Ricardo Caballero

Summary

Country: Spain

Publications

  1. ncbi Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels
    Cristina Arias
    Institute of Pharmacology and Toxicology, CSIC UCM, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 57:660-9. 2003
  2. ncbi Pharmacological approaches in the treatment of atrial fibrillation
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Curr Med Chem 11:13-28. 2004
  3. ncbi Diltiazem inhibits hKv1.5 and Kv4.3 currents at therapeutic concentrations
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 64:457-66. 2004
  4. ncbi Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization
    Eva Delpón
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Trends Pharmacol Sci 26:155-61. 2005
  5. ncbi Investigational positive inotropic agents for acute heart failure
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Cardiovasc Hematol Disord Drug Targets 9:193-205. 2009
  6. ncbi Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040, Madrid, Spain
    Cardiovasc Res 62:86-95. 2004
  7. ncbi Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5)
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Cardiovasc Res 56:104-17. 2002
  8. pmc Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Proc Natl Acad Sci U S A 107:15631-6. 2010
  9. doi In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain
    J Am Coll Cardiol 55:2346-54. 2010
  10. ncbi Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Circulation 107:889-95. 2003

Collaborators

Detail Information

Publications46

  1. ncbi Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels
    Cristina Arias
    Institute of Pharmacology and Toxicology, CSIC UCM, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 57:660-9. 2003
    ..During chronic therapy, it undergoes extensive first-pass hepatic metabolism to 5-hydroxypropafenone. In the present study we have analysed the effects of propafenone and 5-hydroxypropafenone on HERG current...
  2. ncbi Pharmacological approaches in the treatment of atrial fibrillation
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Curr Med Chem 11:13-28. 2004
    ..The advantages and disadvantages of rhythm and rate control, the role pill in a pocket concept and the role of the new ADs are dicussed...
  3. ncbi Diltiazem inhibits hKv1.5 and Kv4.3 currents at therapeutic concentrations
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 64:457-66. 2004
    ..5 and Kv4.3 channels that generate the cardiac ultrarapid delayed rectifier (I(Kur)) and the 4-aminopyridine sensitive transient outward (I(to)) K(+) currents, respectively...
  4. ncbi Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization
    Eva Delpón
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Trends Pharmacol Sci 26:155-61. 2005
    ....
  5. ncbi Investigational positive inotropic agents for acute heart failure
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Cardiovasc Hematol Disord Drug Targets 9:193-205. 2009
    ..This review describes three new classes of investigational agents: levosimendan, a calcium sensitizer and potassium channel opener, istaroxime, the first new luso-inotropic agent and cardiac myosin activators...
  6. ncbi Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040, Madrid, Spain
    Cardiovasc Res 62:86-95. 2004
    ..In the present study, we examined whether angiotensin II (AngII) regulated the Ito as well as the putative intracellular cascade responsible for the effects...
  7. ncbi Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5)
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Cardiovasc Res 56:104-17. 2002
    ..5 channels in a voltage-dependent manner and modified the voltage-dependence of channel activation. The present study was undertaken to localize the putative binding sites involved in the 'agonists' and blocking effects of benzocaine...
  8. pmc Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Proc Natl Acad Sci U S A 107:15631-6. 2010
    ..Moreover, our findings provide noteworthy clues about the structural determinants of the C terminus cytoplasmic domain of Kir2.1 channels involved in the control of gating and rectification...
  9. doi In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain
    J Am Coll Cardiol 55:2346-54. 2010
    ..The purpose of this study was to compare the voltage-dependent K(+) currents of human cells of the right and left atria and determine whether electrical remodeling produced by chronic atrial fibrillation (CAF) is chamber-specific...
  10. ncbi Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Circulation 107:889-95. 2003
    ..In this study, the effects of SP and its metabolite, canrenoic acid (CA), on human ether-a-go-go-related gene (HERG) currents were analyzed...
  11. ncbi Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization
    Ignacio Moreno
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    J Pharmacol Exp Ther 304:862-73. 2003
    ..In hKv1.5, a receptor site is apparent on each alpha-subunit of the channel, whereas in HERG channels a common binding site is present at the pore...
  12. doi Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner
    Irene Amorós
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
    J Mol Cell Cardiol 48:201-10. 2010
    ..These results indicate that at low micromolar concentrations the endocannabinoids AEA and 2-AG directly block human cardiac Kv4.3 channels, which represent a novel molecular target for these compounds...
  13. doi Nitric oxide inhibits Kv4.3 and human cardiac transient outward potassium current (Ito1)
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 80:375-84. 2008
    ..3 (I(Kv4.3)) and on human transient outward K(+) (I(to1)) currents as well as the signalling pathways responsible for them. We also analysed the expression of NO synthase 3 (NOS3) in patients with CAF...
  14. pmc Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block
