Diego Franco

Summary

Country: Spain

Publications

  1. ncbi request reprint Multiple transcriptional domains, with distinct left and right components, in the atrial chambers of the developing heart
    D Franco
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 87:984-91. 2000
  2. doi request reprint Analysis of microRNA Microarrays in Cardiogenesis
    Diego Franco
    Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, Edificio B 3, Campus Las Lagunillas, Jaen, 23071, Spain
    Methods Mol Biol 1375:207-21. 2016
  3. pmc Transgenic insights linking pitx2 and atrial arrhythmias
    Diego Franco
    Department of Experimental Biology, University of Jaen Jaen, Spain
    Front Physiol 3:206. 2012
  4. doi request reprint Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis
    Diego Franco
    Department of Experimental Biology B3 362, University of Jaen, Jaén 23071, Spain Electronic address
    Trends Cardiovasc Med 24:23-31. 2014
  5. ncbi request reprint Non-resident stem cell populations in regenerative cardiac medicine
    D Franco
    Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain
    Cell Mol Life Sci 64:683-91. 2007
  6. ncbi request reprint Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart
    Diego Franco
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, 23071 Jaen, Spain
    Dev Biol 294:366-75. 2006
  7. doi request reprint Developmental expression profile of the CXCL12gamma isoform: insights into its tissue-specific role
    Diego Franco
    Department of Experimental Biology, Cardiovascular Development Laboratory, University of Jaen, Jaen, Spain
    Anat Rec (Hoboken) 292:891-901. 2009
  8. doi request reprint Modulation of conductive elements by Pitx2 and their impact on atrial arrhythmogenesis
    Diego Franco
    Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, CU Las Lagunillas B3 362, 23071 Jaen, Spain
    Cardiovasc Res 91:223-31. 2011
  9. ncbi request reprint Molecular diversity of the developing and adult myocardium: implications for tissue targeting
    María del Pilar de Castro
    Department of Experimental Biology, University of Jaen, Spain
    Curr Drug Targets Cardiovasc Haematol Disord 3:227-39. 2003
  10. ncbi request reprint The role of Pitx2 during cardiac development. Linking left-right signaling and congenital heart diseases
    Diego Franco
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    Trends Cardiovasc Med 13:157-63. 2003

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Multiple transcriptional domains, with distinct left and right components, in the atrial chambers of the developing heart
    D Franco
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 87:984-91. 2000
    ..Furthermore, this work will allow the contribution of each of these myocardial components to be studied in congenitally malformed hearts, such as those with abnormal venous return...
  2. doi request reprint Analysis of microRNA Microarrays in Cardiogenesis
    Diego Franco
    Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, Edificio B 3, Campus Las Lagunillas, Jaen, 23071, Spain
    Methods Mol Biol 1375:207-21. 2016
    ..In this chapter, we provide insights into the usage of this uprising technology in the context of cardiac development and disease...
  3. pmc Transgenic insights linking pitx2 and atrial arrhythmias
    Diego Franco
    Department of Experimental Biology, University of Jaen Jaen, Spain
    Front Physiol 3:206. 2012
    ..Since then several transgenic approaches have provided evidences of the role of the homeobox transcription factor PITX2 and atrial arrhythmias. Here, we review new insights into the cellular and molecular links between PITX2 and AF...
  4. doi request reprint Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis
    Diego Franco
    Department of Experimental Biology B3 362, University of Jaen, Jaén 23071, Spain Electronic address
    Trends Cardiovasc Med 24:23-31. 2014
    ..In this review we will revise the role of Pitx2 in the developing heart, starting from the early events of left-right determination followed by its role in cardiac morphogenesis and ending with its role in cardiac arrhythmogenesis. ..
  5. ncbi request reprint Non-resident stem cell populations in regenerative cardiac medicine
    D Franco
    Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain
    Cell Mol Life Sci 64:683-91. 2007
    ..Several constrains should nonetheless be overcome before entering the clinical arena, such as the ability to direct and control the generation of cardiomyocytes into a single myocardial lineage...
  6. ncbi request reprint Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart
    Diego Franco
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, 23071 Jaen, Spain
    Dev Biol 294:366-75. 2006
    ..Examination of the orientation as well as the distribution of labeled cells in clusters provides new insights into the morphogenesis of the septum...
