic thrombophilic defects...
  30. ncbi Biological risk factors for deep vein trombosis
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 26:41-53. 2002
    ..05). Our results suggest that hypercholesterolemia and hyperfibrinogenemia should be added to the list of known DVT risk factors and we recommend adopting measures to decrease these variables in the population with a high risk of DVT...
  31. ncbi The role of the complexed-to-total prostate-specific antigen ratio in predicting the final pathological stage of clinically localized prostate cancer
    Manuel Martinez
    Department of Urology, La Fe University Hospital, Valencia, Spain
    Eur Urol 43:609-14. 2003
    ....
  32. ncbi Factor V Leiden and prothrombin G20210A in relation to arterial and/or vein rethrombosis: two cases
    Y Mira
    Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Appl Thromb Hemost 7:234-7. 2001
    ....
  33. ncbi Erythrocyte deformability in survivors of acute myocardial infarction measured by two different methodologies
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 27:17-25. 2002
    ..Red blood cell deformability does not appear to contribute to impaired microcirculatory blood flow in chronic coronary syndromes...
  34. ncbi Erythrocyte aggregation determined with the Myrenne aggregometer at two modes (M0, M1) and at two times (5 and 10 sec)
    Amparo Vaya
    Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 29:119-27. 2003
    ....
  35. ncbi Inherited abnormalities in the protein C activation pathway
    Francisco Espana
    Research Center, La Fe University Hospital, Valencia, Spain
    Pathophysiol Haemost Thromb 32:241-4. 2002
    ..Here, we describe the previously reported mutations in the TM and EPCR genes, and present the design and evaluation of a new strategy to investigate TM, EPCR, PC and prothrombin gene mutations in arterial and venous thrombosis...
  36. ncbi Erythrocyte promotion of platelet reactivity decreases the effectiveness of aspirin as an antithrombotic therapeutic modality: the effect of low-dose aspirin is less than optimal in patients with vascular disease due to prothrombotic effects of erythrocyt
    J Valles
    Research Center, University Hospital La Fe, Valencia, Spain
    Circulation 97:350-5. 1998
    ....
  37. ncbi Red blood cell deformability in iron deficiency anaemia
    Amparo Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 33:75-80. 2005
    ..Rheodyn SSD, as an ektacytometric technique, is very sensitive to alterations in red blood cell geometry, for what seems to be a useful tool for detecting diminished erythrocyte deformability in IDA patients...
  38. ncbi Inflammation, fibrinogen and thrombin generation in patients with previous myocardial infarction
    Edelmiro Reganon
    Research Center, La Fe University Hospital, Valencia, Spain
    Haematologica 87:740-5; discussion 745. 2002
    ..The aim of this study was to investigate the relationship between inflammatory activity, fibrinogen and thrombin generation in patients 5 years after the acute phase of myocardial infarction...
  39. ncbi Spontaneous renal subcapsular hematoma in an anticoagulated patient
    Fernando Ferrando
    Thrombosis and Haemostasis Unit, La Fe University Hospital, Valencia, Spain
    Clin Appl Thromb Hemost 12:89-92. 2006
    ..The patient was observed expectantly with serial abdominal computed tomography and abdominal ultrasound during her stay in the hospital. When diminution of the hematoma was detected, oral anticoagulation was resumed...
  40. ncbi Erythrocyte aggregability and disaggregability in thalassemia trait carriers analyzed by a laser backscattering technique
    C Falco
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 28:245-9. 2003
    ....
  41. ncbi Evaluation of an automated method for the quantification of von Willebrand factor antigen. Its application in the study of vascular dysfunction
    P Villa
    Department of Clinical Pathology, La Fe University Hospital, Avda Campanar 21, 46009 Valencia, Spain
    Haematologica 86:1180-5. 2001
    ..The aim of this study was to evaluate the performance characteristics of the immunoturbidimetric assay IL Test VWF:Ag and the use of this determination in the study of vascular dysfunction...