    Teresa Gonzalez
    Institute of Pharmacology and Toxicology, CSIC UCM, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Br J Pharmacol 137:1269-79. 2002
    ..All these results suggest that: (1) these drugs bind to the open and the inactivated states of HERG channels, (2) they stabilize HERG channels in the inactivated state, and (3) block induced by bupivacaine enantiomers is stereoselective...
  15. pmc Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channels
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 146:146-61. 2005
    ..Blockade of these cardiac K(+) currents, together with the antagonism of the aldosterone proarrhythmic effects produced by SP, might be highly desirable for the treatment of supraventricular arrhythmias...
  16. ncbi Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism
    Lucía Núñez
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 72:80-9. 2006
    ..5, which generates the ultrarapid delayed rectifier current (IKur) that determines the height and duration of atrial action potentials...
  17. doi Chronic atrial fibrillation up-regulates β1-Adrenoceptors affecting repolarizing currents and action potential duration
    Marta González de la Fuente
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid 28040, Spain
    Cardiovasc Res 97:379-88. 2013
    ....
  18. doi Cardiac electrophysiological effects of nitric oxide
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 87:593-600. 2010
    ....
  19. doi Pitx2c increases in atrial myocytes from chronic atrial fibrillation patients enhancing IKs and decreasing ICa,L
    Marta Pérez-Hernández
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid 28040, Spain Instituto de Investigación Sanitaria Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid 28040, Spain
    Cardiovasc Res 109:431-41. 2016
    ..Recent evidences suggested that Pitx2c, a bicoid-related homeodomain transcription factor involved in directing cardiac asymmetric morphogenesis, could play a role in atrial remodelling. However, its effects on IKs and ICa,L are unknown...
  20. doi Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid 28040, Spain
    Cardiovasc Res 104:337-46. 2014
    ..1 homotetramers (IKir2.1) and thus, exhibit pro- and/or antiarrhythmic effects particularly at the ventricular level. To test this hypothesis, we analysed the effects of propafenone, atenolol, dronedarone, and timolol on Kir2.x channels...
  21. doi Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore
    Irene Amorós
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Biochem Pharmacol 86:267-78. 2013
    ....
  22. doi Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner
    Adriana Barana
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Cardiovasc Res 85:56-67. 2010
    ..5 channels, which generate the ultrarapid delayed rectifier current (I(Kur))...
  23. ncbi Pharmacology of cardiac potassium channels
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 62:9-33. 2004
    ....
  24. ncbi Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels
    Teresa Gonzalez
    Institute of Pharmacology and Toxicology Consejo Superior de Investigaciones Cientificas, School of Medicine, Universidad Complutense, Madrid, Spain
    Mol Pharmacol 62:1456-63. 2002
    ..3 subunit does not modify the affinity of the charged bupivacaine for its external receptor site but markedly reduces the affinity of bupivacaine and quinidine for their internal receptor site in hKv1.5 channels...
  25. doi Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current
    Adriana Barana
    From the Department of Pharmacology A B, M M, P D G, M P H, i A, M N, S S, J T, E D, R C, and Instituto de Investigación Sanitaria Gregorio Marañón A B, M M, P D G, M P H, i A, M N, S S, J T, E D, R C, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain and Cardiology and Cardiovascular Surgery Services, Hospital General Universitario Gregorio Maranon, Madrid, Spain Á P, A P, F F A
    Circ Arrhythm Electrophysiol 7:861-8. 2014
    ....
  26. doi Nitric oxide increases cardiac IK1 by nitrosylation of cysteine 76 of Kir2.1 channels
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Circ Res 105:383-92. 2009
    ..The cardiac inwardly rectifying K(+) current (I(K1)) plays a critical role in modulating excitability by setting the resting membrane potential and shaping phase 3 of the cardiac action potential...
  27. pmc Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels
    Marcos Matamoros
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid 28040, Spain Instituto de Investigación Sanitaria Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid 28040, Spain
    Cardiovasc Res 110:279-90. 2016
    ..5 channels. We have focused on how Nav1.5 and Kir2.x function within a macromolecular complex by elucidating the molecular determinants that govern Nav1.5/Kir2.x reciprocal modulation...
  28. pmc Functional characterization of a novel frameshift mutation in the C-terminus of the Nav1.5 channel underlying a Brugada syndrome with variable expression in a Spanish family
    Pablo Dolz-Gaitón
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain
    PLoS ONE 8:e81493. 2013
    ..Seven relatives also carry the mutation and showed a Brugada syndrome with an incomplete and variable expression. The mutation (p.D1816VfsX7) resulted in a severe truncation (201 residues) of the Nav1.5 C-terminus...
  29. ncbi Lipid-lowering therapy with statins, a new approach to antiarrhythmic therapy
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Pharmacol Ther 114:107-26. 2007
    ....
  30. pmc Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 138:1475-84. 2003
    ..4. These results point to an important role for S6 valines at positions 402 and 404 in mediating voltage-dependent block by quinidine and flecainide...
  31. ncbi Genetically engineered mice as a model for studying cardiac arrhythmias