  7. doi request reprint Developmental expression profile of the CXCL12gamma isoform: insights into its tissue-specific role
    Diego Franco
    Department of Experimental Biology, Cardiovascular Development Laboratory, University of Jaen, Jaen, Spain
    Anat Rec (Hoboken) 292:891-901. 2009
    ....
  8. doi request reprint Modulation of conductive elements by Pitx2 and their impact on atrial arrhythmogenesis
    Diego Franco
    Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, CU Las Lagunillas B3 362, 23071 Jaen, Spain
    Cardiovasc Res 91:223-31. 2011
    ..Here, we review new insights into the cellular and molecular links between PITX2 and AF...
  9. ncbi request reprint Molecular diversity of the developing and adult myocardium: implications for tissue targeting
    María del Pilar de Castro
    Department of Experimental Biology, University of Jaen, Spain
    Curr Drug Targets Cardiovasc Haematol Disord 3:227-39. 2003
    ..Thus, these data reveal that the molecular diversity of the myocardium should be taken into account on the design of drug targets as well as on gene and cell therapy approaches...
  10. ncbi request reprint The role of Pitx2 during cardiac development. Linking left-right signaling and congenital heart diseases
    Diego Franco
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    Trends Cardiovasc Med 13:157-63. 2003
    ..These data suggest that altered left-right signaling underlies the etiology of several common congenital cardiac malformations...
  11. ncbi request reprint Species-specific differences of myosin content in the developing cardiac chambers of fish, birds, and mammals
    Diego Franco
    Experimental and Molecular Cardiology Group, Cardiovascular Research Institute Amsterdam, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Anat Rec 268:27-37. 2002
    ..canicula), mouse (M. musculus), rat (R. norvegicus), and chicken (G. gallus)). These observations indicate that in the adult heart of vertebrates the atrial myocardium contains more myosin than the ventricular myocardium...
  12. ncbi request reprint [Regulation of myocardial gene expression during heart development]
    Diego Franco
    Departamento de Biologia Experimental, Area de Biología Celular, Facultad de Ciencias Experimentales, Universidad de Jaen, Spain
    Rev Esp Cardiol 55:167-84. 2002
    ..Therefore, such molecular diversity should be taken into account on the design of future gene therapy approaches, having thus direct clinical implications...
  13. ncbi request reprint Divergent expression of delayed rectifier K(+) channel subunits during mouse heart development
    D Franco
    Experimental Molecular Cardiology Group, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 52:65-75. 2001
    ....
  14. ncbi request reprint MLC3F transgene expression in iv mutant mice reveals the importance of left-right signalling pathways for the acquisition of left and right atrial but not ventricular compartment identity
    D Franco
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Dyn 221:206-15. 2001
    ..These data suggest that molecular specification of left and right atrial but not ventricular chambers is dependent on left-right axial cues...
  15. ncbi request reprint Molecular characterization of the ventricular conduction system in the developing mouse heart: topographical correlation in normal and congenitally malformed hearts
    D Franco
    Department of Experimental Biology, Faculty of Experimental and Health Sciences, University of Jaen, Paraje Las Lagunillas s n, 23071, Jaen, Spain
    Cardiovasc Res 49:417-29. 2001
    ....
  16. doi request reprint PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis
    Ana Chinchilla
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    Circ Cardiovasc Genet 4:269-79. 2011
    ..These studies have independently reported several risk variants close to the PITX2 locus on chromosome 4q25 that are strongly associated with atrial fibrillation in humans...
  17. doi request reprint Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis
    Angel J De La Rosa
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje de Lagunillas, S N, Jaén 23071, Spain
    Cardiovasc Res 98:504-14. 2013
    ....
  18. doi request reprint Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development
    Jorge N Domínguez
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje de las Lagunillas, S N, Jaén 23071, Spain
    Cardiovasc Res 78:45-52. 2008
    ..The aim of this study was to analyse the mRNA expression levels and protein distribution of the cardiac sodium channel Scn5a/Nav1.5 during mouse cardiogenesis...
  19. doi request reprint Pitx2c modulates cardiac-specific transcription factors networks in differentiating cardiomyocytes from murine embryonic stem cells
    Estefanía Lozano-Velasco
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    Cells Tissues Organs 194:349-62. 2011
    ..The aim of this study was to unravel the molecular mechanisms driven by Pitx2 during the process of cardiomyocyte differentiation in vitro in mouse embryonic stem cell-derived cardiomyocytes...