  42. ncbi mRNA analysis of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis using a real-time quantitative RT-PCR assay
    L Ramon
    Research Center, Hospital Universitario La Fe, Valencia, Spain
    Hum Reprod 20:272-8. 2005
    ..The aim of this study was to analyse mRNA and protein levels of several components of the PA and MMP systems in endometriotic tissue and endometrium from women with and without endometriosis. METHODS and..
  43. ncbi Relationship between fibrinogen protein and fibrinogen function in postmyocardial infarction patients
    E Reganon
    Research Center, La Fe University Hospital, Avda Campanar, 21 46009 Valencia, Spain
    Thromb Res 104:413-9. 2001
    ..The FgFI as an indicator of clotting potential of fibrinogen appears to be associated with ischemic events in chronic coronary artery disease...
  44. ncbi Factor V Leiden and antibodies against phospholipids and protein S in a young woman with recurrent thromboses and abortion
    F Espana
    Centro de Investigacion, Hospital Universitario La Fe, Valencia, Spain
    Haematologica 84:80-4. 1999
    ..The impairment of the protein C pathway at various points could well explain the recurrent thromboses in the patient and supports the role of a disturbed protein C system in the pathophysiology of thrombosis in patients with APAs...
  45. ncbi Plasma PAI-1 levels in obese children--effect of weight loss and influence of PAI-1 promoter 4G/5G genotype
    A Estelles
    Research Center, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 86:647-52. 2001
    ..In conclusion, a decrease in BMI in obese children shows a favourable effect on the fibrinolytic system due to a decrease in PAI-1 levels. However, no influence of 4G/5G genotype on PAI-1 levels was observed...
  46. ncbi The multifunctional protein C system
    F Espana
    Hospital Universitario La Fe, Centro de Investigacion, Av Campanar 21, 46009 Valencia, Spain
    Curr Med Chem Cardiovasc Hematol Agents 3:119-31. 2005
    ..This review will summarize the mechanisms that contribute to these biological activities of the protein C pathway...
  47. ncbi Effects of unfractionated and low molecular weight heparins on plasma levels of hemostatic factors in patients with acute coronary syndromes
    V Vila
    Research Center, La Fe University Hospital, Valencia, Spain
    Haematologica 86:729-34. 2001
    ..The purpose of the present study was to investigate the effect that treatment with either UFH or enoxaparin has on plasma hemostatic markers in 24 patients with ACS...
  48. ncbi The effect of acenocoumarol on hemorheological parameters
    A Vaya
    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 24:111-5. 2001
    ..These results suggest that acenocoumarol does not affect rheological parameters and can therefore be used as a "neutral drug" for rheological studies in cardiovascular patients under oral anticoagulant therapy...
  49. ncbi Spontaneous cervical epidural hematoma associated with oral anticoagulant therapy
    A Vaya
    Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Appl Thromb Hemost 7:166-8. 2001
    ..This unusual clinical entity definitely should be suspected in patients on anticoagulants who complain of severe localized neck pain, most often with radicular irradiation...
  50. ncbi Upper extremity deep vein thrombosis in a young patient double heterozygous for factor V Leiden and prothrombin G20210A mutation
    A Vaya
    Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
    Clin Appl Thromb Hemost 7:72-4. 2001
    ....
  51. ncbi Participation of tyrosine phosphorylation in cytoskeletal reorganization, alpha(IIb)beta(3) integrin receptor activation, and aspirin-insensitive mechanisms of thrombin-stimulated human platelets
    M T Santos
    Research Center and Department of Clinical Pathology, University Hospital La Fe, Valencia, Spain
    Circulation 102:1924-30. 2000
    ..We studied the participation of tyrosine kinases on these aspects of platelet reactivity and their importance in cyclooxygenase (COX)-1-independent mechanisms in thrombin-stimulated human platelets...
