Antonio M Estevez

Summary

Country: Spain

Publications

  1. ncbi request reprint The roles of intersubunit interactions in exosome stability
    Antonio M Estevez
    Zentrum fur Molekulare Biologie, Heidelberg Universitat, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    J Biol Chem 278:34943-51. 2003
  2. pmc The RNA-binding protein TbDRBD3 regulates the stability of a specific subset of mRNAs in trypanosomes
    Antonio M Estevez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC Avda del Conocimiento s n, Armilla, 18100 Granada, Spain
    Nucleic Acids Res 36:4573-86. 2008
  3. ncbi request reprint Effects of depletion and overexpression of the Trypanosoma brucei ribonuclease L inhibitor homologue
    Antonio M Estevez
    Zentrum fur Molekulare Biologie, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Mol Biochem Parasitol 133:137-41. 2004
  4. pmc Alterations in DRBD3 ribonucleoprotein complexes in response to stress in Trypanosoma brucei
    Sandra M Fernández-Moya
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Armilla, Granada, Spain
    PLoS ONE 7:e48870. 2012
  5. pmc A short RNA stem-loop is necessary and sufficient for repression of gene expression during early logarithmic phase in trypanosomes
    Sandra M Fernández-Moya
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Parque Tecnológico de Ciencias de la Salud, Avda del Conocimiento, S N, 18016 Armilla, Granada, Spain
    Nucleic Acids Res 42:7201-9. 2014
  6. ncbi request reprint Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide
    Claribel Gallego
    Instituto de Parasitologia y Biomedicina, Lopez Neyra, CSIC Avda del Conocimiento s n Parque Tecnológico de Ciencias de la Salud, 18100 Armilla, Granada, Spain
    Mol Biochem Parasitol 141:191-7. 2005
  7. pmc Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate
    Aurora Ortiz-Gómez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Avda del Conocimiento s n, Parque Tecnologico Ciencias de la Salud, 18100 Armilla, Granada, Spain
    Eukaryot Cell 5:1057-64. 2006
  8. ncbi request reprint The subcellular localisation of trypanosome RRP6 and its association with the exosome
    Simon Haile
    ZMBH, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Mol Biochem Parasitol 151:52-8. 2007
  9. pmc Depletion of the RNA-binding protein RBP33 results in increased expression of silenced RNA polymerase II transcripts in Trypanosoma brucei
    Sandra M Fernández-Moya
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Armilla, Granada, Spain
    PLoS ONE 9:e107608. 2014
  10. doi request reprint Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei
    Victor M Castillo-Acosta
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento, s n 18100 Armilla, Granada, Spain
    Int J Biochem Cell Biol 40:2901-13. 2008

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The roles of intersubunit interactions in exosome stability
    Antonio M Estevez
    Zentrum fur Molekulare Biologie, Heidelberg Universitat, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    J Biol Chem 278:34943-51. 2003
    ..Our results are partially consistent with the proposed model of the exosome, but indicate a different arrangement of the RNase PH proteins...
  2. pmc The RNA-binding protein TbDRBD3 regulates the stability of a specific subset of mRNAs in trypanosomes
    Antonio M Estevez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC Avda del Conocimiento s n, Armilla, 18100 Granada, Spain
    Nucleic Acids Res 36:4573-86. 2008
    ..These observations raise the possibility that TbDRBD3-mRNA complexes act as a post-transcriptional operon, and provide a framework to interpret how trypanosomes regulate gene expression in the absence of transcriptional control...
  3. ncbi request reprint Effects of depletion and overexpression of the Trypanosoma brucei ribonuclease L inhibitor homologue
    Antonio M Estevez
    Zentrum fur Molekulare Biologie, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Mol Biochem Parasitol 133:137-41. 2004
  4. pmc Alterations in DRBD3 ribonucleoprotein complexes in response to stress in Trypanosoma brucei
    Sandra M Fernández-Moya
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Armilla, Granada, Spain
    PLoS ONE 7:e48870. 2012
    ..Our results suggest that DRBD3 transports regulated mRNAs within the cell in the form of ribonucleoprotein complexes that are remodeled in response to environmental cues...
  5. pmc A short RNA stem-loop is necessary and sufficient for repression of gene expression during early logarithmic phase in trypanosomes
    Sandra M Fernández-Moya
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Parque Tecnológico de Ciencias de la Salud, Avda del Conocimiento, S N, 18016 Armilla, Granada, Spain
    Nucleic Acids Res 42:7201-9. 2014
    ....
  6. ncbi request reprint Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide
    Claribel Gallego
    Instituto de Parasitologia y Biomedicina, Lopez Neyra, CSIC Avda del Conocimiento s n Parque Tecnológico de Ciencias de la Salud, 18100 Armilla, Granada, Spain
    Mol Biochem Parasitol 141:191-7. 2005
    ..Moreover, DNA fragmentation caused by MTX was prevented in cells overexpressing APLM. Our results suggest that APLM is a key enzyme in mediating repair of AP sites in these pathogens...
  7. pmc Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate
    Aurora Ortiz-Gómez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Avda del Conocimiento s n, Parque Tecnologico Ciencias de la Salud, 18100 Armilla, Granada, Spain
    Eukaryot Cell 5:1057-64. 2006
    ..The overproduction of protein under different conditions of exposure to risedronate further supports the hypothesis that this enzyme is the main target of aminobisphosphonates in Leishmania cells...
  8. ncbi request reprint The subcellular localisation of trypanosome RRP6 and its association with the exosome
    Simon Haile
    ZMBH, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Mol Biochem Parasitol 151:52-8. 2007
    ..The level of RRP6 was unaffected by depletion of core exosome subunits by RNA interference and over-expression of tagged RRP6 was possible, indicating that RRP6 can be present independent of exosome association...
  9. pmc Depletion of the RNA-binding protein RBP33 results in increased expression of silenced RNA polymerase II transcripts in Trypanosoma brucei
    Sandra M Fernández-Moya
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Armilla, Granada, Spain
    PLoS ONE 9:e107608. 2014
    ..Our work provides the first example of an RNA-binding protein involved in the regulation of gene silencing in trypanosomes. ..
  10. doi request reprint Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei
    Victor M Castillo-Acosta
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento, s n 18100 Armilla, Granada, Spain
    Int J Biochem Cell Biol 40:2901-13. 2008
    ..We conclude that dimeric dUTPases are strongly involved in the control of dUTP incorporation and that adequate levels of enzyme are indispensable for efficient cell cycle progression and DNA replication...
  11. doi request reprint Posttranscriptional control and the role of RNA-binding proteins in gene regulation in trypanosomatid protozoan parasites
    Sandra M Fernández-Moya
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Avenida del Conocimiento, S N, 18100 Armilla, Granada, Spain
    Wiley Interdiscip Rev RNA 1:34-46. 2010
    ..We suggest that trypanosomatids transduce environmental signals into mRNA and protein abundance through posttranslational modification of RBPs...