  20. doi request reprint Pitx2c modulates Pax3+/Pax7+ cell populations and regulates Pax3 expression by repressing miR27 expression during myogenesis
    Estefanía Lozano-Velasco
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Spain
    Dev Biol 357:165-78. 2011
    ..Therefore, this study sheds light on previously unknown function of Pitx2c balancing the different myogenic progenitor populations during myogenesis...
  21. doi request reprint MicroRNA profiling during mouse ventricular maturation: a role for miR-27 modulating Mef2c expression
    Ana Chinchilla
    Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain
    Cardiovasc Res 89:98-108. 2011
    ..In this study, we have gained insight from the expression profiles of microRNAs during mouse ventricular development by microarray and qRT-PCR analysis...
  22. doi request reprint Pitx2 impairs calcium handling in a dose-dependent manner by modulating Wnt signalling
    Estefanía Lozano-Velasco
    Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, Jaen, Spain
    Cardiovasc Res 109:55-66. 2016
    ..However, the functional role of these AF GWAS-related genes in AF and their inter-relationship remain elusive...
  23. ncbi request reprint Pitx2c overexpression promotes cell proliferation and arrests differentiation in myoblasts
    Sergio Martínez-Fernández
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    Dev Dyn 235:2930-9. 2006
    ..This study sheds light on previously unknown functions of the Pitx2c isoform in balancing proliferation vs. differentiation in a myogenic cell line...
  24. ncbi request reprint Temporal and spatial expression pattern of beta1 sodium channel subunit during heart development
    Jorge N Domínguez
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Paraje de las Lagunillas, S N, 23071 Jaen, Spain
    Cardiovasc Res 65:842-50. 2005
    ..The aim of this study is to analyze Scn1b mRNA expression levels and protein distribution of Scn1b, a putative modulator of the pore-forming Na(+) channel subunit in the heart, during mouse cardiac development...
  25. ncbi request reprint Protein distribution of Kcnq1, Kcnh2, and Kcne3 potassium channel subunits during mouse embryonic development
    María Pilar de Castro
    Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, Jaen, Spain
    Anat Rec A Discov Mol Cell Evol Biol 288:304-15. 2006
    ....
  26. ncbi request reprint Regulatory mechanisms of cardiac development and repair
    Ana Chinchilla
    Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain
    Cardiovasc Hematol Disord Drug Targets 6:101-12. 2006
    ..Identification of key elements provides important resources to which drugs can be targeted and eventually can result in promising tools to control and expand cardiomyocyte determination...
  27. doi request reprint Expression patterns and immunohistochemical localization of PITX2B transcription factor in the developing mouse heart
    Francisco Hernández-Torres
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Jaen, Spain
    Int J Dev Biol 59:247-54. 2015
    ....
  28. doi request reprint Regulation of SCN5A by microRNAs: miR-219 modulates SCN5A transcript expression and the effects of flecainide intoxication in mice
    Houria Daimi
    Department of Experimental Biology, University of Jaen, Jaen, Spain Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia
    Heart Rhythm 12:1333-42. 2015
    ..Hence, numerous recent studies have focused on the regulatory mechanisms of Nav1.5 biosynthetic and degradation processes as well as its subcellular localization...
  29. ncbi request reprint Regional expression of L-type calcium channel subunits during cardiac development
    Lourdes Acosta
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    Dev Dyn 230:131-6. 2004
    ..These findings suggest that beta subunits might play a major role in conferring calcium handling heterogeneity within the developing embryonic myocardium, while alpha1C subunits might contribute just transiently...
  30. pmc A Pitx2-MicroRNA Pathway Modulates Cell Proliferation in Myoblasts and Skeletal-Muscle Satellite Cells and Promotes Their Commitment to a Myogenic Cell Fate
    Estefanía Lozano-Velasco
    Cardiac and Skeletal Myogenesis Group, Department of Experimental Biology, University of Jaen, Jaen, Spain
    Mol Cell Biol 35:2892-909. 2015
    ..This study reveals unknown functions of several miRNAs in myoblast and satellite cell behavior and thus may have future applications in regenerative medicine. ..