  52. ncbi Elevated high molecular weight fibrinogen in plasma is predictive of coronary ischemic events after acute myocardial infarction
    E Reganon
    Research Center, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 82:1403-5. 1999
    ..We conclude that after myocardial infarction an elevated plasma level of HMW-fibrinogen and a high FbFR value at the time of hospital admission are associated with new coronary ischemic events during a three-day follow-up period...
  53. ncbi Low level of circulating activated protein C is a risk factor for venous thromboembolism
    F Espana
    Research Center, La Fe University Hospital, Valencia, Spain
    Thromb Haemost 86:1368-73. 2001
    ..We conclude that a low level of circulating APC in individuals without any of the most recognized thrombophilic defects is a prevalent, independent risk factor for VTE, and that it predisposes to recurrent VTE...
  54. ncbi High and low molecular weight heparins do not modify red blood cell aggregability in vitro
    M Martinez
    Department of Clinical Pathology, University La Fe Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 23:67-70. 2000
    ..The results show that heparins do not increase this rheological parameter but show a slight tendency to lower it...
  55. ncbi Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis
    J Gilabert-Estelles
    Maternal Hospital, Hospital Universitario La Fe, Valencia, Spain
    Hum Reprod 18:1516-22. 2003
    ....
  56. ncbi Plasma lipids and blood fluidity in patients with polygenic hypercholesterolaemia treated with fluvastatin
    F Pinon
    Endocrinology and Nutrition Department, La Fe University Hospital, Valencia, Spain
    Clin Hemorheol Microcirc 27:193-9. 2002
    ..19+/-1.29) and increased plasma viscosity (1.26+/-0.06 vs 1.23+/-0.05 mPa.s). Notable lipid changes after 6 months fluvastatin treatment were not accompanied by measurable changes in the haemorheological alterations of the PHC patients...
  57. ncbi Changes in molecular forms of prostate-specific antigen during treatment with finasteride
    F Espana
    Research Center and Department of Urology, La Fe University Hospital, Valencia, Spain
    BJU Int 90:672-7. 2002
    ..To study the influence of finasteride treatment on the molecular forms of prostate-specific antigen (PSA) in patients with benign prostatic hyperplasia (BPH)...
  58. ncbi Quantitative real-time reverse transcription-PCR assay for urokinase plasminogen activator, plasminogen activator inhibitor type 1, and tissue metalloproteinase inhibitor type 1 gene expressions in primary breast cancer
    Remedios Castello
    Hospital Universitario La Fe, Centro de Investigacion, Avda Campanar 21, 46009 Valencia, Spain
    Clin Chem 48:1288-95. 2002
    ..The plasminogen activation system and matrix metalloproteinases (MMPs) play a key role in the degradation of basement membrane and extracellular matrix in tissue remodeling, cancer cell invasion, and metastasis...
  59. ncbi Effect of unfractionated heparin and a low molecular weight heparin (enoxaparin) on coagulant activity of cultured human endothelial cells
    Vicenta Martinez-Sales
    Centro de Investigacion, La Fe University Hospital, Valencia, Spain
    Haematologica 88:694-9. 2003
    ..We compared the influence of unfractionated heparin and enoxaparin on the anticoagulant function of cultured human endothelial cells...
  60. ncbi The proportion of prostate-specific antigen (PSA) complexed to alpha(1)-antichymotrypsin improves the discrimination between prostate cancer and benign prostatic hyperplasia in men with a total PSA of 10 to 30 microg/L
    Manuel Martinez
    Department of Urology, Research Center, La Fe University Hospital, 46009 Valencia, Spain
    Clin Chem 48:1251-6. 2002
    ....
  61. ncbi Flow cytometric analysis of platelet activation in hypertensive patients. Effect of doxazosin
    Manuel Labiós
    Hypertension Unit, Internal Medicine, Hospital Clinico Universitario, Valencia, Spain
    Thromb Res 110:203-8. 2003
    ..05; phosphatidylserine-positive results 0.3+/-0.2% vs. 0.7+/-0.4%, p<0.05). No significant differences were noted in GPIIb/IIIa*. The clinical significance of normalization of platelet activity by doxazosin remains to be established...