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid
    Front Biosci 12:22-38. 2007
    ..This article reviews the results of the main genetically modified mice addressing the genesis of cardiac arrhythmias and sudden cardiac death...
  32. ncbi New therapeutic targets for the development of positive inotropic agents
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, 28040, Spain
    Discov Med 12:381-92. 2011
    ..This review describes the mechanism of action and preliminary clinical results obtained with these new investigational positive inotropic agents...
  33. doi Functional effects of a missense mutation in HERG associated with type 2 long QT syndrome
    Irene Amorós
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Heart Rhythm 8:463-70. 2011
    ..Congenital LQTS type 2 (LQT2) is due to loss-of-function mutations in the KCNH2 gene encoding Kv11.1 channels responsible for the rapid component of the delayed rectifier current...
  34. ncbi I(Kur)/Kv1.5 channel blockers for the treatment of atrial fibrillation
    Juan Tamargo
    Universidad Complutense, School of Medicine, Department of Pharmacology, Madrid, Spain
    Expert Opin Investig Drugs 18:399-416. 2009
    ....
  35. pmc Tbx20 controls the expression of the KCNH2 gene and of hERG channels
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, 28040 Madrid, Spain
    Proc Natl Acad Sci U S A . 2017
    ..On the contrary, p.R311C Tbx20 specifically disables the Tbx20 protranscriptional activity over KCNH2 Therefore, TBX20 can be considered a KCNH2-modifying gene...
  36. ncbi Cinaciguat, a soluble guanylate cyclase activator for the potential treatment of acute heart failure
    Juan Tamargo
    Universidad Complutense de Madrid, School of Medicine, Department of Pharmacology, Ciudad Universitaria, 28040 Madrid, Spain
    Curr Opin Investig Drugs 11:1039-47. 2010
    ..Thus, caution should be exerted before extrapolating the present preliminary data to the clinical practice...
  37. ncbi The safety of digoxin as a pharmacological treatment of atrial fibrillation
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Expert Opin Drug Saf 5:453-67. 2006
    ....
  38. doi miR-208b upregulation interferes with calcium handling in HL-1 atrial myocytes: Implications in human chronic atrial fibrillation
    Susana Cañon
    Cardiovascular Development and Repair Department, Spanish National Cardiovascular Research Center CNIC, Madrid, Spain Department of Immunology and Oncology, Centro Nacional de Biotecnologia CNB CSIC, Madrid, Spain
    J Mol Cell Cardiol 99:162-173. 2016
    ..These findings clearly pointed to CAF-specific upregulated miR-208b as an important mediator in Ca2+ handling impairment during atrial remodeling...
  39. ncbi Drug-induced atrial fibrillation: does it matter?
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid 28040, Spain
    Discov Med 14:295-9. 2012
    ..Meanwhile, when a patient presents a new-onset AF, it is recommended to review his/her medical and pharmacological history to identify whether any of the prescribed drugs may be responsible for the episode...
  40. doi Drug-induced atrial fibrillation
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Expert Opin Drug Saf 11:615-34. 2012
    ..A myriad of drugs can induce AF. However, drug-induced AF (DIAF) receives little attention. Thus, this review is an attempt to attract the attention on this adverse effect...
  41. ncbi New drugs for the treatment of hyperkalemia in patients treated with renin-angiotensin-aldosterone system inhibitors -- hype or hope?
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, 28040, Spain
    Discov Med 18:249-54. 2014
    ..We review two new polymer-based, non-systemic agents under clinical development, patiromer calcium and zirconium silicate, designed to increase potassium loss via the gastrointestinal tract for the management of hyperkalemia. ..
  42. doi Cancer chemotherapy and cardiac arrhythmias: a review
    Juan Tamargo
    Department of Pharmacology, School of Medicine, University Complutense, 28040, Madrid, Spain
    Drug Saf 38:129-52. 2015
    ..The final objective is to understand the mechanisms of proarrhythmia and evaluate its real incidence and clinical relevance so as to select the safest and most effective treatment for cancer patients. ..
  43. doi Ranolazine: an antianginal drug with antiarrhythmic properties
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Expert Rev Cardiovasc Ther 9:815-27. 2011
    ..This article reviews the role of the I(NaL) and provides an update on experimental and clinical evidence supporting the efficacy and safety of ranolazine across a broad spectrum of arrhythmias...
  44. pmc Association of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems
    Antonio S Tutor
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Mol Biol Cell 17:4666-74. 2006
    ..Our results suggest that the dynamic association of 14-3-3 proteins to both beta(1)AR and Kv11.1 channels is involved in the adrenergic modulation of this critical regulator of cardiac repolarization and refractoriness...
  45. ncbi The Kv4.2 N-terminal restores fast inactivation and confers KChlP2 modulatory effects on N-terminal-deleted Kv1.4 channels
    Marc Pourrier
    Research Center, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec HIT 1C8, Canada
    Pflugers Arch 449:235-47. 2004
    ..4, indicating the ability of Kvl.4 subunits to display these properties and the sufficiency of the Kv4.2 N-terminal to convey them...
  46. pmc A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?
    Manjula Weerapura
    Research Center, Montreal Heart Institute, Department of Pharmacology and Therapeutics, McGill University, Quebec, Canada
    J Physiol 540:15-27. 2002
    ..These results suggest that the physiological role of MiRP1 may not be to act as an essential consituent of the HERG channel complex carrying native I(Kr)...