  31. pmc Comparative Analyses of MicroRNA Microarrays during Cardiogenesis: Functional Perspectives
    Fernando Bonet
    Cardiovascular Research Group, Department of Experimental Biology, University of Jaen, Jaén 23071, Spain
    Microarrays (Basel) 2:81-96. 2013
    ....
  32. doi request reprint Identification of regulatory elements directing miR-23a-miR-27a-miR-24-2 transcriptional regulation in response to muscle hypertrophic stimuli
    Francisco Hernández-Torres
    Cardiovascular Research Group, Department of Experimental Biology, University of Jaen, Jaen, Spain
    Biochim Biophys Acta 1839:885-97. 2014
    ..Taking together, our results provide new insights into the regulatory networks driving miR-23a-miR-27a-miR-24-2 cluster expression in cardiac and skeletal muscles. ..
  33. doi request reprint Absence of family history and phenotype-genotype correlation in pediatric Brugada syndrome: more burden to bear in clinical and genetic diagnosis
    Houria Daimi
    Department of Experimental Biology, University of Jaen, 23071, Jaen, Spain
    Pediatr Cardiol 36:1090-6. 2015
    ..Similarly, our study suggests that pediatrician should be encouraged to perform an ECG profiling in suspicious febrile children and quickly manage fever since it is the most important factor unmasking BrS in children...
  34. doi request reprint MiR-23b and miR-199a impair epithelial-to-mesenchymal transition during atrioventricular endocardial cushion formation
    Fernando Bonet
    Cardiovascular Research Group, Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, Jaen, Spain
    Dev Dyn 244:1259-75. 2015
    ..We now analyzed the expression profile of 20 candidate microRNAs in atrial, ventricular, and atrioventricular canal regions at four different developmental stages...
  35. pmc miR-27 and miR-125 Distinctly Regulate Muscle-Enriched Transcription Factors in Cardiac and Skeletal Myocytes
    Estefanía Lozano-Velasco
    Cardiovascular Research Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain
    Biomed Res Int 2015:391306. 2015
    ..Taken together our data demonstrate that a single microRNA, that is, miR-27 or miR-125, can selectively upregulate and downregulate discrete number of target mRNAs in a cell-type specific manner. ..
  36. pmc The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins
    Patricia Rueda
    Departamento de Biologia Experimental, Universidad de Jaen, Jaen, Spain
    PLoS ONE 3:e2543. 2008
    ....
  37. pmc Cardiac conduction system anomalies and sudden cardiac death: insights from murine models
    Amelia Aránega
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen Jaen, Spain
    Front Physiol 3:211. 2012
    ..In this paper, we review a series of studies with murine transgenic models that revealed that some arrhythmias are associated with the CCS and may lead to SCD...
  38. ncbi request reprint Cardiovascular development: toward biomedical applicability
    Marina Campione
    University of Jaen, Spain
    Dev Dyn 235:843-5. 2006
  39. pmc BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
    Hanying Chen
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 131:2219-31. 2004
    ..This may provide an underlying mechanism for understanding the pathogenesis of both structural and functional congenital heart defects...
  40. ncbi request reprint Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha
    Veerle Compernolle
    Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 60:569-79. 2003
    ..We attempted to further characterize the underlying mechanisms resulting in abnormal cardiogenesis and defective angiogenesis in mice deficient for HIF-1alpha (HIF-1alpha(-/-))...
  41. ncbi request reprint Unveiling the transcriptional control of the developing cardiac conduction system
    Diego Franco
    Cardiovasc Res 62:444-6. 2004
  42. ncbi request reprint Predominant fusion of bone marrow-derived cardiomyocytes
    Jacob Andrade
    Institute of Molecular Medicine, University of California San Diego, San Diego, CA, USA
    Cardiovasc Res 68:387-93. 2005
    ..Here we address the capacity of bone marrow-derived cells (BMDCs) to trans-differentiate into mature myocytes under the physiological stimulus of exercise training...
  43. pmc Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth
    Hanying Chen
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Division of Pediatric Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 281:27481-91. 2006
    ..This is the first demonstration that cardiac postnatal hypertrophic growth can be specifically modified genetically and dissected out from physiological and pathological hypertrophies...
  44. ncbi request reprint FGF signalling in the cardiac fields
    Diego Franco
    Cardiovasc Res 71:1-3. 2006