  62. ncbi Circulating activated protein C is reduced in young survivors of myocardial infarction and inversely correlates with the severity of coronary lesions
    E Zorio
    Department of Cardiology, Hospital Universitario La Fe, Centro de Investigacion, Av Campanar 21, 46009 Valencia, Spain
    J Thromb Haemost 4:1530-6. 2006
    ..As activated protein C (APC) provides systemic anticoagulant and anti-inflammatory protection, a low plasma APC level may be an arterial thrombotic risk factor...
  63. ncbi Platelet-erythrocyte interactions enhance alpha(IIb)beta(3) integrin receptor activation and P-selectin expression during platelet recruitment: down-regulation by aspirin ex vivo
    Juana Valles
    Research Center and Department of Clinical Pathology, University Hospital La Fe, Valencia, Spain
    Blood 99:3978-84. 2002
    ..We conclude that by these mechanisms, erythrocytes can actively contribute to platelet-driven thrombogenesis and microvascular occlusion...
  64. ncbi Fibrinolysis and lipoprotein(a) in women with coronary artery disease. Influence of hormone replacement therapy
    C Falco
    Research Center, La Fe University Hospital, Valencia, Spain
    Haematologica 86:92-8. 2001
    ..HRT could modify the cardiovascular risk via several mechanisms, including modifications in the fibrinolytic system and lipoprotein (a) levels. Our study was aimed at investigating some of these modifications...
  65. ncbi Enoxaparin-related fatal spontaneous retroperitoneal hematoma in the elderly
    Amparo Vaya
    Thromb Res 110:69-71. 2003
  66. ncbi Prothrombotic activity of oral contraceptives in patients with congenital thrombophilia
    Justo Aznar
    Clin Appl Thromb Hemost 8:91-2. 2002
  67. ncbi Erythrocyte aggregation and -455G/A polymorphism of the beta-fibrinogen gene in survivors of acute myocardial infarction
    Amparo Vaya
    Thromb Haemost 92:223-4. 2004
  68. ncbi Evolution of erythrocyte aggregation in transmural myocardial infarction survivors. A 12-month follow-up study
    Amparo Vaya
    Clin Hemorheol Microcirc 29:117-8. 2003
  69. ncbi Does obesity constitute a risk factor for upper-extremity deep vein thrombosis?
    Amparo Vaya
    Thromb Haemost 94:228-30. 2005
  70. ncbi Homozygous deficiency of heparin cofactor II: relevance of P17 glutamate residue in serpins, relationship with conformational diseases, and role in thrombosis
    Javier Corral
    University of Murcia, Centro Regional de Hemodonación de Murcia, Murcia, Spain
    Circulation 110:1303-7. 2004
    ..Recent data obtained in mice lacking HCII suggest that this serpin might inhibit thrombosis in the arterial circulation. However, the clinical relevance and molecular mechanisms associated with deficiency of HCII in humans are unclear...
  71. ncbi Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly)
    Katrin Hoffmann
    Gene Mapping Center, Max Delbrück Center for Molecular Medicine and Franz Volhard Clinic, HELIOS Klinikum, Charite, Humboldt University, Berlin, Germany
    Nat Genet 31:410-4. 2002
    ..Our findings have implications for understanding nuclear envelope-heterochromatin interactions, the pathogenesis of Pelger-like conditions in leukemia, infection and toxic drug reactions, and the evolution of neutrophil nuclear shape...
  72. ncbi Transient ischaemic attack associated with the new contraceptive Yasmin
    Amparo Vaya
    Thromb Res 112:121. 2003
  73. ncbi Is Yasmin as safe as other contraceptive pills?
    Yolanda Mira
    Clin Appl Thromb Hemost 12:378-9. 2006
  74. ncbi Oral contraceptives and thrombosis
    Justo Aznar
    Clin Appl Thromb Hemost 10:189-90. 2004